-
1
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
2
-
-
0027517374
-
Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group
-
Seshadri R, Firgaira FA, Horsfall DJ, et al. Clinical significance of HER-2/neu oncogene amplification in primary breast cancer. The South Australian Breast Cancer Study Group. J Clin Oncol 1993;11:1936-42
-
(1993)
J Clin Oncol
, vol.11
, pp. 1936-1942
-
-
Seshadri, R.1
Firgaira, F.A.2
Horsfall, D.J.3
-
3
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-48
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
4
-
-
0036467826
-
Efficacy and safety of trastuzumab as single agent in first-line treatment of HER-2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as single agent in first-line treatment of HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20:719-26
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
5
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castañeda-Soto NJ et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23:2162-71
-
(2005)
J Clin Oncol
, vol.23
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castañeda-Soto, N.J.3
-
6
-
-
0035869407
-
-
Slamon DL, Lejland-Jones B, Shalt S, et al. Use of chemotherapy plus monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 200 1;344:783-92
-
Slamon DL, Lejland-Jones B, Shalt S, et al. Use of chemotherapy plus monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 200 1;344:783-92
-
-
-
-
7
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epiderma growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epiderma growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005;23:4265-74
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
8
-
-
0035873822
-
Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
-
Burstein HJ, Kuter I, Campos SM, et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol 2001;19:2722-30
-
(2001)
J Clin Oncol
, vol.19
, pp. 2722-2730
-
-
Burstein, H.J.1
Kuter, I.2
Campos, S.M.3
-
9
-
-
0036409086
-
Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2+ metastatic breast cancer
-
Jahanzeb M, Mortimer JE, Yunus F, et al. Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2+ metastatic breast cancer. Oncologist 2002;7:410-7
-
(2002)
Oncologist
, vol.7
, pp. 410-417
-
-
Jahanzeb, M.1
Mortimer, J.E.2
Yunus, F.3
-
10
-
-
0041885349
-
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
-
Burstein HJ, Harris LN, Marcom PK, et al. Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol 2003;21:2889-95
-
(2003)
J Clin Oncol
, vol.21
, pp. 2889-2895
-
-
Burstein, H.J.1
Harris, L.N.2
Marcom, P.K.3
-
11
-
-
11144274359
-
Trastuzumab (T) plus vinorelbine (VNR) as first-line combination in HER-2 overexpressing patients with metastatic breast cancer
-
Glogowska I, Sienkiewicz-Kozlowska R, Bauer-Kosinska B, et al. Trastuzumab (T) plus vinorelbine (VNR) as first-line combination in HER-2 overexpressing patients with metastatic breast cancer. Proc Am Soc Clin Oncol 2004;23:235
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 235
-
-
Glogowska, I.1
Sienkiewicz-Kozlowska, R.2
Bauer-Kosinska, B.3
-
12
-
-
11144328789
-
Trastuzumab and vinorelbine combination in the treatment of HER2 positive metastatic breast cancer
-
Bayo J, Mayordomo JL, Sanchez-Rovira P, et al. Trastuzumab and vinorelbine combination in the treatment of HER2 positive metastatic breast cancer. Proc Am Soc Clin Oncol 2004;23:67
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 67
-
-
Bayo, J.1
Mayordomo, J.L.2
Sanchez-Rovira, P.3
-
13
-
-
33645284988
-
A phase II study on metastatic breast cancer patients treated with weekly vinorelbine with or without trastuzumab according to HER2 expression: Changing the natural history of HER2-positive disease
-
Papaldo P, Fabi A, Ferretti G, et al. A phase II study on metastatic breast cancer patients treated with weekly vinorelbine with or without trastuzumab according to HER2 expression: changing the natural history of HER2-positive disease. Ann Oncol 2006;17:630-6
-
(2006)
Ann Oncol
, vol.17
, pp. 630-636
-
-
Papaldo, P.1
Fabi, A.2
Ferretti, G.3
-
14
-
-
33749344930
-
Vinorelbine plus trastuzumab combination as first-line therapy for HER 2-positive metastatic breast cancer patients: An international phase II trial
-
Chan A, Martin M, Untch M, et al. Vinorelbine plus trastuzumab combination as first-line therapy for HER 2-positive metastatic breast cancer patients: an international phase II trial. Br J Cancer 2006;95:788-93
-
(2006)
Br J Cancer
, vol.95
, pp. 788-793
-
-
Chan, A.1
Martin, M.2
Untch, M.3
-
15
-
-
34548178720
-
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
-
Burstein HJ, Keshaviah A, Baron AD, et al. Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study. Cancer 2007;110:965-72
-
(2007)
Cancer
, vol.110
, pp. 965-972
-
-
Burstein, H.J.1
Keshaviah, A.2
Baron, A.D.3
-
16
-
-
2942659576
-
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
Pegram MD, Konecny GE, O'callaghan C, et al. Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 2004;96:739-49
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'callaghan, C.3
-
17
-
-
0036186287
-
Antitumor activity of combination of anti-HER2-antibody trastuzumab and oral fluoropyrimidines capecitabine/5′-dFUrd in human breast ancer models
-
Fujimoto-Ouchi K, Sekiguchi F, Tanaka Y. Antitumor activity of combination of anti-HER2-antibody trastuzumab and oral fluoropyrimidines capecitabine/5′-dFUrd in human breast ancer models. Cancer Chemother Pharmacol 2002;49:211-6
-
(2002)
Cancer Chemother Pharmacol
, vol.49
, pp. 211-216
-
-
Fujimoto-Ouchi, K.1
Sekiguchi, F.2
Tanaka, Y.3
-
18
-
-
21044458866
-
Results of a phase II trial of Herceptin plus Xeloda in patients with previously untreated HER2-positive metastatic breast cancer
-
Xu L, Song S, Zhu J, et al. Results of a phase II trial of Herceptin plus Xeloda in patients with previously untreated HER2-positive metastatic breast cancer. 27th San Antonio Breast Cancer Symposium 2004;88:Abstr. 128
