Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

Neuroscience Letters

Volumn 306, Issue 1-2, 2001, Pages 37-40

  Takashima, Akihiko ^a   Murayama, Miyuki ^a   Yasutake, Kaori ^b   Takahashi, Hiroshi ^b   Yokoyama, Minesuke ^b   Ishiguro, Koichi ^b  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

Author keywords

Alzheimer's disease; Cyclin dependent kinase5; Neurofibrillary tangles; P25; Tau

Indexed keywords

CALCIMYCIN; CYCLIN DEPENDENT KINASE 5; PROTEIN P25; PROTEIN P35; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPOPHYSIS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

AGED; ALZHEIMER DISEASE; ANIMALS; BRAIN; CALCIMYCIN; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; IONOPHORES; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; PITUITARY DISEASES; TAU PROTEINS;

EID: 0035933621     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01864-X     Document Type: Article

References (16)

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3. Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease
4. A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope
5. Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites
6. Proteolytic cleavage of the p35 Cdk5 activator to p25 by calpain
7. Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein
8. Neurotoxicity induces cleavage of p35 to p25 by calpain
9. Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells
10. Proline-directed and non-proline-directed phosphorylation of PHF-tau
11. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
12. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
13. Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells
14. Precursor of Cdk5 activator, the 23 kDa subunit of tau protein kinase II: Its sequence and developmental change in brain
15. Co-expression of human Cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice
16. In vivo phosphorylation sites in fetal and adult rat tau