An HSV-1 vector containing the rat tyrosine hydroxylase promoter enhances both long-term and cell type-specific expression in the midbrain

Journal of Neurochemistry

Volumn 68, Issue 5, 1997, Pages 1792-1803

  Song, Song ^a   Wang, Yaming ^a   Bak, Sun Yung ^a   Lang, Phung ^a   Ullrey, Donna ^a   Neve, Rachael L ^b,c   O'Malley, Karen L ^d   Geller, Alfred I ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MCLEAN HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell type specific expression; Genetic intervention.; HSV 1 vector; In vivo gene transfer; Long term expression; Tyrosine hydroxylase promoter

Indexed keywords

BETA GALACTOSIDASE; CATECHOLAMINE; DNA; TYROSINE 3 MONOOXYGENASE;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE NERVE CELL; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC MANIPULATION; HERPES SIMPLEX VIRUS 1; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1;

EID: 0030988505     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68051792.x     Document Type: Article

References (65)

1. Adam R. L., Springall D. R., Levene M. N., and Bushell T. E. (1984) The immunohistochemical detection of herpes simplex virus in cervical smears. J. Pathol. 143, 241-247.
2. Andersen J. K., Garber D., Meaney C. A., and Breakefield X. O. (1992) Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial LacZ in neurons using the neuron specific enolase promoter. Hum. Gene Ther. 3, 487-499.
3. Andersen J. K., Frim D. M., Isacson O., and Breakefield X. O. (1993) Herpes virus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron specific enolase promoter. Cell. Mol. Neurobiol. 13, 503-515.
4. Banerjee S. A., Hoppe P., Brilliant M., and Chikaraishi D. M. (1992) 5′ flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. J. Neurosci. 12, 4460-4467.
5. Battleman D. S., Geller A. I., and Chao M. V. (1993) HSV-1 vector mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high affinity NGF binding. J. Neurosci. 13, 941-951.
6. Bergold P. J., Casaccia-Bonnefil P., Xiu-Liu Z., and Federoff H. J. (1993) Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proc. Natl. Acad. Sci. USA 90, 6165-6169.
7. Brown E. R., Coker G. T. III, and O'Malley K. L. (1987) Organization and evolution of the rat tyrosine hydroxylase gene. Biochemistry 26, 5208-5212.
8. Cambi F., Fung B., and Chikaraishi D. (1989) 5′ flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase. J. Neurochem. 53, 1656-1659.
9. Choi D. W., Maulucci-Gedde M., and Kriegstein A. R. (1987) Glutamate neurotoxicity in cortical cell cultures. J. Neurosci. 7, 357-368.
10. Choi H. K., Won L. A., Kontur P. J., Hammond D. N., Fox A. P., Wainer B. H., Hoffmann P. C., and Heller A. (1991) Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion. Brain Res. 552, 67-76.
11. Coker G. T. III, Vinnedge L., and O'Malley K. L. (1988) Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and nonneuronal cell types. Biochem. Biophys. Res. Commun. 157, 1341-1347.
12. Davidson I. and Stow N. D. (1985) Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA. Virology 141, 77-88.
13. DeLuca N. A., McCarthy A. M., and Schaeffer P. A. (1985) Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J. Virol. 56, 558-570.
14. Deshmane S. L. and Fraser N. W. (1989) During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J. Virol. 63, 943-947.
15. Dobson A. T., Margolis T. P., Sedarati F., Stevens J. G., and Feldman L. T. (1990) A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons. Neuron 5, 353-360.
16. During M. J., Naegele J., O'Malley K. L., and Geller A. I. (1994) Long-term behavioral recovery in a model of Parkinson's disease by intrastriatal expression of tyrosine hydroxylase. Science 266, 1399-1403.
17. Emson P. C., Shoham S., Feler C., Buss T., Price J., and Wilson C. J. (1990) The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum. Exp. Brain Res. 79, 427-430.
18. Federoff H. J., Geschwind M. D., Geller A. I., and Kessler J. A. (1992) Expression of NGF in vivo, from a defective HSV-1 vector, prevents effects of axotomy on sympathetic neurons. Proc. Natl. Acad. Sci. USA 89, 1636-1640.
19. Forss-Petter S., Danielson P. E., Catsicas S., Battenberg E., Price J., Norenberg M., and Sutcliffe J. G. (1990) Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 5, 187-197.
