Modeling depression in animal models

Methods in Molecular Biology

Volumn 829, Issue , 2012, Pages 125-144

  Overstreet, David H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic mild stress; Forced swim test; Rat models of depression (FSL, WKY, FH, LH); Social interaction test; Sucrose preference test

Indexed keywords

ANTIDEPRESSANT AGENT;

ANIMAL; ANIMAL BEHAVIOR; DEPRESSION; DISEASE MODEL; MENTAL STRESS; RAT; RAT STRAIN; REVIEW; SWIMMING; WISTAR KYOTO RAT; WISTAR RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; RATS; RATS, INBRED STRAINS; RATS, INBRED WKY; RATS, WISTAR; STRESS, PSYCHOLOGICAL; SWIMMING;

ANIMALIA; RATTUS;

EID: 84856351442     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-458-2_7     Document Type: Review

References (83)

1. Overstreet, D.H.; Russell, R.W.; Helps, S.C.; Messenger, M. (1979) Selective breeding for sensitivity to the anticholinesterase, DFP. Psychopharmacology 65, 15-20. (Pubitemid 10222232)
2. Janowsky, D.S.; Nurnberger, J.I.Jr.; Overstreet, D.H. (1994) Is cholinergic sensitivity a genetic marker for the affective disorders? Am. J. Med. Genet. 54, 335-344.
3. Overstreet, D.H. (1986) Selective breeding for increased cholinergic function: Development of a new animal model of depression. Biol. Psychiatry 21, 49-58. (Pubitemid 16043733)
4. Overstreet, D.H. (1993) The Flinders Sensitive Line rats: A genetic animal model of depression. Neurosci. Biobehav. Rev. 17, 51-68. (Pubitemid 23068942)
5. Schiller, G.D.; Daws, L.C.; Overstreet, D.H.; Orbach, J. (1991) Lack of anxiety in an animal model of depression with cholinergic supersensitivity. Brain Res. Bull. 26, 433-435.
6. Overstreet, D.H.; Keeney, A.; Hogg, S. (2004) Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression. Eur. J. Pharmacol. 492, 195-201. (Pubitemid 38721372)
7. Overstreet, D.H.; Hlavka, J.; Feighner, J.P.; Nicolau, G.; Freed, J.S. (2004) Antidepressant-like effects of a novel pentapeptide, nemifi tide, in an animal model of depression. Psychopharmacology 125, 303-309. (Pubitemid 39361919)
8. Benca, R.M.; Overstreet, D.H.; Gillilland, M.A.; Russell, D.; Bergmann, B.M.; Obermeyer, W.H. (1996) Increased basal REM sleep but no difference in dark-induced induction or light suppression of REM sleep in Flinders rats with cholinergic supersensitivity. Neuropsychopharmacology 15, 45-51. (Pubitemid 26233390)
9. Shiromani, P.J.; Overstreet, D.H.; Levy, D.; Goodrich, S.S.; Gillin, J.C. (1988) Increased REM sleep in rats selectively bred for cholinergic hyperactivity. Neuropsychopharmacology 1, 127-133. (Pubitemid 19124799)
10. Overstreet, D.H.; Friedman, E.F.; Mathe, A.A.; Yadid, G. (2005) The Flinders Sensitive Line rat: A selectively bred putative animal model of depression. Neurosci. Biobehav. Rev. 29, 739-759. (Pubitemid 40762598)
11. Yadid, G.; Overstreet, D.H.; Zangen A. (2001) Limbic dopaminergic adaptation to a stressful stimulus in a rat model of depression. Brain Res. 896, 43-47. (Pubitemid 32244145)
12. Jimenez-Vasquez, P.A.; Overstreet, D.H.; Mathe, A.A. (2000) Neuropeptide Y in male and female brains of Flinders Sensitive Line, a rat model of depression. Effect of electroconvulsive stimuli. J. Psychiatric Res. 34, 405-412. (Pubitemid 32101557)
13. Elfving, B.; Ploughmann, P.H, Muller H.K.; Mathe, A.A.; Rosenberg, R.; Wegener, G. (2010) Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Internat. J. Neuropsychopharmacol 13, 563-572.
