Studies on regioselective hydrogenation of thebaine and its conversion to hydrocodone

Tetrahedron Letters

Volumn 48, Issue 23, 2007, Pages 3979-3981

  Leisch, Hannes ^a   Carroll, Robert J ^a   Hudlicky, Tomas ^a   Cox, D Phillip ^b  

^a BROCK UNIVERSITY   (Canada)

^b Noramco Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; HYDROCODONE; THEBAINE;

ARTICLE; CHEMICAL STRUCTURE; HYDROGENATION;

EID: 34247877458     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.04.051     Document Type: Article

References (24)

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19. 3, pH 2.8 adjusted with 2 N HCl:MeOH (75:25). Retention times are as follows: thebaine 1, 44.7 min; 8,14-dihydrothebaine 4, 41.2 min; tetrahydrothebaine 7, 31.0 min.
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24. The use of thebaine and other morphinans was carried out in accordance with Health Canada guidelines and procedures. [licence # 2006/7531].