-
27th San Antonio Breast Cancer Symposium 2004;88:Abstr
, pp. 128
-
-
Xu, L.1
Song, S.2
Zhu, J.3
-
19
-
-
34548256855
-
Phase II study of capecitabine plus trastuzumab in human epidermal growth factor receptor 2 overexpressing metastatic breast cancer pretreated with anthracyclines or taxanes
-
Schaller G, Fuchs I, Gonsch T, et al. Phase II study of capecitabine plus trastuzumab in human epidermal growth factor receptor 2 overexpressing metastatic breast cancer pretreated with anthracyclines or taxanes. J Clin Oncol 2007;25:3246-50
-
(2007)
J Clin Oncol
, vol.25
, pp. 3246-3250
-
-
Schaller, G.1
Fuchs, I.2
Gonsch, T.3
-
20
-
-
55249093437
-
Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2-overexpressing metastatic breast cancer after failure of both anthracyclines and taxanes
-
Ishida T, Kiba T, Takeda M, et al. Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2-overexpressing metastatic breast cancer after failure of both anthracyclines and taxanes. Proc Am Soc Clin Oncol 2008;26:1117
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1117
-
-
Ishida, T.1
Kiba, T.2
Takeda, M.3
-
21
-
-
37249055069
-
Phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial
-
Yamamoto D, Iwase S, Kitamura K, et al. Phase II study of trastuzumab and capecitabine for patients with HER2-overexpressing metastatic breast cancer: Japan Breast Cancer Research Network (JBCRN) 00 Trial. Cancer Chemother Pharmacol 2008;61:509-14
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 509-514
-
-
Yamamoto, D.1
Iwase, S.2
Kitamura, K.3
-
22
-
-
0347909165
-
Gemcitabine and trastuzumab combination as salvage treatment in patients with HER2-positive metastatic breast cancer
-
Christodoulou C, Fountzilas G, Razi E, et al. Gemcitabine and trastuzumab combination as salvage treatment in patients with HER2-positive metastatic breast cancer. Proc Am Soc Clin Oncol 2003;22:42
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 42
-
-
Christodoulou, C.1
Fountzilas, G.2
Razi, E.3
-
23
-
-
3543091572
-
Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer
-
O'shaughnessy JA, Vukelja S, Marsland T, et al. Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer. Clin Breast Cancer 2004;5:142-7
-
(2004)
Clin Breast Cancer
, vol.5
, pp. 142-147
-
-
O'shaughnessy, J.A.1
Vukelja, S.2
Marsland, T.3
-
24
-
-
55249117745
-
Phase II study of gemcitabine (Gem) and trastuzumab (T) combination therapy in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC). First stage results
-
Brufsky A, Orlando M, Fox K, et al. Phase II study of gemcitabine (Gem) and trastuzumab (T) combination therapy in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC). First stage results. 27th San Antonio Breast Cancer Symposium 2004;88.Abstr. 3047
-
27th San Antonio Breast Cancer Symposium 2004;88.Abstr
, pp. 3047
-
-
Brufsky, A.1
Orlando, M.2
Fox, K.3
-
25
-
-
11144357506
-
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX™/Doxil®) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
-
O'brien Mer, Wigler N, Inbar M, et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX™/Doxil®) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004;15:440-9
-
(2004)
Ann Oncol
, vol.15
, pp. 440-449
-
-
Mer, O.1
Wigler, N.2
Inbar, M.3
-
26
-
-
33745552216
-
Pegylated liposomal doxorubicin and trastuzumab in HER-2 overexpressing metastatic breast cancer: A multicenter phase II trial
-
Chia S, Clemons M, Martin L, et al. Pegylated liposomal doxorubicin and trastuzumab in HER-2 overexpressing metastatic breast cancer: a multicenter phase II trial. J Clin Oncol 2006;24: 2773-8
-
(2006)
J Clin Oncol
, vol.24
, pp. 2773-2778
-
-
Chia, S.1
Clemons, M.2
Martin, L.3
-
27
-
-
0003291391
-
TLC D99 (D, Myocet) and Herceptin (H) is safe in advanced breast cancer (ABC): Final cardiac safety and efficacy analysis
-
Theodoulou M, Campos S, Batist G, et al. TLC D99 (D, Myocet) and Herceptin (H) is safe in advanced breast cancer (ABC): final cardiac safety and efficacy analysis. Proc Am Soc Clin Oncol 2002;21:55
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 55
-
-
Theodoulou, M.1
Campos, S.2
Batist, G.3
-
28
-
-
0025986825
-
A monoclonal antibody against c-erbB-2 proteins enhance the cytotoxicity of cisdiamminedichloroplatinum against human breast and ovarian tumor cell lines
-
Hancock MC, langton BC, Chan T, et al. A monoclonal antibody against c-erbB-2 proteins enhance the cytotoxicity of cisdiamminedichloroplatinum against human breast and ovarian tumor cell lines. Cancer Res 1991;51:4575-80
-
(1991)
Cancer Res
, vol.51
, pp. 4575-4580
-
-
Hancock, M.C.1
langton, B.C.2
Chan, T.3
-
29
-
-
0033118889
-
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
-
Pegram M, Hsu S, Lewis G, et al. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 1999;18:2241-51
-
(1999)
Oncogene
, vol.18
, pp. 2241-2251
-
-
Pegram, M.1
Hsu, S.2
Lewis, G.3
-
30
-
-
0031903646
-
Phase 11 study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monodonal antibody plus cisplatin in patients with HER2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram MD, Lipton A, Hayes DF, et al. Phase 11 study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monodonal antibody plus cisplatin in patients with HER2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998;16:2659-71
-
(1998)
J Clin Oncol
, vol.16
, pp. 2659-2671
-
-
Pegram, M.D.1
Lipton, A.2
Hayes, D.F.3
-
31
-
-
32444442786
-
Multicenter phase II study of trastuzumab in combination with epirubicin and docetaxel as first-line treatment for HER2-overexpressing metastatic breast cancer
-
Venturini M, Bighin C, Monfardini S, et al. Multicenter phase II study of trastuzumab in combination with epirubicin and docetaxel as first-line treatment for HER2-overexpressing metastatic breast cancer. Breast Cancer Res Treat 2006;95:45-53
-
(2006)