14. Zangen, A.; Overstreet, D.H.; Yadid, G. (1997) High serotonin and 5-Hydroxindoleacetic acid levels in limbic regions in a rat model of depression: normalization by chronic antidepressant treatment. J. Neurochem. 69, 2477-2483. (Pubitemid 27495434)
15. Zangen, A.; Overstreet, D.H.; Yadid, G. (1999) Increased catecholamine levels in specifi c brain regions of a rat model of depression: normalization by chronic antidepressant treatment. Brain Res. 824, 243-250. (Pubitemid 29225530)
16. Roth-Deri, I.; Friedman A.; Abraham L.; Lax, E.; Flaumenhaff Y.; Dikshtein Y, Yadid, G. (2009) Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression. Eur. J. Neurosci. 30, 485-492.
17. Kotsovolou O.; Ingelman-Sundberg M.; Lang, M.A.; Marselos, M.; Overstreet, D.H.; Papadopolou-Daifoti, A.; Johanson, I.; Fotopoulos, A.; Konstandi, M. (2010) Hepatic drug metabolizing profi le of Flinders Sensitive Line rat model of depression. Prog. Neuropschopharmacol. Biol Psychiatry June 4 [Epub ahead of print].
18. Musazzi L.; Mallei A, Tardito, D.;, Gruber, S.H.; El Khoury A.; Racagni, G.; Mathe, A.A.; Popoli, M. (2010) Early-life stress and antidepressant treatment involve synaptic signaling and ERK kinases in a gene-environment model of depression. J. Psychiatric Res. 44, 511-510.
19. Koavacev, T.; Skelin, I.; Diksic, M. (2010) Chronic fl uoxetine treatment has a larger effect on the density of a serotonin transporter in Flinders Sensitive Line (FSL) rat model of depression than in normal rats. Synapse 64, 231-240.
20. Jaehne, E.J.; Majumder, I.; Salem, A.; Irvine, R.J. (2010) Increased effects of 3,4-methylenedioxymethamphetamaine (ecstasy) in a rat model of depression. Addict. Biol. Feb. 26, Epub ahead of print.
21. Wegner, G, Harvey, B.H.; Bonelfl eld, G.; Mjuller, H.K.; Volke V.; Overstreet, D.H.; Elfving, G. (2010) Increased stress-evoked nitric oxide signaling in the Flinders Sensitive Line (FSL) rat: a genetic animal model of depression. Int. J. Neuropsychopharmacol 13, 563-572.
22. Liebenberg, N.; Harvey, B.H.; Brand, L.; Brink, C.B. (2010) Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependence in a genetic rat model of depression. Behav. Pharmacol. June [Epub ahead of print].
23. Pucilowski, O.; Overstreet, D.H. (1993) Effect of chronic antidepressant treatment on responses to apomorphine in selectively bred rat strains. Brain Res. Bull. 32, 471-475. (Pubitemid 23251950)
24. Overstreet, D.H.; Rettori, M.C.; Delagrange, P.; Gardiola-Lemaitre, B. (1998) Effects of melatonin receptor ligands on swim test immobility. NeuroReport 9, 249-253. (Pubitemid 28081397)
25. Tizabi, Y.; Overstreet, D.H.; Rezvani, A.H.; Louis, V.A.; Clark, E.Jr.; Janowsky, D.S.; Kling, M.A. (1999) Antidepressant effect of nicotine in an animal model of depression. Psychopharmacology 142, 193-199. (Pubitemid 29190855)
26. Overstreet, D.H. and Griebel, G. (2004) Antidepressant-like effect of the CRF1 receptor antagonist SSR125543 in an animal model of depression. Eur. J. Pharmacol. 497, 49-53. (Pubitemid 39092427)
27. Overstreet, D.H. and Griebel, G. (2005) Antidepressant-like effects of the vasopressin V1b antagonist SSR149 415 in the Flinders Sensitive Line rat. Pharmacol. Biochem. Behav. 82, 223-227. (Pubitemid 41423507)
28. Overstreet, D.H.; Stemmelin J.; Griebel, G. (2008) Confirmation of the antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacol. Biochem. Behav. 89, 623-626.
