-
1
-
-
62649085032
-
Variability in response to medicines in older people: Phenotypic and genotypic factors
-
McLachlan AJ, Hilmer SN, Le Couteur DG. Variability in response to medicines in older people: phenotypic and genotypic factors. Clin Pharmacol Ther. 2009;85:431-433.
-
(2009)
Clin Pharmacol Ther.
, vol.85
, pp. 431-433
-
-
McLachlan, A.J.1
Hilmer, S.N.2
Le Couteur, D.G.3
-
3
-
-
19444376971
-
Drug metabolism and variability among patients in drug response
-
Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med. 2005;352:2211-2221.
-
(2005)
N Engl J Med.
, vol.352
, pp. 2211-2221
-
-
Wilkinson, G.R.1
-
4
-
-
59149085120
-
Clinical implications of changes in hepatic drug metabolism in older people
-
Hilmer SN, Shenfield GM, Le Couteur DG. Clinical implications of changes in hepatic drug metabolism in older people. Ther Clin Risk Manag. 2005;1:151-156.
-
(2005)
Ther Clin Risk Manag.
, vol.1
, pp. 151-156
-
-
Hilmer, S.N.1
Shenfield, G.M.2
Le Couteur, D.G.3
-
5
-
-
0028936263
-
Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis
-
Fraser R, Dobbs BR, Rogers GT. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology. 1995;21:863-874.
-
(1995)
Hepatology.
, vol.21
, pp. 863-874
-
-
Fraser, R.1
Dobbs, B.R.2
Rogers, G.T.3
-
6
-
-
13244297157
-
The hepatic sinusoid in aging and cirrhosis: Effects on hepatic substrate disposition and drug clearance
-
DOI 10.2165/00003088-200544020-00004
-
Le Couteur DG, Fraser R, Hilmer SN, Rivory LP, McLean AJ. The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clin Pharmacokinet. 2005;44:187-200. (Pubitemid 40188940)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.2
, pp. 187-200
-
-
Le Couteur, D.G.1
Fraser, R.2
Hilmer, S.3
Rivory, L.P.4
McLean, A.J.5
-
7
-
-
32944468701
-
Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat
-
DOI 10.1002/hep.20937
-
Hilmer SN, Cogger VC, Fraser R, McLean AJ, Sullivan D, Le Couteur DG. Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology. 2005;42:1349-1354. (Pubitemid 43260037)
-
(2005)
Hepatology
, vol.42
, Issue.6
, pp. 1349-1354
-
-
Hilmer, S.N.1
Cogger, V.C.2
Fraser, R.3
McLean, A.J.4
Sullivan, D.5
Le Couteur, D.G.6
-
8
-
-
0035120774
-
Pseudocapillarization and associated energy limitation in the aged rat liver
-
DOI 10.1053/jhep.2001.22754
-
Le Couteur DG, Cogger VC, Markus AMA, Harvey PJ, Yin Z-L, Ansselin AD, McLean AJ. Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology. 2001;33:537-543. (Pubitemid 32185214)
-
(2001)
Hepatology
, vol.33
, Issue.3
, pp. 537-543
-
-
Le Couteur, D.G.1
Cogger, V.C.2
Markus, A.M.A.3
Harvey, P.J.4
Yin, Z.-L.5
Ansselin, A.D.6
McLean, A.J.7
-
9
-
-
2642572647
-
Aging biology and geriatric clinical pharmacology
-
DOI 10.1124/pr.56.2.4
-
McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56:163-184. (Pubitemid 38720828)
-
(2004)
Pharmacological Reviews
, vol.56
, Issue.2
, pp. 163-184
-
-
McLean, A.J.1
Le Couteur, D.G.2
-
10
-
-
0023691250
-
Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly
-
Woodhouse KW, Wynne HA. Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly. Clin Pharmacokinet. 1988;15:287-294.
