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Volumn 204, Issue 3, 2012, Pages 317-330

Osteocytes: Central conductors of bone biology in normal and pathological conditions

Author keywords

Bone disease; Machanotransduction; Osteocytes

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CALCITRIOL RECEPTOR; COLLAGENASE 3; DENTIN MATRIX PROTEIN 1; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; EXCITATORY AMINO ACID TRANSPORTER 1; FIBROBLAST GROWTH FACTOR 23; GELATINASE A; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; NITRIC OXIDE; OSTEOCALCIN; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; PROSTAGLANDIN E2; SCLEROSTIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; WNT PROTEIN;

EID: 84856552724     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2011.02385.x     Document Type: Review
Times cited : (48)

References (128)
  • 1
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle, H., Bauer, A., Stappert, J., Kispert, A. & Kemler, R. 1997. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J16, 3797-3804.
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 2
    • 68249137198 scopus 로고    scopus 로고
    • Calcium response in single osteocytes to locally applied mechanical stimulus: differences in cell process and cell body
    • Adachi, T., Aonuma, Y., Tanaka, M., Hojo, M., Takano-Yamamoto, T. & Kamioka, H. 2009. Calcium response in single osteocytes to locally applied mechanical stimulus: differences in cell process and cell body. J Biomech42, 1989-1995.
    • (2009) J Biomech , vol.42 , pp. 1989-1995
    • Adachi, T.1    Aonuma, Y.2    Tanaka, M.3    Hojo, M.4    Takano-Yamamoto, T.5    Kamioka, H.6
  • 3
    • 52949134423 scopus 로고    scopus 로고
    • MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM
    • Addison, W.N., Nakano, Y., Loisel, T., Crine, P. & McKee, M.D. 2008. MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res23, 1638-1649.
    • (2008) J Bone Miner Res , vol.23 , pp. 1638-1649
    • Addison, W.N.1    Nakano, Y.2    Loisel, T.3    Crine, P.4    McKee, M.D.5
  • 5
    • 84860390133 scopus 로고    scopus 로고
    • Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro
    • Al-Dujaili, S.A., Lau, E., Al-Dujaili, H., Tsang, K., Guenther, A. & You, L. 2011. Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro. J Cell Biochem112, 2412-2423.
    • (2011) J Cell Biochem , vol.112 , pp. 2412-2423
    • Al-Dujaili, S.A.1    Lau, E.2    Al-Dujaili, H.3    Tsang, K.4    Guenther, A.5    You, L.6
  • 6
    • 33746497177 scopus 로고    scopus 로고
    • Paget's disease of bone
    • Koopman. WJ (ed.), 14th edn. Lippincott Williams Wilkins, Philadelphia.
    • Altman, R.D. 2001. Paget's disease of bone. In: Koopman. WJ (ed.) Arthritis and Allied Conditions, 14th edn. pp. 2514-2527. Lippincott Williams Wilkins, Philadelphia.
    • (2001) Arthritis and Allied Conditions , pp. 2514-2527
    • Altman, R.D.1
  • 7
    • 79954637641 scopus 로고    scopus 로고
    • Sclerostin is a locally acting regulator of late-osteoblast/pre-osteocyte differentiation and regulates mineralization through a MEPE-ASARM dependent mechanism
    • Atkins, G.J., Rowe, P.S., Lim, H.P., Welldon, K.J., Ormsby, R., Wijenayaka, A.R., Zelenchuk, L., Evdokiou, A. & Findlay, D.M. 2011. Sclerostin is a locally acting regulator of late-osteoblast/pre-osteocyte differentiation and regulates mineralization through a MEPE-ASARM dependent mechanism. J Bone Miner Res26, 1425-1436.
    • (2011) J Bone Miner Res , vol.26 , pp. 1425-1436
    • Atkins, G.J.1    Rowe, P.S.2    Lim, H.P.3    Welldon, K.J.4    Ormsby, R.5    Wijenayaka, A.R.6    Zelenchuk, L.7    Evdokiou, A.8    Findlay, D.M.9
  • 11
    • 73849173755 scopus 로고
    • Morphology and inframicroscopic structure of osteocytes
    • Baud, C.A. 1962. Morphology and inframicroscopic structure of osteocytes. Acta Anat (Basel)51, 209-225.
    • (1962) Acta Anat (Basel) , vol.51 , pp. 209-225
    • Baud, C.A.1
  • 12
    • 0034919394 scopus 로고    scopus 로고
    • Colocalization of glucocorticoid and mineralocorticoid receptors in human bone
    • Beavan, S., Horner, A., Bord, S., Ireland, D. & Compston, J. 2001. Colocalization of glucocorticoid and mineralocorticoid receptors in human bone. J Bone Miner Res16, 1496-1504.
    • (2001) J Bone Miner Res , vol.16 , pp. 1496-1504
    • Beavan, S.1    Horner, A.2    Bord, S.3    Ireland, D.4    Compston, J.5
  • 14
    • 0342591802 scopus 로고
    • Resorption without osteoclasts (osteolysis
    • Sognaes.R (ed.). American Association for the Advancement of Science, Washington DC.
    • Belanger, L., Robichin, J., Migicovsky, B., Coop, D. & Vincent, J. 1963. Resorption without osteoclasts (osteolysis). In: Sognaes.R (ed.) Mechanism of Hard Tissue Destruction. pp. 531-556. American Association for the Advancement of Science, Washington DC.
