E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor

Biotechnology and Bioengineering

Volumn 107, Issue 6, 2010, Pages 964-973

  Wang, Zhenyu ^a   Ly, Mellisa ^b   Zhang, Fuming ^c   Zhong, Weihong ^d   Suen, Amy ^a   Hickey, Anne Marie ^c   Dordick, Jonathan S ^a,c   Linhardt, Robert J ^a,b,c  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^d ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Capsule; E. coli; Fermentation; Heparin; Heparosan; Polysaccharide

Indexed keywords

ACIDIC POLYSACCHARIDES; CAPSULAR POLYSACCHARIDES; CAPSULE; CHEMO-ENZYMATIC SYNTHESIS; E. COLI; FED BATCHES; FOURIER TRANSFORM MASS SPECTROMETRY; GLUCOSE ADDITION; HEPARIN; HEPAROSAN; HIGH YIELD; NATURAL PRODUCTS; NUMBER AVERAGE MOLECULAR WEIGHT; OXYGEN ENRICHMENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; VOLUMETRIC PRODUCTIVITY; WEIGHT-AVERAGE MOLECULAR WEIGHT;

BIOCHEMISTRY; ELECTROPHORESIS; ESCHERICHIA COLI; FERMENTATION; FOURIER TRANSFORMS; GLUCOSE; MASS SPECTROMETRY; MOLECULAR OXYGEN; MOLECULAR WEIGHT;

POLYSACCHARIDES;

GLYCOSAMINOGLYCAN POLYSULFATE;

ARTICLE; BACTERIAL GROWTH; BIOENGINEERING; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); ESCHERICHIA COLI; FED BATCH FERMENTATION; FOURIER TRANSFORM MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRODUCTIVITY; PROTON NUCLEAR MAGNETIC RESONANCE;

ESCHERICHIA COLI; FERMENTATION; GLYCOSAMINOGLYCANS; HEPARIN; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; POLYSACCHARIDES, BACTERIAL;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 78149433667     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22898     Document Type: Article

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