Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity

Diabetes Care

Volumn 34, Issue 2, 2011, Pages 437-441

  Anderwald, Christian ^a,b   Tura, Andrea ^a   Grassi, Angela ^a   Krebs, Michael ^b   Szendroedi, Julia ^c   Roden, Michael ^c   Bischof, Martin G ^b,d   Luger, Anton ^b   Pacini, Giovanni ^a  

^a CNR   (Italy)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d ELISABETHINEN HOSPITAL   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINEMIA; INSULIN INFUSION; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS;

EID: 79951705213     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-1137     Document Type: Article

References (25)

1. Mari A, Tura A, Pacini G, Kautzky-Willer A, Ferrannini E. Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes. Diabet Med 2008;25:671-677 (Pubitemid 351782827)
2. Liu S, Okada T, Assmann A, et al. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS ONE 2009; 4:e7983
3. Anderwald C. Novel aspects on insulin resistance. A quick overview. Endocrinologist 2009;19:302-305
4. Kraegen EW, Lazarus L, Campbell LV. Failure of insulin infusion during euglycemia to influence endogenous basal insulin secretion. Metabolism 1983;32:622-627 (Pubitemid 13099168)
5. Zilker T, Paterek K, Ermler R, Bottermann P. (Studies on the question of a possible autoregulation of insulin secretion [author's translation]). Klin Wochenschr 1977;55: 475-479
6. Shima K, Morishta S, Sawazaki N, Tanaka R, Tarui S. Failure of exogenous insulin to inhibit insulin secretion in man. Horm Metab Res 1977;9:441-443 (Pubitemid 8247972)
7. DeFronzo RA, Binder C,Wahren J, Felig P, Ferrannini E, Faber OK. Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia. Acta Endocrinol (Copenh) 1981;98:81-86 (Pubitemid 11023925)
8. Waldhäusl WK, Gasić S, Bratusch-Marrain P, Korn A, Nowotny P. Feedback inhibition by biosynthetic human insulin of insulin release in healthy human subjects. Am J Physiol 1982;243: E476-E482 (Pubitemid 13166230)
9. Garvey WT, Revers RR, Kolterman OG, Rubenstein AH, Olefsky JM. Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus. J Clin Endocrinol Metab 1985;60:559-568 (Pubitemid 15133861)
10. Argoud GM, Schade DS, Eaton RP. Insulin suppresses its own secretion in vivo. Diabetes 1987;36:959-962 (Pubitemid 17136810)
11. Bouche C, Lopez X, Fleischman A, et al. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A 2010;107:4770-4775
12. Szendroedi J, Anderwald C, Krssak M, et al. Effects of high-dose simvastatin therapy on glucose metabolism and ectopic lipid deposition in nonobese type 2 diabetic patients. Diabetes Care 2009;32:209-214
13. Anderwald C, Pfeiler G, Nowotny P, et al. Glucose turnover and intima media thickness of internal carotid artery in type 2 diabetes offspring. Eur J Clin Invest 2008; 38:227-237 (Pubitemid 351389138)
14. Anderwald C, Anderwald-Stadler M, Promintzer M, et al. The Clamp-Like Index: a novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance tests in nondiabetic subjects. Diabetes Care 2007;30: 2374-2380 (Pubitemid 47359049)
15. Anderwald-Stadler M, Krebs M, Promintzer M, et al. Plasma obestatin is lower at fasting and not suppressed by insulin in insulinresistant humans. Am J Physiol Endocrinol Metab 2007;293:E1393-E1398 (Pubitemid 350106609)
16. Anderwald C, Stadler M, Golay A, Krebs M, Petrie J, Luger A; RISC Investigators. Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults. Heart 2010;96:1191-1200
17. Stadler M, Pacini G, Petrie J, Luger A, Anderwald C; RISC Investigators. Beta cell (dys)function in non-diabetic offspring of diabetic patients. Diabetologia 2009;52: 2435-2444
18. Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 1992;41: 368-377
19. Veldhuis JD, Keenan DM, Pincus SM. Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 2008;29:823-864
20. Mari A, Ahrén B, Pacini G. Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care 2005;8:529-533 (Pubitemid 41192329)
21. Tura A, Ludvik B, Nolan JJ, Pacini G, Thomaseth K. Insulin and C-peptide secretion and kinetics in humans: direct and model-based measurements during OGTT. Am J Physiol Endocrinol Metab 2001;281:E966-E974
22. Kulkarni RN, Almind K, Goren HJ, et al. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 2003;52:1528-1534 (Pubitemid 36666210)
23. Kulkarni RN, Winnay JN, Daniels M, et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999;104: R69-R75 (Pubitemid 30053195)
24. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999;96:329-339 (Pubitemid 29077587)
25. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318-368