    • (1963) Mechanism of Hard Tissue Destruction , pp. 531-556
    • Belanger, L.1    Robichin, J.2    Migicovsky, B.3    Coop, D.4    Vincent, J.5
  • 17
    • 0023630532 scopus 로고
    • Ultrastructural immunocytochemical localization of endogenous 1,25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria
    • Boivin, G., Mesguich, P., Pike, J.W., Bouillon, R., Meunier, P.J., Haussler, M.R., Dubois, P.M. & Morel, G. 1987. Ultrastructural immunocytochemical localization of endogenous 1, 25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. Bone Miner3, 125-136.
    • (1987) Bone Miner , vol.3 , pp. 125-136
    • Boivin, G.1    Mesguich, P.2    Pike, J.W.3    Bouillon, R.4    Meunier, P.J.5    Haussler, M.R.6    Dubois, P.M.7    Morel, G.8
  • 18
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald, L.F. & Johnson, M.L. 2008. Osteocytes, mechanosensing and Wnt signaling. Bone42, 606-615.
    • (2008) Bone , vol.42 , pp. 606-615
    • Bonewald, L.F.1    Johnson, M.L.2
  • 19
    • 0017149830 scopus 로고
    • Bone changes in hemodialyzed uremic subjects. Comparative light and electron microscope investigations
    • Bonucci, E., Gherardi, G. & Faraggiana, T. 1976. Bone changes in hemodialyzed uremic subjects. Comparative light and electron microscope investigations. Virchows Arch A Pathol Anat Histol371, 183-198.
    • (1976) Virchows Arch A Pathol Anat Histol , vol.371 , pp. 183-198
    • Bonucci, E.1    Gherardi, G.2    Faraggiana, T.3
  • 20
    • 0035010706 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta are differentially expressed in developing human bone
    • Bord, S., Horner, A., Beavan, S. & Compston, J. 2001. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab86, 2309-2314.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2309-2314
    • Bord, S.1    Horner, A.2    Beavan, S.3    Compston, J.4
  • 23
    • 79251544283 scopus 로고    scopus 로고
    • Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis
    • Brennan, O., Kennedy, O.D., Lee, T.C., Rackard, S.M. & O'Brien, F.J. 2011. Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis. J Orthop Res29, 419-424.
    • (2011) J Orthop Res , vol.29 , pp. 419-424
    • Brennan, O.1    Kennedy, O.D.2    Lee, T.C.3    Rackard, S.M.4    O'Brien, F.J.5
  • 24
    • 78249262917 scopus 로고    scopus 로고
    • Decrease in the osteocyte lacunar density accompained by hipermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone
    • Busse, B., Djonic, D., Milovanovic, P., Hahn, M., Püschel, K., Ritchie, R.O., Djuric, M. & Amling, M. 2010. Decrease in the osteocyte lacunar density accompained by hipermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell9, 1065-1075.
    • (2010) Aging Cell , vol.9 , pp. 1065-1075
    • Busse, B.1    Djonic, D.2    Milovanovic, P.3    Hahn, M.4    Püschel, K.5    Ritchie, R.O.6    Djuric, M.7    Amling, M.8
  • 26
    • 0031934350 scopus 로고    scopus 로고
    • Role for parathyroid hormone in mechanical responsiveness of rat bone
    • Chow, J.W., Fox, S., Jagger, C.J. & Chambers, T.J. 1998. Role for parathyroid hormone in mechanical responsiveness of rat bone. Am J Physiol274, E146-E154.
    • (1998) Am J Physiol , vol.274
    • Chow, J.W.1    Fox, S.2    Jagger, C.J.3    Chambers, T.J.4
  • 27
    • 0029395299 scopus 로고
    • A case for bone canaliculi as the anatomical site of strain generated potentials
    • Cowin, S.C., Weinbaum, S. & Zeng, Y. 1995. A case for bone canaliculi as the anatomical site of strain generated potentials. J Biomech28, 1281-1297.
    • (1995) J Biomech , vol.28 , pp. 1281-1297
    • Cowin, S.C.1    Weinbaum, S.2    Zeng, Y.3
  • 30
    • 0025363948 scopus 로고
    • Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption
    • Elmardi, A.S., Katchburian, M.V. & Katchburian, E. 1990. Electron microscopy of developing calvaria reveals images that suggest that osteoclasts engulf and destroy osteocytes during bone resorption. Calcif Tissue Int46, 239-245.
    • (1990) Calcif Tissue Int , vol.46 , pp. 239-245
    • Elmardi, A.S.1    Katchburian, M.V.2    Katchburian, E.3
  • 32
    • 77953516035 scopus 로고    scopus 로고
    • Genetic aspects of the Paget's disease of bone: concerns on the introduction of DNA-based tests in the clinical practice. Advantages and disadvantages of its application
    • Falchetti, A., Marini, F., Masi, L., Amedei, A. & Brandi, M.L. 2010. Genetic aspects of the Paget's disease of bone: concerns on the introduction of DNA-based tests in the clinical practice. Advantages and disadvantages of its application. Eur J Clin Invest40, 655-667.