29. Walker, M.W.; Wolinsky, T.D.; Jabion, V.; Chandransnan, G.; Zhonf, H.; Huang, X.; Miller, S.; Hegde, L.G.; Marsteller, D.A.; Marzabuti, Papp, M.; Overstreet, D.H.; Gerald, L.F.; Craig, D.A. (2010) The novel neuropeptide Y Y5 receptor antagonist, LuAA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino [5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]- methanesulfonamide] exerts anxiolytic and antidepressant effects in rat models of stress sensitivity. J. Pharmacol. Exp. Ther. 328, 900-911.
30. Overstreet, D.H.; Fredericks, K.; Knapp, D.; Breese, G.; McMichael, J. (2010) Nerve growth factor (NGF) has novel antidepressant-like properties in rats. Pharmacol. Biochem. Behav. 94, 553-560.
31. Overstreet, D.H.; Naimoli, V.M.; Griebel, G. (2010) Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Pharmacol. Biochem. Behav. 96, 206-210.
32. Overstreet, D.H.; Miller, C.S.; Janowsky, D.S.; Russell, R.W. (1996) Potential animal model of multiple chemical sensitivity with cholinergic supersensitivity. Toxicology 111, 119-134. (Pubitemid 26247038)
33. Mattson, H.; Arani, Z.; Astin, M.; Bagati, A.; Overstreet, D.H.; Lehmann, A. (2005) Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat. Neurogastrenterol. Motil. 17, 166-174. (Pubitemid 40476676)
34. Padley, J.R.; Overstreet, D.H.; Pilowsky, P.; Goodchild, A.K. (2005) Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity. Am. J. Physiol. Circ. Physiol. 289, H1985-H1992. (Pubitemid 41507348)
35. Friedman, E.M.; Becker, K.A.; Overstreet, D.H.; Laurence, D.A. (2002) Reduced primary antibody responses in a genetic animal of depression. Psychosom. Med. 64, 267-273. (Pubitemid 34260464)
36. Lerman, L.O.; Chader, A.R.; Sica, V.; Napoli, C. (2005) Animal models of hypertension: an overview. J. Lab. Clin. Med. 146, 160-173. (Pubitemid 41208265)
37. Pare, W.P. (1989) "Behavioral despair" test predicts stress ulcer in WKY rats. Physiol. Behav. 46, 483-487. (Pubitemid 19253864)
38. Pare, W.P. (1989) Stress ulcer susceptibility and depression in Wistar Kyoto (WKY) rats. Physiol Behav 46, 993-996.
39. Pare, W.P. (1992) The performance of the WKY rat on three tests of emotional behavior. Physiol. Behav. 51, 1051-1056.
40. Will, C.C, Aird, F.; Redei, E.E. (2003) Selectively bred Wistat-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants. Molec. Psychiatry 8, 925-932. (Pubitemid 37421699)
41. Solberg C.; Baum, A.E.; Ahmadiyeh, N.; Shimomura K.; Li, R.; Tarek, F.W.; Churchill, C.A.; Takahashi, J.S.; Redei EE. (2004) Sex- and lineage-specifi c inheritance of depression- like behavior in the rat. Mamm. Genome 15, 648-662. (Pubitemid 39050027)
42. Carr, D.R.; Bangasser, D.A, Bethea, T.; Young, M, Valentino, R.J.; Lucki, I. (2010) Antidepressant-like effects of kappa opioid receptor antagonist in Wistar Kyoto rats. Neuropsychopharmacology 35, 752-763.
43. Jeannotte, A.M.; McCarthy, J.G.; Redei E.E.; Sidhu, A. (2009) Desipramine modulation of alpha-gamma-synuclein and the norepinephrine transporter in an animal model of depression. 34, 987-998.
44. Malkesman, O.; Braw, Y.; Weller, A. (2007) Assessment of antidepressant and anxiolytic properties of NK1 antagonists and substance P in Wistar Kyoto rats. Physiol. Behav. 90, 619-625. (Pubitemid 46329709)
45. Malkesman, O.; Weller, A. (2009) Two different putative genetic animal models of childhood depression - a review. Prog. Neurobiol. 88, 153-169.
46. Rezvani, A.H.; Overstreet, D.H.; Janowsky, D.S. (1990) Genetic serotonin defi ciency and alcohol preference in the Fawn-Hooded rat. Alcohol Alcohol. 25, 573-575.
