-
1
-
-
33947457625
-
The synthesis of morphine
-
Gates M, Tschudi G (1952) The synthesis of morphine. J Am Chem Soc 74:1109-1110
-
(1952)
J Am Chem Soc
, vol.74
, pp. 1109-1110
-
-
Gates, M.1
Tschudi, G.2
-
2
-
-
33947469818
-
The synthesis of morphine
-
Gates M, Tschudi G (1956) The synthesis of morphine. J Am Chem Soc 78:1380-1393
-
(1956)
J Am Chem Soc
, vol.78
, pp. 1380-1393
-
-
Gates, M.1
Tschudi, G.2
-
3
-
-
0018751273
-
Behavioral methods for the assessment of alcohol tolerance and dependence
-
DOI 10.1016/0376-8716(79)90017-6
-
Altshuler HL (1979) Behavioral methods for the assessment of alcohol tolerance and dependence. Drug Alcohol Depend 4:333-346 (Pubitemid 9167889)
-
(1979)
Drug and Alcohol Dependence
, vol.4
, Issue.3-4
, pp. 333-346
-
-
Altshuler, H.L.1
-
4
-
-
0019363555
-
Operant analysis of human heroin self-administration and the effects of naltrexone
-
Mello NK, Mendelson JH, Kuehnle JC, Sellers MS (1981) Operant analysis of human heroin self-administration and the effects of naltrexone. J Pharmacol Exp Ther 216:45-54 (Pubitemid 11167856)
-
(1981)
Journal of Pharmacology and Experimental Therapeutics
, vol.216
, Issue.1
, pp. 45-54
-
-
Mello, N.K.1
Mendelson, J.H.2
Kuehnle, J.C.3
Sellers, M.S.4
-
5
-
-
0042133443
-
Antagonists, inverse agonists, and protagonists
-
DOI 10.1097/01.jcp.0000087502.38434.6c
-
Shader RI (2003) Antagonists, inverse agonists, and protagonists. J Clin Psychopharm 23:321-322 (Pubitemid 36951171)
-
(2003)
Journal of Clinical Psychopharmacology
, vol.23
, Issue.4
, pp. 321-322
-
-
Shader, R.I.1
-
6
-
-
0032882252
-
The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain
-
DOI 10.1016/S0304-3959(99)00119-0, PII S0304395999001190
-
Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD (1999) The kappa opioid nalbuphine produces gender-and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain 83:339-345 (Pubitemid 29479294)
-
(1999)
Pain
, vol.83
, Issue.2
, pp. 339-345
-
-
Gear, R.W.1
Miaskowski, C.2
Gordon, N.C.3
Paul, S.M.4
Heller, P.H.5
Levine, J.D.6
-
7
-
-
0004207821
-
-
St. Martin's Press, New York
-
Booth M (1998) Opium: a history. St. Martin's Press, New York
-
(1998)
Opium: A History
-
-
Booth, M.1
-
10
-
-
4243687710
-
The dose-response of caudal morphine in children undergoing open-heart-surgery
-
Carr AS, Holtby HM, Hartley EJ, Cox P,Macpherson BA (1994) The dose-response of caudal morphine in children undergoing open-heart-surgery. Anesthesiology 81:A1348-A1348
-
(1994)
Anesthesiology
, vol.81
-
-
Carr, A.S.1
Holtby, H.M.2
Hartley, E.J.3
Cox, P.4
MacPherson, B.A.5
-
12
-
-
0037903823
-
Darstellung der reinen Mohnsäure (Opiumsäure) nebst einer Chemischen Untersuchung des Opiums mit vorzüglicher Hinsicht auf einen darin neu entdeckten Stoff und die dahin gehörigen Bemerkungen
-
Sertürner FW (1806) Darstellung der reinen Mohnsäure (Opiumsäure) nebst einer Chemischen Untersuchung des Opiums mit vorzüglicher Hinsicht auf einen darin neu entdeckten Stoff und die dahin gehörigen Bemerkungen. Trommsdorff's J Pharm 14:47-93
-
(1806)
Trommsdorff's J Pharm
, vol.14
, pp. 47-93
-
-
Sertürner, F.W.1
-
13
-
-
84977496150
-
Über das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums
-
Sertürner FW (1817) Über das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums. Ann Phys Berlin 55:56-89
-
(1817)
Ann Phys Berlin
, vol.55
, pp. 56-89
-
-
Sertürner, F.W.1
-
14
-
-
0002033537
-
The story of morphine structure elucidation: One hundred years of deductive reasoning
-
Hudlicky T (ed) JAI Press, Greenwich
-
Butora G, Hudlicky T (1998) The story of morphine structure elucidation: one hundred years of deductive reasoning. In: Hudlicky T (ed) Organic synthesis: theory and applications. JAI Press, Greenwich
-
(1998)
Organic Synthesis: Theory and Applications
-
-
Butora, G.1
Hudlicky, T.2
-
15
-
-
70349972966
-
Chemoenzymatic enantiodivergent total syntheses of ( +)-and (-)-codeine
