Adducin polymorphism affects renal proximal tubule reabsorption in hypertension

Hypertension

Volumn 33, Issue 2, 1999, Pages 694-697

  Manunta, Paolo ^a,c   Burnier, Michel ^b   D'Amico, Marco ^a   Buzzi, Laura ^a   Maillard, Marc ^b   Barlassina, Cristina ^a   Lanella, Giovanna ^a   Cusi, Daniele ^a   Bianchi, Giuseppe ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Adducin; Blood pressure; Genes; Genetic; Human; Hypertension; Lithium; Renal function

Indexed keywords

ADDUCIN; LITHIUM; SODIUM ION;

ADULT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; FEMALE; GENE CONTROL; HUMAN; HYPERTENSION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM;

EID: 0033063295     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.33.2.694     Document Type: Article

References (22)

1. Ferrari P, Bianchi G. Lessons from experimental genetic hypertension. Hypertension: Pathophysiology, Diagnosis and Managment. 2nd edition. New York: Raven Press; 1995:1261-1279.
2. Guidi E, Menghetti D, Milani S, Montagnino G, Palazzi P, Bianchi G. Hypertension may be transplanted with the kidney in humans: a long term historical prospective follow-up of recipients grafted with kidneys coming from donors with or without hypertension in their families. J Am Soc Nephrol. 1996;7:1131-1138.
3. Cusi D. Genetic renal mechanisms of hypertension. Curr Opin Nephrol Hypertens. 1997;6:192-204.
4. Parenti P, Hanozet G, Bianchi G. Sodium and glucose transport across renal brush-border membranes of Milan Hypertensive rats. Hypertension. 1986;8:932-939.
5. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia P, Leoni P, Torielli L, Cusi D, Ferrandi M, Pinna LA, Baralle FE. Two point mutations in the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci U S A. 1994;91:3999-4003.
6. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertension associated point-mutation in the adducin α and β subunits affect actin cytoskeleton and ion transport. J Clin Invest. 1996;97:2815-2822.
7. Ferrandi M, Ferrari P, Salardi S, Barassi P, Rivera R, Manunta P, Bianchi G. Influence of the hypertensive related adducin polymorphism on the Na-K-ATPase activity. J Hypertens. 1997;15(suppl 4):S60. Abstract.
8. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G. Polymorphism of α-adducin and salt sensitivity in patients with essential hypertension. Lancet. 1997;349: 1353-1357.
9. Tamaki S, Iwai N, Tsujita Y, Nakamura Y, Kinoshita M. Polymorphism of alpha-adducin in Japanese patients with essential hypertension. Hypertens Res. 1998;21:29-32.
10. Ishikawa K, Katsuya T, Sato N, Nakata Y, Takami S, Takiuchi S, Fu Y, Higaki J, Ogihara T. No association between alpha-adducin 460 polymorphism and essential hypertension in a Japanese population. Am J Hypertens. 1998;11:502-506.
11. Manunta P, Cusi D, Barlassina C, Righetti M, Lanzani C, D'Amico M, Buzzi L, Citterio L, Stella P, Rivera R, Bianchi G. α-Adducin polymorphism and renal sodium handling in essential hypertensive patients. Kidney Int. 1998;53:1471-1478.
12. Cappuccio FP, Strazzullo P, Farinaro E, Trevisan M. Uric acid metabolism and tubular sodium handling: results from a population-based study. JAMA. 1993;270:354-359.
13. Cappuccio FP, Strazzullo P, Siani A. Increased proximal sodium reabsorption is associated with increased cardiovascular risk in men. J Hypertens. 1996;14:909-914.
14. Boer WH, Koomans HA, Mees EJD, Gaillard CA, Rabelink AJ. Lithium clearance during variation of sodium intake in man: effect of sodium restriction and amiloride. Eur J Clin Invest. 1988;18:279-283.
15. Bumier M, Biollaz J, Magnin JL, Bildlingmeyer M, Brunner HR. Renal sodium handling in patients with untreated hypertension and white coat hypertension. Hypertension. 1993;23:496-502.
16. Kahn AM, Weinman EJ. Urate transport in the proximal tubule: in vivo and vesicle studies. Am J Physiol. 1985;249:F789-F798.
17. Strazzullo P, Cappuccio FP, Barba G, Trevisan M, Ciacci C, Iacone R, Russo L. Altered renal tubular function in men with high erythrocyte sodium-lithium countertransport. J Hypertens. 1989;7(suppl 6):S154-S155.
18. Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med. 1980;93:817-821.
19. Kuhlman PA, Hughes CA, Bennet V, Fowler VM. A new function for adducin: calcium/calmodulin-regulated capping of the barbed ends of actin filaments. J Biol Chem 1996;271:7986-7991.
20. Cantiello HF. Role of the actin cytoskeleton on epithelial sodium channel regulation. Kidney Int. 1995;48:970-984.
21. Berdiev BK, Prat AG, Cantiello HF, Ausiello DA, Fuller GM, Jovov B, Benos DJ, Ismilov II. Regulation of epithelial sodium channels by short actin filaments. J Biol Chem. 1996;271:17704-17710.
22. Wu MS, Bens M, Cluzeaud F, Vandewalle A. Role of F-actin in the activation of Na+-N(+)-Cl cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells. J Membr Biol. 1994; 142:323-336.