Synthesis and biological evaluation of 14-alkoxymorphinans. 18.1 N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: Extending the scope of common structure-activity relationships

Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2003, Pages 1758-1763

  Greiner, Elisabeth ^a,e   Spetea, Mariana ^a   Krassnig, Roland ^a   Schüllner, Falko ^a   Aceto, Mario ^b   Harris, Louis S ^b   Traynor, John R ^c   Woods, James H ^c   Coop, Andrew ^d   Schmidhammer, Helmut ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14 METHOXYMETOPON; 14 O METHYLOXYMORPHONE; 17 CYCLOPROPYLMETHYL 4,5ALPHA DIEPOXY 3 HYDROXY 14BETA (3 PHENYLPROPYLOXY)MORPHINAN 6 ONE; 4,5ALPHA DIEPOXY 3 HYDROXY 14BETA (3 PHENYLPROPYLOXY) 17 (N PROPYL)MORPHINAN 6 ONE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NALTREXONE; THEBAINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST; WRITHING TEST;

ANALGESICS, OPIOID; ANIMALS; CHO CELLS; CRICETINAE; LIGANDS; MALE; MICE; MICE, INBRED ICR; MORPHINANS; PAIN MEASUREMENT; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037464482     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021118o     Document Type: Article

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