-
1
-
-
0023821179
-
Gerstmann-Straussler-Scheinker disease: immunohistological and experimental studies
-
Tateishi J., Kitamoto T., Hashiguchi H., and Shii H. Gerstmann-Straussler-Scheinker disease: immunohistological and experimental studies. Ann. Neurol. 24 (1988) 35-40
-
(1988)
Ann. Neurol.
, vol.24
, pp. 35-40
-
-
Tateishi, J.1
Kitamoto, T.2
Hashiguchi, H.3
Shii, H.4
-
2
-
-
0027332116
-
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
-
Pan K.M., Baldwin M., Nguyen J., Gasset M., Serban A., Groth D., Mehlhorn I., Huang Z., Fletterick R.J., Cohen F.E., et al. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 90 (1993) 10962-10966
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10962-10966
-
-
Pan, K.M.1
Baldwin, M.2
Nguyen, J.3
Gasset, M.4
Serban, A.5
Groth, D.6
Mehlhorn, I.7
Huang, Z.8
Fletterick, R.J.9
Cohen, F.E.10
-
3
-
-
0025910229
-
Molecular biology of prion diseases
-
Prusiner S.B. Molecular biology of prion diseases. Science 252 (1991) 1515-1522
-
(1991)
Science
, vol.252
, pp. 1515-1522
-
-
Prusiner, S.B.1
-
4
-
-
0031847332
-
Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease
-
Hainfellner J.A., Wanschitz J., Jellinger K., Liberski P.P., Gullotta F., and Budka H. Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease. Acta Neuropathol. 96 (1998) 116-122
-
(1998)
Acta Neuropathol.
, vol.96
, pp. 116-122
-
-
Hainfellner, J.A.1
Wanschitz, J.2
Jellinger, K.3
Liberski, P.P.4
Gullotta, F.5
Budka, H.6
-
5
-
-
19444386089
-
Prion protein (PrP(c)) promotes beta-amyloid plaque formation
-
Schwarze-Eicker K., Keyvani K., Gortz N., Westaway D., Sachser N., and Paulus W. Prion protein (PrP(c)) promotes beta-amyloid plaque formation. Neurobiol. Aging 26 (2005) 1177-1182
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 1177-1182
-
-
Schwarze-Eicker, K.1
Keyvani, K.2
Gortz, N.3
Westaway, D.4
Sachser, N.5
Paulus, W.6
-
6
-
-
0035708762
-
Spatial correlations between the vacuolation, prion protein deposits, and surviving neurons in the cerebral cortex in sporadic Creutzfeldt-Jakob disease
-
Armstrong R.A., Lantos P.L., and Cairns N.J. Spatial correlations between the vacuolation, prion protein deposits, and surviving neurons in the cerebral cortex in sporadic Creutzfeldt-Jakob disease. Neuropathology 21 (2001) 266-271
-
(2001)
Neuropathology
, vol.21
, pp. 266-271
-
-
Armstrong, R.A.1
Lantos, P.L.2
Cairns, N.J.3
-
7
-
-
0036158912
-
Aging, the brain and human prion disease
-
Kovacs G.G., and Budka H. Aging, the brain and human prion disease. Exp. Gerontol. 37 (2002) 603-606
-
(2002)
Exp. Gerontol.
, vol.37
, pp. 603-606
-
-
Kovacs, G.G.1
Budka, H.2
-
8
-
-
0026559760
-
Colocalization of prion protein and beta protein in the same amyloid plaques in patients with Gerstmann-Straussler syndrome
-
Miyazono M., Kitamoto T., Iwaki T., and Tateishi J. Colocalization of prion protein and beta protein in the same amyloid plaques in patients with Gerstmann-Straussler syndrome. Acta Neuropathol. 83 (1992) 333-339
-
(1992)
Acta Neuropathol.