20. Fraefel C., Song S., Lim F., Lang P., Yu L., Wang Y., Wild P., and Geller A. I. (1996) Helper virus-free transfer of HSV-1 plasmid vectors into neural cells. J. Virol. 70, 7190-7197.
21. Fung B. P., Yoon S. O., and Chikaraishi D. M. (1992) Sequences that direct rat tyrosine hydroxylase gene expression. J. Neurochem. 58, 2044-2052.
22. Gandelman K.-Y., Coker G. T. III, Moffat M., and O'Malley K. L. (1990) Species and regional differences in the expression of cell-type specific elements at the human and rat tyrosine hydroxylase gene loci. J. Neurochem. 55, 2149-2152.
23. Geller A. I. and Breakefield X. O. (1988) A defective HSV-1 vector expresses Escherichia coli β-galactosidase in cultured peripheral neurons. Science 241, 1667-1669.
24. Geller A. I. and Freese A. (1990) Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli β-galactosidase. Proc. Natl. Acad. Sci. USA 87, 1149-1153.
25. Geller A. I., Keyomarski K., Bryan J., and Pardee A. B. (1990) An efficient deletion mutant packaging system for defective HSV-1 vectors; potential applications to neuronal physiology and human gene therapy. Proc. Natl. Acad. Sci. USA 87, 8950-8954.
26. Geller A. I., During M. J., and Neve R. L. (1991) Molecular analysis of neuronal physiology by gene transfer into neurons with herpes simplex virus vectors. Trends Neurosci. 14, 428-432.
27. Geller A. I., During M. J., Haycock J. W., Freese A., and Neve R. L. (1993) Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a HSV-1 vector. Proc. Natl. Acad. Sci. USA 90, 7603-7607.
28. Geller A. I., During M. J., Oh Y. J., Freese A., and O'Malley K. (1995) An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-DOPA from cultured rat striatal cells. J. Neurochem. 64, 487-496.
29. Geschwind M. D., Kessler J. A., Geller A. I., and Federoff H. J. (1994) Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Mol. Brain Res. 24, 327-335.
30. Gizang-Ginsberg E. and Ziff E. B. (1990) Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleo-protein complex that contains c-fos. Genes Dev. 4, 477-491.
31. Gizang-Ginsberg E. and Ziff E. B. (1994) Fos family members successively occupy the tyrosine hydroxylase gene AP-1 site after nerve growth factor or epidermal growth factor stimulation and can repress transcription. Mol. Endocrinol. 8, 249-262.
32. Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
33. Harrington C. A., Lewis E. J., Krzemien D., and Chikaraishi D. M. (1987) Identification and cell type specificity of the tyrosine hydroxylase gene promoter. Nucleic Acids Res. 15, 2363-2384.
34. Higuchi R. (1989) Rapid, efficient DNA extraction for PCR from cells or blood. Amplifications 2, 1-3.
35. Ho D. Y., Mocarski E. S., and Sapolsky R. M. (1993) Altering central nervous system physiology with a defective HSV-1 vector expressing the glucose transporter gene. Proc. Natl. Acad. Sci. USA 90, 3655-3659.
36. Icard-Liepkalns C., Faucon Biguet N. F., Vyas S., Robert J. J., Sassone-Corsi P., and Mallet J. (1992) AP-1 complex and c-fos transcription are involved in TPA provoked and transsynaptic inductions of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms. J. Neurosci. Res. 32, 290-298.
37. Ivins K. J., Neve K. A., Feller D. J., Fidel S. A., and Neve R. L. (1993) Antisense GAP-43 inhibits the evoked release of dopamine from PC12 cells. J. Neurochem. 60, 626-633.
38. Kalnin A., Otto K., Ruether U., and Mueller-Hill B. (1983) Sequence of the LacZ gene of E. coli. EMBO J. 2, 593-597.
39. Kaneda N., Sasaoka T., Kobayashi K., Kiuchi K., Nagatsu I., Kurosawa Y., Fujita K., Yokoyama M., Nomura T., Katsuki M., and Nagatsu T. (1991) Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice. Neuron 6, 583-594.
40. Kaplitt M. G., Leone P., Samulski R. J., Xiao X., Pfaff D. W., O'Malley K. L., and During M. J. (1994a) Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8, 148-154.
41. Kaplitt M. G., Kwong A. D., Kleopoulos S. P., Mobbs C. V., Rabkin S. D., and Pfaff D. W. (1994a) Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector Proc. Natl. Acad. Sci. USA 91, 8979-8983.
42. Kim K. S., Lee M. K., Carroll J., and Joh T. H. (1993) Both the basal and inducible transcription of the TH gene are dependent upon a cAMP response element. J. Biol. Chem. 268, 15689-15695.
43. Kobayashi K., Kaneda N., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., and Nagatsu T. (1988) Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. J. Biochem. (Tokyo) 103, 907-912.
