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Volumn 34, Issue 2, 2009, Pages 117-128

Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research

Author keywords

Clearance; Drug discovery; Exploratory; Half life; NONMEM; Population pharmacokinetics; Post hoc; Prediction

Indexed keywords

ARTICLE; BODY SIZE; COMPARTMENT MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG CONCENTRATION; DRUG ELIMINATION; DRUG RESEARCH; EXPLORATORY POPULATION PHARMACOKINETIC; HUMAN; LIVER BLOOD FLOW; NONHUMAN; PLASMA VOLUME; RAT; SIMULATION; STATISTICAL MODEL; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DOG; DRUG DEVELOPMENT; HAPLORHINI; LIVER; METABOLISM; METHODOLOGY; NONLINEAR SYSTEM; PHARMACOKINETICS; RETROSPECTIVE STUDY; SPECIES DIFFERENCE; TIME; TISSUE DISTRIBUTION; VALIDATION STUDY; VASCULARIZATION;

EID: 68949135785     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03191160     Document Type: Article
Times cited : (9)

References (28)
  • 1
    • 34748925493 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs
    • De Buck S.S., Shiha V.K., Fene L.A., Nijsen M.J., Mackie CE., Gilissen R.A.. (2007): Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs. Drug Metab. Dispos., 35, 1766-1780.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1766-1780
    • De Buck, S.S.1    Shiha, V.K.2    Fene, L.A.3    Nijsen, M.J.4    Mackie, C.E.5    Gilissen, R.A.6
  • 2
    • 33646124969 scopus 로고    scopus 로고
    • A novel strategy for physiologically based predictions of human pharmacokinetics
    • Jones H.M., Parrot N., Jorga K., Lavé T. (2006): A novel strategy for physiologically based predictions of human pharmacokinetics. Clin. Pharmacokinet., 45, 511-542.
    • (2006) Clin. Pharmacokinet. , vol.45 , pp. 511-542
    • Jones, H.M.1    Parrot, N.2    Jorga, K.3    Lavé, T.4
  • 3
    • 0037452445 scopus 로고    scopus 로고
    • Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
    • Theil F.P., Guentert T.W., Haddad S., Poulin P. (2003): Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxico. Lett., 138, 29-49.
    • (2003) Toxico. Lett. , vol.138 , pp. 29-49
    • Theil, F.P.1    Guentert, T.W.2    Haddad, S.3    Poulin, P.4
  • 4
    • 0025689878 scopus 로고
    • Prediction of intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes
    • Bayliss M.K., Bell J.A., Jenner W.N., Wilson K. (1990): Prediction of intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes. Biochem. Soc. Trans. 18, 1198-1199.
    • (1990) Biochem. Soc. Trans. , vol.18 , pp. 1198-1199
    • Bayliss, M.K.1    Bell, J.A.2    Jenner, W.N.3    Wilson, K.4
  • 7
    • 0034835463 scopus 로고    scopus 로고
    • Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans
    • Naritomi Y., Terashita S., Kimura S., Kagayama A., Sugiyama Y. (2001): Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. Drug Metab. Dispos., 29, 1316-1324.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1316-1324
    • Naritomi, Y.1    Terashita, S.2    Kimura, S.3    Kagayama, A.4    Sugiyama, Y.5
  • 8
    • 23944475573 scopus 로고    scopus 로고
    • Accuracy of allometrically predicted pharmacokinetic parameters in humans: Role of species selection
    • Tang H., Mayersohn M. (2005): Accuracy of allometrically predicted pharmacokinetic parameters in humans: Role of species selection. Drug Metab. Dispos., 33, 1288-1293.
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1288-1293
    • Tang, H.1    Mayersohn, M.2
  • 9
    • 33746829030 scopus 로고    scopus 로고
    • Prediction of metabolic drug clearance in humans: In vitro-in vivo extrapolation vs. allometric scaling
    • Shiran M.R., Proctor N.J., Howgate E.M., Yeo K.R., Tucker G.T., Hodjegan A.R. (2006): Prediction of metabolic drug clearance in humans: In vitro-in vivo extrapolation vs. allometric scaling. Xenobiotica, 36, 567-580.
    • (2006) Xenobiotica , vol.36 , pp. 567-580
    • Shiran, M.R.1    Proctor, N.J.2    Howgate, E.M.3    Yeo, K.R.4    Tucker, G.T.5    Hodjegan, A.R.6
  • 10
    • 41149180911 scopus 로고    scopus 로고
    • Mechanism-based concepts of size and maturity in pharmacokinetics
    • Anderson B.J., Holford N.H.G. (2008): Mechanism-based concepts of size and maturity in pharmacokinetics. Annu. Rev. Pharmacol. Toxicol., 48, 303-332.
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 303-332
    • Anderson, B.J.1    Holford, N.H.G.2
  • 11
    • 34047157087 scopus 로고    scopus 로고
    • The Prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools
    • De Buck S.S., Shiha V.K., Fene L.A., Gilissen R.A., Mackie C.E., Nijsen M.J. (2007): The Prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools. Drug Metab. Dispos., 35, 649-659.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 649-659
    • De Buck, S.S.1    Shiha, V.K.2    Fene, L.A.3    Gilissen, R.A.4    Mackie, C.E.5    Nijsen, M.J.6
  • 12
