Overexpression of either lysine-specific demethylase-1 or CLOCK, but not Co-Rest, improves long-term expression from a modified neurofilament promoter, in a helper virus-free HSV-1 vector system

Brain Research

Volumn 1436, Issue , 2012, Pages 157-167

  Zhang, Guo Rong ^a   Zhao, Hua ^a   Cao, Haiyan ^a   Geller, Alfred I ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chromatin modifying enzyme; Enhancer; Herpes Simplex Virus vector; Long term expression; Striatal neuron; Transcription factor

Indexed keywords

BETA GLOBIN; HERPESVIRUS VECTOR; LYSINE SPECIFIC DEMETHYLASE 1; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN; PROTEIN CO REST; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS INCLUSION BODY; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION REGULATION; HERPES SIMPLEX VIRUS 1; NERVE CELL; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VIRUS GENOME;

ANIMALS; CHICKENS; CLOCK PROTEINS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HISTONE DEMETHYLASES; NEURONS; PROMOTER REGIONS, GENETIC; RATS; REPRESSOR PROTEINS; TRANS-ACTIVATORS;

HUMAN HERPESVIRUS 1; RATTUS; SIMPLEXVIRUS;

EID: 84856020722     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.12.011     Document Type: Article

References (52)

1. M.E. Andres, C. Burger, M.J. Peral-Rubio, E. Battaglioli, M.E. Anderson, J. Grimes, J. Dallman, N. Ballas, and G. Mandel CoREST: a functional corepressor required for regulation of neural-specific gene expression Proc. Natl. Acad. Sci. U. S. A. 96 1999 9873 9878 (Pubitemid 29398825)
2. N. Ballas, and G. Mandel The many faces of REST oversee epigenetic programming of neuronal genes Curr. Opin. Neurobiol. 15 2005 500 506 (Pubitemid 41394393)
3. R. Bernardi, and P.P. Pandolfi Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies Nat. Rev. Mol. Cell Biol. 8 2007 1006 1016 (Pubitemid 350174636)
4. E.R. Brown, G.T.D. Coker, and K.L. O'Malley Organization and evolution of the rat tyrosine hydroxylase gene Biochemistry 26 1987 5208 5212
5. H. Cao, G.R. Zhang, X. Wang, L. Kong, and A.I. Geller Enhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles BMC Neurosci. 9 2008 37
6. J.A. Chong, J. Tapia-Ramirez, S. Kim, J.J. Toledo-Aral, Y. Zheng, M.C. Boutros, Y.M. Altshuller, M.A. Frohman, S.D. Kraner, and G. Mandel REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons Cell 80 1995 949 957
7. R.D. Everett, and G.G. Maul HSV-1 IE protein Vmw110 causes redistribution of PML EMBO J. 13 1994 5062 5069 (Pubitemid 24341087)
8. R.D. Everett, and J. Murray ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection J. Virol. 79 2005 5078 5089 (Pubitemid 40464258)
9. R.D. Everett, J. Murray, A. Orr, and C.M. Preston Herpes simplex virus type 1 genomes are associated with ND10 nuclear substructures in quiescently infected human fibroblasts J. Virol. 81 2007 10991 11004 (Pubitemid 47536073)
10. C. Fraefel, S. Song, F. Lim, P. Lang, L. Yu, Y. Wang, P. Wild, and A.I. Geller Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells J. Virol. 70 1996 7190 7197 (Pubitemid 26307436)
11. Q. Gao, M. Sun, X. Wang, and A.I. Geller Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system Brain Res. 1130 2007 1 16 (Pubitemid 46053873)
12. A.I. Geller, and X.O. Breakefield A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons Science 241 1988 1667 1669
13. H. Gu, Y. Liang, G. Mandel, and B. Roizman Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells Proc. Natl. Acad. Sci. U. S. A. 102 2005 7571 7576 (Pubitemid 40741012)
14. H. Gu, and B. Roizman Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex Proc. Natl. Acad. Sci. U. S. A. 104 2007 17134 17139 (Pubitemid 350211004)
15. H. Gu, and B. Roizman Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1 J. Virol. 83 2009 4376 4385