44. Le Bourdellès B., Boularand S., Boni C., Horellou P., Dumas S., Grima B., and Mallet J. (1988) Analysis of the 5′ region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. J. Neurochem. 50, 988-991.
45. Le Gal La Salle G., Robert J. J., Berrard S., Reidoux V., Stratford-Perricaudet L. D., Perricaudet M., and Mallet J. (1993) An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259, 988-990.
46. Leone P., Dragunow M., Davis K., Ullrey D., O'Malley K. L., Neve R. L., Geller A. I., and During M. (1993) Hippocampal injection of a HSV-1 vector expressing an unregulated PKC from the TH promoter increases NE release, induces Krox 24 expression in dentate granule cells, and improves spatial navigation performance in rats. Soc. Neurosci. Abstr. 19, 806.
47. Lewis E. J., Harrington C. A., and Chikaraishi D. M. (1987) Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. Proc. Natl. Acad. Sci. USA 84, 3550-3554.
48. Lim F., Hartley D., Starr P., Lang P., Song S., Yu L., Wang Y., and Geller A. I. (1996) Packaging detective HSV-1 vectors using an IE 2 deletion mutant supports efficient expression in cultured cortical cells. Biotechniques 20, 460-470.
49. Liu J., Nichol M. C., Wong S. C., Merlie J. P., and O'Malley K. L. (1994) Increasing length of tyrosine hydroxylase promoter sequence increases cell type-specific expression in vivo. Soc. Neurosci. Abstr. 20, 633.
50. Maniatis T., Fritsch E. F., and Sambrook J. (1982) Molecular Cloning. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
51. Min N., Joh T. H., Kim K. S., Peng C., and Son J. H. (1994) 5′ upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Mol. Brain Res. 27, 281-289.
52. Naldine L., Ulrike B., Gallay P., Ory D., Mulligan R., Gage F. H., Verma I. M., and Trono D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267.
53. Neve R. L., Harris P., Kosik K. S., Kurnit D. M., and Donlon T. A. (1986) Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Mol. Brain Res. 1, 271-280.
54. O'Malley K. L., Anhalt M. J., Martin B. M., Kelsoe J. R., Winfield S. L., and Ginns E. I. (1987) Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5′ alternative splice sites responsible for multiple mRNAs. Biochemistry 26, 6910-6914.
55. Paterson T. and Everett R. D. (1990) A prominent serine-rich region in Vmw175, the major transcriptional regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture. J. Gen. Virol. 71, 1775-1783.
56. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd edit. Academic Press, New York.
57. Rock D. L. and Fraser N. W. (1985) Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J. Virol. 55, 849-852.
58. Rohrer H., Acheson A. L., Thibault J., and Thoenen H. (1986) Developmental potential of quail dorsal root ganglion cells analyzed in vitro and in vivo. J. Neurosci. 6, 2616-2624.
59. Sasaoka K. T., Kobayashi K., Nagatsu I., Takahashi R., Kimura M., Yokoyama M., Nomura T., Katsuki M., and Nagatsu T. (1992) Analysis of the human tyrosine hydroxylase promoter-chloramphenicol acetyltransferase chimeric gene expression in transgenic mice. Mol. Brain Res. 16, 274-286.
60. Smith R. L., Geller A. I., Escudero K. W., and Wilcox C. L. (1995) Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in a HSV-1-derived vector. J. Virol. 69, 4593-4599.
61. Snyder E. Y., Deitcher D. L., Walsh C., Arnold-Aldea S., Hartwieg E. A., and Cepko C. (1992) Multi-potent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 68, 33-51.
62. Song S., Wang Y., Hartley D., Ullrey D., Bak S. Y., Ashe O., Bryan J., Haycock J.. During M., Neve R. L., O'Malley K. L., and Geller A. I. (1994) Cell type-specific expression from the tyrosine hydroxylase promoter may account for the rotational behavior induced by activation of the protein kinase C pathway in substantia nigra pars compacta neurons with a HSV-1 vector. Soc Neurosci. Abstr. 20, 586.10.
63. Wood M. J. A., Byrnes A. P., Pfaff D. W., Rabkin S. D., and Charlton H. M. (1994) Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors. Gene Ther. 1, 283-291.
64. Xu H., Federoff H. J., Maragos J., Parada L. F., and Kessler J. A. (1994) Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness. Dev. Biol. 163, 152-161.
65. Yoon S. O. and Chikaraishi D. M. (1992) Tissue-specific transcription of the rat TH gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. Neuron 9, 55-67.