Breast Cancer Res Treat
, vol.95
, pp. 45-53
-
-
Venturini, M.1
Bighin, C.2
Monfardini, S.3
-
32
-
-
11144260020
-
First-line treatment with weekly docetaxel, vinorelbine, and trastuzumab in HER2 overxpressing metastatic breast cancer (HER2+ MBC):a Minnie Pearl Cancer Research Network Phase II trial
-
Yardley DA, Greco FA, Porter LL, et al. First-line treatment with weekly docetaxel, vinorelbine, and trastuzumab in HER2 overxpressing metastatic breast cancer (HER2+ MBC):a Minnie Pearl Cancer Research Network Phase II trial. Proc Am Soc Clin Oncol 2004;22:34
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
, pp. 34
-
-
Yardley, D.A.1
Greco, F.A.2
Porter, L.L.3
-
33
-
-
2942691785
-
Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer
-
Pegram MD, Pienkowski T, Northfelt DW, et al. Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer. J Natl Cancer Inst 2004;96:759-69
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 759-769
-
-
Pegram, M.D.1
Pienkowski, T.2
Northfelt, D.W.3
-
34
-
-
0002295953
-
Results of two open-label multicenter pilot phase II trials of Herceptin in combination with docetaxel and platinum salts (cis- or carboplatin) as therapy for advanced breast cancer in women overexpressing HER-2
-
Nabholtz JM, Crown J, Yonemoto L, et al. Results of two open-label multicenter pilot phase II trials of Herceptin in combination with docetaxel and platinum salts (cis- or carboplatin) as therapy for advanced breast cancer in women overexpressing HER-2. 23rd San Antonio Breast Cancer Symposium 2000;64:Abstr. 83
-
23rd San Antonio Breast Cancer Symposium 2000;64:Abstr
, pp. 83
-
-
Nabholtz, J.M.1
Crown, J.2
Yonemoto, L.3
-
35
-
-
19944428805
-
Paclitaxel and gemcitabine, as first-line chemotherapy, combined with trastuzumab in patients with advanced breast cancer: A phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG)
-
Fountzilas G, Christodoulou C, Tsavaridis D, et al. Paclitaxel and gemcitabine, as first-line chemotherapy, combined with trastuzumab in patients with advanced breast cancer: a phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG). Cancer Invest 2004;22:655-62
-
(2004)
Cancer Invest
, vol.22
, pp. 655-662
-
-
Fountzilas, G.1
Christodoulou, C.2
Tsavaridis, D.3
-
36
-
-
30544441239
-
Two concurrent phase II trials of paclitaxel/carboplatin/trasuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG Study 983252
-
Perez EA, Suman VJ, Rowland KM, et al. Two concurrent phase II trials of paclitaxel/carboplatin/trasuzumab (weekly or every-3-week schedule) as first-line therapy in women with HER2-overexpressing metastatic breast cancer: NCCTG Study 983252. Clin Breast Cancer 2005;5:425-32
-
(2005)
Clin Breast Cancer
, vol.5
, pp. 425-432
-
-
Perez, E.A.1
Suman, V.J.2
Rowland, K.M.3
-
37
-
-
2442645508
-
Phase II trial of trastuzumab followed by weekly paclitaxel/carboplatin as first-line treatment for patients with metastatic breast cancer
-
Burris III H, Yardley D, Jones S, et al. Phase II trial of trastuzumab followed by weekly paclitaxel/carboplatin as first-line treatment for patients with metastatic breast cancer. J Clin Oncol 2004;22:1621-9
-
(2004)
J Clin Oncol
, vol.22
, pp. 1621-1629
-
-
Burris III, H.1
Yardley, D.2
Jones, S.3
-
38
-
-
21844438623
-
Updated results of a phase II study (M77035) of Myocet (R) combined with weekly Herceptin (R) and paclitaxel in patients (pts) with HER2-positive locally advanced or metastatic breast cancer (LABC/MBC)
-
Cortes J, Climent M, Lluch A, et al. Updated results of a phase II study (M77035) of Myocet (R) combined with weekly Herceptin (R) and paclitaxel in patients (pts) with HER2-positive locally advanced or metastatic breast cancer (LABC/MBC). 27th San Antonio Breast Cancer Symposium 2004;88:Abstr. 3041
-
27th San Antonio Breast Cancer Symposium 2004;88:Abstr
, pp. 3041
-
-
Cortes, J.1
Climent, M.2
Lluch, A.3
-
39
-
-
0141698435
-
Cardiac safety of trastuzumab (H) in combination with pegylated liposomal doxorubicin (D) and docetaxel (T) in HER2-positive metastatic breast cancer: Preliminary results of ECOG 3198
-
Wolff AC, Bonetti M, Sparano JA, et al. Cardiac safety of trastuzumab (H) in combination with pegylated liposomal doxorubicin (D) and docetaxel (T) in HER2-positive metastatic breast cancer: preliminary results of ECOG 3198. Proc Am Soc Clin Oncol 2003;22:18
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 18
-
-
Wolff, A.C.1
Bonetti, M.2
Sparano, J.A.3
-
40
-
-
11144357922
-
Cardiac safety of trastuzumab in combination with epirubicin and cyclophosphamide in women with metastatic breast cancer: Results of a phase I trial
-
Untch M, Eidtmann H, Du Bois A, et al. Cardiac safety of trastuzumab in combination with epirubicin and cyclophosphamide in women with metastatic breast cancer: results of a phase I trial. Eur J Cancer 2004;40:988-97
-
(2004)
Eur J Cancer
, vol.40
, pp. 988-997
-
-
Untch, M.1
Eidtmann, H.2
Du Bois, A.3
-
41
-
-
55249119793
-
-
Wardley A, Anton-Torres A, Pivot X, et al. Evaluation of trastuzumab, docetaxel and capecitabine as first-line therapy for HER2-positive locally advanced or metastatic breast cancer. 30th San Antonio Breast Cancer Symposium. 2007;106: Abstr. 309
-
Wardley A, Anton-Torres A, Pivot X, et al. Evaluation of trastuzumab, docetaxel and capecitabine as first-line therapy for HER2-positive locally advanced or metastatic breast cancer. 30th San Antonio Breast Cancer Symposium. 2007;106: Abstr. 309
-
-
-
-
42
-
-
33749037869
-
BCIRG007: Randomized phase III trial of trastuzumab plus docetaxel with or without carboplatin first line in HER2 positive metastatic breast cancer (MBC)
-
Forbes JF, Pienkowsko T, Valero V, et al. BCIRG007: randomized phase III trial of trastuzumab plus docetaxel with or without carboplatin first line in HER2 positive metastatic breast cancer (MBC). Proc Am Soc Clin Oncol 2006;24:516
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