16. H. Gu, and B. Roizman The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem J. Virol. 83 2009 181 187
17. B.K. Jin, M. Belloni, B. Conti, H.J. Federoff, R. Starr, J.H. Son, H. Baker, and T.H. Joh Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector Hum. Gene Ther. 7 1996 2015 2024 (Pubitemid 26390241)
18. M. Kalamvoki, and B. Roizman Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1 Proc. Natl. Acad. Sci. U. S. A. 105 2008 20488 20493
19. M. Kalamvoki, and B. Roizman Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression Proc. Natl. Acad. Sci. U. S. A. 107 2010 17721 17726
20. H. Kameda, T. Furuta, W. Matsuda, K. Ohira, K. Nakamura, H. Hioki, and T. Kaneko Targeting green fluorescent protein to dendritic membrane in central neurons Neurosci. Res. 61 2008 79 91
21. M.G. Kaplitt, A.D. Kwong, S.P. Kleopoulos, C.V. Mobbs, S.D. Rabkin, and D.W. Pfaff Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector Proc. Natl. Acad. Sci. U. S. A. 91 1994 8979 8983
22. H. Kwon, Q. Bai, H.J. Baek, K. Felmet, E.A. Burton, W.F. Goins, J.B. Cohen, and J.C. Glorioso Soluble v domain of nectin-1/HveC enables entry of herpes simplex virus type 1 (HSV-1) into HSV-resistant cells by binding to viral glycoprotein D J. Virol. 80 2006 138 148
23. V. Lallemand-Breitenbach, and H. de The PML nuclear bodies Cold Spring Harb. Perspect. Biol. 2 2010 a000661
24. M.G. Lee, C. Wynder, N. Cooch, and R. Shiekhattar An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation Nature 437 2005 432 435 (Pubitemid 41613507)
25. Y. Liang, J.L. Vogel, A. Narayanan, H. Peng, and T.M. Kristie Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency Nat. Med. 15 2009 1312 1317
26. F. Lim, D. Hartley, P. Starr, P. Lang, S. Song, L. Yu, Y. Wang, and A.I. Geller Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells Biotechniques 20 1996 460 469 (Pubitemid 26080882)
27. M. Liu, J. Tang, X. Wang, T. Yang, and A.I. Geller Enhanced long-term expression from helper virus-free HSV-1 vectors packaged in the presence of deletions in genes that modulate the function of VP16, UL46 and UL47 J. Neurosci. Methods 145 2005 1 9 (Pubitemid 40732428)
28. M. Liu, X. Wang, and A.I. Geller Helper virus-free HSV-1 vectors packaged in the presence of combinations of mutations in the protein kinase UL13 and the VP16 transcriptional complex enhance long-term expression BMC Mol. Biol. 10 2009 58
29. M. Moffat, S. Harmon, J. Haycock, and K.L. O'Malley l-Dopa and dopamine-producing gene cassettes for gene therapy approaches to Parkinson's disease Exp. Neurol. 144 1997 69 73 (Pubitemid 27149605)
30. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates., Vol 1986 Academic Press Sidney
31. M. Rasmussen, L. Kong, G. Zhang, M. Liu, X. Wang, G. Szabo, N.P. Curthoys, and A.I. Geller Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter Brain Res. 1144 2007 19 32 (Pubitemid 46440832)
32. M.L. Schwartz, C. Katagi, J. Bruce, and W.W. Schlaepfer Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro J. Biol. Chem. 269 1994 13444 13450 (Pubitemid 24206118)
33. I.L. Smith, M.A. Hardwicke, and R.M. Sandri-Goldin Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression Virology 186 1992 74 86
34. S. Song, Y. Wang, S.Y. Bak, P. Lang, D. Ullrey, R.L. Neve, K.L. O'Malley, and A.I. Geller An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain J. Neurochem. 68 1997 1792 1803 (Pubitemid 27176113)
35. G. Sourvinos, and R.D. Everett Visualization of parental HSV-1 genomes and replication compartments in association with ND10 in live infected cells EMBO J. 21 2002 4989 4997
36. M. Sun, G.R. Zhang, T. Yang, L. Yu, and A.I. Geller Improved titers for helper virus-free herpes simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of noninfectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packaging procedure Hum. Gene Ther. 10 1999 2005 2011 (Pubitemid 29387914)
