Discovery of a novel selective PPARγ modulator from (-)-Cercosporamide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2095-2098

  Furukawa, Akihiro ^a   Arita, Tsuyoshi ^a   Satoh, Susumu ^a   Wakabayashi, Kenji ^a   Hayashi, Shinko ^a   Matsui, Yumi ^a   Araki, Kazushi ^a   Kuroha, Masanori ^a   Ohsumi, Jun ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Cercosporamide; Diabetes; Modulator; PPAR

Indexed keywords

AMIDE; ANTIDIABETIC AGENT; FARGLITAZAR; GLUCOSE; LIGAND; N (1 NAPHTHYL)METHYLCARBOXAMIDE DERIVATIVE; N BENZYLCARBOXAMIDE DERIVATIVE; NITROGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BINDING SITE; BODY FLUID; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEART WEIGHT; LIGAND BINDING; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYSTEMATIC REVIEW; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOFURANS; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; MICE; MODELS, MOLECULAR; PPAR GAMMA;

MUS;

EID: 77949485859     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.073     Document Type: Article

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