Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration

Human Molecular Genetics

Volumn 16, Issue 7, 2007, Pages 837-847

  Zhang, Zhongjian ^a   Lee, Yi Ching ^a   Kim, Sung Jo ^a   Choi, Moonsuk S ^a   Tsai, Pei Chih ^a   Saha, Arjun ^a   Wei, Hui ^a   Xu, Yan ^b,d   Xiao, Yi Jin ^b   Zhang, Peng ^c   Heffer, Alison ^a   Mukherjee, Anil B ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 4; CEROID; GALECTIN 3; LYSOPHOSPHATIDYLCHOLINE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PALMITOYL PROTEIN THIOESTERASE; PHOSPHOLIPASE A2; TUMOR NECROSIS FACTOR ALPHA; GALECTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; PALMITOYL-PROTEIN THIOESTERASE; PHOSPHOLIPASE A; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CELL MIGRATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; INFANT DISEASE; KNOCKOUT MOUSE; LIPID STORAGE; MOUSE; NERVE CELL NECROSIS; NEURONAL CEROID LIPOFUSCINOSIS; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; ANIMAL; BIOLOGICAL MODEL; BRAIN; CELL MOTION; CYTOLOGY; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WESTERN BLOTTING;

MUS;

ANIMALS; BLOTTING, WESTERN; BRAIN; CELL MOVEMENT; ENZYME ACTIVATION; GALECTINS; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; LYSOPHOSPHATIDYLCHOLINES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, BIOLOGICAL; PHAGOCYTES; PHOSPHOLIPASES A; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOLESTER HYDROLASES; TIME FACTORS;

EID: 34447315554     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm029     Document Type: Article

References (44)