-
Leisch H, Omori AT, Finn KJ, Gilmet J, Bissett T, Ilceski D, Hudlicky T (2009) Chemoenzymatic enantiodivergent total syntheses of ( +)-and (-)-codeine. Tetrahedron 65: 9862-9875
-
(2009)
Tetrahedron
, vol.65
, pp. 9862-9875
-
-
Leisch, H.1
Omori, A.T.2
Finn, K.J.3
Gilmet, J.4
Bissett, T.5
Ilceski, D.6
Hudlicky, T.7
-
16
-
-
0000221405
-
Synthetic opium-alkaloids and derivatives - A short total synthesis of ( +-)-dihydrothebainone, ( +-)-dihydrocodeinone, and ( +-)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners
-
Rice KC (1980) Synthetic opium-alkaloids and derivatives-a short total synthesis of ( +-)-dihydrothebainone, ( +-)-dihydrocodeinone, and ( +-)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners. J Org Chem 45:3135-3137
-
(1980)
J Org Chem
, vol.45
, pp. 3135-3137
-
-
Rice, K.C.1
-
17
-
-
70450173919
-
Concise syntheses of (-)-galanthamine and ( +-)-codeine via intramolecular alkylation of a phenol derivative
-
Magnus P, Sane N, Fauber BP, Lynch V (2009) Concise syntheses of (-)-galanthamine and ( +-)-codeine via intramolecular alkylation of a phenol derivative. J Am Chem Soc 131: 16045-16047
-
(2009)
J Am Chem Soc
, vol.131
, pp. 16045-16047
-
-
Magnus, P.1
Sane, N.2
Fauber, B.P.3
Lynch, V.4
-
18
-
-
14644392139
-
Recent progress in the synthesis of morphine alkaloids
-
DOI 10.1055/s-2005-862383, A35604ST
-
Zezula J, Hudlicky T (2005) Recent progress in the synthesis of morphine alkaloids. Synlett 388-405 (Pubitemid 40314102)
-
(2005)
Synlett
, Issue.3
, pp. 388-405
-
-
Zezula, J.1
Hudlicky, T.2
-
20
-
-
15644378136
-
Use of cyclopropanes and their derivatives in organic-synthesis
-
Wong HNC, Hon MY, Tse CW, Yip YC, Tanko J, Hudlicky T (1989) Use of cyclopropanes and their derivatives in organic-synthesis. Chem Rev 89:165-198
-
(1989)
Chem Rev
, vol.89
, pp. 165-198
-
-
Wong, H.N.C.1
Hon, M.Y.2
Tse, C.W.3
Yip, Y.C.4
Tanko, J.5
Hudlicky, T.6
-
21
-
-
0034042314
-
Morphine synthesis and biosynthesis-an update
-
Novak BH, Hudlicky T, Reed JW, Mulzer J, Trauner D (2000) Morphine synthesis and biosynthesis-an update. Curr Org Chem 4:343-362
-
(2000)
Curr Org Chem
, vol.4
, pp. 343-362
-
-
Novak, B.H.1
Hudlicky, T.2
Reed, J.W.3
Mulzer, J.4
Trauner, D.5
-
23
-
-
0037161883
-
Morphine, the proteus of organic molecules
-
Blakemore PR, White JD (2002) Morphine, the proteus of organic molecules. Chem Commun 1159-1168 (Pubitemid 34579430)
-
(2002)
Chemical Communications
, Issue.11
, pp. 1159-1168
-
-
Blakemore, P.R.1
White, J.D.2
-
24
-
-
84856159198
-
-
Rahman AU (ed) Elsevier, Amsterdam
-
Hudlicky T, Butora G, Fernley S, Gum A, Stabile M (1996) A historical perspective of morphine syntheses. In: Rahman AU (ed) Elsevier, Amsterdam
-
(1996)
A Historical Perspective of Morphine Syntheses
-
-
Hudlicky, T.1
Butora, G.2
Fernley, S.3
Gum, A.4
Stabile, M.5
-
25
-
-
84856156821
-
Synthesis of calicheamicin
-
Waldmann H (ed VCH, Weinheim
-
Waldmann H (1995) Synthesis of calicheamicin. In: Waldmann H (ed) Organic synthesis highlights II. VCH, Weinheim
-
(1995)
Organic Synthesis Highlights II
-
-
Waldmann, H.1
-
26
-
-
84856163683
-
Syntheses of morphine
-
Waldmann H (ed VCH, Weinheim
-
Maier M (1995) Syntheses of morphine. In: Waldmann H (ed) Organic synthesis highlights II. VCH, Weinheim
-
(1995)
Organic Synthesis Highlights II
-
-
Maier, M.1
-
27
-
-
37049164050
-
Syntheses in the morphine series 6. The synthesis of morphine
-
Elad D, Ginsburg D (1954) Syntheses in the morphine series 6. The synthesis of morphine. J Chem Soc 3052-3056
-
(1954)
J Chem Soc
, pp. 3052-3056
-
-
Elad, D.1
Ginsburg, D.2
-
28
-
-
33947455036
-
The synthesis of morphine
-
Elad D, Ginsburg D (1954) The synthesis of morphine. J Am Chem Soc 76:312-313
-
(1954)
J Am Chem Soc
, vol.76
, pp. 312-313
-
-
Elad, D.1
Ginsburg, D.2
-
29
-
-
0014178250
-
Die cyclisierung von octahydro-isochinolinderivaten durch morphinan-ringschluss. Synthese Der Dihydrothebainons