, pp. 516
-
-
Forbes, J.F.1
Pienkowsko, T.2
Valero, V.3
-
43
-
-
33745530224
-
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2 overexpressing metastatic breast cancer
-
Robert N, Leyland-Jones B, Asmar L, et al. Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2 overexpressing metastatic breast cancer. J Clin Oncol 2006;24:2786-92
-
(2006)
J Clin Oncol
, vol.24
, pp. 2786-2792
-
-
Robert, N.1
Leyland-Jones, B.2
Asmar, L.3
-
44
-
-
42049121934
-
Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: Molecular mechanism and clinical implications for endocrine therapy resistance
-
Arpino G, Wiechmann L, Osborne CK, Schiff R. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocrinol Rev 2008;29:217-33
-
(2008)
Endocrinol Rev
, vol.29
, pp. 217-233
-
-
Arpino, G.1
Wiechmann, L.2
Osborne, C.K.3
Schiff, R.4
-
45
-
-
27644597480
-
A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer
-
De Laurentiis M, Arpino G, Massarelli E, et al. A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer. Clin Cancer Res 2005;11:4741-8
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4741-4748
-
-
De Laurentiis, M.1
Arpino, G.2
Massarelli, E.3
-
46
-
-
33847147996
-
The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers
-
Marcom PK, Isaacs C, Harris L, et al. The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers. Breast Cancer Res Treat 2007;102:43-9
-
(2007)
Breast Cancer Res Treat
, vol.102
, pp. 43-49
-
-
Marcom, P.K.1
Isaacs, C.2
Harris, L.3
-
48
-
-
55249105483
-
-
Clemens M, Kaufman B, Mackey JR, et al. Trastuzumab plus anastrozole may prolong overall survival in postmenopausal women with HER2-positive, hormone-dependent metastatic breast cancer: Results of a post-hoc analysis from the tandem study. 30th San Antonio Breast Cancer Symposium 2007; Abstr. 231
-
Clemens M, Kaufman B, Mackey JR, et al. Trastuzumab plus anastrozole may prolong overall survival in postmenopausal women with HER2-positive, hormone-dependent metastatic breast cancer: Results of a post-hoc analysis from the tandem study. 30th San Antonio Breast Cancer Symposium 2007; Abstr. 231
-
-
-
-
49
-
-
0346017700
-
Pharmacokinetics, safety and efficacy of trastuzumab administered every three weeks in combination with paclitaxel
-
Leyland-Jones B, Gelmon K, Ayoub JP, et al. Pharmacokinetics, safety and efficacy of trastuzumab administered every three weeks in combination with paclitaxel. J Clin Oncol 2003;21:3965-71
-
(2003)
J Clin Oncol
, vol.21
, pp. 3965-3971
-
-
Leyland-Jones, B.1
Gelmon, K.2
Ayoub, J.P.3
-
50
-
-
55249084943
-
Dose scheduling and pbarmacokinetic (PK) study of trastuzumab in patients (pts) with HER2/ neu overexpressing breast cancer
-
Felici A, Di Segni S, Contestabile M, et al. Dose scheduling and pbarmacokinetic (PK) study of trastuzumab in patients (pts) with HER2/ neu overexpressing breast cancer. Proc Am Soc Clin Oncol 2007;20:1109
-
(2007)
Proc Am Soc Clin Oncol
, vol.20
, pp. 1109
-
-
Felici, A.1
Di Segni, S.2
Contestabile, M.3
-
51
-
-
0025940676
-
Interrupted versus continuous chemotherapy in patients with metastatic breast cancer. The Piedmont Oncology Association
-
Muss HB, Case LD, Richards F II, et al. Interrupted versus continuous chemotherapy in patients with metastatic breast cancer. The Piedmont Oncology Association. N Engl J Med 1991;325:1342-8
-
(1991)
N Engl J Med
, vol.325
, pp. 1342-1348
-
-
Muss, H.B.1
Case, L.D.2
Richards II, F.3
-
52
-
-
0031409093
-
A randomised trial of six versus twelve courses of chemotherapy in metastatic carcinoma of the breast
-
Gregory RK, Powles TJ, Chang JC, Ashley S. A randomised trial of six versus twelve courses of chemotherapy in metastatic carcinoma of the breast. Eur J Cancer 1997;33:2194-7
-
(1997)
Eur J Cancer
, vol.33
, pp. 2194-2197
-
-
Gregory, R.K.1
Powles, T.J.2
Chang, J.C.3
Ashley, S.4
-
53
-
-
0031859604
-
Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment
-
Falkson G, Gelman RS, Pandya KJ, et al. Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment. J Clin Oncol 1998;16:1669-76
-
(1998)
J Clin Oncol
, vol.16
, pp. 1669-1676
-
-
Falkson, G.1
Gelman, R.S.2
Pandya, K.J.3
-
54
-
-
1842614245
-
Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
-
Tripathy D, Slamon DJ, Cobleigh M, et al. Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 2004;22:1063-70
-
(2004)
J Clin Oncol
, vol.22
, pp. 1063-1070
-
-
Tripathy, D.1
Slamon, D.J.2
Cobleigh, M.3
-
55
-
-
33748642331
-
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: The MD Anderson Cancer Center experience
-
Guarneri V, Lenihan DJ, Valero V, et al. Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the MD Anderson Cancer Center experience. J Clin Oncol 2006;24:4107-15
-
(2006)
J Clin Oncol
, vol.24
, pp. 4107-4115
-
-
Guarneri, V.1
Lenihan, D.J.2
Valero, V.3
-
56
-
-
0032578797
-
Remission of human breast cancer xenografts an therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs
-
Pietras RJ, Pegram MD, Finn RS, et al. Remission of human breast cancer xenografts an therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Oncogene 1998;17:2235-49
-
(1998)
Oncogene
, vol.17
, pp. 2235-2249
-
-
Pietras, R.J.1
Pegram, M.D.2
Finn, R.S.3
-
57
-
-
53149132545
-
Clinical benefit of trastuzumab (H) among patients with HER2-positive metastatic breast cancer (MBC) not achieving objective responses when treated with H plus chemotherapy (CT)
-
Yeon CH, Slamon D, Patel R, et al. Clinical benefit of trastuzumab (H) among patients with HER2-positive metastatic breast cancer (MBC) not achieving objective responses when treated with H plus chemotherapy (CT). Proc Am Soc Clin Oncol 2004;22:680
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
, pp. 680
-
-
Yeon, C.H.1
Slamon, D.2
Patel, R.3
-
58
-
-
0032127350
-
Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
-
Baselga J, Norton L, Albanell J, et al. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 1998;58:2825-31
