Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 5, 2010, Pages

  Zhang, Jin ^a   Ren, Chongyu ^a,f   Chen, Ling ^a   Navedo, Manuel F ^b   Antos, Laura K ^a   Kinsey, Stephen P ^a   Iwamoto, Takahiro ^c   Philipson, Kenneth D ^d   Kotlikoff, Michael I ^e   Santana, Luis F ^b   Wier, W Gil ^a   Matteson, Donald R ^a   Blaustein, Mordecai P ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Bay K 8644; Calcium sparklets; Mesenteric arteries; Myogenic tone; Patch clamp

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; CALCIUM CHANNEL L TYPE; CRE RECOMBINASE; OUABAIN; PHENYLEPHRINE; POTASSIUM; SODIUM CALCIUM EXCHANGE PROTEIN; VOLTAGE GATED CALCIUM CHANNEL; ANILINE DERIVATIVE; CALCIUM CHANNEL STIMULATING AGENT; DIAGNOSTIC AGENT; DIPHENYL ETHER DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; GREEN FLUORESCENT PROTEIN; SODIUM CALCIUM EXCHANGER 1; SODIUM-CALCIUM EXCHANGER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HETEROZYGOTE; ISOLATED HEART; MALE; MESENTERIC ARTERY; MOUSE; MUSCLE CELL; MUTATION; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE; VASOCONSTRICTION; WILD TYPE; ANIMAL; ARTERY; BLOOD PRESSURE; C57BL MOUSE; CALCIUM SIGNALING; DRUG ANTAGONISM; ELECTROPHYSIOLOGY; GENETICS; HISTOLOGY; MOUSE MUTANT; MUSCLE TONE; PATCH CLAMP; PHYSIOLOGY; SMOOTH MUSCLE FIBER; TELEMETRY; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANILINE COMPOUNDS; ANIMALS; ARTERIES; BLOOD PRESSURE; BLOTTING, WESTERN; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; ELECTROPHYSIOLOGY; GREEN FLUORESCENT PROTEINS; INDICATORS AND REAGENTS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PHENYL ETHERS; SODIUM-CALCIUM EXCHANGER; TELEMETRY; VASOCONSTRICTION;

EID: 77951864034     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00964.2009     Document Type: Article

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