Engineering of routes to heparin and related polysaccharides

Applied Microbiology and Biotechnology

Volumn 93, Issue 1, 2012, Pages 1-16

  Bhaskar, Ujjwal ^a   Sterner, Eric ^a   Hickey, Anne Marie ^b   Onishi, Akihiro ^b   Zhang, Fuming ^a,b   Dordick, Jonathan S ^a,b   Linhardt, Robert J ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Applied enzymology; Bioengineered heparin; Biosynthesis; Chemical synthesis; Chemoenzymatic synthesis; Metabolic engineering

Indexed keywords

APPLIED ENZYMOLOGY; BIOENGINEERED HEPARIN; CHEMICAL SYNTHESIS; CHEMO-ENZYMATIC SYNTHESIS; METABOLIC ENGINEERING;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; METABOLISM; METALS; TISSUE;

POLYSACCHARIDES;

ARDEPARIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CHONDROITIN SULFATE; DALTEPARIN; ENOXAPARIN; FONDAPARINUX; GLUCOSE DEHYDROGENASE; GLYCOSAMINOGLYCAN; GLYCOSAMINOGLYCAN POLYSULFATE; HEPARAN SULFATE; HEPARIN; HEPARIN BINDING PROTEIN; LOW MOLECULAR WEIGHT HEPARIN; POLYSACCHARIDE; TINZAPARIN;

BIOCHEMISTRY; CARBOHYDRATE; COAGULATION; ENZYME ACTIVITY; METABOLISM; PHYSIOLOGICAL RESPONSE; POLYMER; POLYSACCHARIDE; PROTEIN;

AFFINITY CHROMATOGRAPHY; ANION EXCHANGE; ANTICOAGULATION; BINDING SITE; BIOCHEMISTRY; BIOENGINEERING; CAPILLARY ELECTROPHORESIS; CARBON SOURCE; CELL DENSITY; CELL WALL; DEPOLYMERIZATION; DRUG CONTAMINATION; DRUG DEVELOPMENT; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; ENZYME SYNTHESIS; ENZYMOLOGY; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; LARGE SCALE PRODUCTION; LIQUID CHROMATOGRAPHY; NONHUMAN; OXIDATION; PH; PHARMACODYNAMICS; PHARMACOKINETICS; REVIEW; STRUCTURE ACTIVITY RELATION; SULFATION; SULFONATION; SURFACE PLASMON RESONANCE;

ANIMALS; BIOTECHNOLOGY; HEPARIN; METABOLIC ENGINEERING; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 84856260396     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3641-4     Document Type: Review

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