메뉴 건너뛰기




Volumn 145, Issue 1-2, 2005, Pages 1-9

Enhanced long-term expression from helper virus-free HSV-1 vectors packaged in the presence of deletions in genes that modulate the function of VP16, UL46 and UL47

Author keywords

Gene therapy; Gene transfer; Herpes simplex virus vector; Long term expression; Neurofilament promoter; UL46; UL47; VP16

Indexed keywords

PROTEIN VP16; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS VECTOR;

EID: 19544372620     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2004.09.030     Document Type: Article
Times cited : (10)

References (43)
  • 1
    • 0023751179 scopus 로고
    • Mutational analysis of the herpes simplex virus type 1 trans-inducing factor Vmw65
    • C.I. Ace, M.A. Dalrymple, F.H. Ramsay, V.G. Preston, and C.M. Preston Mutational analysis of the herpes simplex virus type 1 trans-inducing factor Vmw65 J Gen Virol 69 1988 2595 2605
    • (1988) J Gen Virol , vol.69 , pp. 2595-2605
    • Ace, C.I.1    Dalrymple, M.A.2    Ramsay, F.H.3    Preston, V.G.4    Preston, C.M.5
  • 2
    • 0024536120 scopus 로고
    • Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression
    • C.I. Ace, T.A. McKee, J.M. Ryan, J.M. Cameron, and C.M. Preston Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression J Virol 63 1989 2260 2269
    • (1989) J Virol , vol.63 , pp. 2260-2269
    • Ace, C.I.1    McKee, T.A.2    Ryan, J.M.3    Cameron, J.M.4    Preston, C.M.5
  • 3
    • 0029977774 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
    • C. Chartier, E. Degryse, M. Gantzer, A. Dieterle, A. Pavirani, and M. Mehtali Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli J Virol 70 1996 4805 4810
    • (1996) J Virol , vol.70 , pp. 4805-4810
    • Chartier, C.1    Degryse, E.2    Gantzer, M.3    Dieterle, A.4    Pavirani, A.5    Mehtali, M.6
  • 4
    • 0027456840 scopus 로고
    • A mutant of herpes simplex virus type 1 in which the UL13 protein kinase gene is disrupted
    • L.J. Coulter, H.W. Moss, J. Lang, and D.J. McGeoch A mutant of herpes simplex virus type 1 in which the UL13 protein kinase gene is disrupted J Gen Virol 74 1993 387 395
    • (1993) J Gen Virol , vol.74 , pp. 387-395
    • Coulter, L.J.1    Moss, H.W.2    Lang, J.3    McGeoch, D.J.4
  • 5
    • 0027514853 scopus 로고
    • A cosmid-based system for constructing mutants of herpes simplex virus type 1
    • C. Cunningham, and A.J. Davison A cosmid-based system for constructing mutants of herpes simplex virus type 1 Virology 197 1993 116 124
    • (1993) Virology , vol.197 , pp. 116-124
    • Cunningham, C.1    Davison, A.J.2
  • 6
    • 0025100883 scopus 로고
    • The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum
    • P.C. Emson, S. Shoham, C. Feler, T. Buss, J. Price, and C.J. Wilson The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum Exp Brain Res 79 1990 427 430
    • (1990) Exp Brain Res , vol.79 , pp. 427-430
    • Emson, P.C.1    Shoham, S.2    Feler, C.3    Buss, T.4    Price, J.5    Wilson, C.J.6
  • 7
    • 0029844849 scopus 로고    scopus 로고
    • Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells
    • C. Fraefel, S. Song, F. Lim, P. Lang, L. Yu, Y. Wang, P. Wild, and A.I. Geller Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells J Virol 70 1996 7190 7197
    • (1996) J Virol , vol.70 , pp. 7190-7197
    • Fraefel, C.1    Song, S.2    Lim, F.3    Lang, P.4    Yu, L.5    Wang, Y.6    Wild, P.7    Geller, A.I.8
  • 8
    • 0024802931 scopus 로고
    • Herpes simplex virus Vmw65-octamer binding protein interaction: A paradigm for combinatorial control of transcription