    • (2010) Eur J Clin Invest , vol.40 , pp. 655-667
    • Falchetti, A.1    Marini, F.2    Masi, L.3    Amedei, A.4    Brandi, M.L.5
  • 33
    • 0842313070 scopus 로고    scopus 로고
    • Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells
    • Fan, X., Roy, E., Zhu, L., Murphy, T.C., Ackert-Bicknell, C., Hart, C.M., Rosen, C., Nanes, M.S. & Rubin, J. 2004. Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology145, 751-759.
    • (2004) Endocrinology , vol.145 , pp. 751-759
    • Fan, X.1    Roy, E.2    Zhu, L.3    Murphy, T.C.4    Ackert-Bicknell, C.5    Hart, C.M.6    Rosen, C.7    Nanes, M.S.8    Rubin, J.9
  • 35
    • 34548497123 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    • MMKD Study Group
    • Fliser, D., Kollerits, B., Neyer, U., Ankerst, D.P., Lhotta, K., Lingenhel, A., Ritz, E., Kronenberg, F., MMKD Study Group, Kuen, E.et al.2007. Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. J Am Soc Nephrol18, 2600-2608.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2600-2608
    • Fliser, D.1    Kollerits, B.2    Neyer, U.3    Ankerst, D.P.4    Lhotta, K.5    Lingenhel, A.6    Ritz, E.7    Kronenberg, F.8    Kuen, E.9
  • 36
    • 79959744312 scopus 로고    scopus 로고
    • Voluntary exercise has long-term in vivo protective effects on osteocyte viability and bone strength following ovariectomy
    • Fonseca, H., Moreira-Gonçalves, D., Esteves, J.L., Viriato, N., Vaz, M., Mota, M.P. & Duarte, J.A. 2011. Voluntary exercise has long-term in vivo protective effects on osteocyte viability and bone strength following ovariectomy. Calcif Tissue Int88, 443-454.
    • (2011) Calcif Tissue Int , vol.88 , pp. 443-454
    • Fonseca, H.1    Moreira-Gonçalves, D.2    Esteves, J.L.3    Viriato, N.4    Vaz, M.5    Mota, M.P.6    Duarte, J.A.7
  • 39
    • 24044540751 scopus 로고    scopus 로고
    • Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption
    • Gu, G., Mulari, M., Peng, Z., Hentunen, T.A. & Väänänen, H.K. 2005. Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption. Biochem Biophys Res Commun335, 1095-1101.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 1095-1101
    • Gu, G.1    Mulari, M.2    Peng, Z.3    Hentunen, T.A.4    Väänänen, H.K.5
  • 40
  • 41
    • 27744545673 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    • Gutierrez, O., Isakova, T., Rhee, E., Shah, A., Holmes, J., Collerone, G., Jüppner, H. & Wolf, M. 2005. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol16, 2205-2215.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2205-2215
    • Gutierrez, O.1    Isakova, T.2    Rhee, E.3    Shah, A.4    Holmes, J.5    Collerone, G.6    Jüppner, H.7    Wolf, M.8
  • 43
    • 1842457814 scopus 로고    scopus 로고
    • Osteoblasts and osteocytes express MMP2 and -8 and TIMP1, -2, and -3 along with extracellular matrix molecules during appositional bone formation
    • Hatori, K., Sasano, Y., Takahashi, I., Kamakura, S., Kagayama, M. & Sasaki, K. 2004. Osteoblasts and osteocytes express MMP2 and -8 and TIMP1, -2, and -3 along with extracellular matrix molecules during appositional bone formation. Anat Rec A Discov Mol Cell Evol Biol277, 262-271.
    • (2004) Anat Rec A Discov Mol Cell Evol Biol , vol.277 , pp. 262-271
    • Hatori, K.1    Sasano, Y.2    Takahashi, I.3    Kamakura, S.4    Kagayama, M.5    Sasaki, K.6
  • 44
    • 26444486391 scopus 로고    scopus 로고
    • Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitation
    • Hino, S., Tanji, C., Nakayama, K.I. & Kikuchi, A. 2005. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitation. Mol Cell Biol25, 9063-9072.
    • (2005) Mol Cell Biol , vol.25 , pp. 9063-9072
    • Hino, S.1    Tanji, C.2    Nakayama, K.I.3    Kikuchi, A.4
  • 45
    • 67649441082 scopus 로고    scopus 로고
    • Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density - is there a role for mechanosensing?
    • van Hove, R.P., Nolte, P.A., Vatsa, A., Semeins, C.M., Salmon, P.L., Smit, T.H. & Klein-Nulend, J. 2009. Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density - is there a role for mechanosensing? Bone 45, 321-329.
    • (2009) Bone , vol.45 , pp. 321-329
    • van Hove, R.P.1    Nolte, P.A.2    Vatsa, A.3    Semeins, C.M.4    Salmon, P.L.5    Smit, T.H.6    Klein-Nulend, J.7
  • 46
    • 0036865272 scopus 로고    scopus 로고
    • The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration
    • Huggett, J.F., Mustafa, A., O'neal, L. & Mason, D.J. 2002. The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration. Biochem Soc Trans30, 890-893.
    • (2002) Biochem Soc Trans , vol.30 , pp. 890-893
    • Huggett, J.F.1    Mustafa, A.2    O'neal, L.3    Mason, D.J.4
  • 47
    • 0029798819 scopus 로고    scopus 로고
    • Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β
    • Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R. & Boyce, B.F. 1996. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β. Nat Med2, 1132-1136.
