Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies

Acta Neuropathologica

Volumn 119, Issue 5, 2010, Pages 579-589

  Ihara, Masafumi ^a   Polvikoski, Tuomo M ^a   Hall, Ros ^a   Slade, Janet Y ^a   Perry, Robert H ^a   Oakley, Arthur E ^a   Englund, Elisabet ^b   O'brien, John T ^a   Ince, Paul G ^c   Kalaria, Raj N ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Alzheimer's disease; Myelin; Myelin basic protein; Oligodendrocyte; Vascular dementia; White matter

Indexed keywords

BIOLOGICAL MARKER; GLUTATHIONE TRANSFERASE; MYELIN; MYELIN BASIC PROTEIN;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL DENSITY; CELL MATURATION; CELL SIZE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMYELINATION; DIFFUSE LEWY BODY DISEASE; FEMALE; FRONTAL LOBE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIINFARCT DEMENTIA; NERVE FIBER DEGENERATION; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; TEMPORAL LOBE; WHITE MATTER;

AGED; AGED, 80 AND OVER; DEMENTIA; FEMALE; FRONTAL LOBE; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MYELIN BASIC PROTEINS; MYELIN SHEATH; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; REGRESSION ANALYSIS; TEMPORAL LOBE;

EID: 77953025222     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-009-0635-8     Document Type: Article

References (51)