, vol.83
, pp. 333-339
-
-
Miyazono, M.1
Kitamoto, T.2
Iwaki, T.3
Tateishi, J.4
-
9
-
-
0033555887
-
Ultrastructural localization of cellular prion protein (PrPc) at the neuromuscular junction
-
Gohel C., Grigoriev V., Escaig-Haye F., Lasmezas C.I., Deslys J.P., Langeveld J., Akaaboune M., Hantai D., and Fournier J.G. Ultrastructural localization of cellular prion protein (PrPc) at the neuromuscular junction. J. Neurosci. Res. 55 (1999) 261-267
-
(1999)
J. Neurosci. Res.
, vol.55
, pp. 261-267
-
-
Gohel, C.1
Grigoriev, V.2
Escaig-Haye, F.3
Lasmezas, C.I.4
Deslys, J.P.5
Langeveld, J.6
Akaaboune, M.7
Hantai, D.8
Fournier, J.G.9
-
10
-
-
33745001700
-
-
S. Petrakis, I. Paspaltsis, J. Lindstrom, T. Sklaviadis, PrPC coimmunoprecipitates with nicotinic acetylcholine receptor B4 subunit in normal human brain. First international congress of neuroprion (France) (2004).
-
-
-
-
11
-
-
0027252644
-
Localization of the mRNA for a chicken prion protein by in situ hybridization
-
Harris D.A., Lele P., and Snider W.D. Localization of the mRNA for a chicken prion protein by in situ hybridization. Proc. Natl. Acad. Sci. USA 90 (1993) 4309-4313
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4309-4313
-
-
Harris, D.A.1
Lele, P.2
Snider, W.D.3
-
12
-
-
0029863697
-
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme
-
Inestrosa N.C., Alvarez A., Perez C.A., Moreno R.D., Vicente M., Linker C., Casanueva O.I., Soto C., and Garrido J. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron 16 (1996) 881-891
-
(1996)
Neuron
, vol.16
, pp. 881-891
-
-
Inestrosa, N.C.1
Alvarez, A.2
Perez, C.A.3
Moreno, R.D.4
Vicente, M.5
Linker, C.6
Casanueva, O.I.7
Soto, C.8
Garrido, J.9
-
13
-
-
0031587286
-
Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils
-
Alvarez A., Opazo C., Alarcon R., Garrido J., and Inestrosa N.C. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. J. Mol. Biol. 272 (1997) 348-361
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 348-361
-
-
Alvarez, A.1
Opazo, C.2
Alarcon, R.3
Garrido, J.4
Inestrosa, N.C.5
-
14
-
-
0037298750
-
beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
-
Bartolini M., Bertucci C., Cavrini V., and Andrisano V. beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem. Pharmacol. 65 (2003) 407-416
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 407-416
-
-
Bartolini, M.1
Bertucci, C.2
Cavrini, V.3
Andrisano, V.4
-
15
-
-
0033524414
-
Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect
-
Szegletes T., Mallender W.D., Thomas P.J., and Rosenberry T.L. Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry 38 (1999) 122-133
-
(1999)
Biochemistry
, vol.38
, pp. 122-133
-
-
Szegletes, T.1
Mallender, W.D.2
Thomas, P.J.3
Rosenberry, T.L.4
-
16
-
-
0031886982
-
Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptides
-
Campos E.O., Alvarez A., and Inestrosa N.C. Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptides. Neurochem. Res. 23 (1998) 135-140
-
(1998)
Neurochem. Res.