    • (1996) Nat Med , vol.2 , pp. 1132-1136
    • Hughes, D.E.1    Dai, A.2    Tiffee, J.C.3    Li, H.H.4    Mundy, G.R.5    Boyce, B.F.6
  • 49
    • 2942750269 scopus 로고    scopus 로고
    • Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    • Kalajzic, I., Braut, A., Guo, D., Jiang, X., Kronenberg, M.S., Mina, M., Harris, M.A., Harris, S.E. & Rowe, D.W. 2004. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone35, 74-82.
    • (2004) Bone , vol.35 , pp. 74-82
    • Kalajzic, I.1    Braut, A.2    Guo, D.3    Jiang, X.4    Kronenberg, M.S.5    Mina, M.6    Harris, M.A.7    Harris, S.E.8    Rowe, D.W.9
  • 50
    • 2942715408 scopus 로고    scopus 로고
    • Terminal differentiation of osteoblasts to osteocytes is accompanied by dramatic changes in the distribution of actin-binding proteins
    • Kamioka, H., Sugawara, Y., Honjo, T., Yamashiro, T. & Takano-Yamamoto, T. 2004. Terminal differentiation of osteoblasts to osteocytes is accompanied by dramatic changes in the distribution of actin-binding proteins. J Bone Miner Res19, 471-478.
    • (2004) J Bone Miner Res , vol.19 , pp. 471-478
    • Kamioka, H.1    Sugawara, Y.2    Honjo, T.3    Yamashiro, T.4    Takano-Yamamoto, T.5
  • 51
    • 0035570760 scopus 로고    scopus 로고
    • Differential expression of dentin matrix protein 1, type I collagen and osteocalcin genes in rat developing mandibular bone
    • Kamiya, N. & Takagi, M. 2001. Differential expression of dentin matrix protein 1, type I collagen and osteocalcin genes in rat developing mandibular bone. Histochem J33, 545-552.
    • (2001) Histochem J , vol.33 , pp. 545-552
    • Kamiya, N.1    Takagi, M.2
  • 53
    • 34948866160 scopus 로고    scopus 로고
    • Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism
    • Kawata, T., Imanishi, Y., Kobayashi, K., Miki, T., Arnold, A., Inaba, M. & Nishizawa, Y. 2007. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol18, 2683-2688.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2683-2688
    • Kawata, T.1    Imanishi, Y.2    Kobayashi, K.3    Miki, T.4    Arnold, A.5    Inaba, M.6    Nishizawa, Y.7
  • 54
    • 78649542978 scopus 로고    scopus 로고
    • Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways
    • Kitase, Y., Barragan, L., Qing, H., Kondoh, S., Jiang, J.X., Johnson, M.L. & Bonewald, L.F. 2010. Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. J Bone Miner Res25, 2657-2668.
    • (2010) J Bone Miner Res , vol.25 , pp. 2657-2668
    • Kitase, Y.1    Barragan, L.2    Qing, H.3    Kondoh, S.4    Jiang, J.X.5    Johnson, M.L.6    Bonewald, L.F.7
  • 55
    • 0141630244 scopus 로고    scopus 로고
    • "Whither flows the fluid in bone?" An osteocyte's perspective
    • Knothe Tate, M.L. 2003. "Whither flows the fluid in bone?" An osteocyte's perspective. J Biomech36, 1409-1424.
    • (2003) J Biomech , vol.36 , pp. 1409-1424
    • Knothe Tate, M.L.1
  • 56
    • 49349132105 scopus 로고
    • Effects of parathyroid hormone on osteocytes. Ultrastructural evidence for anisotropic osteolysis and involvement of the cytoskeleton
    • Krempien, B. & Ritz, E. 1978. Effects of parathyroid hormone on osteocytes. Ultrastructural evidence for anisotropic osteolysis and involvement of the cytoskeleton. Metab Bone Dis Relat Res1, 55-65.
    • (1978) Metab Bone Dis Relat Res , vol.1 , pp. 55-65
    • Krempien, B.1    Ritz, E.2
  • 57
    • 78650180083 scopus 로고    scopus 로고
    • Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE
    • Kulkarni, R.N., Bakker, A.D., Everts, V. & Klein-Nulend, J. 2010. Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE. Calcif Tissue Int87, 461-468.
    • (2010) Calcif Tissue Int , vol.87 , pp. 461-468
    • Kulkarni, R.N.1    Bakker, A.D.2    Everts, V.3    Klein-Nulend, J.4
  • 58
    • 33644549962 scopus 로고    scopus 로고
    • Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice
    • Lane, N.E., Yao, W., Balooch, M., Nalla, R.K., Balooch, G., Habelitz, S., Kinney, J.H. & Bonewald, L.F. 2006. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res21, 466-476.
    • (2006) J Bone Miner Res , vol.21 , pp. 466-476
    • Lane, N.E.1    Yao, W.2    Balooch, M.3    Nalla, R.K.4    Balooch, G.5    Habelitz, S.6    Kinney, J.H.7    Bonewald, L.F.8
  • 59
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • Larsson, T., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, O., Tenenhouse, H.S., Jüppner, H. & Jonsson, K.B. 2004. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology145, 3087-3094.
    • (2004) Endocrinology , vol.145 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6    Jüppner, H.7    Jonsson, K.B.8
  • 60
    • 4444314796 scopus 로고    scopus 로고
    • The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
    • Lee, K.C., Jessop, H., Suswillo, R., Zaman, G. & Lanyon, L.E. 2004. The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. J Endocrinol182, 193-201.
