Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 3, 2010, Pages

  Zulian, Alessandra ^a   Baryshnikov, Sergey G ^a   Linde, Cristina I ^a   Hamlyn, John M ^a   Ferrari, Patrizia ^b   Golovina, Vera A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Prassis Sigma Tau Research Institute   (Italy)

Author keywords

Adducin; C type transient receptor potential channels; Hypertension; Milan normotensive rats; Receptor operated calcium entry

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BARIUM ION; CALCIUM ION; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; CALCIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRRP6 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CONTROLLED STUDY; HYPERTENSION; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; SODIUM CELL LEVEL; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASCULAR RESISTANCE; VASOCONSTRICTION; ANALYSIS OF VARIANCE; ANIMAL; ARTERY; CELL CULTURE; CYTOLOGY; GENETICS; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ARTERIES; BLOTTING, WESTERN; CALCIUM; CELLS, CULTURED; HOMEOSTASIS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; SODIUM-CALCIUM EXCHANGER; TRPC CATION CHANNELS; UP-REGULATION;

EID: 77956701115     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00356.2010     Document Type: Article

References (82)

1. Agarwal A, Williams GH, Fisher ND. Genetics of human hypertension. Trends Endocrinol Metab 16: 127-133, 2005.
2. Akaike N, Kostyuk PG, Osipchuk YV. Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones. J Physiol 412: 181-195, 1989. (Pubitemid 19134477)
3. Albert AP, Large WA. Signal transduction pathways and gating mechanisms of native TRP-like cation channels in vascular myocytes. J Physiol 570: 45-51, 2006.
4. 2+ signaling in arterial myocytes. Am J Physiol Cell Physiol 278: C163-C173, 2000.
5. Bae YM, Kim A, Lee YJ, Lim W, Noh YH, Kim EJ, Kim J, Kim TK, Park SW, Kim B, Cho SI, Kim DK, Ho WK. Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive rats. J Hypertens 25: 809-817, 2007.
6. Beech DJ, Muraki K, Flemming R. Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 559: 685-706, 2004.
7. 2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture. Am J Physiol Cell Physiol 295: C779-C790, 2008.
8. Bianchi G, Cusi D. Association and linkage analysis of alpha-adducin polymorphism: is the glass half full or half empty? Am J Hypertens 13: 739-743, 2000. (Pubitemid 30459890)
9. Bianchi G, Ferrari P, Staessen JA. Adducin polymorphism: detection and impact on hypertension and related disorders. Hypertension 45: 331-340, 2005.
10. Bianchi G, Tripodi G. Genetics of hypertension: the adducin paradigm. Ann NY Acad Sci 986: 660-668, 2003.
11. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, Leoni P, Torielli L, Cusi D, Ferrandi M, Pinna LA, Baralle FE, Ferrari P. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91: 3999-4003, 1994.
12. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev 79: 763-854, 1999.
13. Bohr DF, Dominiczak AF, Webb RC. Pathophysiology of the vasculature in hypertension. Hypertension 18: III69 -III75, 1991.
14. Briones AM, Xavier FE, Arribas SM, Gonzalez MC, Rossoni LV, Alonso MJ, Salaices M. Alterations in structure and mechanics of resistance arteries from ouabain-induced hypertensive rats. Am J Physiol Heart Circ Physiol 291: H193-H201, 2006.
15. 2+ signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. Br J Pharmacol 129: 1365-1374, 2000.
16. Condrescu M, Gardner JP, Chernaya G, Aceto JF, Kroupis C, Reeves JP. ATP-dependent regulation of sodium-calcium exchange in Chinese hamster ovary cells transfected with the bovine cardiac sodium-calcium exchanger. J Biol Chem 270: 9137-9146, 1995.
17. Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev 72: 231-300, 1992.
18. Cusi D, Barlassina C, Azzani T, Casari G, Citterio L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 349: 1353-1357, 1997.
19. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387-423, 1999. (Pubitemid 29210926)
20. Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T. Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther 112: 744-760, 2006.
