Covering a broad dynamic range: Information processing at the erythropoietin receptor

Science

Volumn 328, Issue 5984, 2010, Pages 1404-1408

  Becker, Verena ^a,b   Schilling, Marcel ^a   Bachmann, Julie ^a   Baumann, Ute ^a   Raue, Andreas ^c   Maiwald, Thomas ^c,d   Timmer, Jens ^c   Klingmüller, Ursula ^a,b  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; LIGAND;

BIOCHEMISTRY; CYTOLOGY; LIGAND; NUMERICAL MODEL; SIGNAL PROCESSING;

ARTICLE; COMPLEX FORMATION; HEMATOPOIETIC SYSTEM; INFORMATION PROCESSING; LIGAND BINDING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ANIMALS; CELL LINE; CELL MEMBRANE; COMPUTER SIMULATION; ENDOCYTOSIS; EPOETIN ALFA; ERYTHROPOIETIN; KINETICS; LIGANDS; MICE; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION;

EID: 77953582302     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1184913     Document Type: Article

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21. We thank R. EiIs, U. Kummer, R. Meyer, A. C. Pfeifer, J. P. Schiöder, C. Schultz, and V. Starkuviene for critically reading the manuscript; S. N. Constantinescu for HA-EpoR constructs; and S. Manthey and S. Lattermann for technical assistance. This work was supported by the Helmholtz Alliance on Systems Biology (SBCancer) (V.B., M.S., J.T., and U.K.), the German Federal Ministry of Education and Research (BMBF)-funded MedSys-Network LungSys (J.B., A.R., and U.K.), and the Excellence Initiative of the German Federal and State Governments (EXC 294) (J.T.).