-
(1998)
Cancer Res
, vol.58
, pp. 2825-2831
-
-
Baselga, J.1
Norton, L.2
Albanell, J.3
-
59
-
-
55249094116
-
Phenotypic and proteomic alterations of acquired trastuzumab resistance
-
Tripathy D, Hassan S, Verma U, et al. Phenotypic and proteomic alterations of acquired trastuzumab resistance. Proc Am Soc Clin Oncol 2005;23:3121
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
, pp. 3121
-
-
Tripathy, D.1
Hassan, S.2
Verma, U.3
-
60
-
-
34948911758
-
Preclinical study of continuous administration of trastuzumab as combination therapy after disease progression with trastuzumab monotherapy
-
Fujimoto-Ouchi K, Sekiguchi F, Mori K. Preclinical study of continuous administration of trastuzumab as combination therapy after disease progression with trastuzumab monotherapy. Proc Am Assoc Cancer Res 2005;46:5062
-
(2005)
Proc Am Assoc Cancer Res
, vol.46
, pp. 5062
-
-
Fujimoto-Ouchi, K.1
Sekiguchi, F.2
Mori, K.3
-
61
-
-
0037231194
-
Prolonged administration of weekly paclitaxel and trastuzumab in patients with advanced breast cancer
-
Christodoulou C, Klouvas G, Pateli A, et al. Prolonged administration of weekly paclitaxel and trastuzumab in patients with advanced breast cancer. Anticancer Res 2003;23:737-44
-
(2003)
Anticancer Res
, vol.23
, pp. 737-744
-
-
Christodoulou, C.1
Klouvas, G.2
Pateli, A.3
-
62
-
-
0041696794
-
Continuation of trastuzumab beyond disease progression is Feasible and safe in patients with metastatic breast cancer: A retrospective analysis of 80 cases by the Hellenic Cooperative Oncology Group
-
Fountzilas G, Razis E, Tsavdaridis D, et al. Continuation of trastuzumab beyond disease progression is Feasible and safe in patients with metastatic breast cancer: a retrospective analysis of 80 cases by the Hellenic Cooperative Oncology Group. Clin Breast Cancer 2003;4:120-5
-
(2003)
Clin Breast Cancer
, vol.4
, pp. 120-125
-
-
Fountzilas, G.1
Razis, E.2
Tsavdaridis, D.3
-
63
-
-
3042676349
-
Use of trastuzumab beyond disease progression: Observations from a retrospective review of case histories
-
Gelmon KA, Mackey J, Verma S, et al. Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories. Clin Breast Cancer 2004;5:52-8
-
(2004)
Clin Breast Cancer
, vol.5
, pp. 52-58
-
-
Gelmon, K.A.1
Mackey, J.2
Verma, S.3
-
64
-
-
27244438620
-
Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC)
-
Stemmler HJ, Kahlert S, Siekiera W, et al. Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC). Onkologie 2005;28:582-6
-
(2005)
Onkologie
, vol.28
, pp. 582-586
-
-
Stemmler, H.J.1
Kahlert, S.2
Siekiera, W.3
-
65
-
-
28344441711
-
Trastuzumab associated with successive cytotoxic therapies beyond disease progression in metastatic breast cancer
-
Garcia-Saenz JA, Martin M, Puente J, et al. Trastuzumab associated with successive cytotoxic therapies beyond disease progression in metastatic breast cancer. Clin Breast Cancer 2005;6:325-9
-
(2005)
Clin Breast Cancer
, vol.6
, pp. 325-329
-
-
Garcia-Saenz, J.A.1
Martin, M.2
Puente, J.3
-
66
-
-
77249177646
-
Retrospective evaluation of clinical outcomes in HER2-positive advanced breast cancer patients progressing on trastuzumab-based therapy in the pre-lapatinib era
-
Montemurro F, Viale G, Donadio M, et al. Retrospective evaluation of clinical outcomes in HER2-positive advanced breast cancer patients progressing on trastuzumab-based therapy in the pre-lapatinib era. 30th San Antonio Breast Cancer Symposium 2007;Abstr. 4057
-
30th San Antonio Breast Cancer Symposium 2007;Abstr
, pp. 4057
-
-
Montemurro, F.1
Viale, G.2
Donadio, M.3
-
67
-
-
53149089557
-
Favourable effect of continued trastuzumab treatment in metastastic breast cancer patients: Results from the French Hermine Cohort Study
-
Extra JM, Antoine EC, Vincent-Salomon A, et al. Favourable effect of continued trastuzumab treatment in metastastic breast cancer patients: results from the French Hermine Cohort Study. 29th San Antonio Breast Cancer Symposium 2006;2064
-
(2006)
29th San Antonio Breast Cancer Symposium
, pp. 2064
-
-
Extra, J.M.1
Antoine, E.C.2
Vincent-Salomon, A.3
-
68
-
-
53149153173
-
Do HER-2 positive metastatic breast cancer patients benefit from the use of trastuzumab beyond disease progression? A mono-institutional experience and systematic review of observational studies
-
In press. doi: 10.1016/ j.breast.2008.03.006
-
Fabi A, Metro G, Ferretti G, et al. Do HER-2 positive metastatic breast cancer patients benefit from the use of trastuzumab beyond disease progression? A mono-institutional experience and systematic review of observational studies. Breast 2008. In press. doi: 10.1016/ j.breast.2008.03.006
-
(2008)
Breast
-
-
Fabi, A.1
Metro, G.2
Ferretti, G.3
-
69
-
-
54049149104
-
Capecitabine vs. capecitabine + trastuzumab in patients with HER-2 positive metastatic breast cancer progressing during trastuzumab treatment: The TBP phase III study (GBG 26/BIG 3-05)
-
Von Minckwitz G, Zielinski C, Maartense E, et al. Capecitabine vs. capecitabine + trastuzumab in patients with HER-2 positive metastatic breast cancer progressing during trastuzumab treatment: the TBP phase III study (GBG 26/BIG 3-05). Proc Am Soc Clin Oncol 2008;26:1025
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1025
-
-
Von Minckwitz, G.1
Zielinski, C.2
Maartense, E.3
-
72
-
-
0038010542
-
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma
-
Bendell JC, Domchek SM, Burstein HJ, et al. Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 2003;97:2972-7
-
(2003)
Cancer
, vol.97
, pp. 2972-2977
-
-
Bendell, J.C.1
Domchek, S.M.2
Burstein, H.J.3
-
73
-
-
4344691784
-
Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer
-
Clayton AJ, Danson S, Jolly S, et al. Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 2004;91:639-43
-
(2004)
Br J Cancer
, vol.91
, pp. 639-643
-
-
Clayton, A.J.1
Danson, S.2
Jolly, S.3
-
74
-
-
34548241776
-