-
Grewe R, Friedriccsen W(1967) Die cyclisierung von octahydro- isochinolinderivaten durch morphinan-ringschluss. Synthese Der Dihydrothebainons. Chem Ber Recl 100:1550
-
(1967)
Chem Ber Recl
, vol.100
, pp. 1550
-
-
Grewe, R.1
Friedriccsen, W.2
-
30
-
-
84856197873
-
Die Partielle Birch-Reduktion von 1-Benzyl-Isochinolin-Derivaten
-
Grewe R, Fischer H, Friedric W (1967) Die Partielle Birch-Reduktion Von 1-Benzyl-Isochinolin-Derivaten. Chem Ber Recl 100:1
-
(1967)
Chem Ber Recl
, vol.100
, pp. 1
-
-
Grewe, R.1
Fischer, H.2
Friedric, W.3
-
31
-
-
0020059535
-
Studies directed towards the total synthesis of morphine alkaloids
-
Evans DA, Mitch CH (1982) Studies directed towards the total synthesis of morphine alkaloids. Tetrahedron Lett 23:285-288 (Pubitemid 12137145)
-
(1982)
Tetrahedron Letters
, vol.23
, Issue.3
, pp. 285-288
-
-
Evans, D.A.1
Mitch, C.H.2
-
32
-
-
0020545142
-
Biomimetic total synthesis of (-)-codeine
-
DOI 10.1016/S0040-4020(01)91965-9
-
White JD, Caravatti G, Kline TB, Edstrom E, Rice KC, Brossi A (1983) Biomimetic total synthesis of (-)-codeine. Tetrahedron 39:2393-2397 (Pubitemid 13011317)
-
(1983)
Tetrahedron
, vol.39
, Issue.14
, pp. 2393-2397
-
-
White, J.D.1
Caravatti, G.2
Kline, T.B.3
-
33
-
-
0020587259
-
Codeine analogues. Synthesis of 4a-aryldecahydroisoquinolines containing nitrogen ring functionality and of octahydro-1H-indeno[1,2,3-ef]isoquinolines. A total synthesis of codeine
-
Moos WH, Gless RD, Rapoport H (1983) Codeine analogs-synthesis of 4a-aryldecahydroisoquinolines containing nitrogen ring functionality and of octahydro-1 h-indeno[1,2,3-ef]isoquinolines-a total synthesis of codeine. J Org Chem 48:227-238 (Pubitemid 13135831)
-
(1983)
Journal of Organic Chemistry
, vol.48
, Issue.2
, pp. 227-238
-
-
Moos, W.H.1
Gless, R.D.2
Rapoport, H.3
-
34
-
-
0023151035
-
Syntheses via vinyl sulfones. 21. Total synthesis of dl-morphine
-
Toth JE, Fuchs PL (1987) Syntheses via vinyl sulfones. 21. Total synthesis of dl-morphine. J Org Chem 52:473-475
-
(1987)
J Org Chem
, vol.52
, pp. 473-475
-
-
Toth, J.E.1
Fuchs, P.L.2
-
35
-
-
0023807584
-
Synthesis via vinyl sulfones. 29. Studies culminating in the total synthesis of (dl)-morphine
-
Toth JE, Hamann PR, Fuchs PL (1988) Synthesis via vinyl sulfones. 29. Studies culminating in the total synthesis of (dl)-morphine. J Org Chem 53:4694-4708
-
(1988)
J Org Chem
, vol.53
, pp. 4694-4708
-
-
Toth, J.E.1
Hamann, P.R.2
Fuchs, P.L.3
-
36
-
-
0026687198
-
A novel-approach to the synthesis of morphine alkaloids - The synthesis of (D, L)-thebainone-A
-
Tius MA, Kerr MA (1992) A novel-approach to the synthesis of morphine alkaloids-the synthesis of (D, L)-thebainone-A. J Am Chem Soc 114:5959-5966
-
(1992)
J Am Chem Soc
, vol.114
, pp. 5959-5966
-
-
Tius, M.A.1
Kerr, M.A.2
-
37
-
-
0027075049
-
Convergent synthesis of (±)-dihydroisocodeine in 11 steps by the tandem radical cyclization strategy. A formal total synthesis of [±)-morphine
-
DOI 10.1021/ja00050a075
-
Parker KA, Fokas D (1992) Convergent synthesis of ( +-)-dihydroisocodeine in 11 steps by the tandem radical cyclization strategy-a formal total synthesis of ( +-)-morphine. J Am Chem Soc 114:9688-9689 (Pubitemid 23017196)
-
(1992)
Journal of the American Chemical Society
, vol.114
, Issue.24
, pp. 9688-9689
-
-
Parker, K.A.1
Fokas, D.2
-
38
-
-
30744458121
-
Enantioselective synthesis of (-)-dihydrocodeinone: A short formal synthesis of (-)-morphine
-
DOI 10.1021/jo0513008
-
Parker KA, Fokas D (2006) Enantioselective synthesis of (-)-dihydrocodeinone: a short formal synthesis of (-)-morphine. J Org Chem 71:449-455 (Pubitemid 43100732)
-
(2006)
Journal of Organic Chemistry
, vol.71
, Issue.2
, pp. 449-455
-
-
Parker, K.A.1
Fokas, D.2
-
39
-
-
0027764253
-
Asymmetric-synthesis of either enantiomer of opium-alkaloids and morphinans-total synthesis of (-)-dihydrocodeinone and ( +)-dihydrocodeinone and (-)-morphine and ( +)-morphine
