Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

Oncogene

Volumn 21, Issue 41, 2002, Pages 6255-6263

  Xia, Wenle ^a   Mullin, Robert J ^a   Keith, Barry R ^a   Liu, Lei Hua ^a   Ma, Hong ^a   Rusnak, David W ^a   Owens, Gary ^a   Alligood, Krystal J ^a   Spector, Neil L ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

AKT; EGFR; erbB2; Erk1 2; Tumor xenograft; Tyrosine kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE; N [3 CHLORO 4 [(3 FLUOROBENZYL)OXY]PHENYL] 6 [5 [[[2 (METHYLSULFONYL)ETHYL]AMINO]METHYL] 2 FURYL] 4 QUINAZOLINAMINE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR REGRESSION; TUMOR XENOGRAFT;

ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0037068741     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205794     Document Type: Article

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