Central nervous system metastases in HER-2 positive metastatic breast cancer patients treated with trastuzumab: Incidence, survival, and risk factors
-
Gori S, Rimondini S, De Angelis V, et al. Central nervous system metastases in HER-2 positive metastatic breast cancer patients treated with trastuzumab: incidence, survival, and risk factors. Oncologist 2007;12:766-73
-
(2007)
Oncologist
, vol.12
, pp. 766-773
-
-
Gori, S.1
Rimondini, S.2
De Angelis, V.3
-
75
-
-
38049075754
-
Clinical utility of continuing trastuzumab beyond brain progression in HER-2 positive metastatic breast cancer
-
Metro G, Sperduti I, Russillo M, et al. Clinical utility of continuing trastuzumab beyond brain progression in HER-2 positive metastatic breast cancer. Oncologist 2007;12:1467-9
-
(2007)
Oncologist
, vol.12
, pp. 1467-1469
-
-
Metro, G.1
Sperduti, I.2
Russillo, M.3
-
76
-
-
33646869874
-
Identifying breast cancer patients at risk for central nervous system (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG)
-
Pestalozzi BC, Zahrieh D, Price KN, et al. Identifying breast cancer patients at risk for central nervous system (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). Ann Oncol 2006;17:935-44
-
(2006)
Ann Oncol
, vol.17
, pp. 935-944
-
-
Pestalozzi, B.C.1
Zahrieh, D.2
Price, K.N.3
-
77
-
-
33845599378
-
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier
-
Stemmler HJ, Schmitt M, Willems A, et al. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs 2007;18:23-8
-
(2007)
Anticancer Drugs
, vol.18
, pp. 23-28
-
-
Stemmler, H.J.1
Schmitt, M.2
Willems, A.3
-
78
-
-
15744372470
-
Survival after brain metastases from breast cancer in the trastuzumab era
-
Kirsch DG, Ledezma CJ, Mathews CS, et al. Survival after brain metastases from breast cancer in the trastuzumab era. J Clin Oncol 2005;23:2114-6
-
(2005)
J Clin Oncol
, vol.23
, pp. 2114-2116
-
-
Kirsch, D.G.1
Ledezma, C.J.2
Mathews, C.S.3
-
79
-
-
46249099391
-
Defining prognosis for women with breast cancer and CNS metastases by HER2 status
-
Dawood S, Broglio K, Esteva FJ, et al. Defining prognosis for women with breast cancer and CNS metastases by HER2 status. Ann Oncol 2008;19:1242-8
-
(2008)
Ann Oncol
, vol.19
, pp. 1242-1248
-
-
Dawood, S.1
Broglio, K.2
Esteva, F.J.3
-
80
-
-
56549113680
-
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
-
In press. doi:10.1007/s10549-007-9885-0
-
Cameron D, Casey M, Press M, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008. In press. doi:10.1007/s10549-007-9885-0
-
(2008)
Breast Cancer Res Treat
-
-
Cameron, D.1
Casey, M.2
Press, M.3
-
81
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2008;26:1993-9
-
(2008)
J Clin Oncol
, vol.26
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
Liu, M.C.3
-
82
-
-
34848899905
-
EGF105084, a phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT)
-
Lin MU, Dieras V, Paul D, et al. EGF105084, a phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT). Proc Am Soc Clin Oncol 2007;25:1012
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
, pp. 1012
-
-
Lin, M.U.1
Dieras, V.2
Paul, D.3
-
83
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, Ravetch JM. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000;6:373-4
-
(2000)
Nat Med
, vol.6
, pp. 373-374
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.M.4
-
84
-
-
0035874981
-
Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, et al. Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Ret 2001;61:4744-9
-
(2001)
Cancer Ret
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
-
85
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, et al. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002;62:4132-41
-
(2002)
Cancer Res
, vol.62
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
-
86
-
-
0037149539
-
Tumor biology: Herceptin acts as an anti-angiogenic cocktail
-
Izumi Y, Xu L, Di Tomaso E, et al. Tumor biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002;416:279-80
-
(2002)
Nature
, vol.416
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
Di Tomaso, E.3
-
87
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004;6:117-27
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
-
88
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007;12:395-402
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
-
89
-
-
55249106686
-
PTEN and phospho-MAP kinase are independent predictors of response only in metastatic breast cancer patients treated with trastuzumab plus chemotherapy as first-line option
-
Mottolese M, Fabi A, Nisticò C, et al. PTEN and phospho-MAP kinase are independent predictors of response only in metastatic breast cancer patients treated with trastuzumab plus chemotherapy as first-line option. 29th San Antonio Breast Cancer Symposium 2006;Abstr. 3046
-
29th San Antonio Breast Cancer Symposium 2006;Abstr
, pp. 3046
-
-
Mottolese, M.1
Fabi, A.2
Nisticò, C.3
-
90
-
-
28244432561
-
Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R, Yuan LX, Zhang B, et al. Insulin-like growth factor-I receptor/ human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005;65:1118-28
-
(2005)
Cancer Res
, vol.65
, pp. 1118-1128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
-
91
-
-
18344382431
-
TGFalpha expression impairs trastuzumab-induced HER2 downregulation
-
Valabrega G, Montemurro F, Sarotto I, et al. TGFalpha expression impairs trastuzumab-induced HER2 downregulation. Oncogene 2005;24:3002-10
-
(2005)
Oncogene
, vol.24
, pp. 3002-3010
-
-
Valabrega, G.1
Montemurro, F.2
Sarotto, I.3
-
92
-
-
12544250996
-
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4-expressing breast cancer cell line
-
Nagy P, Friedländer E, Tanner M, et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a Herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Ret 2005;65:473-82
-
(2005)
Cancer Ret
, vol.65
, pp. 473-482
-
-
Nagy, P.1
Friedländer, E.2
Tanner, M.3
-
93
-
-