    • 0036892637 scopus 로고    scopus 로고
    • Prediction of human clearance from animal data and molecular structural parameters using multivariate regression analysis
    • Wajima T., Fukumura K., Yano Y, Oguma T. (2002): Prediction of human clearance from animal data and molecular structural parameters using multivariate regression analysis. J. Pharm. Sci., 91, 2498-2499.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 2498-2499
    • Wajima, T.1    Fukumura, K.2    Yano, Y.3    Oguma, T.4
  • 13
    • 0041664968 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: Volume of distribution at steady state
    • Wajima T., Fukumura K., Yano Y, Oguma T. (2003): Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state. J. Pharm. Pharmacol., 55, 939-949.
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 939-949
    • Wajima, T.1    Fukumura, K.2    Yano, Y.3    Oguma, T.4
  • 15
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies B., Morris T. (1993): Physiological parameters in laboratory animals and humans. Pharm. Res., 10, 1093-1095.
    • (1993) Pharm. Res. , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 16
    • 0003747347 scopus 로고
    • Beal S.L., Sheiner L.B (eds): NONMEM Project Group, University of California at San Francisco, San Francisco
    • Beal S.L., Sheiner L.B (eds): NONMEM Users Guides. NONMEM Project Group, University of California at San Francisco, San Francisco, 1992
    • (1992) NONMEM Users Guides
  • 17
    • 0022609024 scopus 로고
    • Correlation between in vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: Analysis with a dispersion model
    • Roberts M.S., Rowland M. (1986): Correlation between in vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model. J. Pharm. Pharmacol, 38, 177-181.
    • (1986) J. Pharm. Pharmacol , vol.38 , pp. 177-181
    • Roberts, M.S.1    Rowland, M.2
  • 18
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., Lombardo F., Dominy B.W., Feeney PJ. (1997): Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev., 23, 3-25.
    • (1997) Adv. Drug Del. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 19
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict the intestinal absorption of drugs in humans
    • Palm K., Stenberg P., Luthman K., Artursson P. (1997): Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res., 14, 568-571.
    • (1997) Pharm. Res. , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 20
    • 46449114275 scopus 로고    scopus 로고
    • Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds
    • Obach R.S., Lombardo R, Waters N.J. (2008): Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug Metab. Dispos., 36, 1385-1405.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 1385-1405
    • Obach, R.S.1    Lombardo, R.2    Waters, N.J.3
  • 21
    • 0024571757 scopus 로고
    • The absorption oral bioavailability of selected drugs
    • Sietsema WK. ( 1989): The absorption oral bioavailability of selected drugs. Int. J. Clin. Pharmacol. Ther. Toxicol., 21, 179-211.
    • (1989) Int. J. Clin. Pharmacol. Ther. Toxicol. , vol.21 , pp. 179-211
    • Sietsema, W.K.1
  • 22
    • 0031786518 scopus 로고    scopus 로고
    • Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats
    • Chiou W.L., Barve A. (1998): Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats. Pharm. Res., 15, 1792-1795.
    • (1998) Pharm. Res. , vol.15 , pp. 1792-1795
    • Chiou, W.L.1    Barve, A.2
  • 23
    • 0034017007 scopus 로고    scopus 로고
    • Evaluation of using dogs as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans
    • Chiou W.L., Jeomg H., Chung S.M., Wu T.C. (2000): Evaluation of using dogs as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans. Pharm. Res., 17, 135-140.
    • (2000) Pharm. Res. , vol.17 , pp. 135-140
    • Chiou, W.L.1    Jeomg, H.2    Chung, S.M.3    Wu, T.C.4
  • 24
    • 0036296060 scopus 로고    scopus 로고
    • Comparision of oral absorption and bioavailability of drugs between monkey and human
    • Chiou W.L., Buchler P.W. (2002): Comparision of oral absorption and bioavailability of drugs between monkey and human. Pharm. Res., 19, 868-874.
    • (2002) Pharm. Res. , vol.19 , pp. 868-874
    • Chiou, W.L.1    Buchler, P.W.2
  • 26
    • 0020359255 scopus 로고
    • Bayesian individualization of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods
    • Sheiner L.B., Beal S.L. (1982): Bayesian individualization of pharmacokinetics: simple implementation and comparison with non-Bayesian methods. J. Pharm. Sci., 71, 1344-1348.
    • (1982) J. Pharm. Sci. , vol.71 , pp. 1344-1348
    • Sheiner, L.B.1    Beal, S.L.2
  • 28
    • 69249192883 scopus 로고    scopus 로고
    • Available on the following website
    • Available on the following website: http://www.pharm.kyoto-u.ac.jp/ byoyaku/English/index.html


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.