    • (2004) J Endocrinol , vol.182 , pp. 193-201
    • Lee, K.C.1    Jessop, H.2    Suswillo, R.3    Zaman, G.4    Lanyon, L.E.5
  • 61
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S.E. & Wu, D. 2005. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem280, 19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4    Liu, P.5    Zhang, J.6    Harris, S.E.7    Wu, D.8
  • 62
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li, X., Ominsky, M.S., Warmington, K.S., Morony, S., Gong, J., Cao, J., Gao, Y., Shalhoub, V., Tipton, B., Haldankar, R.et al.2009. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res24, 578-588.
    • (2009) J Bone Miner Res , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3    Morony, S.4    Gong, J.5    Cao, J.6    Gao, Y.7    Shalhoub, V.8    Tipton, B.9    Haldankar, R.10
  • 64
    • 33947385485 scopus 로고    scopus 로고
    • Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
    • Liu, S., Rowe, P.S., Vierthaler, L., Zhou, J. & Quarles, L.D. 2007. Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. J Endocrinol192, 261-267.
    • (2007) J Endocrinol , vol.192 , pp. 261-267
    • Liu, S.1    Rowe, P.S.2    Vierthaler, L.3    Zhou, J.4    Quarles, L.D.5
  • 65
  • 67
    • 57449105121 scopus 로고    scopus 로고
    • Studies of the DMP1 57-kDa functional domain both in vivo and in vitro
    • Lu, Y., Qin, C., Xie, Y., Bonewald, L.F. & & Feng, J.Q. 2009. Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs189, 175-185.
    • (2009) Cells Tissues Organs , vol.189 , pp. 175-185
    • Lu, Y.1    Qin, C.2    Xie, Y.3    Bonewald, L.F.4    Feng, J.Q.5
  • 69
    • 0032970789 scopus 로고    scopus 로고
    • Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal corticalbone
    • Ma, Y., Jee, W.S., Yuan, Z., Wei, W., Chen, H., Pun, S., Liang, H. & Lin, C. 1999. Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal corticalbone. J Bone Miner Res14, 439-448.
    • (1999) J Bone Miner Res , vol.14 , pp. 439-448
    • Ma, Y.1    Jee, W.S.2    Yuan, Z.3    Wei, W.4    Chen, H.5    Pun, S.6    Liang, H.7    Lin, C.8
  • 70
    • 33846255349 scopus 로고    scopus 로고
    • The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone
    • Mann, V., Huber, C., Kogianni, G., Jones, D. & Noble, B. 2006. The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone. J Musculoskelet Neuronal Interact6, 408-417.
    • (2006) J Musculoskelet Neuronal Interact , vol.6 , pp. 408-417
    • Mann, V.1    Huber, C.2    Kogianni, G.3    Jones, D.4    Noble, B.5
  • 71
    • 0000216815 scopus 로고    scopus 로고
    • Opposite effects of estrogen on the life span of osteoblasts/osteocytes vs. osteoclasts in vivo and in vitro: an explanation of the imbalance between formation and resorption in estrogen deficiency
    • Manolagas, S.C., Weinstein, R.S., Bellido, T. & Bodenner, D.L. 1999. Opposite effects of estrogen on the life span of osteoblasts/osteocytes vs. osteoclasts in vivo and in vitro: an explanation of the imbalance between formation and resorption in estrogen deficiency. J Bone Miner Res14, S169.
    • (1999) J Bone Miner Res , vol.14
    • Manolagas, S.C.1    Weinstein, R.S.2    Bellido, T.3    Bodenner, D.L.4
  • 72
    • 0017078687 scopus 로고
    • Number, size and arrangement of osteoblasts in osteons at different stages of formation
    • Marotti, G., Zallone, A.Z. & Ledda, M. 1976. Number, size and arrangement of osteoblasts in osteons at different stages of formation. Calcif Tissue Res21(Suppl), 96-101.
    • (1976) Calcif Tissue Res , vol.21 , Issue.SUPPL. , pp. 96-101
    • Marotti, G.1    Zallone, A.Z.2    Ledda, M.3
  • 73
    • 0030948207 scopus 로고    scopus 로고
    • Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents?
    • Mason, D.J., Suva, L.J., Genever, P.G., Patton, A.J., Steuckle, S., Hillam, R.A. & Skerry, T.M. 1997. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents? Bone 20, 199-205.
    • (1997) Bone , vol.20 , pp. 199-205
    • Mason, D.J.1    Suva, L.J.2    Genever, P.G.3    Patton, A.J.4    Steuckle, S.5    Hillam, R.A.6    Skerry, T.M.7
  • 75
    • 0021995537 scopus 로고
    • The role of osteocytes in bone resorption during lactation: morphometric observations
    • Mercer, R.R. & Crenshaw, M.A. 1985. The role of osteocytes in bone resorption during lactation: morphometric observations. Bone6, 269-274.
    • (1985) Bone , vol.6 , pp. 269-274
    • Mercer, R.R.1    Crenshaw, M.A.2
  • 76
    • 77951644377 scopus 로고    scopus 로고
    • Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women
    • Mirza, F.S., Padhi, I.D., Raisz, L.G. & Lorenzo, J.A. 2010. Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women. J Clin Endocrinol Metab95, 1991-1997.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1991-1997
    • Mirza, F.S.1    Padhi, I.D.2    Raisz, L.G.3    Lorenzo, J.A.4
  • 77
    • 0022506089 scopus 로고
    • Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes
    • Murray, A.B., Schmidt, J. & Rieke, L. 1986. Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes. Am J Pathol124, 319-323.