18044392064
-
Modified trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
-
Bussolati G, Montemurro F, Righi L, et al. Modified trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer. Br J Cancer 2005;92:1261-7
-
(2005)
Br J Cancer
, vol.92
, pp. 1261-1267
-
-
Bussolati, G.1
Montemurro, F.2
Righi, L.3
-
95
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD, Venkatesan N, et al. Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Ret 2006;66:1630-9
-
(2006)
Cancer Ret
, vol.66
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
-
96
-
-
1242273590
-
Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
-
Xia W, Liu LH, Ho P, Spector NL. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene 2004;23:646-53
-
(2004)
Oncogene
, vol.23
, pp. 646-653
-
-
Xia, W.1
Liu, L.H.2
Ho, P.3
Spector, N.L.4
-
97
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to and-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocaña A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to and-HER2 therapies in breast cancer. J Natl Cancer Inst 2007;99:628-38
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocaña, A.3
-
98
-
-
23944476155
-
Phase I safety, pharmacokinetics, and dinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
Burns HA III, Hurwitz HI, Dees EC, et al. Phase I safety, pharmacokinetics, and dinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005;23:5305-13
-
(2005)
J Clin Oncol
, vol.23
, pp. 5305-5313
-
-
Burns III, H.A.1
Hurwitz, H.I.2
Dees, E.C.3
-
99
-
-
44849108294
-
A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer
-
Burstein HJ, Storniolo AM, Franco S, et al. A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer. Ann Oncol 2008;19:1068-74
-
(2008)
Ann Oncol
, vol.19
, pp. 1068-1074
-
-
Burstein, H.J.1
Storniolo, A.M.2
Franco, S.3
-
100
-
-
33747089049
-
Phase I clinical, biology & pharmacokinetic study of the combination of GW 572016 and capecitabine in patients with advanced solid tumors
-
Schwartz G, Chu Qs-C, Hammond LA, et al. Phase I clinical, biology & pharmacokinetic study of the combination of GW 572016 and capecitabine in patients with advanced solid tumors. Proc Am Soc Clin Oncol 2004;22:3070
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
, pp. 3070
-
-
Schwartz, G.1
Chu, Q.-C.2
Hammond, L.A.3
-
102
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-43
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
103
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for erbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, Doval DC, Chavez MA, et al. Efficacy and safety of lapatinib as first-line therapy for erbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26:2999-3005
-
(2008)
J Clin Oncol
, vol.26
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
Chavez, M.A.3
-
104
-
-
54249153119
-
A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy
-
O'shaughnessy J, Blackwell KL, Bursrein H, et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. Proc Am Soc Clin Oncol 2008;26:1015
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1015
-
-
O'shaughnessy, J.1
Blackwell, K.L.2
Bursrein, H.3
-
105
-
-
55249083983
-
-
Clinicaltrials.Gov: ALTTO (adjuvant lapatinib and/or trastuzumab treatment optimisation) Study; BIG 2-06/N063D Available from: http://clinicaltrials.gov/ct2/results?term=NCT00490139 [Last accessed 1 July 2008]
-
Clinicaltrials.Gov: ALTTO (adjuvant lapatinib and/or trastuzumab treatment optimisation) Study; BIG 2-06/N063D Available from: http://clinicaltrials.gov/ct2/results?term=NCT00490139 [Last accessed 1 July 2008]
-
-
-
-
106
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 2004;64:2343-6
-
(2004)
Cancer Res
, vol.64
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
107
-
-
55249121207
-
-
Gelmon KA, Fumoleau P, Verma 5, et al. Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients who had progressed during trastuzumab therapy. Proc Am Soc Clin Oncol 2008;26:1026
-
Gelmon KA, Fumoleau P, Verma 5, et al. Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients who had progressed during trastuzumab therapy. Proc Am Soc Clin Oncol 2008;26:1026
-
-
-
-
108
-
-
52049088286
-
Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with trastuzumab-insensitive human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Portera CC, Walshe JM, Rosing DR, et al. Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with trastuzumab-insensitive human epidermal growth factor receptor 2-positive metastatic breast cancer. Clin Cancer Res 2008;14:2710-6
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2710-2716
-
-
Portera, C.C.1
Walshe, J.M.2
Rosing, D.R.3
-
109
-
-
22844443043
-
Systemic therapy for metastatic colorectal cancer: Current options, current evidence
-
Kelly H, Goldberg RM. Systemic therapy for metastatic colorectal cancer: current options, current evidence. J Clin Oncol 2005;23:4553-60
-
(2005)
J Clin Oncol
, vol.23
, pp. 4553-4560
-
-
Kelly, H.1
Goldberg, R.M.2
-
110
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone fin metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone fin metastatic breast cancer. N Engl J Med 2007;27(57):2666-76
-
(2007)
N Engl J Med
, vol.27
, Issue.57
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
111
-
-
54249120945
-
Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO
-
Miles D, Chan A, Romieu G, et al. Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. Proc Am Soc Clin Oncol 2008;26:1011
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1011
-
-
Miles, D.1
Chan, A.2
Romieu, G.3
-
112
-
-
0034691674
-
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
-
Yen L, You XL, Al Moustafa AE, et al. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 2000;19:3460-9
-
(2000)
Oncogene
, vol.19
, pp. 3460-3469
-
-
Yen, L.1
You, X.L.2
Al Moustafa, A.E.3
-
113
-
-
12144291334
-
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
-