    • C.R. Goding, and P. O'Hare Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription Virology 173 1989 363 367
    • (1989) Virology , vol.173 , pp. 363-367
    • Goding, C.R.1    O'Hare, P.2
  • 9
    • 0033055019 scopus 로고    scopus 로고
    • Allele replacement: An application that permits rapid manipulation of herpes simplex virus type 1 genomes
    • B.C. Horsburgh, M.M. Hubinette, D. Qiang, M.L. MacDonald, and F. Tufaro Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes Gene Ther 6 1999 922 930
    • (1999) Gene Ther , vol.6 , pp. 922-930
    • Horsburgh, B.C.1    Hubinette, M.M.2    Qiang, D.3    MacDonald, M.L.4    Tufaro, F.5
  • 10
    • 0029840183 scopus 로고    scopus 로고
    • Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector
    • B.K. Jin, M. Belloni, B. Conti, H.J. Federoff, R. Starr, J.H. Son, H. Baker, and T.H. Joh Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector Hum Gene Ther 7 1996 2015 2024
    • (1996) Hum Gene Ther , vol.7 , pp. 2015-2024
    • Jin, B.K.1    Belloni, M.2    Conti, B.3    Federoff, H.J.4    Starr, R.5    Son, J.H.6    Baker, H.7    Joh, T.H.8
  • 11
    • 0026545146 scopus 로고
    • Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1
    • P.A. Johnson, A. Miyanohara, F. Levine, T. Cahill, and T. Friedmann Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1 J Virol 66 1992 2952 2965
    • (1992) J Virol , vol.66 , pp. 2952-2965
    • Johnson, P.A.1    Miyanohara, A.2    Levine, F.3    Cahill, T.4    Friedmann, T.5
  • 12
    • 0028048737 scopus 로고
    • Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function
    • P.A. Johnson, M.J. Wang, and T. Friedmann Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function J Virol 68 1994 6347 6362
    • (1994) J Virol , vol.68 , pp. 6347-6362
    • Johnson, P.A.1    Wang, M.J.2    Friedmann, T.3
  • 13
    • 0029019122 scopus 로고
    • Mutational analysis of the herpes simplex virus virion host shutoff protein: Evidence that vhs functions in the absence of other viral proteins
    • F.E. Jones, C.A. Smibert, and J.R. Smiley Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins J Virol 69 1995 4863 4871
    • (1995) J Virol , vol.69 , pp. 4863-4871
    • Jones, F.E.1    Smibert, C.A.2    Smiley, J.R.3
  • 14
    • 0028557216 scopus 로고
    • Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector
    • M.G. Kaplitt, A.D. Kwong, S.P. Kleopoulos, C.V. Mobbs, S.D. Rabkin, and D.W. Pfaff Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector Proc Natl Acad Sci U S A 91 1994 8979 8983
    • (1994) Proc Natl Acad Sci U S a , vol.91 , pp. 8979-8983
    • Kaplitt, M.G.1    Kwong, A.D.2    Kleopoulos, S.P.3    Mobbs, C.V.4    Rabkin, S.D.5    Pfaff, D.W.6
  • 15
    • 0032789284 scopus 로고    scopus 로고
    • An efficient in vivo recombination cloning procedure for modifying and combining HSV-1 cosmids
    • Y. Kong, T. Yang, and A.I. Geller An efficient in vivo recombination cloning procedure for modifying and combining HSV-1 cosmids J Virol Meth 80 1999 129 136
    • (1999) J Virol Meth , vol.80 , pp. 129-136
    • Kong, Y.1    Yang, T.2    Geller, A.I.3
  • 16
    • 0029990068 scopus 로고    scopus 로고
    • Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells
    • F. Lim, D. Hartley, P. Starr, P. Lang, S. Song, L. Yu, Y. Wang, and A.I. Geller Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells Biotechniques 20 1996 460 469
    • (1996) Biotechniques , vol.20 , pp. 460-469
    • Lim, F.1    Hartley, D.2    Starr, P.3    Lang, P.4    Song, S.5    Yu, L.6    Wang, Y.7    Geller, A.I.8
  • 17
    • 0004136246 scopus 로고
    • 2nd ed. Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
