Synthesis and biological activity of 8β-substituted hydrocodone indole and hydromorphone indole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 2, 2002, Pages 165-168

  Yu, Han ^a   Prisinzano, Thomas ^a   Dersch, Christina M ^b   Marcus, Jamila ^b   Rothman, Richard B ^b   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NIDA Addiction Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; 6,7 DEHYDRO 4,5ALPHA EPOXY 8BETA METHYL 6,7,2',3' INDOLOMORPHINAN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; INDOLE DERIVATIVE; METHYL GROUP; MORPHINAN DERIVATIVE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

HYDROCODONE; HYDROMORPHONE; INDOLES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037147797     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00689-8     Document Type: Article

References (21)