-
Hong CY, Kado N, Overman LE (1993) Asymmetric-synthesis of either enantiomer of opium-alkaloids and morphinans-total synthesis of (-)-dihydrocodeinone and ( +)-dihydrocodeinone and (-)-morphine and ( +)-morphine. J Am Chem Soc 115:11028-11029
-
(1993)
J Am Chem Soc
, vol.115
, pp. 11028-11029
-
-
Hong, C.Y.1
Kado, N.2
Overman, L.E.3
-
41
-
-
0001146788
-
Tandem reactions in organic synthesis: Novel strategies for natural product elaboration and the development of new synthetic methodology
-
Parsons PJ, Penkett CS, Shell AJ (1996) Tandem reactions in organic synthesis: novel strategies for natural product elaboration and the development of new synthetic methodology. Chem Rev 96:195-206 (Pubitemid 126637718)
-
(1996)
Chemical Reviews
, vol.96
, Issue.1
, pp. 195-206
-
-
Parsons, P.J.1
Penkett, C.S.2
Shell, A.J.3
-
42
-
-
0030837809
-
Asymmetric synthesis of (+)-morphine. The phenanthrene route revisited
-
DOI 10.1021/jo9710994
-
White JD, Hrnciar P, Stappenbeck F (1997) Asymmetric synthesis of ( +)-morphine. The phenanthrene route revisited. J Org Chem 62:5250-5251 (Pubitemid 27366322)
-
(1997)
Journal of Organic Chemistry
, vol.62
, Issue.16
, pp. 5250-5251
-
-
White, J.D.1
Hrnciar, P.2
Stappenbeck, F.3
-
43
-
-
0002672380
-
The phenanthrenone approach to opium alkaloids: Formal total synthesis of morphine by sigmatropic rearrangement
-
Mulzer J, Bats JW, List B, Opatz T, Trauner D (1997) The phenanthrenone approach to opium alkaloids: formal total synthesis of morphine by sigmatropic rearrangement. Synlett 441-444
-
(1997)
Synlett
, pp. 441-444
-
-
Mulzer, J.1
Bats, J.W.2
List, B.3
Opatz, T.4
Trauner, D.5
-
45
-
-
0035979031
-
Tandem Single-Step Construction of Chiral Hexahydrophenanthrenes: A Concise Route to (+)-Ferruginol
-
DOI 10.1021/ol015929i
-
Nagata H, Miyazawa N, Ogasawara K (2001) Tandem single-step construction of chiral hexahydrophenanthrenes: a concise route to ( +)-ferruginol. Org Lett 3:1737-1740 (Pubitemid 33631678)
-
(2001)
Organic Letters
, vol.3
, Issue.11
, pp. 1737-1740
-
-
Nagata, H.1
Miyazawa, N.2
Ogasawara, K.3
-
47
-
-
0037065316
-
Enantioselective synthesis of (-)-codeine and (-)-morphine
-
DOI 10.1021/ja0283394
-
Trost BM, Tang WP (2002) Enantioselective synthesis of (-)-codeine and (-)-morphine. J Am Chem Soc 124:14542-14543 (Pubitemid 35425020)
-
(2002)
Journal of the American Chemical Society
, vol.124
, Issue.49
, pp. 14542-14543
-
-
Trost, B.M.1
Tang, W.2
-
48
-
-
27144524460
-
Divergent enantioselective synthesis of (-)-galanthamine and (-)-morphine
-
DOI 10.1021/ja054449+
-
Trost BM, Tang WP, Toste FD (2005) Divergent enantioselective synthesis of (-)-galanthamine and (-)-morphine. J Am Chem Soc 127:14785-14803 (Pubitemid 41511017)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.42
, pp. 14785-14803
-
-
Trost, B.M.1
Tang, W.2
Toste, F.D.3
-
50
-
-
36549037084
-
Chemoenzymatic total synthesis of (+)-codeine by sequential intramolecular Heck cyclizations via C-B-D ring construction
-
DOI 10.1055/s-2007-990833
-
Omori AT, Finn KJ, Leisch H, Carroll RJ, Hudlicky T (2007) Chemoenzymatic total synthesis of ( +)-codeine by sequential intramolecular Heck cyclizations via C-B-D ring construction. Synlett 2859-2862 (Pubitemid 350189837)
-
(2007)
Synlett
, Issue.18
, pp. 2859-2862
-
-
Omori, A.T.1
Finn, K.J.2
Leisch, H.3
Carroll, R.J.4
Hudlicky, T.5
-
51
-
-
53849091312
-
Diastereoselective total synthesis of ( +-)-codeine
-
Varin M, Barre E, Iorga B, Guillou C (2008) Diastereoselective total synthesis of ( +-)-codeine. Chem Eur J 14:6606-6608
-
(2008)
Chem Eur J
, vol.14
, pp. 6606-6608
-
-
Varin, M.1
Barre, E.2
Iorga, B.3
Guillou, C.4
-
52
-
-
37249082658
-
Formal synthesis of (-)-morphine from d-glucal based on the cascade Claisen rearrangement
-
DOI 10.1016/j.tetlet.2007.11.037, PII S0040403907022137