37. M. Sun, G. Zhang, L. Kong, C. Holmes, X. Wang, W. Zhang, D.S. Goldstein, and A.I. Geller Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector Hum. Gene Ther. 14 2003 415 424 (Pubitemid 36403534)
38. M. Sun, L. Kong, X. Wang, C. Holmes, Q. Gao, W. Zhang, J. Pfeilschifter, D.S. Goldstein, and A.I. Geller Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter-2 from a helper virus-free HSV-1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease Hum. Gene Ther. 15 2004 1177 1196 (Pubitemid 40052431)
39. M. Sun, L. Kong, X. Wang, X. Lu, Q. Gao, and A.I. Geller Comparison of protection of nigrostriatal neurons by expression of GDNF, BDNF, or both neurotrophic factors Brain Res. 1052 2005 119 129
40. Q. Tang, L. Li, A.M. Ishov, V. Revol, A.L. Epstein, and G.G. Maul Determination of minimum herpes simplex virus type 1 components necessary to localize transcriptionally active DNA to ND10 J. Virol. 77 2003 5821 5828 (Pubitemid 36538975)
41. R. Wade-Martins, Y. Saeki, and E.A. Chiocca Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells Mol. Ther. 7 2003 604 612 (Pubitemid 36626240)
42. X. Wang, G. Zhang, T. Yang, W. Zhang, and A.I. Geller Fifty-one kilobase HSV-1 plasmid vector can be packaged using a helper virus-free system and supports expression in the rat brain Biotechniques 27 2000 102 106 (Pubitemid 30036824)
43. X. Wang, G. Zhang, M. Sun, and A.I. Geller General strategy for constructing large HSV-1 plasmid vectors that co-express multiple genes Biotechniques 31 2001 204 212 (Pubitemid 32645926)
44. Y. Wang, L. Yu, and A.I. Geller Diverse stabilities of expression in the rat brain from different cellular promoters in a helper virus-free herpes simplex virus type 1 vector system Hum. Gene Ther. 10 1999 1763 1771 (Pubitemid 29357682)
45. T. Yang, G. Zhang, W. Zhang, M. Sun, X. Wang, and A.I. Geller Enhanced reporter gene expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of specific mutated HSV-1 proteins that affect the virion Mol. Brain. Res. 90 2001 1 16 (Pubitemid 32497167)
46. C. Zhang, Z. Xuan, S. Otto, J.R. Hover, S.R. McCorkle, G. Mandel, and M.Q. Zhang A clustering property of highly-degenerate transcription factor binding sites in the mammalian genome Nucleic Acids Res. 34 2006 2238 2246 (Pubitemid 43985662)
47. G. Zhang, X. Wang, T. Yang, M. Sun, W. Zhang, Y. Wang, and A.I. Geller A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors Mol. Brain. Res. 84 2000 17 31
48. G. Zhang, X. Wang, L. Kong, X. Lu, B. Lee, M. Liu, M. Sun, C. Franklin, R.G. Cook, and A.I. Geller Genetic enhancement of visual learning by activation of protein kinase C pathways in small groups of rat cortical neurons J. Neurosci. 25 2005 8468 8481 (Pubitemid 41324733)
49. G. Zhang, M. Liu, H. Cao, L. Kong, X. Wang, R.G. Cook, and A.I. Geller Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of rat hippocampal neurons Hippocampus 19 2009 413 423
50. G. Zhang, H. Cao, L. Kong, J. O'Brien, A. Baughns, M. Jan, H. Zhao, X. Wang, X. Lu, R.G. Cook, and A.I. Geller Identified circuit in rat postrhinal cortex encodes essential information for performing specific visual shape discriminations Proc. Natl. Acad. Sci. U. S. A. 107 2010 14478 14483
51. G. Zhang, and A.I. Geller An HSV-1 vector containing the VGLUT1 promoter is expressed only in VGLUT1-, and not VGLUT2-, containing glutamatergic neurons Brain Res. 1331 2010 12 19
52. G. Zhang, X. Li, H. Cao, H. Zhao, and A.I. Geller The vesicular glutamate transporter-1 upstream promoter and first intron each support glutamatergic-specific expression in rat postrhinal cortex Brain Res. 1377 2011 1 12