    • T. Maniatis, E.F. Fritsch, and J. Sambrook Molecular Cloning 2nd ed. 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
    • (1989) Molecular Cloning
    • Maniatis, T.1    Fritsch, E.F.2    Sambrook, J.3
  • 19
    • 0023098140 scopus 로고
    • Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes
    • J.L. McKnight, P.E. Pellett, F.J. Jenkins, and B. Roizman Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes J Virol 61 1987 992 1001
    • (1987) J Virol , vol.61 , pp. 992-1001
    • McKnight, J.L.1    Pellett, P.E.2    Jenkins, F.J.3    Roizman, B.4
  • 20
    • 0026697724 scopus 로고
    • NeuN, a neuronal specific nuclear protein in vertebrates
    • R.J. Mullen, C.R. Buck, and A.M. Smith NeuN, a neuronal specific nuclear protein in vertebrates Development 116 1992 201 211
    • (1992) Development , vol.116 , pp. 201-211
    • Mullen, R.J.1    Buck, C.R.2    Smith, A.M.3
  • 22
    • 0023281035 scopus 로고
    • Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture
    • F.C. Purves, R.M. Longnecker, D.P. Leader, and B. Roizman Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture J Virol 61 1987 2896 2901
    • (1987) J Virol , vol.61 , pp. 2896-2901
    • Purves, F.C.1    Longnecker, R.M.2    Leader, D.P.3    Roizman, B.4
  • 23
    • 0002088545 scopus 로고
    • Herpes simplex viruses and their replication
    • B. Roizman R.J. Whitley C. Lopez Raven Press New York
    • B. Roizman, and A.E. Sears Herpes simplex viruses and their replication B. Roizman R.J. Whitley C. Lopez The Human Herpesviruses 1993 Raven Press New York pp. 11-68
    • (1993) The Human Herpesviruses
    • Roizman, B.1    Sears, A.E.2
  • 24
    • 0029878581 scopus 로고    scopus 로고
    • Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: Mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro
    • R.J. Roller, L.L. Monk, D. Stuart, and B. Roizman Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro J Virol 70 1996 2842 2851
    • (1996) J Virol , vol.70 , pp. 2842-2851
    • Roller, R.J.1    Monk, L.L.2    Stuart, D.3    Roizman, B.4
  • 25
    • 0032506707 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: Rescue of replication-competent virus progeny and packaging of amplicon vectors
    • Y. Saeki, T. Ichikawa, A. Saeki, E.A. Chiocca, K. Tobler, M. Ackermann, X.O. Breakefield, and C. Fraefel Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors Hum Gene Ther 9 1998 2787 2794
    • (1998) Hum Gene Ther , vol.9 , pp. 2787-2794
    • Saeki, Y.1    Ichikawa, T.2    Saeki, A.3    Chiocca, E.A.4    Tobler, K.5    Ackermann, M.6    Breakefield, X.O.7    Fraefel, C.8
  • 26
    • 0028290274 scopus 로고
    • Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro
    • M.L. Schwartz, C. Katagi, J. Bruce, and W.W. Schlaepfer Brain-specific enhancement of the mouse neurofilament heavy gene promoter in vitro J Biol Chem 269 1994 13444 13450
    • (1994) J Biol Chem , vol.269 , pp. 13444-13450
    • Schwartz, M.L.1    Katagi, C.2    Bruce, J.3    Schlaepfer, W.W.4
  • 27
    • 0026547375 scopus 로고
    • Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression
    • I.L. Smith, M.A. Hardwicke, and R.M. Sandri-Goldin Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression Virology 186 1992 74 86
    • (1992) Virology , vol.186 , pp. 74-86
    • Smith, I.L.1    Hardwicke, M.A.2    Sandri-Goldin, R.M.3
  • 28
    • 0030988505 scopus 로고    scopus 로고
    • An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain
    • S. Song, Y. Wang, S.Y. Bak, P. Lang, D. Ullrey, R.L. Neve, K.L. O'Malley, and A.I. Geller An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain J Neurochem 68 1997 1792 1803