-
Tanimoto H, Saito R, Chida N (2008) Formal synthesis of (-)-morphine from D-glucal based on the cascade Claisen rearrangement. Tetrahedron Lett 49:358-362 (Pubitemid 350262785)
-
(2008)
Tetrahedron Letters
, vol.49
, Issue.2
, pp. 358-362
-
-
Tanimoto, H.1
Saito, R.2
Chida, N.3
-
53
-
-
68949112541
-
Regiospecific and stereoselective syntheses of ( +-) morphine, codeine, and thebaine via a highly stereocontrolled intramolecular 4 +2 cycloaddition leading to a phenanthrofuran system
-
Stork G, Yamashita A, Adams J, Schulte GR, Chesworth R, Miyazaki Y, Farmer JJ (2009) Regiospecific and stereoselective syntheses of ( +-) morphine, codeine, and thebaine via a highly stereocontrolled intramolecular 4 +2 cycloaddition leading to a phenanthrofuran system. J Am Chem Soc 131:11402-11406
-
(2009)
J Am Chem Soc
, vol.131
, pp. 11402-11406
-
-
Stork, G.1
Yamashita, A.2
Adams, J.3
Schulte, G.R.4
Chesworth, R.5
Miyazaki, Y.6
Farmer, J.J.7
-
55
-
-
0017354485
-
A rapid, high yield conversion of codeine to morphine
-
Rice KC (1977) Rapid, high-yield conversion of codeine to morphine. J Med Chem 20: 164-165 (Pubitemid 8056030)
-
(1977)
Journal of Medicinal Chemistry
, vol.20
, Issue.1
, pp. 164-165
-
-
Rice, K.C.1
-
56
-
-
78149232497
-
On the practical limits of determining isolated product yields and ratios of stereoisomers: Reflections, analysis, and redemption
-
Wernerova M, Hudlicky T (2010) On the practical limits of determining isolated product yields and ratios of stereoisomers: reflections, analysis, and redemption. Synlett 2701-2707
-
(2010)
Synlett
, pp. 2701-2707
-
-
Wernerova, M.1
Hudlicky, T.2
-
58
-
-
0000561357
-
The synthesis of ring systems related to morphine. 3. 5,6-Dimethoxy-4-cyanomethyl-1,2-naphthoquinone and its condensation with dienes
-
Gates M (1950) The synthesis of ring systems related to morphine. 3. 5,6-Dimethoxy-4-cyanomethyl-1,2-naphthoquinone and its condensation with dienes. J Am Chem Soc 72: 228-234
-
(1950)
J Am Chem Soc
, vol.72
, pp. 228-234
-
-
Gates, M.1
-
60
-
-
0001304372
-
Studies in ( +)-morphinan series. 1. Alternate conversion of ( +)-dihydrocodeinone into ( +)-codeine
-
Iijima I, Rice KC, Silverton JV (1977) Studies in ( +)-morphinan series. 1. Alternate conversion of ( +)-dihydrocodeinone into ( +)-codeine. Heterocycles 6:1157-1165
-
(1977)
Heterocycles
, vol.6
, pp. 1157-1165
-
-
Iijima, I.1
Rice, K.C.2
Silverton, J.V.3
-
63
-
-
0024427069
-
Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli
-
Zylstra GJ, Gibson DT (1989) Toluene degradation by pseudomonas-putida f1-nucleotidesequence of the Todc1c2bade genes and their expression in Escherichia coli. J Biol Chem 264:14940-14946 (Pubitemid 19237321)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.25
, pp. 14940-14946
-
-
Zylstra, G.J.1
Gibson, D.T.2
-
64
-
-
34547700961
-
Total synthesis of (+)-galanthamine starting from d-glucose
-
DOI 10.1016/j.tetlet.2007.07.042, PII S0040403907013366
-
Tanimoto H, Kato T, Chida N (2007) Total synthesis of ( +)-galanthamine starting from D-glucose. Tetrahedron Lett 48:6267-6270 (Pubitemid 47211253)
-
(2007)
Tetrahedron Letters
, vol.48
, Issue.36
, pp. 6267-6270
-
-
Tanimoto, H.1
Kato, T.2
Chida, N.3
-
65
-
-
0000234345
-
Direct preparation of 2-deoxy-D-glucopyranosides from glucals without Ferrier rearrangement
-
Bolitt V, Mioskowski C, Lee SG, Falck JR (1990) Direct preparation of 2-deoxy-D-glucopyranosides from glucals without Ferrier rearrangement. J Org Chem 55:5812-5813
-
(1990)
J Org Chem
, vol.55
, pp. 5812-5813
-
-
Bolitt, V.1
Mioskowski, C.2
Lee, S.G.3
Falck, J.R.4
-
66
-
-
0028024493
-
Asymmetric transformation of either enantiomer of narwedine via total spontaneous resolution process, a concise solution of the synthesis of (-)-galanthamine
-
DOI 10.1021/jo00097a060
-