-
(1988)
Clin Pharmacokinet
, vol.15
, pp. 287-294
-
-
Woodhouse, K.W.1
Wynne, H.A.2
-
11
-
-
41949104871
-
Free drug metabolic clearance in elderly people
-
DOI 10.2165/00003088-200847050-00002
-
Butler JM, Begg EJ. Free drug metabolic clearance in elderly people. Clin Pharmacokinet. 2008;47:297-321. (Pubitemid 351508117)
-
(2008)
Clinical Pharmacokinetics
, vol.47
, Issue.5
, pp. 297-321
-
-
Butler, J.M.1
Begg, E.J.2
-
12
-
-
0342547065
-
The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans
-
DOI 10.1016/S0169-409X(97)00040-9, PII S0169409X97000409
-
Wilkinson GR. The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans. Adv Drug Deliv Rev. 1997;27:129-159. (Pubitemid 27417870)
-
(1997)
Advanced Drug Delivery Reviews
, vol.27
, Issue.2-3
, pp. 129-159
-
-
Wilkinson, G.R.1
-
13
-
-
0030973784
-
Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
-
DOI 10.1016/S0009-9236(97)90166-1
-
Sotaniemi EA, Arranto AJ, Pelkonen O, Pasanen M. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther. 1997;61:331-339. (Pubitemid 27145435)
-
(1997)
Clinical Pharmacology and Therapeutics
, vol.61
, Issue.3
, pp. 331-339
-
-
Sotaniemi, E.A.1
Arranto, A.J.2
Pelkonen, O.3
Pasanen, M.4
-
14
-
-
21044454600
-
Drug metabolism and ageing
-
DOI 10.1258/136218005775544589
-
Wynne H. Drug metabolism and ageing. J Br Menopause Soc. 2005;11:51-56. (Pubitemid 40872876)
-
(2005)
Journal of the British Menopause Society
, vol.11
, Issue.2
, pp. 51-56
-
-
Wynne, H.1
-
15
-
-
0035695389
-
Liver function and phase I drug metabolism in the elderly: A paradox
-
Schmucker DL. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging. 2001;18:837-851. (Pubitemid 34073129)
-
(2001)
Drugs and Aging
, vol.18
, Issue.11
, pp. 837-851
-
-
Schmucker, D.L.1
-
16
-
-
70149103802
-
Pharmacokinetics and drug metabolism in the elderly
-
Klotz U. Pharmacokinetics and drug metabolism in the elderly. Drug Metab Rev. 2009;41:67-76.
-
(2009)
Drug Metab Rev.
, vol.41
, pp. 67-76
-
-
Klotz, U.1
-
17
-
-
77953507378
-
The 'apparent clearance' of free phenytoin in elderly vs. younger adults
-
Wright DF, Begg EJ. The 'apparent clearance' of free phenytoin in elderly vs. younger adults. Br J Clin Pharmacol. 2010;70:132-138.
-
(2010)
Br J Clin Pharmacol.
, vol.70
, pp. 132-138
-
-
Wright, D.F.1
Begg, E.J.2
-
18
-
-
4444278991
-
The effects of gender, age, ethnicity, and liver microsomes and inducibility in cultured human hepatocytes
-
Parkinson A, Mudra DR, Johnson C, Dwyer A, Carroll KM. The effects of gender, age, ethnicity, and liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol. 2004;199:193-209.
-
(2004)
Toxicol Appl Pharmacol.
, vol.199
, pp. 193-209
-
-
Parkinson, A.1
Mudra, D.R.2
Johnson, C.3
Dwyer, A.4
Carroll, K.M.5
-
19
-
-
74549132748
-
Interindividual variability in hepatic drug glucuronidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system
-
Court MH. Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system. Drug Metab Rev. 2010;42:209-224.
-
(2010)
Drug Metab Rev.
, vol.42
, pp. 209-224
-
-
Court, M.H.1
-
20
-
-
0025245869
-
The association of age and frailty with paracetamol conjugation in man
-
Wynne HA, Cope LH, Herd B, Rawlins MD, James OF, Woodhouse KW. The association of age and frailty with paracetamol conjugation in man. Age Ageing. 1990;19:419-424.
-
(1990)
Age Ageing.