    • (1997) J Neurochem , vol.68 , pp. 1792-1803
    • Song, S.1    Wang, Y.2    Bak, S.Y.3    Lang, P.4    Ullrey, D.5    Neve, R.L.6    O'Malley, K.L.7    Geller, A.I.8
  • 29
    • 0031870243 scopus 로고    scopus 로고
    • An enhanced packaging system for helper-dependent herpes simplex virus vectors
    • T.A. Stavropoulos, and C.A. Strathdee An enhanced packaging system for helper-dependent herpes simplex virus vectors J Virol 72 1998 7137 7143
    • (1998) J Virol , vol.72 , pp. 7137-7143
    • Stavropoulos, T.A.1    Strathdee, C.A.2
  • 30
    • 0016422164 scopus 로고
    • Latent herpes simplex virus and the nervous system
    • J.G. Stevens Latent herpes simplex virus and the nervous system Curr Top Microbiol Immunol 70 1975 31 50
    • (1975) Curr Top Microbiol Immunol , vol.70 , pp. 31-50
    • Stevens, J.G.1
  • 31
    • 0033543074 scopus 로고    scopus 로고
    • Improved titers for helper virus-free herpes simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of non-infectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packaging procedure
    • M. Sun, G.R. Zhang, T. Yang, L. Yu, and A.I. Geller Improved titers for helper virus-free herpes simplex virus type 1 plasmid vectors by optimization of the packaging protocol and addition of non-infectious herpes simplex virus-related particles (previral DNA replication enveloped particles) to the packaging procedure Hum Gene Ther 10 1999 2005 2011
    • (1999) Hum Gene Ther , vol.10 , pp. 2005-2011
    • Sun, M.1    Zhang, G.R.2    Yang, T.3    Yu, L.4    Geller, A.I.5
  • 32
    • 0037456986 scopus 로고    scopus 로고
    • Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
    • M. Sun, G. Zhang, L. Kong, C. Holmes, X. Wang, W. Zhang, D.S. Goldstein, and A.I. Geller Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector Hum Gene Ther 14 2003 415 424
    • (2003) Hum Gene Ther , vol.14 , pp. 415-424
    • Sun, M.1    Zhang, G.2    Kong, L.3    Holmes, C.4    Wang, X.5    Zhang, W.6    Goldstein, D.S.7    Geller, A.I.8
  • 33
    • 11144245251 scopus 로고    scopus 로고
    • Co-expression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter-2 from a helper virus-free HSV-1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease
    • M. Sun, L. Kong, X. Wang, C. Holmes, Q. Gao, G. Zhang, J. Pfeilschifter, D.S. Goldstein, and A.I. Geller Co-expression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter-2 from a helper virus-free HSV-1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease Hum Gene Ther 15 2004 1177 1196
    • (2004) Hum Gene Ther , vol.15 , pp. 1177-1196
    • Sun, M.1    Kong, L.2    Wang, X.3    Holmes, C.4    Gao, Q.5    Zhang, G.6    Pfeilschifter, J.7    Goldstein, D.S.8    Geller, A.I.9
  • 34
    • 0035675992 scopus 로고    scopus 로고
    • Helper virus-free HSV-1 vectors packaged both in the presence of VSV G protein and in the absence of HSV-1 glycoprotein B support gene transfer into neurons in the rat striatum
    • J. Tang, T. Yang, H.P. Ghosh, and A.I. Geller Helper virus-free HSV-1 vectors packaged both in the presence of VSV G protein and in the absence of HSV-1 glycoprotein B support gene transfer into neurons in the rat striatum J NeuroVirol 7 2001 548 555
    • (2001) J NeuroVirol , vol.7 , pp. 548-555
    • Tang, J.1    Yang, T.2    Ghosh, H.P.3    Geller, A.I.4
  • 35
    • 0033587486 scopus 로고    scopus 로고
    • Diverse stabilities of expression in the rat brain from different cellular promoters in a helper virus-free herpes simplex virus type 1 vector system
