Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 4 33-4, 1996, Pages

  Turner, Charles H ^a   Takano, Yuichi ^b   Owan, Ichiro ^b   Murrell, George A C ^b  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

bone density; free radical; mechanotransduction; N( ) nitro L arginine methyl ester; nitric oxide synthase; osteoblasts

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIBIA;

EID: 0029940159     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.4.e634     Document Type: Article

References (34)

1. Akhter, M. P., D. M. Raab, C. H. Turner, D. B. Kimmel, and R. R. Recker. Characterization of in vivo strain in the rat tibia during external application of four-point bending load. J. Biomechanics 25: 1241-1246, 1992.
2. Arnal, J.-F., L. Warin, and J.-B. Michel. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 90: 647-652, 1992.
3. Brandi, M. L., M. Hukkanen, T. Umeda, N. Moradi-Bidhendi, S. Bianchi, S. S. Gross, J. M. Polak, and I. Macintyre. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc. Natl. Acad. Sci. USA 92: 2954-2958, 1995.
4. Chow, J. W. M., and T. J. Chambers. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E287-E292, 1994.
5. Chow, J. W. M., C. J. Jagger, and T. J. Chambers. Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae. Am. J. Physiol. 265 (Endocrinol. Metab. 28): B340-E347, 1993.
6. Damoulis, P. K., and P. V. Hauschka. Cytokines induce nitric oxide production in mouse osteoblasts. Biochem. Biophys. Res. Commun. 201: 924-931, 1994.
7. Forwood, M. R., and C. H. Turner. Response of rat tibiae to incremental loading: a quantum concept for bone formation. Bone 15: 603-609, 1994.
8. Frangos, J. A., and D. Johnson. Flow stimulates rapid and continuous release of nitric oxide in osteoblasts (Abstract). FASEB J. 9: A673, 1995.
9. Garthwaite, J., S. L. Charles, and R. Chess-Williams. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature Lond. 336: 385-388, 1988.
10. Ignarro, L. J., G. M. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84: 9265-9269, 1987.
11. Jagger, C. J., T. J. Chambers, and J. W. M. Chow. Stimulation of bone formation by dynamic mechanical loading of rat caudal vertebrae is not suppressed by 3-amino-1-hydroxypropyldene-1-bisphosphonate (AHPrBP). Bone 16: 309-313, 1995.
12. Kasten, T. P., P. Collin-Osdoby, N. Patel, P. Osdoby, M. Krukowski, T. P. Misko, S. L. Settle, M. G. Currie, and G. A. Nickols. Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc. Natl. Acad. Sci. USA 91: 3569-3573, 1994.
13. Klein-Nulend, J., A. van der Plas, C. M. Semeins, N. E. Ajubi, J. A. Frangos, P. J. Nijweide, and E. H. Berger. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. 9: 441-445, 1995.
14. Knowles, R. G., and S. Moncada. Nitric oxide synthases in mammals. Biochem. J. 298: 249-258, 1994.
15. Lean, J. M., C. J. Jagger, T. J. Chambers, and J. W. M. Chow. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E318-E327, 1995.
16. Lowik, C. W. G. M., P. H. Nibbering, M. van de Ruit, and S. E. Papapoulos. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J. Clin. Invest. 93: 1465-1472, 1994.
17. MacIntyre, I., M. Zaidi, A. S. M. T. Alam, H. K. Datta, B. S. Moonga, P. S. Lidbury, M. Hecker, and J. R. Vane. Osteoclas-tic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc. Natl. Acad. Sci. USA 88: 2936-2940, 1991.
18. Marietta, M. A., P. S. Yoon, R. Iyengar, C. D. Leaf, and J. S. Wishnok. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 27: 8706-8711, 1988.
19. Mattson, D. L., S. Lu, K. Nakanishi, P. E. Papanek, and A. W. Cowley, Jr. Effect of chronic renal medullary nitric oxide inhibition on blood pressure. Am. J. Physiol. 266 (Heart Circ. Physiol. 35). H1918-H1926, 1994.
20. Nerem, R. M., D. B. Harrison, W. R. Taylor, and R. W. Alexander. Hemodynamics and vascular endothelial biology. J. Cardiovasc. Pharm. 21: S6-S10, 1993.
21. Palmer, R. M. J., D. S. Ashton, and S. Moncada. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature Lond. 333: 664-666, 1988.
22. Palmer, R. M. J., A. G. Ferrige, and S. Moncada. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature Lond. 327: 524-526, 1987.
23. Ralston, S. H., D. Todd, M. Helfrich, N. Benjamin, and P. S. Grabowski. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330-336, 1994.
24. Rawlinson, S. C. F., A. J. El-Haj, S. L. Minter, I. A. Tavares, A. Bennett, and L. E. Lanyon. Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J. Bone Miner. Res. 6: 1345-1351, 1991.
25. Recker, R. R. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: CRC, 1983.
26. 2 and inositol trisphosphate levels in ostcoblasts. Am. J. Physiol. 261 (Cell Physiol. 30): C428-C432, 1991.
27. Riancho, J. A., E. Salas, M. T. Zarrabeitia, J. M. Olmos, J. A. Amado, J. L. Fernández-Luna, and J. González-Macías. Expression and functional role of nitric oxide synthase in osteoblast-like cells. J. Bone Miner. Res. 10: 439-446, 1995.
28. Rubin, C. T., and L. E. Lanyon. Regulation of bone mass by mechanical strain magnitude. Calcif. Tissue Int. 37: 411-417, 1985.
29. Skerry, T. M., L. Bitensky, J. Chayen, and L. E. Lanyon. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo. J. Bone Miner. Res. 4: 783-788, 1989.
30. Turner, C. H., M. P. Akhter, D. M. Raab, D. B. Kimmel, and R. R. Recker. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone 12: 73-79, 1991.
31. Turner, C. H., M. R. Forwood, and M. W. Otter. Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J. 8: 875-878, 1994.
32. Turner, C. H., M. R. Forwood, J.-Y. Rho, and T. Yoshikawa. Mechanical loading thresholds for lamellar and woven bone formation. J. Bone Miner. Res. 9: 87-97, 1994.
33. Gnitro-arginine in conscious rats are antagonized by L- but not D-arginine. Eur. J. Pharmacol. 200: 77-81, 1991.
34. Weinbaum, S., S. C. Cowin, and Y. Zeng. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomechanics 27: 339-360, 1994.