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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1348-1351

Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists

(11) Furukawa, Akihiro a Arita, Tsuyoshi a Fukuzaki, Takehiro a Satoh, Susumu a Mori, Makoto a Honda, Takeshi a Matsui, Yumi a Wakabayashi, Kenji a Hayashi, Shinko a Araki, Kazushi a Ohsumi, Jun a

a DAIICHI SANKYO CO (Japan)

Author keywords

( ) Cercosporamide; Diabetes; PPAR modulator; SPPAR M; SPPARM

Indexed keywords

CERCOSPORAMIDE DERIVATIVE; NAPHTHALENE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BENZOFURANS; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION REGULATION; HUMANS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; PPAR GAMMA;

EID: 84856217905 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.12.066 Document Type: Article

Times cited : (13)

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