1. Akiguchi I, Tomimoto H, Suenaga T, Wakita H, Budka H (1997) Alterations in glia and axons in the brains of Binswanger's disease patients. Stroke 28:1423-1429.
2. Akiguchi I, Tomimoto H, Wakita H et al (2004) Topographical and cytopathological lesion analysis of the white matter in Binswanger's disease brains. Acta Neuropathol 107:563-570.
3. Alafuzoff I, Thal DR, Arzberger T et al (2009) Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. Acta Neuropathol 117:309-320.
4. Bannykh SI, Stolt CC, Kim J, Perry A, Wegner M (2006) Oligodendroglial- specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas. J Neurooncol 76:115-127.
5. Barber R, Scheltens P, Gholkar A et al (1999) White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging. J Neurol Neurosurg Psychiatry 67:66-72.
6. Bartzokis G, Sultzer D, Lu PH, Nuechterlein KH, Mintz J, Cummings JL (2004) Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease. Neurobiol Aging 25:843-851.
7. Bozzali M, Falini A, Cercignani M et al (2005) Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain 128:1595-1604.
8. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112:389-404.
9. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259.
10. Burton EJ, Kenny RA, O'Brien J et al (2004) White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients. Stroke 35:1270-1275.
11. Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT (2006) Progression of white matter hyperintensities in Alzheimer disease, dementia with Lewy bodies, and Parkinson disease dementia: a comparison with normal aging. Am J Geriatr Psychiatry 14:842-849.
12. Connor JR (2004) Myelin breakdown in Alzheimer's disease: a commentary. Neurobiol Aging 25:45-47.
13. Duce JA, Hollander W, Jaffe R, Abraham CR (2006) Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiol Aging 27:633-644.
14. Englund E (1998) Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord 9(SUPPL. 1):6-12.
15. Englund E (2000) Neuropathology of white matter disease: parenchymal changes. In: ID Pantoni L, Wallin A (eds) The Matter of white matter. Clinical and pathophysiological aspects of white matter disease related to cognitive decline and vascular dementia, vol 10. Academic Pharmaceutical Productions, Utrecht, pp 223-246.
16. Erkinjuntti T, Benavente O, Eliasziw M et al (1996) Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia. Arch Neurol 53:325-332.
17. Fernando MS, Simpson JE, Matthews F et al (2006) White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 37:1391-1398.
18. Firbank MJ, Minett T, O'Brien JT (2003) Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. Neurology 61:950-954.
19. Furuta A, Ishii N, Nishihara Y, Horie A (1991) Medullary arteries in aging and dementia. Stroke 22:442-446.
20. Gil V, Nicolas O, Mingorance A et al (2006) Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. J Neuropathol Exp Neurol 65:433-444.
21. Gouw AA, Seewann A, Vrenken H et al (2008) Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology. Brain 131:3286-3298.
22. Haglund M, Kalaria R, Slade JY, Englund E (2006) Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia. Acta Neuropathol 111:430-435.
23. Jellinger KA (2007) The enigma of vascular cognitive disorder and vascular dementia. Acta Neuropathol 113:349-388.
24. Jellinger KA (2003) Prevalence of vascular lesions in dementia with Lewy bodies. A postmortem study. J Neural Transm 110:771-778.
25. Kalaria R (2002) Similarities between Alzheimer's disease and vascular dementia. J Neurol Sci 203-204:29-34.
26. Kalaria RN (1996) Cerebral vessels in ageing and Alzheimer's disease. Pharmacol Ther 72:193-214.
27. Kalaria RN, Hedera P (1995) Differential degeneration of the cerebral microvasculature in Alzheimer's disease. Neuroreport 6:477-480.
28. Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T (2004) Towards defining the neuropathological substrates of vascular dementia. J Neurol Sci 226:75-80.
29. Koga H, Yuzuriha T, Yao H et al (2002) Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects. J Neurol Neurosurg Psychiatry 72:737-741.
30. Lewis H, Beher D, Cookson N et al (2006) Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathol Appl Neurobiol 32:103-118.
31. Londos E, Passant U, Brun A, Gustafson L (2000) Clinical Lewy body dementia and the impact of vascular components. Int J Geriatr Psychiatry 15:40-49.
32. Londos E, Passant U, Gustafson L, Brun A (2001) Neuropathological correlates to clinically defined dementia with Lewy bodies. Int J Geriatr Psychiatry 16:667-679.
33. Makris N, Papadimitriou GM, van der Kouwe A et al (2007) Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging 28:1556-1567.
34. Matsuo A, Lee GC, Terai K et al (1997) Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens. Am J Pathol 150:1253-1266.
35. McKeith IG, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863-1872.
36. Medana IM, Esiri MM (2003) Axonal damage: a key predictor of outcome in human CNS diseases. Brain 126:515-530.
37. Mirra SS (1997) The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary. Neurobiol Aging 18:S91- S94.
38. Pantoni L, Garcia JH (1997) Pathogenesis of leukoaraiosis: a review. Stroke 28:652-659.
39. Pantoni L, Garcia JH (1995) The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 26:1293-1301.
40. Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN (1996) Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 148:2083-2095.
41. Salat DH, Tuch DS, Greve DN et al (2005) Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging 26:1215-1227.
42. Sjobeck M, Englund E (2003) Glial levels determine severity of white matter disease in Alzheimer's disease: a neuropathological study of glial changes. Neuropathol Appl Neurobiol 29:159-169.
43. Sjobeck M, Haglund M, Englund E (2005) Decreasing myelin density reflected increasing white matter pathology in Alzheimer's disease-a neuropathological study. Int J Geriatr Psychiatry 20:919-926.
44. Tanaka K, Nogawa S, Suzuki S, Dembo T, Kosakai A (2003) Upregulation of oligodendrocyte progenitor cells associated with restoration of mature oligodendrocytes and myelination in periinfarct area in the rat brain. Brain Res 989:172-179.
45. Tansey FA, Cammer W (1991) A pi form of glutathione-Stransferase is a myelin- and oligodendrocyte-associated enzyme in mouse brain. J Neurochem 57:95-102.
46. Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A betadeposition in the human brain and its relevance for the development of AD. Neurology 58:1791-1800.
47. Tomimoto H, Akiguchi I, Matsuo A et al (1997) Encephalitogenic peptide (EP) in human cerebrovascular white matter lesions. Neuroreport 8:3727-3730.
48. Tullberg M, Fletcher E, DeCarli C et al (2004) White matter lesions impair frontal lobe function regardless of their location. Neurology 63:246-253.
49. Wakita H, Tomimoto H, Akiguchi I et al (2002) Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Brain Res 924:63-70. (Pubitemid 34017465)
50. Wolswijk G (2000) Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Brain 123(Pt 1):105-115.
51. Yamamoto Y, Ihara M, Tham C et al (2009) Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL. Stroke 40:2004-2011.