Konecny GE, Meng YG, Untch M, et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004;10:1706-16
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1706-1716
-
-
Konecny, G.E.1
Meng, Y.G.2
Untch, M.3
-
114
-
-
21044443432
-
Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endotheial growth factor (VEGF)
-
Pegram MD, yeon C, Ku NC, et al. Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endotheial growth factor (VEGF). 27th San Antonio Breast Cancer Symposium 2004;Abstr. 3039
-
27th San Antonio Breast Cancer Symposium 2004;Abstr
, pp. 3039
-
-
Pegram, M.D.1
yeon, C.2
Ku, N.C.3
-
115
-
-
55249104358
-
-
Pegram M, Chan D, Dichmann RA, et al. Phase II combined biological therapy targeting the HER2 proto-oncogene and the vacular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first-line treatment of HER2-amplified breast cancer. 29th San Antonio Breast Cancer Symposium 2006; Abstr.301
-
Pegram M, Chan D, Dichmann RA, et al. Phase II combined biological therapy targeting the HER2 proto-oncogene and the vacular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first-line treatment of HER2-amplified breast cancer. 29th San Antonio Breast Cancer Symposium 2006; Abstr.301
-
-
-
-
117
-
-
53449094091
-
Phase II evaluation of lapatinib and bevacizumab in HER2+ metastatic breast cancer (MBC)
-
Rugo H, Franco S, Stopeck A, et al. Phase II evaluation of lapatinib and bevacizumab in HER2+ metastatic breast cancer (MBC). Proc Am Soc Clin Oncol 2008;26:1042
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1042
-
-
Rugo, H.1
Franco, S.2
Stopeck, A.3
-
118
-
-
55249101007
-
Randomized phase II study of pazopanib + lapatinib vs lapatinib alone in patients with HER2+ advanced or metastatic breast cancer
-
Slamon O, Gomez H, Kabbinawar F, et al. Randomized phase II study of pazopanib + lapatinib vs lapatinib alone in patients with HER2+ advanced or metastatic breast cancer. Proc Am Soc Clin Oncol 2008;26:1016
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1016
-
-
Slamon, O.1
Gomez, H.2
Kabbinawar, F.3
-
119
-
-
4344674482
-
Targeting multiple signal transduction pathways through inhibition of Hsp90
-
Zhang H, Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med 2004;82(8):488-9
-
(2004)
J Mol Med
, vol.82
, Issue.8
, pp. 488-489
-
-
Zhang, H.1
Burrows, F.2
-
120
-
-
36849055007
-
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase I dose-escalation study
-
Modi S, Stopeck AT, Gordon MS, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007;25:5410-7
-
(2007)
J Clin Oncol
, vol.25
, pp. 5410-5417
-
-
Modi, S.1
Stopeck, A.T.2
Gordon, M.S.3
-
121
-
-
51449107427
-
Phase II trial of the inhibitor tanespimycin (Tan) + trastuzumab (T) in patients (pts) with HER2 positive metastatic breast cancer (MBC)
-
Modi S, Sugarman A, Stopeck A, et al. Phase II trial of the inhibitor tanespimycin (Tan) + trastuzumab (T) in patients (pts) with HER2 positive metastatic breast cancer (MBC). Proc Am Soc Clin Oncol 2008;26:1027
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1027
-
-
Modi, S.1
Sugarman, A.2
Stopeck, A.3
-
122
-
-
65349194552
-
A phase I study of trastuzumab-DM1 (T-DM1), a first-in-class HER2 antibody-drug conjugate (ADC), in patients (pts) with advanced HER2+ breast cancer
-
Beeram M, Burris III HA, MODI S, et al. A phase I study of trastuzumab-DM1 (T-DM1), a first-in-class HER2 antibody-drug conjugate (ADC), in patients (pts) with advanced HER2+ breast cancer. Proc Am Soc Clin Oncol 2008;26:1028
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1028
-
-
Beeram, M.1
Burris III, H.A.2
MODI, S.3
-
125
-
-
61749100826
-
Multicenter phase I clinical trial of daily and weekly everolimus (RAD001) in combination with weekly paclitaxel and trastuzumab in patients with HER2-overexpressing metastatic breast cancer with prior resistance to trastuzumab
-
Andre F, Campone M, Hurvitz S, et al. Multicenter phase I clinical trial of daily and weekly everolimus (RAD001) in combination with weekly paclitaxel and trastuzumab in patients with HER2-overexpressing metastatic breast cancer with prior resistance to trastuzumab. Proc Am Soc Clin Oncol 2008;26:1003
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1003
-
-
Andre, F.1
Campone, M.2
Hurvitz, S.3
-
126
-
-
34250619165
-
The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
-
Abraham RT, Gibbons JJ. The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Rca 2007;13:3109-14
-
(2007)
Clin Cancer Rca
, vol.13
, pp. 3109-3114
-
-
Abraham, R.T.1
Gibbons, J.J.2
-
127
-
-
1442358746
-
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
-
Sahin U, Weskamp G, Kelly K, et al. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 2004;164:769-79
-
(2004)
J Cell Biol
, vol.164
, pp. 769-779
-
-
Sahin, U.1
Weskamp, G.2
Kelly, K.3
-
128
-
-
33745765680
-
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
-
Liu PC, Lu X, Li Y, et al. Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells. Cancer Biol Ther 2006;5:657-64
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 657-664
-
-
Liu, P.C.1
Lu, X.2
Li, Y.3
-
129
-
-
45149119734
-
-
Pestalozzi B, Castiglione M. SMO GUIDELINES WORKING GROUP: primary breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008;19(Suppl 12):7-10
-
Pestalozzi B, Castiglione M. SMO GUIDELINES WORKING GROUP: primary breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008;19(Suppl 12):7-10
-
-
-
-
130
-
-
79955865346
-
Time to first tumor progression as outcome predictor of a second trastuzumab-based therapy beyond progression in HER-2 positive metastatic breast cancer
-
Metro G, Fabi A, Giannarelli D, et al. Time to first tumor progression as outcome predictor of a second trastuzumab-based therapy beyond progression in HER-2 positive metastatic breast cancer. Proc Am Soc Clin Oncol 2008;26:1071
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
, pp. 1071
-
-
Metro, G.1
Fabi, A.2
Giannarelli, D.3
|