Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity

Journal of Theoretical Biology

Volumn 265, Issue 4, 2010, Pages 718-733

  Sheikh Bahaei, Shahab ^a   Maher, Jacquelyn J ^b   Anthony Hunt, C ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

Computational biology; Hepatic zonation; Hepatotoxicity; Modeling; Simulation

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A2; MESSENGER RNA; TOXIN; XENOBIOTIC AGENT;

ALGORITHM; BIOLOGICAL ANALYSIS; DETECTION METHOD; EXPERIMENTAL STUDY; GENE EXPRESSION; MODELING; TOXICITY; XENOBIOTICS;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOMIMETICS; COMPUTER ANALYSIS; COMPUTER MODEL; COMPUTER SYSTEM; CONTROLLED STUDY; FEASIBILITY STUDY; GENE EXPRESSION; LIVER CLEARANCE; LIVER SINUSOID; LIVER STRUCTURE; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROCESS MODEL; QUANTITATIVE ANALYSIS; RAT; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; XENOBIOTIC METABOLISM; ZONATION; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG EFFECTS; DRUG INACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; REPRODUCIBILITY; TOXICITY;

ANIMALS; COMPUTER SIMULATION; CYTOCHROME P-450 CYP1A2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; METABOLIC DETOXICATION, DRUG; MODELS, BIOLOGICAL; RATS; REPRODUCIBILITY OF RESULTS; TOXINS, BIOLOGICAL; XENOBIOTICS; INACTIVATION, METABOLIC;

RATTUS;

EID: 77954484528     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2010.06.011     Document Type: Article

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