21. 2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am J Physiol Heart Circ Physiol 288: H477-H485, 2005.
22. +-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 95: 1100-1108, 2004.
23. 2+ exchange. Am J Physiol Renal Physiol 294: F212-F219, 2008.
24. Ferrandi M, Manunta P, Balzan S, Hamlyn JM, Bianchi G, Ferrari P. Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays. Hypertension 30: 886-896, 1997.
25. Ferrandi M, Minotti E, Salardi S, Florio M, Bianchi G, Ferrari P. Ouabainlike factor in Milan hypertensive rats. Am J Physiol Renal Fluid Electrolyte Physiol 263: F739-F748, 1992.
26. +-ATPase: relation to genetic hypertension. Am J Physiol Heart Circ Physiol 277: H1338-H1349, 1999.
27. Ferrandi M, Tripodi G, Salardi S, Florio M, Modica R, Barassi P, Parenti P, Shainskaya A, Karlish S, Bianchi G, Ferrari P. Renal Na,K-ATPase in genetic hypertension. Hypertension 28: 1018-1025, 1996.
28. Firth AL, Remillard CV, Yuan JX. TRP channels in hypertension. Biochim Biophys Acta 1772: 895-906, 2007.
29. Gardner K, Bennett V. Modulation of spectrin-actin assembly by erythrocyte adducin. Nature 328: 359-362, 1987. (Pubitemid 17097660)
30. 2+ entry and the regulation of smooth muscle tone. Trends Pharmacol Sci 19: 266-269, 1998.
31. 2+ entry in human arterial myocytes. Am J Physiol Cell Physiol 277: C343-C349, 1999.
32. Golovina VA. Visualization of localized store-operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulum. J Physiol 564: 737-749, 2005.
33. Golovina VA, Blaustein MP. Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies. Nat Protoc 1: 2681-2687, 2006.
34. Guyton AC, Granger HJ, Coleman TG. Autoregulation of the total systemic circulation and its relation to control of cardiac output and arterial pressure. Circ Res 28, Suppl 1: 93-97, 1971.
35. Hill AJ, Hinton JM, Cheng H, Gao Z, Bates DO, Hancox JC, Langton PD, James AF. A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium 40: 29-40, 2006.
36. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259-263, 1999. (Pubitemid 129601064)
37. Inoue R, Jensen LJ, Shi J, Morita H, Nishida M, Honda A, Ito Y. Transient receptor potential channels in cardiovascular function and disease. Circ Res 99: 119-131, 2006.
38. 2+-permeable cation channel. Circ Res 88: 325-332, 2001.
39. 2+ exchanger type-1 in vascular smooth muscle. Nat Med 10: 1193-1199, 2004.
40. 2+ exchanger in vascular smooth muscle, and in neurons and astrocytes. Ann NY Acad Sci 779: 318-335, 1996.
41. 2+ of agonist-stimulated divalent cation entry from the refilling of the agonist-sensitive intracellular pool. J Biol Chem 265: 678-684, 1990.
42. 2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 95: 496-505, 2004.
43. Liu D, Yang D, He H, Chen X, Cao T, Feng X, Ma L, Luo Z, Wang L, Yan Z, Zhu Z, Tepel M. Increased transient receptor potential canonical type 3 channels in vasculature from hypertensive rats. Hypertension 53: 70-76, 2009.
44. Luft FC. Molecular genetics of salt-sensitivity and hypertension. Drug Metab Dispos 29: 500-504, 2001.
45. Manunta P, Barlassina C, Bianchi G. Adducin in essential hypertension. FEBS Lett 430: 41-44, 1998.
46. Manunta P, Bianchi G. Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives - the adducin paradigm. J Am Soc Nephrol 17: S30-S35, 2006.
47. Manunta P, Maillard M, Tantardini C, Simonini M, Lanzani C, Citterio L, Stella P, Casamassima N, Burnier M, Hamlyn JM, Bianchi G. Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension. J Hypertens 26: 914-920, 2008.
48. +-ATPase distributions in polarized epithelia. J Cell Biol 123: 149-164, 1993.
49. Martinez-Lemus LA, Hill MA, Meininger GA. The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology (Bethesda) 24: 45-57, 2009.
50. Matsuoka Y, Li X, Bennett V. Adducin: structure, function and regulation. Cell Mol Life Sci 57: 884-895, 2000.
51. Morrison AC, Bray MS, Folsom AR, Boerwinkle E. ADD1 460W allele associated with cardiovascular disease in hypertensive individuals. Hypertension 39: 1053-1057, 2002.
52. Mulvany MJ. Small artery remodeling in hypertension. Curr Hypertens Rep 4: 49-55, 2002.
