Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Volumn 17, Issue 10, 2003, Pages 1340-1342

  Hribal, Marta L ^a   Perego, Lucia ^a   Lovari, Sarah ^a   Andreozzi, Francesco ^a   Menghini, Rossella ^a   Perego, Carla ^a   Finzi, Giovanna ^a   Usellini, Luciana ^a   Placidi, Claudia ^a   Capella, Carlo ^a   Guzzi, Valeria ^a   Lauro, Davide ^a   Bertuzzi, Federico ^a   Davalli, Alberto ^a   Pozza, Guido ^a   Pontiroli, Antonio ^a   Federici, Massimo ^a   Lauro, Renato ^a   Brunetti, Antonio ^a   Folli, Franco ^a   Sesti, Giorgio ^a   more..

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN, HUMAN; CARRIER PROTEIN; EIF4EBP1 PROTEIN, HUMAN; GLUCOSE; HIGH MOBILITY GROUP A1A PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; ISOPROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; S6 KINASE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PANCREAS; PANCREAS ISLET; RNA SPLICING; SECRETION; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; CELL LINE; GLUCOSE; HMGA1A PROTEIN; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; PANCREAS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

MLCS; MLOWN;

EID: 0037590155     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.02-0685fje     Document Type: Article

References (0)