    • (1986) Am J Pathol , vol.124 , pp. 319-323
    • Murray, A.B.1    Schmidt, J.2    Rieke, L.3
  • 78
    • 0942278947 scopus 로고    scopus 로고
    • Immunolocalization of matrix etalloproteinase-13 on bone surface under osteoclasts in rat tibia
    • Nakamura, H., Sato, G., Hirata, A. & Yamamoto, T. 2004. Immunolocalization of matrix etalloproteinase-13 on bone surface under osteoclasts in rat tibia. Bone34, 48-56.
    • (2004) Bone , vol.34 , pp. 48-56
    • Nakamura, H.1    Sato, G.2    Hirata, A.3    Yamamoto, T.4
  • 79
    • 8744310726 scopus 로고    scopus 로고
    • Eccentric localization of osteocytes expressing enzymatic activities, protein, and mRNA signals for type 5 tartrate-resistant acid phosphatase (TRAP)
    • Nakano, Y., Toyosawa, S. & Takano, Y. 2004. Eccentric localization of osteocytes expressing enzymatic activities, protein, and mRNA signals for type 5 tartrate-resistant acid phosphatase (TRAP). J Histochem Cytochem52, 1475-1482.
    • (2004) J Histochem Cytochem , vol.52 , pp. 1475-1482
    • Nakano, Y.1    Toyosawa, S.2    Takano, Y.3
  • 82
    • 1642546419 scopus 로고    scopus 로고
    • Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength
    • O'Brien, C.A., Jia, D., Plotkin, L.I., Bellido, T., Powers, C.C., Stewart, S.A., Manolagas, S.C. & Weinstein, R.S. 2004. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology145, 1835-1841.
    • (2004) Endocrinology , vol.145 , pp. 1835-1841
    • O'Brien, C.A.1    Jia, D.2    Plotkin, L.I.3    Bellido, T.4    Powers, C.C.5    Stewart, S.A.6    Manolagas, S.C.7    Weinstein, R.S.8
  • 84
    • 37849046926 scopus 로고    scopus 로고
    • A unified theory for osteonal and hemi-osteonal remodeling
    • van Oers, R.F., Ruimerman, R., Tanck, E., Hilbers, P.A. & Huiskes, R. 2008. A unified theory for osteonal and hemi-osteonal remodeling. Bone42, 250-259.
    • (2008) Bone , vol.42 , pp. 250-259
    • van Oers, R.F.1    Ruimerman, R.2    Tanck, E.3    Hilbers, P.A.4    Huiskes, R.5
  • 85
    • 0025874934 scopus 로고
    • Immunoelectron microscopic demonstration of estrogen receptors in osteogenic cells of Japanese quail
    • Ohashi, T., Kusuhara, S. & Ishida, K. 1991. Immunoelectron microscopic demonstration of estrogen receptors in osteogenic cells of Japanese quail. Histochemistry96, 41-44.
    • (1991) Histochemistry , vol.96 , pp. 41-44
    • Ohashi, T.1    Kusuhara, S.2    Ishida, K.3
  • 86
    • 0022496620 scopus 로고
    • A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos
    • Palumbo, C. 1986. A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos. Cell Tissue Res246, 125-131.
    • (1986) Cell Tissue Res , vol.246 , pp. 125-131
    • Palumbo, C.1
  • 87
    • 0017642753 scopus 로고
    • The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption - bone flow theory
    • Parfitt, A.M. 1977. The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption - bone flow theory. Clin Orthop Relat Res127, 236-247.
    • (1977) Clin Orthop Relat Res , vol.127 , pp. 236-247
    • Parfitt, A.M.1
  • 88
    • 0030039250 scopus 로고    scopus 로고
    • A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates
    • Parfitt, A.M., Mundy, G.R., Roodman, G.D., Hughes, D.E. & Boyce, B.F. 1996. A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res11, 150-159.
    • (1996) J Bone Miner Res , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.F.5
  • 91
    • 79953701946 scopus 로고    scopus 로고
    • Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses
    • Powell, W.F. Jr, Barry, K.J., Tulum, I., Kobayashi, T., Harris, S.E., Bringhurst, F.R. & Pajevic, P.D. 2011. Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. J Endocrinol209, 21-32.
    • (2011) J Endocrinol , vol.209 , pp. 21-32
    • Powell Jr., W.F.1    Barry, K.J.2    Tulum, I.3    Kobayashi, T.4    Harris, S.E.5    Bringhurst, F.R.6    Pajevic, P.D.7
  • 92
    • 77955301116 scopus 로고    scopus 로고
    • Osteocyte remodeling of the perilacunar and pericanalicular matrix
    • Qing, H. & Bonewald, L.F. 2009b. Osteocyte remodeling of the perilacunar and pericanalicular matrix. Int J Oral Sci1, 59-65.