, vol.19
, pp. 419-424
-
-
Wynne, H.A.1
Cope, L.H.2
Herd, B.3
Rawlins, M.D.4
James, O.F.5
Woodhouse, K.W.6
-
21
-
-
0027179625
-
The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide
-
Wynne HA, Yelland C, Cope LH, Boddy A, Woodhouse KW, Bateman DN. The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide. Age Ageing. 1993;22:354-359. (Pubitemid 23282362)
-
(1993)
Age and Ageing
, vol.22
, Issue.5
, pp. 354-359
-
-
Wynne, H.A.1
Yelland, C.2
Cope, L.H.3
Boddy, A.4
Woodhouse, K.W.5
Bateman, D.N.6
-
22
-
-
3242702142
-
The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin
-
DOI 10.1124/dmd.32.8.794
-
Hilmer SN, Cogger VC, Muller M, Le Couteur DG. The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin. Drug Metab Dispos. 2004;32:794-799. (Pubitemid 38955607)
-
(2004)
Drug Metabolism and Disposition
, vol.32
, Issue.8
, pp. 794-799
-
-
Hilmer, S.N.1
Cogger, V.C.2
Muller, M.3
Le Couteur, D.G.4
-
23
-
-
12244262786
-
Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver
-
Hong Y, Ramzan I, McLachlan AJ. Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver. J Pharm Sci. 2004;94:169-176.
-
(2004)
J Pharm Sci.
, vol.94
, pp. 169-176
-
-
Hong, Y.1
Ramzan, I.2
McLachlan, A.J.3
-
24
-
-
77955896716
-
Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells
-
Simon-Santamaria J, Malovic I, Warren A, et al. Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells. J Gerontol A Biol Sci Med Sci. 2010;65A:951-960.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65 A
, pp. 951-960
-
-
Simon-Santamaria, J.1
Malovic, I.2
Warren, A.3
-
25
-
-
0036263979
-
Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug
-
DOI 10.1124/jpet.301.3.1079
-
Hung DY, Chang P, Cheung K, McWhinney B, Masci PP, Weiss M, Roberts MS. Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug. J Pharmacol Exp Ther. 2002;301:1079-1087. (Pubitemid 34595100)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.301
, Issue.3
, pp. 1079-1087
-
-
Hung, D.Y.1
Chang, P.2
Cheung, K.3
McWhinney, B.4
Masci, P.P.5
Weiss, M.6
Roberts, M.S.7
-
26
-
-
79957813439
-
Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats
-
Mitchell SJ, Huizer-Pajkos A, Cogger VC, et al. Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats. J Gerontol A Biol Sci Med Sci. 2011;66:400-408.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 400-408
-
-
Mitchell, S.J.1
Huizer-Pajkos, A.2
Cogger, V.C.3
-
27
-
-
78650069556
-
Poloxamer 407 increases the recovery of paracetamol in the isolated perfused rat liver
-
Mitchell SJ, Huizer-Pajkos A, Cogger VC, McLachlan AJ, Couteur DGL, Hilmer SN. Poloxamer 407 increases the recovery of paracetamol in the isolated perfused rat liver. J Pharm Sci. 2011;100:334-340.
-
(2011)
J Pharm Sci.
, vol.100
, pp. 334-340
-
-
Mitchell, S.J.1
Huizer-Pajkos, A.2
Cogger, V.C.3
McLachlan, A.J.4
Dgl, C.5
Hilmer, S.N.6
-
28
-
-
2442699834
-
Cardiovascular health study collaborative research group. Frailty in older adults: Evidence for a phenotype
-
Fried LP, Tangen CM, Walston J. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156.
-
(2001)
J Gerontol A Biol Sci Med Sci.
, vol.56
-
-
Fried, L.P.1
Tangen, C.M.2
Walston, J.3
-
29
-
-
33744913541
-
Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging research conference on frailty in older adults
-
DOI 10.1111/j.1532-5415.2006.00745.x
-
Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991-1001. (Pubitemid 43847040)
-
(2006)
Journal of the American Geriatrics Society
, vol.54
, Issue.6
, pp. 991-1001
-
-
Walston, J.1
Hadley, E.C.2
Ferrucci, L.3
Guralnik, J.M.4
Newman, A.B.5
Studenski, S.A.6
Ershler, W.B.7
Harris, T.8
Fried, L.P.9
-
31
-
-
33646165075
-
Erythromycin breath test results in elderly, very elderly, and frail elderly persons
-
Schwartz JB. Erythromycin breath test results in elderly, very elderly, and frail elderly persons. Clin Pharmacol Ther. 2006;79:440-448.
