Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6- substituted-4,6-diazaspiro[2,4]heptane-5,7-diones

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 338-346

  He, Xianran ^a   Zhong, Min ^b   Zhang, Tao ^a   Yang, Jin ^c   Wu, Zhongyuan ^a   Xiao, Yuling ^a   Guo, Hao ^a   Qiu, Guofu ^a   Hu, Xianming ^a  

^a WUHAN UNIVERSITY   (China)

^b Hubei Research Institute of Chemistry   (China)

^c HUBEI UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

1 (8 (Benzyloxy)quinolin 2 yl 6 substituted 4,6 diazaspiro 2,4 heptane 5, 7 diones; Anticonvulsant activity; MES test; scPTZ test

Indexed keywords

1 [8 (BENZYLOXY)QUINOLIN 2 YL] 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (1 HYDROXYBUTAN 2 YL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (4 BROMOPHENYL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (4 CHLOROPHENYL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (4 FLUOROPHENYL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (4 METHOXYPHENYL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 (4 NITROPHENYL) 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 4 TOLYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 [4 (TRIFLUOROMETHYL)PHENYL] 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 BUTYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 CYCLOHEXYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 ISOPROPYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 METHYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 6 PHENYL 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; 6 BENZYL 1 [8 (BENZYLOXY)QUINOLIN 2 YL] 4,6 DIAZASPIRO[2,4]HEPTANE 5,7 DIONE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; PHENOBARBITAL; PHENYTOIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; MOTOR DYSFUNCTION; MOUSE; NEUROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL ASSAY; ELECTROSHOCK; HEPTANES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MOLECULAR STRUCTURE; QUINOLINES; SEIZURES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 84855983336     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.037     Document Type: Article

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