, vol.23
, pp. 135-140
-
-
Campos, E.O.1
Alvarez, A.2
Inestrosa, N.C.3
-
17
-
-
0027259274
-
Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
-
Selvaggini C., De Gioia L., Cantu L., Ghibaudi E., Diomede L., Passerini F., Forloni G., Bugiani O., Tagliavini F., and Salmona M. Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein. Biochem. Biophys. Res. Commun. 194 (1993) 1380-1386
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.194
, pp. 1380-1386
-
-
Selvaggini, C.1
De Gioia, L.2
Cantu, L.3
Ghibaudi, E.4
Diomede, L.5
Passerini, F.6
Forloni, G.7
Bugiani, O.8
Tagliavini, F.9
Salmona, M.10
-
18
-
-
0027367506
-
Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro
-
Tagliavini F., Prelli F., Verga L., Giaccone G., Sarma R., Gorevic P., Ghetti B., Passerini F., Ghibaudi E., Forloni G., Salmona M., Bugiai O., and Frangione B. Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 90 (1993) 9678-9682
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 9678-9682
-
-
Tagliavini, F.1
Prelli, F.2
Verga, L.3
Giaccone, G.4
Sarma, R.5
Gorevic, P.6
Ghetti, B.7
Passerini, F.8
Ghibaudi, E.9
Forloni, G.10
Salmona, M.11
Bugiai, O.12
Frangione, B.13
-
19
-
-
0028301577
-
Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
-
De Gioia L., Selvaggini C., Ghibaudi E., Diomede L., Bugiani O., Forloni G., Tagliavini F., and Salmona M. Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein. J. Biol. Chem. 269 (1994) 7859-7862
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 7859-7862
-
-
De Gioia, L.1
Selvaggini, C.2
Ghibaudi, E.3
Diomede, L.4
Bugiani, O.5
Forloni, G.6
Tagliavini, F.7
Salmona, M.8
-
20
-
-
0027483615
-
Neurotoxicity of a prion protein fragment
-
Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O., and Tagliavini F. Neurotoxicity of a prion protein fragment. Nature 362 (1993) 543-546
-
(1993)
Nature
, vol.362
, pp. 543-546
-
-
Forloni, G.1
Angeretti, N.2
Chiesa, R.3
Monzani, E.4
Salmona, M.5
Bugiani, O.6
Tagliavini, F.7
-
21
-
-
0034237389
-
Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126
-
Thellung S., Florio T., Corsaro A., Arena S., Merlino M., Salmona M., Tagliavini F., Bugiani O., Forloni G., and Schettini G. Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106-126. Int. J. Dev. Neurosci. 18 (2000) 481-492
-
(2000)
Int. J. Dev. Neurosci.
, vol.18
, pp. 481-492
-
-
Thellung, S.1
Florio, T.2
Corsaro, A.3
Arena, S.4
Merlino, M.5
Salmona, M.6
Tagliavini, F.7
Bugiani, O.8
Forloni, G.9
Schettini, G.10
-
22
-
-
0033826141
-
Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126
-
Thellung S., Florio T., Villa V., Corsaro A., Arena S., Amico C., Robello M., Salmona M., Forloni G., Bugiani O., Tagliavini F., and Schettini G. Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126. Neurobiol. Dis. 7 (2000) 299-309
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 299-309
-
-
Thellung, S.1
Florio, T.2
Villa, V.3
Corsaro, A.4
Arena, S.5
Amico, C.6
Robello, M.7
Salmona, M.8
Forloni, G.9
Bugiani, O.10
Tagliavini, F.11
Schettini, G.12
-
23
-
-
0033774891
-
A model for the mechanism of astrogliosis in prion disease
-
Hafiz F.B., and Brown D.R. A model for the mechanism of astrogliosis in prion disease. Mol. Cell Neurosci. 16 (2000) 221-232
-
(2000)
Mol. Cell Neurosci.
, vol.16
, pp. 221-232
-
-
Hafiz, F.B.1
Brown, D.R.2
-
24
-
-
0037264120
-
Unfolding the role of protein misfolding in neurodegenerative diseases
-
Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci. 4 (2003) 40-60
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 40-60
-
-
Soto, C.1
-
25
-
-
0033567401
-
Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126
-
Salmona M., Malesani P., De Gioia L., Gorla S., Bruschi M., Molinari A., Della V.F., Pedrotti B., Marrari M.A., Awan T., Bugiani O., Forloni G., and Tagliavini F. Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126. Biochem. J. 342 (1999) 207-214
-
(1999)
Biochem. J.
, vol.342
, pp. 207-214
-
-
Salmona, M.1
Malesani, P.2
De Gioia, L.3
Gorla, S.4
Bruschi, M.5
Molinari, A.6
Della, V.F.7
Pedrotti, B.8
Marrari, M.A.9
Awan, T.10
Bugiani, O.11
Forloni, G.12
Tagliavini, F.13
-
26
-
-
0026619343
-
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides
-
Hilbich C., Kisters-Woike B., Reed J., Masters C.L., and Beyreuther K. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J. Mol. Biol. 228 (1992) 460-473
-
(1992)