47. Rezvani, A.H.; Parsian, A.; Overstreet, D.H. (2002) Fawn-Hooded (FH/Wjd) rat: a genetic animal model of cormorbid depression and alcoholism. Psychiatric Genet. 12, 1-16. (Pubitemid 34274489)
48. Overstreet, D.H.; Rezvani, A.H.; Djouma E.; Parsian, P.; Lawrence, A.J. (2007) Depression-like behavior and high alcohol drinking co-occur in the Fawn-Hooded (FH/ Wjd) rat but appear to be under independent genetic control. Neurosci. Biobehav. Rev. 31, 103-114. (Pubitemid 44880076)
49. Rezvani, A.H.; Overstreet, D.H.; Cleves, M.; Parsian, A. (2007) Further genetic characterization of the Fawn-Hooded (FH/Wjd) rat, a genetic animal model of comorbid depression and alcoholism. Psychiatric Genet. 17, 77-83. (Pubitemid 46586678)
50. Patra, B.; Overstreet, D.H.; Rezvani, A.H.; Cleves, M.; Parsian, A. (2007) Analysis of alcohol related phenotypes in F2 progeny derived from FH/Wjd and ACI/N strains reveals independent measures and sex differences. Behav. Brain Res. 177, 37-44. (Pubitemid 46054200)
51. Overstreet, D.H.; Rezvani, A.H.; Cowen, M.; Chen, F.; Lawrence, A.J. (2006) Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: Implications for treatment. Addict. Biol. 11, 356-373. (Pubitemid 46696908)
52. Overstreet, D.H.; Rezvani, A.H.; Parsian, A. (2005) Chronic fl uoxetine treatment reduces swim test immobility but not alcohol intake in the Fawn-Hooded rat, an animal model of depression/alcoholism. Presented at35th annual meeting of the Society for Neuroscience, 2005.
53. Pettinati, H.M. (2004) Antidepressant treatment of co-occurring depression and alcohol dependence. Biol. Psychiatry 56, 785-792. (Pubitemid 39539837)
54. Henn, F.A.; Vollmayr, G. (2005). Stress models of depression: Forming genetically vulnerable strains. Neurosci. Biobehav. Rev. 29, 799-804. (Pubitemid 40755465)
55. Seligmann, M.E.;s Beagley, C. (1975) Learned helplessness in the rat. J. Comp. Physiol. Psychol. 88, 534-541.
56. Jesberger, J.A. and Richardson, J.S. (1985) Animal models of depression: Parallels and correlates to severe depression in humans. Biol. Psychiatry 20, 764-784. (Pubitemid 16048568)
57. Vollmayr, G. and Henn, FA (2001) Learned helplessness in the rat: improvements in validity and reliability. Brain Res. Brain Res. Protoc. 8, 1-7. (Pubitemid 32777872)
58. Sanchi-Segura. C.; Spanagel R.; Henn, F.A.; Vollmayr, G. (2005) Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law. Behav. Pharmacol. 16, 267-270. (Pubitemid 40943901)
59. Bhattamisra, S.K.; Khanna, S.K.; Agrawal, A.K.; Singh, P.U.; Singh, S.K. (2008). Antidepressant activity of standardardized extract of Marsilea minuta Linn. J. Ethnopharmacol. 117, 51-57.
60. Bertaina-Anglade, V.; Larochelle, C.D.; Scheller, A.H. (2006) Antidepressant properties of rotigotine in experimental models of depression. Eur. J. Pharmacol. 548, 106-114. (Pubitemid 44397005)
61. Weiss, J.M.; Cierpial, M.R.; West, C.H. (1998) Selective breeding of rats for high and low motor activity in a swim test. Pharmacol. Bochem. Behav. 61, 49-66.
62. West, C.H.; Weiss, J.M. (1998) Effects of antidepressant drugs on rats bred for low activity in the swim test. Pharmacol. Biochem. Behav, 61, 67-79. (Pubitemid 28477485)
63. West, C.H. and Weiss, J.M. (2005) A selective test for antidepressant treatments using rats bred for stress-induced reduction of motor activity in the swim test. Psychopharmacoloogy 182, 9-23. (Pubitemid 41400857)
64. Piras, G.; Giorgi, O.; Corda, M.G. (2010) Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions. Psychopharmacology June 30 [Epub ahead of print].