    • (2009) Int J Oral Sci , vol.1 , pp. 59-65
    • Qing, H.1    Bonewald, L.F.2
  • 93
    • 79251469023 scopus 로고    scopus 로고
    • Osteocyte Perilacunar Remodeling Is Regulated Hormonally, but Not by Mechanical Unloading
    • Qing, H., Ardeshirpour, L., Dusevich, V., Wysolmerski, J. & Bonewald, L.F. 2009a. Osteocyte Perilacunar Remodeling Is Regulated Hormonally, but Not by Mechanical Unloading. J Bone Miner Res (Suppl 1), MO0255.
    • (2009) J Bone Miner Res , Issue.SUPPL. 1
    • Qing, H.1    Ardeshirpour, L.2    Dusevich, V.3    Wysolmerski, J.4    Bonewald, L.F.5
  • 94
    • 77952584430 scopus 로고    scopus 로고
    • Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow
    • Rath, A.L., Bonewald, L.F., Ling, J., Jiang, J.X., Van Dyke, M.E. & Nicolella, D.P. 2010. Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. J Biomech43, 1560-1564.
    • (2010) J Biomech , vol.43 , pp. 1560-1564
    • Rath, A.L.1    Bonewald, L.F.2    Ling, J.3    Jiang, J.X.4    Van Dyke, M.E.5    Nicolella, D.P.6
  • 96
    • 80052303008 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
    • Rhee, Y., Bivi, N., Farrow, E., Lezcano, V., Plotkin, L.I., White, K.E. & Bellido, T. 2011b. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone49, 636-643.
    • (2011) Bone , vol.49 , pp. 636-643
    • Rhee, Y.1    Bivi, N.2    Farrow, E.3    Lezcano, V.4    Plotkin, L.I.5    White, K.E.6    Bellido, T.7
  • 98
    • 77956461991 scopus 로고    scopus 로고
    • Osteocyte: the unrecognized side of bone tissue
    • Rochefort, G.Y., Pallu, S. & Benhamou, C.L. 2010. Osteocyte: the unrecognized side of bone tissue. Osteoporos Int21, 1457-1469.
    • (2010) Osteoporos Int , vol.21 , pp. 1457-1469
    • Rochefort, G.Y.1    Pallu, S.2    Benhamou, C.L.3
  • 99
    • 12344250943 scopus 로고    scopus 로고
    • Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)
    • Rowe, P.S., Garrett, I.R., Schwarz, P.M., Carnes, D.L., Lafer, E.M., Mundym, G.R. & Gutierrez, G.E. 2005. Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). Bone36, 33-46.
    • (2005) Bone , vol.36 , pp. 33-46
    • Rowe, P.S.1    Garrett, I.R.2    Schwarz, P.M.3    Carnes, D.L.4    Lafer, E.M.5    Mundym, G.R.6    Gutierrez, G.E.7
  • 101
    • 0036180530 scopus 로고    scopus 로고
    • Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb
    • Sasano, Y., Zhu, J.X., Tsubota, M., Takahashi, I., Onodera, K., Mizoguchi, I. & Kagayama, M. 2002. Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb. J Histochem Cytochem50, 325-332.
    • (2002) J Histochem Cytochem , vol.50 , pp. 325-332
    • Sasano, Y.1    Zhu, J.X.2    Tsubota, M.3    Takahashi, I.4    Onodera, K.5    Mizoguchi, I.6    Kagayama, M.7
  • 102
    • 18444375871 scopus 로고    scopus 로고
    • Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo
    • Shimada, T., Muto, T., Urakawa, I., Yoneya, T., Yamazaki, Y., Okawa, K., Takeuchi, Y., Fujita, T., Fukumoto, S. & Yamashita, T. 2002. Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. Endocrinology143, 3179-3182.
    • (2002) Endocrinology , vol.143 , pp. 3179-3182
    • Shimada, T.1    Muto, T.2    Urakawa, I.3    Yoneya, T.4    Yamazaki, Y.5    Okawa, K.6    Takeuchi, Y.7    Fujita, T.8    Fukumoto, S.9    Yamashita, T.10
  • 105
    • 0022644440 scopus 로고
    • Parathyroid hormone stimulates phosphate efflux through an apparently adenosine 3′,5′-monophosphate-independent process in rat parotid cell aggregates
    • Shiraki, M., Gee, M.V., Baum, B.J. & Roth, G.S. 1986. Parathyroid hormone stimulates phosphate efflux through an apparently adenosine 3′, 5′-monophosphate-independent process in rat parotid cell aggregates. Endocrinology118, 2009-2015.
    • (1986) Endocrinology , vol.118 , pp. 2009-2015
    • Shiraki, M.1    Gee, M.V.2    Baum, B.J.3    Roth, G.S.4
  • 108
    • 18144374198 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy
    • Sugawara, Y., Kamioka, H., Honjo, T., Tezuka, K. & Takano-Yamamoto, T. 2005. Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy. Bone36, 877-883.
    • (2005) Bone , vol.36 , pp. 877-883
    • Sugawara, Y.1    Kamioka, H.2    Honjo, T.3    Tezuka, K.4    Takano-Yamamoto, T.5
  • 109
    • 34250296228 scopus 로고
    • An interpretation of acute changes in plasma 45Ca following parathyroid hormone administration to thyroparathyroidectomized rats
    • Talmage, R.V., Doppelt, S.H. & Fondren, F.B. 1976. An interpretation of acute changes in plasma 45Ca following parathyroid hormone administration to thyroparathyroidectomized rats. Calcif Tissue Res22, 117-128.