1. Savill, J., Dransfield, I., Gregory, C. and Haslett, C. (2002) A blast from the past: Clearance of apoptotic cells regulate immune responses. Nat. Rev. Immunol., 2, 965-975.
2. Lauber, K., Blumenthal, S.G., Waibel, M. and Wesselborg, S. (2004) Clearance of apoptotic cells: Getting rid of the corpses. Mol. Cell 14, 277-287.
3. Ravichandran, K.S. (2003) 'Recruitment signals' from apoptotic cells: invitation to a quiet meal. Cell, 113, 817-820.
4. Proia, R.L. and Wu, Y.P. (2004) Blood to brain to the rescue. J. Clin. Invest., 113, 1108-1110.
5. Ohmi, K., Greenberg, D.S., Rajavel, K.S., Ryazantsev, S., Li, H.H. and Neufeld, E.F. (2003) Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB. Proc. Natl Acad. Sci. USA, 100, 1902-1907.
6. Block, M.L., Zecca, L. and Hong, S. (2007) Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat. Rev. Neurosci., 8, 57-69.
7. Minghetti, L., Ajmone-Cat, M.A., De Berardinis, M.A. and De Simone, R. (2005) Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation. Brain Res. Brain Res. Rev., 48, 251-256.
8. Ponomarev, E.D., Shriver, L.P., Maresz, K. and Dittel, B.N. (2005) Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res., 81, 374-389.
9. Kreutzberg, G.W. (1996) Microglia: A sensor for pathological events in the CNS. Trends Neurosci., 19, 312-318.
10. Hendriks, J.J., Teunissen, C.E., de Vries, H.E. and Dijkstra, C.D. (2005) Macrophages and neurodegeneration. Brain Res. Brain Res. Rev. 48, 185-195.
11. Chattopadhyay, S., Ito, M., Cooper, J.D., Brooks, A.I., Curran, T.M., Powers, J.M. and Pearce, D.A. (2002) An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease. Hum. Mol. Genet., 11, 1421-1431.
12. Goebel, H.H. and Wisniewski, K.E. (2004) Current state of clinical and morphological features in human NCL. Brain Pathol., 14, 61-69.
13. Hoffmann, S.L. and Peltonen, L. (2001) InScriver, C.R., Beaudet, A.L., Sly, W.S., Childs, B. and Vogelstein, B. (eds), The Neuronal Ceroid Lipofuscinoses, Vol. 8, McGraw-Hill, New York, pp.3877-3894.
14. Camp, L.A., Verkruyse, L.A., Afendis, S.J., Slaughter, C.A. and Hofmann, S.L. (1994) Molecular cloning and expression of palmitoyl-protein thioesterase. J. Biol. Chem., 269, 23212-23219.
15. Vesa, J., Hellsten, E., Verkruyse, L.A., Camp, L.A., Rapola, J., Santavuori, P., Hofman S.L. and Peltonen, L. (1995) Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis. Nature, 376, 584-587.
16. Gupta, P., Soyombo, A.A., Atashband, A., Wisniewski, K.E., Shelton, J.M., Richardson, J.A., Hammer, R.E. and Hofmann, S.L. (2001) Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Proc. Natl Acad. Sci. USA, 98, 13566-13571.
17. Jalanko, A., Vesa, J., Manninen, T., von Schantz, C., Minye, H., Fabritius, A.L., Salonen, T., Rapola, J., Gentile, M., Kopra, O. et al. (2005) Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. Neurobiol. Dis., 18, 226-241.
18. Bible, E., Gupta, P., Hofmann, S.L. and Cooper, J.D. (2004) Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis. Neurobiol. Dis., 16, 346-359.
19. Riikonen, R., Vanhanen, S.L., Tyynela, J., Santavuori, P. and Turpeinen, U. (2000) CSF insulin-like growth factor-1 in infantile neuronal ceroid lipofuscinosis. Neurology, 54, 1828-1832.
20. Zhang, Z., Butler, J.D., Levin, S.W., Wisniewski, K.E., Brooks, S.S. and Mukherjee, A.B. (2001) Lysosomal ceroid depletion by drugs: Therapeutic implications for a hereditary neurodegenerative disease of childhood. Nat. Med., 7, 478-484.
21. Zhang, Z., Lee, Y.C., Kim, S.J., Choi, M.S., Tsai, P.C., Xu, Y., Xiao, Y.J., Zhang, P., Heffer, A. and Mukherjee, A.B. (2006) Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL. Hum. Mol. Genet., 15, 337-346.
22. Kim, S.J., Zhang, Z., Hitomi, E., Lee, Y.C. and Mukherjee, A.B. (2006) Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. Hum. Mol. Genet., 15 1826-1834.
23. Ridet, J.L., Alonso, G., Chauvet, N., Chapron, J., Koenig, J. and Privat, A. (1996) Immunocytochemical characterization of a new marker of fibrous and reactive astrocytes. Cell Tissue Res., 283, 39-49.
24. Walther, M., Kuklinski, S., Pesheva, P., Guntinas-Lichius, O., Angelov, D.N., Neiss, W.F., Asou, H. and Probstmeier, R. (2000) Galectin-3 is upregulated in microglial cells in response to ischemic brain lesions, but not to facial nerve axotomy. J. Neurosci. Res., 61, 430-435.
25. Sano, H., Hsu, D.K., Apgar, J.R., Yu, L., Sharma, B.B., Kuwabara, I., Izui, S. and Liu, F.T. (2003) Critical role of galectin-3 in phagocytosis by macrophages. J. Clin. Invest., 112, 389-397.
26. Gebicke-Haerter, P.J. (2005) Microarrays and expression profiling in microglia research and in inflammatory brain disorders. J. Neurosci. Res., 81, 327-341.
27. Lauber, K., Bohn, E., Krober, S.M., Xiao, Y.J., Blumenthal, S.G., Lindemann, R.K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S. et al. (2003) Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell, 113, 717-730.
28. Xiao, Y.J., Schwartz, B., Washington, M., Kennedy, A., Webster, K., Belinson, J. and Xu, Y. (2001) Electrospray ionization mass spectrometry analysis of lysophospholipids in human ascitic fluids: Comparison of the lysophospholipid contents in malignant vs. nonmalignant ascitic fluids. Anal. Biochem., 290, 302-313.
29. Murakami, M. and Kudo, I. (2003) Cellular arachidonate-releasing functions of various phospholipase A2s. Adv. Exp. Med. Biol., 525, 87-92.
30. 2 is phosphorylated and activated by MAP kinase. Cell, 72, 269-278.
31. de Carvalho, M.G., McCormack, A.L., Olson, E., Ghomashchi, F., Gelb, M.H., Yates, J.R., III and Leslie, C.C. (1996) Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. J. Biol. Chem., 271, 6987-6997.
32. Haltia, M. (2003) The neuronal ceroid-lipofuscinoses. J. Neuropathol. Exp. Neurol., 62, 1-13.
33. Kim, S.J., Zhang, Z., Lee, Y.C. and Mukherjee, A.B. (2006) Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL. Hum. Mol. Genet., 15, 1580-1586.
34. Hetz, C., Russelakeiro, M., Maundrell, K., Castilla, J. and Soto, C. (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J., 22, 5435-5445.
35. Zhang, K. and Kaufman, R.J. (2006) Protein folding in the endoplasmic reticulum and the unfolded protein response. Handb. Exp. Pharmacol. 172, 69-91.
36. Shashkin, P., Dragulev, B. and Ley, K. (2005) Macrophage differentiation to foam cells. Curr. Pharm. Des., 11, 3061-3072.
37. Oka, K., Sawamura, T., Kikuta, K, Itokawa, S., Kume, N., Kita, T. and Masaki, T. (1998) Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl Acad. Sci. USA, 95, 9535-9540.
38. Schlegel, R.A. and Williamson, P. (2001) Phosphatidylserine, a death knell. Cell Death Differ., 8, 551-563.
39. Krieser, R.J. and White, K. (2002) Engulfment mechanism of apoptotic cells. Curr. Opin. Cell Biol., 14, 734-738.
40. Grimsley, C. and Ravichandran, K.S. (2003) Cues for apoptotic cell engulfment: Eat-me, don't eat-me and come-get-me signals. Trends Cell Biol., 13, 648-666.
41. Xie, Z., Smith, C.J. and Van Eldik, L.J. (2004) Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38. Glia, 45, 170-179.
42. Gonzalez-Scarano, F. and Baltuch, G. (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci., 22, 219-240.
43. Verkhratsky, A. and Toescu, E.C. (2003) Endoplasmic reticulum Ca(2+) homeostasis and neuronal death. J. Cell. Mol. Med., 7, 351-361.
44. Cybulsky, A.V., Takano, T., Papillon, J. and Bijian, K. (2005) Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury. J. Biol. Chem., 280, 24396-24403.