53. 2+ influx and contraction in rat pulmonary artery. Circ Res 89: 923-929, 2001.
54. Nicod J, Frey BM, Frey FJ, Ferrari P. Role of the alpha-adducin genotype on renal disease progression. Kidney Int 61: 1270-1275, 2002. (Pubitemid 34304487)
55. O'Brien WJ, Lingrel JB, Wallick ET. Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate. Arch Biochem Biophys 310: 32-39, 1994.
56. Odell AF, Van Helden DF, Scott JL. The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels. J Biol Chem 283: 4395-4407, 2008.
57. Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 85: 757-810, 2005.
58. 2+ entry in purinergically stimulated aorta smooth muscle cells. Circ Res 101: 1030-1038, 2007.
59. 2+-entry and limit its diffusion into vascular smooth muscle cells. Cell Calcium 40: 359-371, 2006.
60. Psaty BM, Smith NL, Heckbert SR, Vos HL, Lemaitre RN, Reiner AP, Siscovick DS, Bis J, Lumley T, Longstreth WT Jr, Rosendaal FR. Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension. JAMA 287: 1680-1689, 2002.
61. 2+ transporters in arterial smooth muscle from ouabain hypertensive rats. Am J Physiol Heart Circ Physiol 298: H263-H274, 2010.
62. Rizzoni D, Castellano M, Porteri E, Giacche M, Ferrari P, Cusi D, De Ciuceis C, Boari GE, Rosei EA. Functional alterations of mesenteric small resistance arteries in Milan hypertensive and normotensive rats. Hypertens Res 32: 581-585, 2009.
63. 2+ exchanger. J Biol Chem 279: 13696-13704, 2004.
64. Staessen JA, Bianchi G. Adducin and hypertension. Pharmacogenomics 6: 665-669, 2005.
65. Thompson LP, Bruner CA, Lamb FS, King CM, Webb RC. Calcium influx and vascular reactivity in systemic hypertension. Am J Cardiol 59: 29A-34A, 1987.
66. + reabsorption. Am J Physiol Renal Physiol 295: F478-F487, 2008.
67. 2+ entry to contraction in rat aorta. J Pharmacol Exp Ther 285: 759-766, 1998.
68. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 97: 2815-2822, 1996.
69. Venkatachalam K, Ma HT, Ford DL, Gill DL. Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells. J Biol Chem 276: 33980-33985, 2001. (Pubitemid 37384624)
70. Wang JG, Staessen JA, Tizzoni L, Brand E, Birkenhager WH, Fagard R, Herrmann SM, Bianchi G. Renal function in relation to three candidate genes. Am J Kidney Dis 38: 1158-1168, 2001.
71. Ward R. Familiar aggregation and genetic epidemiology of blood pressure. In: Hypertension (2nd ed.), edited by Laragh JH and Brenner BM. New York: Raven Press, 1995, p. 67-88.
72. 2+ and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 289: L5-L13, 2005.
73. Welsh DG, Morielli AD, Nelson MT, Brayden JE. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90: 248-250, 2002.
74. Williams GH. Genetic factors associated with volume-sensitive hypertension. Mol Cell Endocrinol 217: 41-44, 2004. (Pubitemid 38596627)
75. Winnicki M, Somers VK, Accurso V, Hoffmann M, Pawlowski R, Frigo G, Visentin P, Palatini P. alpha-Adducin Gly460Trp polymorphism, left ventricular mass and plasma renin activity. J Hypertens 20: 1771-1777, 2002.
76. 2+ channels in native vascular smooth muscle cells. Circ Res 88: 84-87, 2001.
77. Xu SZ, Boulay G, Flemming R, Beech DJ. E3-targeted anti-TRPC5 antibody inhibits store-operated calcium entry in freshly isolated pial arterioles. Am J Physiol Heart Circ Physiol 291: H2653-H2659, 2006.
78. Yamagishi K, Iso H, Tanigawa T, Cui R, Kudo M, Shimamoto T. Alpha-adducin G460W polymorphism, urinary sodium excretion, and blood pressure in community-based samples. Am J Hypertens 17: 385-390, 2004.
79. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101: 13861-13866, 2004.
80. Zhang J, Hamlyn JM, Karashima E, Raina H, Mauban JR, Izuka M, Berra-Romani R, Zulian A, Wier WG, Blaustein MP. Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance. Am J Physiol Heart Circ Physiol 297: H1140-H1150, 2009.
81. Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Matteson DR, Wier WG, Blaustein MP. Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J Physiol 569: 243-256, 2005.
82. 2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol 292: C2297-C2305, 2007.