J. Mol. Biol.
, vol.228
, pp. 460-473
-
-
Hilbich, C.1
Kisters-Woike, B.2
Reed, J.3
Masters, C.L.4
Beyreuther, K.5
-
27
-
-
0035807054
-
A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation
-
De Ferrari G.V., Canales M.A., Shin I., Weiner L.M., Silman I., and Inestrosa N.C. A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry 40 (2001) 10447-10457
-
(2001)
Biochemistry
, vol.40
, pp. 10447-10457
-
-
De Ferrari, G.V.1
Canales, M.A.2
Shin, I.3
Weiner, L.M.4
Silman, I.5
Inestrosa, N.C.6
-
28
-
-
33644542740
-
Conformational polymorphism of the PrP 106-126 peptide in different environments: a molecular dynamics study
-
Villa A., Mark A.E., Saracino G.A., Cosentino U., Pitea D., Moro G., and Salmona M. Conformational polymorphism of the PrP 106-126 peptide in different environments: a molecular dynamics study. J. Phys. Chem. B Condens. Matter Mater. Surf. Interfaces. Biophys. 110 (2006) 1423-1428
-
(2006)
J. Phys. Chem. B Condens. Matter Mater. Surf. Interfaces. Biophys.
, vol.110
, pp. 1423-1428
-
-
Villa, A.1
Mark, A.E.2
Saracino, G.A.3
Cosentino, U.4
Pitea, D.5
Moro, G.6
Salmona, M.7
-
29
-
-
28544451677
-
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease
-
Munoz-Ruiz P., Rubio L., Garcia-Palomero E., Dorronsoro I., Monte-Millan M., Valenzuela R., Usan P., de Austria C., Bartolini M., Andrisano V., Bidon-Chanal A., Orozco M., Luque F.J., Medina M., and Martinez A. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. J. Med. Chem. 48 (2005) 7223-7233
-
(2005)
J. Med. Chem.
, vol.48
, pp. 7223-7233
-
-
Munoz-Ruiz, P.1
Rubio, L.2
Garcia-Palomero, E.3
Dorronsoro, I.4
Monte-Millan, M.5
Valenzuela, R.6
Usan, P.7
de Austria, C.8
Bartolini, M.9
Andrisano, V.10
Bidon-Chanal, A.11
Orozco, M.12
Luque, F.J.13
Medina, M.14
Martinez, A.15
-
30
-
-
0026504115
-
Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase
-
Berman H.A., and Leonard K. Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. Mol. Pharmacol. 41 (1992) 412-418
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 412-418
-
-
Berman, H.A.1
Leonard, K.2
-
31
-
-
0032190343
-
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors
-
Ariel N., Ordentlich A., Barak D., Bino T., Velan B., and Shafferman A. The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors. Biochem. J. 335 (1998) 95-102
-
(1998)
Biochem. J.
, vol.335
, pp. 95-102
-
-
Ariel, N.1
Ordentlich, A.2
Barak, D.3
Bino, T.4
Velan, B.5
Shafferman, A.6
-
32
-
-
0032054003
-
Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcolinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
-
Badia A., Baños J.E., Camps P., Contreras J., Görbigb D.M., Muñoz-Torrerob D., Simón M., and Vivas N.M. Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcolinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Bioorg. Med. Chem. 6 (1998) 427-440
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 427-440
-
-
Badia, A.1
Baños, J.E.2
Camps, P.3
Contreras, J.4
Görbigb, D.M.5
Muñoz-Torrerob, D.6
Simón, M.7
Vivas, N.M.8
-
33
-
-
13044253491
-
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
-
Camps P., El Achab R., Gorbic D.M., Morral J., Muñoz-Torrero D., Badia A., Baños J.E., Vivas N.M., Barril X., Orozco M., and Luque F.J. Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. J. Med. Chem. 42 (1999) 3227-3242
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3227-3242
-
-
Camps, P.1
El Achab, R.2
Gorbic, D.M.3
Morral, J.4
Muñoz-Torrero, D.5
Badia, A.6
Baños, J.E.7
Vivas, N.M.8
Barril, X.9
Orozco, M.10
Luque, F.J.11
-
34
-
-
0033966913
-
Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease
-
Camps P., Cusack B., Mallender W.D., El Achab R.E., Morral J., Munoz-Torrero D., and Rosenberry T.L. Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease. Mol. Pharmacol. 57 (2000) 409-417
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 409-417
-
-
Camps, P.1
Cusack, B.2
Mallender, W.D.3
El Achab, R.E.4
Morral, J.5
Munoz-Torrero, D.6
Rosenberry, T.L.7
|