L-Dopa and dopamine-producing gene cassettes for gene therapy approaches to Parkinson's disease

Experimental Neurology

Volumn 144, Issue 1, 1997, Pages 69-73

  Moffat, Mark ^a   Harmon, Steve ^a   Haycock, John ^b   O'Malley, Karen L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DOPAMINE; LEVODOPA; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; GENE THERAPY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0031104819     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.6390     Document Type: Article

References (30)

1. 1. ALMAS, B., B. LE BOURDELLES, T. FLATMARK, J. MALLET, AND J. HAAVIK. 1992. Regulation of recombinant human tyrosine hydroxylase isozymes by catecholamine binding and phosphorylation. Structure/activity studies and mechanistic implications. Eur. J. Biochem. 209: 249-255.
2. 2. BRIZZARD, B. L., R. G. CHUBET, AND D. L. VIZARD. 1994. Immunoaffinity purification of FLAG epitope-tagged bacterial alkaline phosphatase using a novel monoclonal antibody and peptide elution. Biotechniques 16: 730-735.
3. 3. DAUBNER, S. C., D. L. LOHSE, AND P. F. FITZPATRICK. 1993. Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase. Protein Sci. 2: 1452-1460.
4. 4. DAUBNER, S. C., AND P. F. FITZPATRICK. 1993. Alleviation of catecholamine inhibition of tyrosine hydroxylase by phosphorylation at serine40. Adv. Exp. Med. & Biol. 338:87-92.
5. 5. DURING, M. J., J. R. NAEGELE, K. L. O'MALLEY, AND A. I. GELLER. 1994. Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266: 1399-1403.
6. 6. DURING, M. J., M. G. KAPLITT, P. LEONE, X. XIAO, J. D. ELSWORTH, R. H. ROTH, J. R. SLADEK, D. E. REDMOND, JR., AND K. L. O'MALLEY. 1994. AAV-mediated transfer of tyrosine hydroxylase and aromatic amino acid decarboxylase genes into the primate brain: a direct gene therapy approach to Parkinson' Disease. Soc. Neurosci. Abst. 20: 1465.
7. 7. FREEMAN, T. B., C. W. OLANOW, R. A. HAUSER, G. M. NAUERT, D. A. SMITH, C. V. BORLONGAN, P. R. SANBERG, D. A. HOLT, J. H. KORDOWER, F. J. VINGERHOETS et al. 1995. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann. Neurol. 38: 379-388.
8. 8. GHATTAS, I. R., J. R. SANES, AND J. E. MAJORS. 1991. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Mol. Cell. Biol. 11: 5848-5849.
9. 9. GRIMA, B., A. LAMOUROUX, F. BLANOT, N. F. BIQUET, AND J. MALLET. 1985. Complete coding sequence of rat tyrosine hydroxylase mRNA. Proc. Natl. Acad. Sci. USA 82: 617-621.
10. 10. GRIMA, B., A. LAMOUROUX, C. BONI, J. F. JULIEN, F. JAVOY-AGID, AND J. MALLET. 1987. A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. Nature 326: 707-711.
11. 11. HIGUCHI, R. 1989. Rapid, efficient DNA extraction for PCR from cells or blood. Amplifications 2:1-3.
12. 12. HORELLOU, P., E. VIGNE, M. N. CASTEL, P. BARNEOUD, P. COLIN, M. PERRICAUDET, P. DELAERE, AND J. MALLET. 1994. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parinson's disease. Neuroreport 6: 49-53.
13. 13. KANG, U. J., L. J. FISHER, T. H. JOH, K. L. O'MALLEY, AND F. H. GAGE. 1993. Regulation of dopamine production by genetically modified primary fibroblasts. J. Neurosci. 13: 5203-5211.
14. 14. KAPLITT, M. G., P. LEONE, R. J. SAMULSKI, X. XIAO, D. W. PFAFF, K. L. O'MALLEY, AND M. J. DURING. 1994. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genet. 8: 148-154.
15. 15. KOUTOUZIS, T. K., D. F. EMERICH, C. V. BORLONGAN, T. B. FREEMAN, D. W. CAHILL, AND P. R. SANBERG. 1994. Cell transplantation for central nervous system disorders. Crit. Rev. Neurobiol. 8: 125-162.
16. 16. LEIDEN, J. M. 1995. Gene therapy - Promise, pitfalls, and prognosis. N. Eng. J. Med. 333: 871-873.
17. 17. LI, X. M., A. V. JUORIO, I. A. PATERSON, W. WALZ, M. Y. ZHU, AND A. A. BOULTON. 1992. Gene expression of aromatic L-amino acid decarboxylase in cultured rat glial cells. J. Neurochem. 59: 1172-1175.
18. 18. LOWRY, O. H., N. J. ROSEBROUGH, A. L. FARR, AND R. J. RANDALL. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
19. 19. O'MALLEY, K. L., S. HARMON, M. MOFFAT, A. UHLAND-SMITH, AND S. WONG. 1995. The human aromatic L-amino acid decarboxylase gene can be alternatively spliced to generate unique protein isoforms. J. Neurochem. 65: 2409-2416.
20. 20. O'MALLEY, K. L., M. J. ANHALT, B. M. MARTIN, J. R. KELSOE, S. L. WINFIELD, AND E. I. GINNS. 1987. Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5′ alternative splice sites responsible for multiple mRNAs. Biochemistry 26: 2910-2914.
21. 21. OH, Y. J., B. C. SWARZENSKI, AND K. L. O'MALLEY. 1996. Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth. Neurosci. Lett. 202: 161-164.
22. 4 receptors. J. Pharm. Exp. Ther. 277: 186-192.
23. 23. SAMULSKI, R. J. 1993. Adeno-associated virus: integration at a specific chromosomal locus. Curr. Opin. Genet. Dev. 3: 74-80.
24. 24. SMITH, A. E. 1995. Viral vectors in gene therapy. Annu. Rev. Microbiol. 49: 807-838.
25. 3 receptors inhibit dopamine release. J. Pharm. Exp. Ther. 270: 475-479.
26. 26. TASHIRO, Y., T. KANEKO, T. SUGIMOTO, I. NAGATSU, H. KIKUCHI, AND N. MIZUNO. 1989. Striatal neurons with aromatic L-amino acid decarboxylase-like immunoreactivity in the rat. Neurosci. Lett. 100: 29-34.
27. 27. WOLFF, J. A., L. J. FISHER, L. Xu, A. J. HYDER, P. J. LANGLAIS, P. M. IUVONE, K. L. O'MALLEY, M. D. ROSENBERT, S. SHIMOHAMA, T. FRIEDMANN, AND F. H. GAGE. 1989. Grafting fibroblasts genetically modified to produce L-DOPA in a rat model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 86: 9011-9014.
28. 28. Wu, J., D. FILER, A. J. FRIEDHOFF, AND M. GOLDSTEIN. 1992. Site-directed mutagenesis of tyrosine hydroxylase. Role of serine 40 in catalysis. J. Biol. Chem. 267: 25754-25758.
29. 29. YUREK, D. M., AND J. R. SLADEK. 1990. Dopamine cell replacement: Parkinson's disease. Annu. Rev. Neurosci. 13: 415-440.
30. 30. YUREK, D. M., W. LU, S. HIPKENS, AND S. J. WIEGAND. 1996. BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons. Exp. Neurol. 137: 105-118.