-
(2006)
Clin Pharmacol Ther.
, vol.79
, pp. 440-448
-
-
Schwartz, J.B.1
-
32
-
-
78650239118
-
Outcome instruments to measure frailty: A systematic review
-
de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JSM, Olde Rikkert MGM, Nijhuis-van der Sanden MWG. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev. 2011;10:104-114.
-
(2011)
Ageing Res Rev.
, vol.10
, pp. 104-114
-
-
De Vries, N.M.1
Staal, J.B.2
Van Ravensberg, C.D.3
Hobbelen, J.S.M.4
Olde Rikkert, M.G.M.5
Nijhuis-Van Der Sanden, M.W.G.6
-
34
-
-
33748075822
-
Validity and reliability of the Edmonton Frail Scale
-
Rolfson DBM. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35:526-529.
-
(2006)
Age Ageing.
, vol.35
, pp. 526-529
-
-
Dbm, R.1
-
35
-
-
70350654805
-
The assessment of frailty in older people in acute care
-
Hilmer SN, Perera V, Mitchell S, et al. The assessment of frailty in older people in acute care. Aust J Ageing. 2009;28:182-188.
-
(2009)
Aust J Ageing.
, vol.28
, pp. 182-188
-
-
Hilmer, S.N.1
Perera, V.2
Mitchell, S.3
-
36
-
-
78650983359
-
Gentamicin pharmacokinetics in old age and frailty
-
Hilmer SN, Tran K, Rubie P, et al. Gentamicin pharmacokinetics in old age and frailty. Br J Clin Pharmacol. 2011;71:224-231.
-
(2011)
Br J Clin Pharmacol.
, vol.71
, pp. 224-231
-
-
Hilmer, S.N.1
Tran, K.2
Rubie, P.3
-
37
-
-
79955778814
-
Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: Impact of ageing and frailty
-
Mitchell SJ, Hilmer SN, Murnion BP, Matthews S. Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. J Clin Pharm Ther. 2011;36:327-335.
-
(2011)
J Clin Pharm Ther.
, vol.36
, pp. 327-335
-
-
Mitchell, S.J.1
Hilmer, S.N.2
Murnion, B.P.3
Matthews, S.4
-
38
-
-
61449167053
-
The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation
-
Perera V, Bajorek BV, Matthews S, Hilmer SN. The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age Ageing. 2009;38:156-162.
-
(2009)
Age Ageing.
, vol.38
, pp. 156-162
-
-
Perera, V.1
Bajorek, B.V.2
Matthews, S.3
Hilmer, S.N.4
-
39
-
-
33747114409
-
Regulation of drug metabolism and disposition during inflammation and infection
-
Renton KW. Regulation of drug metabolism and disposition during inflammation and infection. Expert Opin Drug Metab Toxicol. 2005;1:629-640.
-
(2005)
Expert Opin Drug Metab Toxicol.
, vol.1
, pp. 629-640
-
-
Renton, K.W.1
-
40
-
-
33748051705
-
The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
-
DOI 10.1016/j.clpt.2006.06.002, PII S0009923606002414
-
Kurnik D, Wood AJ, Wilkinson GR. The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity. Clin Pharmacol Ther. 2006;80:228-234. (Pubitemid 44301092)
-
(2006)
Clinical Pharmacology and Therapeutics
, vol.80
, Issue.3
, pp. 228-234
-
-
Kurnik, D.1
Wood, A.J.J.2
Wilkinson, G.R.3
-
41
-
-
57749173132
-
The effects of polypharmacy in older adults
-
Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85:86-88.
-
(2009)
Clin Pharmacol Ther.