65. Liebsch, G.; Montkowski, A.; Holsboer, F.; Landgraph, R. (1998) Behavioral profi le of two Wistar rat lines selectively bred for high or low anxiety-related behavior. Behav. Brain Res. 94, 301-310. (Pubitemid 28352829)
66. Landgraph, R.; Wigger, A. (2003) Born to be anxious, Neuroendocrine and genetic correlates of trait anxiety in HAB rats. Stress 6, 111-119. (Pubitemid 36681961)
67. Overstreet, D.H.; Rezvani, A.H.; Pucilowski, O.; Gause, L.; Janowsky, D.S. (1984) Rapid selection for serotonin-1A sensitivity in rats. Psychiat. Genet. 4, 57-62.
68. Overstreet, D.H.; Rezvani, A.H.; Knapp, D.J.; Crews, F.T.; Janowsky, D.S. (1996) Further selection of rat lines differing in 5-HT-1A receptor sensitivity. Behavioral and functional correlates. Psychiat. Genet. 6, 107-117. (Pubitemid 26371951)
69. Overstreet, D.H.; Daws, L.C.; Schiller, G.R.; Orbach, J.; Janowsky, D.S. (1998) Cholinergic/serotonergic interactions in hypothermia: implications for models of depression. Pharmacol. Biochem. Behav. 59, 777-785. (Pubitemid 28237886)
70. Overstreet, D.H. (2007) The open fi eld test for two. J. Psychopharmacol. 21, 140.
71. Reed, A.L.;erson, J.D.; Bylund, D.B.; Petty, F, ElRefaey, H.; Happe, H.K, (2009) Treatment with escitalopram but not imipramine decreases escape latency times in a learned helplessness model using juvenile rats. Neuropsychopharmacology 134, 319-329.
72. Valentine, G.; Dow, A.; Banasr, M.; Pittman, B.; Duman, R. (2008) Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress. Psychopharmacology 200, 585-596.
73. Willner, P. (1977) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 134, 319-319.
74. Willner, P. (2005) Chronic mild stress (CMS) revisited. Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52, 90-110. (Pubitemid 41160326)
75. Cryan, J.F.; Valentino, R.J.; Lucki, I. (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modifi ed rat forced swim test. Neurosci. Biobehav. Rev. 29, 547-568.
76. Overstreet, D.H.; Kampov-Polevoy, A.B.; Rezvani, A.H.; Murrelle, L.; Halikas, J.A.; Janowsky, D.S. (1993) Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol. Clin. Exp. Res. 17, 366-369. (Pubitemid 23135446)
77. Pucilowski, O.; Overstreet, D.H.; Rezvani, A.H.; Janowsky, D.S. (1993) Chronic mild stress-induced anhedonia: greater effect in a genetic rat model of depression. Physiol. Behav. 54, 1215-1220. (Pubitemid 23343148)
78. File, S.E.; Seth, P. (2003) A review of 25 years of the social interaction test. Eur. J. Pharmacol. 463, 35-53. (Pubitemid 36205071)
79. Overstreet, D.H.; Knapp, D.J.; Breese, G.R. (2002) Accentuated decreases in social interaction in rat subjected to repeated ethanol withdrawals. Alcohol. Clin. Exp. Res. 22, 159-164.
80. Overstreet, D.H.; Knapp, D.J.; Breese, G.R. (2004) Modulation of multiple ethanol withdrawal- induced anxiety-like behavior by CRF and CRF1 receptors. Pharmacol. Biochem. Behav. 77, 405-413. (Pubitemid 38125175)
81. Overstreet, D.H.; Knapp, D.L.; Moy, S.S.; Breese, G.R. (2003) A 5-HT 1A agonist and a 5-HT 2C antagonist reduce social interaction defi cit induced by multiple ethanol withdrawals in rat. Psychopharmacology 167, 344-352. (Pubitemid 36754235)
82. Overstreet, D.H.; Rezvani, A.H.; Janowsky, D.S. (1990) Impaired active avoidance responding in rats selectively bred for increased cholinergic function. Physiol. Behav. 47, 787-788. (Pubitemid 20146772)
83. Dettke, M.S.; Rickels, M.; Lucki, I. (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psycho pharmacology 121, 66-72.