Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20457-20466

  Levy Adam, Flonia ^a   Abboud Jarrous, Ghada ^b   Guerrini, Marco ^c   Beccati, Daniela ^c   Vlodavsky, Israel ^a   Ilan, Neta ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c Istituto di Ricerche Chimiche e Biochimiche G Ronzoni   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG DOSAGE; ENZYME INHIBITION; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; TITRATION; TUMORS;

ANTICANCER DRUGS; HEPARAN SULFATE; HEPARANASE; HEPARIN BINDING DOMAINS;

ENZYMES;

ANTIBODY; ANTINEOPLASTIC AGENT; ASPARAGINE; ASPARTIC ACID; BETA GLUCURONIDASE; ENDOGLYCOSIDASE HEPARANASE; ENZYME INHIBITOR; GLUTAMINE; HEPARAN SULFATE; HEPARANASE; HEPARIN; LYSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ARTICLE; BINDING COMPETITION; CELL INVASION; CELL SURFACE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; HUMAN; HUMAN CELL; INFLAMMATION; METASTASIS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SURVIVAL;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CULTURE MEDIA, CONDITIONED; ENZYME INHIBITORS; GENE DELETION; GLUCURONIDASE; HEPARIN; HEPARITIN SULFATE; HUMANS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA, EXPERIMENTAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 20144376911     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414546200     Document Type: Article

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