Shieh WC, Carlson JA (1994) Asymmetric transformation of either enantiomer of narwedine via total spontaneous resolution process, a concise solution to the synthesis of (-)-galanthamine. J Org Chem 59:5463-5465 (Pubitemid 24310998)
-
(1994)
Journal of Organic Chemistry
, vol.59
, Issue.18
, pp. 5463-5465
-
-
Shieh, W.-C.1
Carlson, J.A.2
-
67
-
-
0016755135
-
Synthesis of thebaine and oripavine from codeine and morphine
-
Barber RB, Rapoport H (1975) Synthesis of thebaine and oripavine from codeine and morphine. J Med Chem 18:1074-1077
-
(1975)
J Med Chem
, vol.18
, pp. 1074-1077
-
-
Barber, R.B.1
Rapoport, H.2
-
68
-
-
0023931859
-
Oxidative coupling of cis-3, N-bis(methoxycarbonyl)-N-norreticuline-an approach to the asymmetric-synthesis of morphine alkaloids
-
Schwartz MA, Pham PTK (1988) Oxidative coupling of cis-3, N-bis(methoxycarbonyl)-N-norreticuline-an approach to the asymmetric-synthesis of morphine alkaloids. J Org Chem 53:2318-2322
-
(1988)
J Org Chem
, vol.53
, pp. 2318-2322
-
-
Schwartz, M.A.1
Ptk, P.2
-
69
-
-
84856159199
-
Intramolecular Diels-Alder cyclizations in an approach to the morphine skeleton
-
Wu C (1991) Intramolecular Diels-Alder cyclizations in an approach to the morphine skeleton. Diss Abstr Int B 53:2044
-
(1991)
Diss Abstr Int B
, vol.53
, pp. 2044
-
-
Wu, C.1
-
71
-
-
84856195382
-
Diverse approaches to chemoenzymatic synthesis of ( +)-codeine
-
Toronto, May 29-June 2
-
Piercy TG, Duchek J, Ilceski D, Hudlicky T (2010) Diverse approaches to chemoenzymatic synthesis of ( +)-codeine. 93rd Canadian Chemistry Conference, Toronto, May 29-June 2
-
(2010)
93rd Canadian Chemistry Conference
-
-
Piercy, T.G.1
Duchek, J.2
Ilceski, D.3
Hudlicky, T.4
-
72
-
-
70350184391
-
Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets
-
Berenyi S, Csutoras C, Sipos A (2009) Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets. Curr Med Chem 16:3215-3242
-
(2009)
Curr Med Chem
, vol.16
, pp. 3215-3242
-
-
Berenyi, S.1
Csutoras, C.2
Sipos, A.3
-
75
-
-
84856195383
-
-
Br. Patent 955493
-
Lewenstein MJ (1964) Br. Patent 955493
-
(1964)
-
-
Lewenstein, M.J.1
-
77
-
-
84856156823
-
-
Br. Patent 1136214
-
Bentley KW (1968) Br. Patent 1136214
-
(1968)
-
-
Bentley, K.W.1
-
78
-
-
0028108831
-
Photooxidation of thebaine. A route to 14-hydroxymorphinones and hydrodibenzofuran analogs of methadone
-
DOI 10.1016/S0040-4039(00)77290-X
-
Lopez D, Quinoa E, Riguera R (1994) Photooxidation of thebaine-a route to 14-hydroxymorphinones and hydrodibenzofuran analogs of methadone. Tetrahedron Lett 35:5727-5730 (Pubitemid 24248549)
-
(1994)
Tetrahedron Letters
, vol.35
, Issue.31
, pp. 5727-5730
-
-
Lopez, D.1
Quinoa, E.2
Riguera, R.3
-
79
-
-
0343526760
-
The [4 + 2] addition of singlet oxygen to thebaine: New access to highly functionalized morphine derivatives via opioid endoperoxides
-
DOI 10.1021/jo000288a
-
Lopez D, Quinoa E, Riguera R (2000) The [4 +2] addition of singlet oxygen to thebaine: new access to highly functionalized morphine derivatives via opioid endoperoxides. J Org Chem 65:4671-4678 (Pubitemid 30620578)
-
(2000)
Journal of Organic Chemistry
, vol.65
, Issue.15
, pp. 4671-4678
-
-
Lopez, D.1
Quinoa, E.2
Riguera, R.3
-
80
-
-
0029744574
-
Optimization of the synthesis of oxycodone and 5-methyloxycodone
-
Krassnig R, Hederer C, Schmidhammer H (1996) Optimization of the synthesis of oxycodone and 5-methyloxycodone. Arch Pharm 329:325-326 (Pubitemid 26260771)
-
(1996)
Archiv der Pharmazie
, vol.329
, Issue.6
, pp. 325-326
-
-
Krassnig, R.1
Hederer, C.2
Schmidhammer, H.3
-
81
-
-
84856205720
-
Ruthenium catalysts for the production of hydrocodone hydromorphone or a derivative thereof
-
CODEN: PIXXD2 WO 2010118273 A1 20101014 CAN 153:530729 AN 2010: 1283630
-
Gindelberger DE (2010) Ruthenium catalysts for the production of hydrocodone, hydromorphone or a derivative thereof: PCT Int. Appl. 32 pp. CODEN: PIXXD2 WO 2010118273 A1 20101014 CAN 153:530729 AN 2010:1283630
-
(2010)
PCT Int. Appl.