, vol.85
, pp. 86-88
-
-
Hilmer, S.N.1
Gnjidic, D.2
-
43
-
-
34447261692
-
The challenge of managing drug interactions in elderly people
-
DOI 10.1016/S0140-6736(07)61092-7, PII S0140673607610927
-
Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet. 2007;370:185-191. (Pubitemid 47042897)
-
(2007)
Lancet
, vol.370
, Issue.9582
, pp. 185-191
-
-
Mallet, L.1
Spinewine, A.2
Huang, A.3
-
44
-
-
0027217141
-
Aging and the response to inhibition and induction of theophylline metabolism
-
Vestal RE, Cusack BJ, Crowley JJ, Loi CM. Aging and the response to inhibition and induction of theophylline metabolism. Exp Gerontol. 1993;28:421-433. (Pubitemid 23226559)
-
(1993)
Experimental Gerontology
, vol.28
, Issue.4-5
, pp. 421-433
-
-
Vestal, R.E.1
Cusack, B.J.2
Crowley, J.J.3
Loi, C.-M.4
-
45
-
-
0042833213
-
The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity
-
DOI 10.1016/S0009-9236(03)00187-5
-
Gorski JC, Vannaprasaht S, Hamman MA, Ambrosius WT, Bruce MA, Haehner-Daniels B, Hall SD. The effect of age, sex and rifampicin administration on intestinal and hepatic cytochrome P4503A activity. Clin Pharmacol Ther. 2003;74:275-287. (Pubitemid 37083103)
-
(2003)
Clinical Pharmacology and Therapeutics
, vol.74
, Issue.3
, pp. 275-287
-
-
Gorski, J.C.1
Vannaprasaht, S.2
Hamman, M.A.3
Ambrosius, W.T.4
Bruce, M.A.5
Haehner-Daniels, B.6
Hall, S.D.7
-
46
-
-
26944440101
-
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics
-
DOI 10.2165/00003088-200544110-00005
-
Ishizawa Y, Yasui-Furukori N, Takahata T, Sasaki M, Tateishi T. The effect of aging on the relationship between the cytochrome P4502C19 genotype and omeprazole pharmacokinetics. Clin Pharmacokinet. 2005;44:1179-1189. (Pubitemid 41483702)
-
(2005)
Clinical Pharmacokinetics
, vol.44
, Issue.11
, pp. 1179-1189
-
-
Ishizawa, Y.1
Yasui-Furukori, N.2
Takahata, T.3
Sasaki, M.4
Tateishi, T.5
-
47
-
-
0037226087
-
Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib
-
DOI 10.2165/00003088-200342030-00003
-
Brenner SS, Herrlinger C, Dilger K, Mürdter TE, Hofmann U, Marx C, Klotz U. Influence of age and cytochrome P4502C9 genotype on the steady-state disposition of diclofenac and celecoxib. Clin Pharmacokinet. 2003;42:283-292. (Pubitemid 36308065)
-
(2003)
Clinical Pharmacokinetics
, vol.42
, Issue.3
, pp. 283-292
-
-
Brenner, S.S.1
Herrlinger, C.2
Dilger, K.3
Murdter, T.E.4
Hofmann, U.5
Marx, C.6
Klotz, U.7
-
48
-
-
36148985283
-
Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: Proposal for a new dosing regimen in Chinese patients
-
DOI 10.1007/s00228-007-0381-6
-
Miao L, Yang J, Huang C, Shen Z. Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients. Eur J Clin Pharmacol. 2007;63:1135-1141. (Pubitemid 350112769)
-
(2007)
European Journal of Clinical Pharmacology
, vol.63
, Issue.12
, pp. 1135-1141
-
-
Miao, L.1
Yang, J.2
Huang, C.3
Shen, Z.4
-
49
-
-
62649101737
-
Pharmacoepigenetics: Its role in interindividual differences in drug response
-
Gomez A, Ingelman-Sundberg M. Pharmacoepigenetics: its role in interindividual differences in drug response. Clin Pharmacol Ther. 2009;85:426-430.
-
(2009)
Clin Pharmacol Ther.
, vol.85
, pp. 426-430
-
-
Gomez, A.1
Ingelman-Sundberg, M.2
|