    • Y. Wang, L. Yu, and A.I. Geller Diverse stabilities of expression in the rat brain from different cellular promoters in a helper virus-free herpes simplex virus type 1 vector system Hum Gene Ther 10 1999 1763 1771
    • (1999) Hum Gene Ther , vol.10 , pp. 1763-1771
    • Wang, Y.1    Yu, L.2    Geller, A.I.3
  • 36
    • 3242718867 scopus 로고    scopus 로고
    • A preproenkephalin-neurofilament chimeric promoter in a helper virus-free HSV-1 vector enhances long-term expression in the rat striatum
    • X. Wang, L. Kong, G. Zhang, M. Sun, and A.I. Geller A preproenkephalin-neurofilament chimeric promoter in a helper virus-free HSV-1 vector enhances long-term expression in the rat striatum Neurobiol Dis 16 2004 596 603
    • (2004) Neurobiol Dis , vol.16 , pp. 596-603
    • Wang, X.1    Kong, L.2    Zhang, G.3    Sun, M.4    Geller, A.I.5
  • 37
    • 0028500549 scopus 로고
    • Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors
    • M.J. Wood, A.P. Byrnes, D.W. Pfaff, S.D. Rabkin, and H.M. Charlton Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors Gene Ther 1 1994 283 291
    • (1994) Gene Ther , vol.1 , pp. 283-291
    • Wood, M.J.1    Byrnes, A.P.2    Pfaff, D.W.3    Rabkin, S.D.4    Charlton, H.M.5
  • 38
    • 0035918481 scopus 로고    scopus 로고
    • Enhanced reporter gene expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of specific mutated HSV-1 proteins that affect the virion
    • T. Yang, G. Zhang, W. Zhang, M. Sun, X. Wang, and A.I. Geller Enhanced reporter gene expression in the rat brain from helper virus-free HSV-1 vectors packaged in the presence of specific mutated HSV-1 proteins that affect the virion Mol Brain Res 90 2001 1 16
    • (2001) Mol Brain Res , vol.90 , pp. 1-16
    • Yang, T.1    Zhang, G.2    Zhang, W.3    Sun, M.4    Wang, X.5    Geller, A.I.6
  • 39
    • 0033582476 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 infection stimulates p38/c-Jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1
    • G. Zachos, B. Clements, and J. Conner Herpes simplex virus type 1 infection stimulates p38/c-Jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1 J Biol Chem 274 1999 5097 5103
    • (1999) J Biol Chem , vol.274 , pp. 5097-5103
    • Zachos, G.1    Clements, B.2    Conner, J.3
  • 40
    • 0026025699 scopus 로고
    • Role of herpes simplex virus type 1 UL46 and UL47 in alpha TIF-mediated transcriptional induction: Characterization of three viral deletion mutants
    • Y. Zhang, D.A. Sirko, and J.L. McKnight Role of herpes simplex virus type 1 UL46 and UL47 in alpha TIF-mediated transcriptional induction: characterization of three viral deletion mutants J Virol 65 1991 829 841
    • (1991) J Virol , vol.65 , pp. 829-841
    • Zhang, Y.1    Sirko, D.A.2    McKnight, J.L.3
  • 41
    • 0034624216 scopus 로고    scopus 로고
    • A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors
    • G. Zhang, X. Wang, T. Yang, M. Sun, W. Zhang, Y. Wang, and A.I. Geller A tyrosine hydroxylase-neurofilament chimeric promoter enhances long-term expression in rat forebrain neurons from helper virus-free HSV-1 vectors Mol Brain Res 84 2000 17 31
    • (2000) Mol Brain Res , vol.84 , pp. 17-31
    • Zhang, G.1    Wang, X.2    Yang, T.3    Sun, M.4    Zhang, W.5    Wang, Y.6    Geller, A.I.7
  • 43
    • 0027476811 scopus 로고
    • Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression
    • Y. Zhang, and J.L. McKnight Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression J Virol 67 1993 1482 1492
    • (1993) J Virol , vol.67 , pp. 1482-1492
    • Zhang, Y.1    McKnight, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.