, pp. 32
-
-
Gindelberger, D.E.1
-
82
-
-
84856165642
-
Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
-
Cont.-in-part of U.S. Ser. No. 973, 031. CODEN: USXXCO US 2006155130 A1 20060713 CAN 145:124776 AN 2006: 681645
-
Wang PX, Moser FW, Cantrell GL, Magparangalan DP, Bao J (2006) Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof: U.S. Pat. Appl. Publ. 9 pp, Cont.-in-part of U.S. Ser. No. 973,031. CODEN: USXXCO US 2006155130 A1 20060713 CAN 145:124776 AN 2006:681645
-
(2006)
U.S. Pat. Appl. Publ.
, pp. 9
-
-
Wang, P.X.1
Moser, F.W.2
Cantrell, G.L.3
Magparangalan, D.P.4
Bao, J.5
-
83
-
-
84856137693
-
Process for the catalytic conversion of codeine and morphine into hydrocodone and hydromorphone
-
Cont.-in-part of U.S. Ser. No. 495, 503. CODEN: USXXCO US 2005124811 A1 20050609 CAN 143:26767 AN 2005: 497544
-
Wang PX, White CR (2005) Process for the catalytic conversion of codeine and morphine into hydrocodone and hydromorphone: U.S. Pat. Appl. Publ. 8 pp., Cont.-in-part of U.S. Ser. No. 495,503. CODEN: USXXCO US 2005124811 A1 20050609 CAN 143:26767 AN 2005: 497544
-
(2005)
U.S. Pat. Appl. Publ.
, pp. 8
-
-
Wang, P.X.1
White, C.R.2
-
84
-
-
34247877458
-
Studies on regioselective hydrogenation of thebaine and its conversion to hydrocodone
-
DOI 10.1016/j.tetlet.2007.04.051, PII S0040403907007204
-
Leisch H, Carroll RJ, Hudlicky T, Cox DP (2007) Studies on regioselective hydrogenation of thebaine and its conversion to hydrocodone. Tetrahedron Lett 48:3979-3981 (Pubitemid 46702268)
-
(2007)
Tetrahedron Letters
, vol.48
, Issue.23
, pp. 3979-3981
-
-
Leisch, H.1
Carroll, R.J.2
Hudlicky, T.3
Cox, D.P.4
-
85
-
-
0018923907
-
Analgesic narcotic-antagonists. 1. 8-beta-Alkyl, 8-beta-acyl, and 8-beta (tertiary alcohol) dihydrocodeinones and dihydromorphinones
-
Kotick MP, Leland DL, Polazzi JO, Schut RN (1980) Analgesic narcotic-antagonists. 1. 8-beta-Alkyl, 8-beta-acyl, and 8-beta (tertiary alcohol) dihydrocodeinones and dihydromorphinones. J Med Chem 23:166-174
-
(1980)
J Med Chem
, vol.23
, pp. 166-174
-
-
Kotick, M.P.1
Leland, D.L.2
Polazzi, J.O.3
Schut, R.N.4
-
86
-
-
0037147797
-
Synthesis and biological activity of 8β-substituted hydrocodone indole and hydromorphone indole derivatives
-
DOI 10.1016/S0960-894X(01)00689-8, PII S0960894X01006898
-
Yu H, Prisinzano T, Dersch CM, Marcus J, Rothman RB, Jacobson AE, Rice KC (2002) Synthesis and biological activity of 8 beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorg Med Chem Lett 12:165-168 (Pubitemid 34037958)
-
(2002)
Bioorganic and Medicinal Chemistry Letters
, vol.12
, Issue.2
, pp. 165-168
-
-
Yu, H.1
Prisinzano, T.2
Dersch, C.M.3
Marcus, J.4
Rothman, R.B.5
Jacobson, A.E.6
Rice, K.C.7
-
88
-
-
37049133259
-
Cleavage of tertiary boses with phenyl chloroformate-reconversion of 21-deoxyajmaline into ajmaline
-
Hobson JD, McCluske JG (1967) Cleavage of tertiary boses with phenyl chloroformate-reconversion of 21-deoxyajmaline into ajmaline. J Chem Soc C 2015-2017
-
(1967)
J Chem Soc C
, pp. 2015-2017
-
-
Hobson, J.D.1
McCluske, J.G.2
-
89
-
-
0016850657
-
Improved procedure for N-demethylation of 6,7-benzomorphans, morphine, and codeine
-
Rice KC (1975) Improved procedure for N-demethylation of 6,7-benzomorphans, morphine, and codeine. J Org Chem 40:1850-1851
-
(1975)
J Org Chem
, vol.40
, pp. 1850-1851
-
-
Rice, K.C.1
-
90
-
-
0037464482
-
1 N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: Extending the scope of common structure-activity relationships
-
DOI 10.1021/jm021118o
-
Greiner E, Spetea M, Krassnig R, Schullner F, Aceto M, Harris LS, Traynor JR, Woods JH, CoopA, SchmidhammerH(2003) Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-Substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships. J Med Chem 46:1758-1763 (Pubitemid 36444228)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.9
, pp. 1758-1763
-
-
Greiner, E.1
Spetea, M.2
Krassnig, R.3
Schullner, F.4
Aceto, M.5
Harris, L.S.6
Traynor, J.R.7
Woods, J.H.8
Coop, A.9
Schmidhammer, H.10
-
91
-
-
33344464242
-
Dealkylative functionalization of tertiary amines with electron deficient heteroaryl chlorides
-
DOI 10.1016/j.tetlet.2006.01.104, PII S0040403906001717
-
Hamilton GL, Backes BJ (2006) Dealkylative functionalization of tertiary amines with electron deficient heteroaryl chlorides. Tetrahedron Lett 47:2229-2231 (Pubitemid 43287888)
-
(2006)
Tetrahedron Letters
, vol.47
, Issue.13
, pp. 2229-2231
-
-
Hamilton, G.L.1
Backes, B.J.2
-
93
-
-
57849151567
-
Palladium-catalyzed N-demethylation/N-acylation of some morphine and tropane alkaloids
-
Carroll RJ, Leisch H, Scocchera E, Hudlicky T, Cox DP (2008) Palladium-catalyzed N-demethylation/N-acylation of some morphine and tropane alkaloids. Adv Synth Catal 350:2984-2992
-
(2008)
Adv Synth Catal
, vol.350
, pp. 2984-2992
-
-
Carroll, R.J.1
Leisch, H.2
Scocchera, E.3
Hudlicky, T.4
Cox, D.P.5
-
94
-
-
84856153254
-
Conversion of thebaine to morphine derivatives
-
Chemical Indexing Equivalent to 150:77839 (WO). CODEN: USXXCO US 2009005563 A1 20090101 CAN 150:77838 AN 2009:1904, US patent # 7,928,234
-
Carroll RJ, Leisch H, Hudlicky T (2009) Conversion of thebaine to morphine derivatives: U.S. Pat. Appl. Publ. 9 pp. Chemical Indexing Equivalent to 150:77839 (WO). CODEN: USXXCO US 2009005563 A1 20090101 CAN 150:77838 AN 2009:1904, US patent # 7,928,234.
