The novel neuropeptide Y Y 5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl] methyl]-methanesulfonamide] exerts anxiolytic- And antidepressant-like effects in rat models of stress sensitivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 900-911

  Walker, Mary W ^a,h   Wolinsky, Toni D ^a,d   Jubian, Vrej ^a   Chandraseria, Gamini ^a   Zhong, Huailing ^a   Huang, Xinyan ^a   Miller, Silke ^a   Hegde, Laxminarayan G ^a,e   Marsteller, Douglas A ^a,f   Marzabadi, Mohammad R ^a   Papp, Mariusz ^b   Overstreet, David H ^c   Gerald, Christophe P G ^a,g   Craig, Douglas A ^a,g  

^a LUNDBECK RESEARCH USA   (United States)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Porsolt and Partners   (France)

^e THERAVANCE INC   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g Transcription Diagnostics Inc   (United States)

^h Lundbeek Research USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CALCIUM; CORTICOTROPIN; CYCLIC AMP; GLUTAMINE; LU AA33810; N [[4 [(4,5 DIHYDRO[1] BENZOTHIEPINO[5,4 D]THIAZOL 2 YL)AMINO]CYCLOHEXYL]METHYL]METHANESULFONAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR; PANCREAS POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; APPETITE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CHRONIC STRESS; CORTICOTROPIN BLOOD LEVEL; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EXPOSURE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FISCHER 344 RAT; FORCED SWIMMING TEST; HUMAN; HUMAN CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIMBIC SYSTEM; LONG TERM CARE; MALE; MOTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SOCIAL INTERACTION; SPRAGUE DAWLEY RAT; STRESS; TRANQUILIZING ACTIVITY; WISTAR RAT;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BENZOTHIEPINS; DISEASE MODELS, ANIMAL; MALE; MODELS, MOLECULAR; RATS; RATS, INBRED F344; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE Y; STRESS, PSYCHOLOGICAL; SULFONAMIDES; THIAZOLES;

EID: 62449098860     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144634     Document Type: Article

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