    • (1976) Calcif Tissue Res , vol.22 , pp. 117-128
    • Talmage, R.V.1    Doppelt, S.H.2    Fondren, F.B.3
  • 111
    • 0031668242 scopus 로고    scopus 로고
    • Osteocyte shape is dependent on actin filaments and osteocyte processes are unique actin-rich projections
    • Tanaka-Kamioka, K., Kamioka, H., Ris, H. & Lim, S.S. 1998. Osteocyte shape is dependent on actin filaments and osteocyte processes are unique actin-rich projections. J Bone Miner Res13, 1555-1568.
    • (1998) J Bone Miner Res , vol.13 , pp. 1555-1568
    • Tanaka-Kamioka, K.1    Kamioka, H.2    Ris, H.3    Lim, S.S.4
  • 113
    • 8744256394 scopus 로고    scopus 로고
    • Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
    • Tazawa, K., Hoshi, K., Kawamoto, S., Tanaka, M., Ejiri, S. & Ozawa, H. 2004. Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. J Bone Miner Metab22, 524-529.
    • (2004) J Bone Miner Metab , vol.22 , pp. 524-529
    • Tazawa, K.1    Hoshi, K.2    Kawamoto, S.3    Tanaka, M.4    Ejiri, S.5    Ozawa, H.6
  • 114
    • 0030884639 scopus 로고    scopus 로고
    • The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
    • Tomkinson, A., Reeve, J., Shaw, R.W. & Noble, B.S. 1997. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. J Clin Endocrinol Metab82, 3128-3135.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3128-3135
    • Tomkinson, A.1    Reeve, J.2    Shaw, R.W.3    Noble, B.S.4
  • 116
    • 0034773406 scopus 로고    scopus 로고
    • Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts
    • Toyosawa, S., Shintani, S., Fujiwara, T., Ooshima, T., Sato, A., Ijuhin, N. & Komori, T. 2001. Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. J Bone Miner Res16, 2017-2026.
    • (2001) J Bone Miner Res , vol.16 , pp. 2017-2026
    • Toyosawa, S.1    Shintani, S.2    Fujiwara, T.3    Ooshima, T.4    Sato, A.5    Ijuhin, N.6    Komori, T.7
  • 117
    • 0029940159 scopus 로고    scopus 로고
    • Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats
    • Turner, C.H., Takano, Y., Owan, I. & Murrell, G.A. 1996. Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am J Physiol270, E634-E639.
    • (1996) Am J Physiol , vol.270
    • Turner, C.H.1    Takano, Y.2    Owan, I.3    Murrell, G.A.4
  • 118
    • 49149090893 scopus 로고    scopus 로고
    • Osteocyte morphology in fibula and calvaria - is there a role for mechanosensing?
    • Vatsa, A., Breuls, R.G., Semeins, C.M., Salmon, P.L., Smit, T.H. & Klein-Nulend, J. 2008. Osteocyte morphology in fibula and calvaria - is there a role for mechanosensing? Bone 43, 452-458.
    • (2008) Bone , vol.43 , pp. 452-458
    • Vatsa, A.1    Breuls, R.G.2    Semeins, C.M.3    Salmon, P.L.4    Smit, T.H.5    Klein-Nulend, J.6
  • 120
    • 77954505723 scopus 로고    scopus 로고
    • Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice
    • Weinstein, R.S., Jilka, R.L., Almeida, M., Roberson, P.K. & Manolagas, S.C. 2010. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology151, 2641-2649.
    • (2010) Endocrinology , vol.151 , pp. 2641-2649
    • Weinstein, R.S.1    Jilka, R.L.2    Almeida, M.3    Roberson, P.K.4    Manolagas, S.C.5
  • 122
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf, J.J., Kahler, R.A. & Schroeder, T.N. 2004. Wnt signaling in osteoblasts and bone diseases. Gene341, 19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.N.3
  • 125
    • 77955625789 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro
    • Yamamoto, R., Minamizaki, T., Yoshiko, Y., Yoshioka, H., Tanne, K., Aubin, J.E. & Maeda, N. 2010. 1alpha, 25-dihydroxyvitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro. J Endocrinol206, 279-286.
    • (2010) J Endocrinol , vol.206 , pp. 279-286
    • Yamamoto, R.1    Minamizaki, T.2    Yoshiko, Y.3    Yoshioka, H.4    Tanne, K.5    Aubin, J.E.6    Maeda, N.7
  • 126
  • 127
    • 0033804637 scopus 로고    scopus 로고
    • Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading induced oscillating fluid flow
    • You, J., Yellowley, C.E., Donahue, H.J., Zhang, Y., Chen, Q. & Jacobs, C.R. 2000. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading induced oscillating fluid flow. J Biomech Eng122, 387-393.
    • (2000) J Biomech Eng , vol.122 , pp. 387-393
    • You, J.1    Yellowley, C.E.2    Donahue, H.J.3    Zhang, Y.4    Chen, Q.5    Jacobs, C.R.6
  • 128
    • 20444404265 scopus 로고    scopus 로고
    • Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations
    • Yu, X., Sabbagh, Y., Davis, S.I., Demay, M.B. & White, K.E. 2005. Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. Bone36, 971-977.
    • (2005) Bone , vol.36 , pp. 971-977
    • Yu, X.1    Sabbagh, Y.2    Davis, S.I.3    Demay, M.B.4    White, K.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.