-
(2009)
U.S. Pat. Appl. Publ.
, pp. 9
-
-
Carroll, R.J.1
Leisch, H.2
Hudlicky, T.3
-
95
-
-
0345529001
-
Efficient N-Demethylation of Opiate Alkaloids Using a Modified Nonclassical Polonovski Reaction
-
DOI 10.1021/jo035243z
-
McCamley K, Ripper JA, Singer RD, Scammells PJ (2003) EfficientN-demethylation of opiate alkaloids using a modified nonclassical Polonovski reaction. J Org Chem 68:9847-9850 (Pubitemid 37509903)
-
(2003)
Journal of Organic Chemistry
, vol.68
, Issue.25
, pp. 9847-9850
-
-
McCamley, K.1
Ripper, J.A.2
Singer, R.D.3
Scammells, P.J.4
-
96
-
-
77954560524
-
Two-step iron(0)-mediated N-demethylation of N-methyl alkaloids
-
Kok GB, Pye CC, Singer RD, Scammells PJ (2010) Two-step iron(0)-mediated N-demethylation of N-methyl alkaloids. J Org Chem 75:4806-4811
-
(2010)
J Org Chem
, vol.75
, pp. 4806-4811
-
-
Kok, G.B.1
Pye, C.C.2
Singer, R.D.3
Scammells, P.J.4
-
97
-
-
58549108427
-
An improved process for the N-demethylation of opiate alkaloids using an iron(II) catalyst in acetate buffer
-
Kok G, Ashton TD, Scammells PJ (2009) An improved process for the N-demethylation of opiate alkaloids using an iron(II) catalyst in acetate buffer. Adv Synth Catal 351:283-286
-
(2009)
Adv Synth Catal
, vol.351
, pp. 283-286
-
-
Kok, G.1
Ashton, T.D.2
Scammells, P.J.3
-
98
-
-
77955417362
-
N-Demethylation of N-methyl alkaloids with ferrocene
-
Kok GB, Scammells PJ (2010) N-Demethylation of N-methyl alkaloids with ferrocene. Bioorg Med Chem Lett 20:4499-4502
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 4499-4502
-
-
Kok, G.B.1
Scammells, P.J.2
-
99
-
-
72149087429
-
Biotransformations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions
-
Chaudhary V, Leisch H, Moudra A, Allen B, De Luca V, Cox DP, Hudlicky T (2009) Biotransformations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions. Collect Czech Chem Commun 74:1179-1193
-
(2009)
Collect Czech Chem Commun
, vol.74
, pp. 1179-1193
-
-
Chaudhary, V.1
Leisch, H.2
Moudra, A.3
Allen, B.4
De Luca, V.5
Cox, D.P.6
Hudlicky, T.7
-
100
-
-
84856181962
-
Morphinone reductase for the preparation of hydromorphone and hydrocodone
-
CODEN: PIXXD2 WO 9400565 A1 19940106 CAN 120:128514 AN, 1994:128514
-
Hailes AM, French CE, Bruce NC (1994) Morphinone reductase for the preparation of hydromorphone and hydrocodone: PCT Int. Appl. 23 pp. CODEN: PIXXD2 WO 9400565 A1 19940106 CAN 120:128514 AN 1994:128514
-
(1994)
PCT Int. Appl.
, pp. 23
-
-
Hailes, A.M.1
French, C.E.2
Bruce, N.C.3
-
101
-
-
0033152629
-
Molecular cloning and functional expression of codeinone reductase: The penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum
-
Unterlinner B, Lenz R, Kutchan TM (1999) Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum. Plant J 18:465-475
-
(1999)
Plant J
, vol.18
, pp. 465-475
-
-
Unterlinner, B.1
Lenz, R.2
Kutchan, T.M.3
|