The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

British Journal of Pharmacology

Volumn 146, Issue 1, 2005, Pages 41-48

  Vijayakumar, Maleppillil Vavachan ^a   Singh, Sandeep ^a   Chhipa, Rishi Raj ^a   Bhat, Manoj Kumar ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Dialysed fenugreek seed extract; Glucose uptake; GLUT4 translocation; Hypoglycaemic activity; In vitro cell models; Insulin signalling pathway; Phosphorylation

Indexed keywords

BISINDOLYLMALEIMIDE; FENUGREEK EXTRACT; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLANT EXTRACT; PROTEIN KINASE C INHIBITOR; PROTEIN P85; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; FENUGREEK; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

3T3 CELLS; ALLOXAN; ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; PLANT EXTRACTS; PROTEIN KINASE C; SEEDS; SIGNAL TRANSDUCTION; TRIGONELLA;

EID: 30644477939     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706312     Document Type: Article

References (32)

1. ABDEL-BARRY, J.A., ABDEL-HASSAN, I.A. & AL-HAKIEM, M.H. (1997). Hypoglycemic and antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J. Ethnopharmacol, 58, 149-155.
2. BASCH, E., ULBRICHT, C., KUO, G., SZAPARY, P. & SMITH, M. (2003). Therapeutic applications of fenugreek. Altern. Med. Rev., 8, 20-27.
3. CHEATHAM, B., VLAHOS, C.J., CHEATHAM, L., WANG, L., BLENIS, J. & KAHN, C.R. (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol., 14, 4902-4911.
4. CHHIPA, R.R., SINGH, S., SURVE, S.V., VIJAYAKUMAR, M.V. & BHAT, M.K. (2005). Doxycycline potentiates antitumor effect of cyclophosphamide in mice. Toxicol. Appl. Pharmacol., 202, 268-277.
5. CLANCY, B.M. & CZECH, M.P. (1990). Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes. J. Biol. Chem., 265, 12434-12443.
6. CUSHMAN, S.W. & WARDZALA, L.J. (1980). Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J. Biol. Chem., 25, 4758-4762.
7. DAY, C. (1998). Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br. J. Nutr., 80, 5-6.
8. DOBSON, S.P., LIVINGSTONE, C., GOULD, G.W. & TAVARE, J.M. (1996). Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualized using green fluorescent protein. FEBS Lett., 393, 179-184.
9. FABRICANT, D.S & FARNSWORTH, N.R. (2001). The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect., 109, 69-75.
10. GRAY, A.M., ABDEL-WAHAB, Y.H. & FLATT, P.R. (2000). The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J. Nutr., 130, 15-20.
11. HABECK, M. (2003). Diabetes treatments get sweet help from nature. Nat. Med., 9, 1228.
12. HAUSDORFF, S.F., FINGAR, D.C., MORIOKA, K., GARZA, L.A., WHITEMAN, E.L., SUMMERS, S.A. & BIRNBAUM, M.J. (1999). Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. Dissociation of insulin stimulated glucose uptake and GLUT4 translocation. J. Biol. Chem., 274, 24677-24684.
13. INOUE, G., CHEATHAM, B. & KAHN, C.R. (1999). Development of an in vitro reconstitution assay for glucose transporter 4 translocation. Proc. Natl. Acad. Sci. U.S.A., 96, 14919-14924.
14. HANG, Z.Y., CHAWLA, A., BOSE, A., WAY, M. & CZECH, M.P. (2002). A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J. Biol. Chem., 277, 509-515.
15. KAHN, A.H. & PESSIN, J.E. (2002). Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia, 45, 1475-1483.
16. KAMEI, R., KITAGAWA, Y., KADOKURA, M., HATTORI, F., HAZEKI, O., EBINA, Y., NISHIHARA, T. & OIKAWA, S. (2002). Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway. Biochem. Biophys. Res. Commun., 292, 642-651.
17. KANAI, F., NISHIOKA, Y., HAYASHI, H., KAMOHARA, S., TODAKA, M. & EBINA, Y. (1993). Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain. J. Biol. Chem., 268, 14523-14526.
18. KITAMURA, T., OGAWA, W., SAKAUE, H., HINO, Y., KURODA, S., TAKATA, M., MATSUMOTO, M., MAEDA, T., KONISHI, H., KIKKAWA, U. & KASUGA, M. (1998). Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol. Cell. Biol, 18, 3708-3717.
19. KOTANI, K., OGAWA, W., MATSUMOTO, M., KITAMURA, T., SAKAUE, H., HINO, Y., MIYAKE, K., SANO, W., AKIMOTO, K., OHNO, S. & KASUGA, M. (1998). Requirement of atypical protein kinase c lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol. Cell. Biol., 18, 6971-6982.
20. LIU, F., KIM, J., LI, Y., LIU, X., LI, J. & CHEN, X. (2001). An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J. Nutr., 131, 2242-2247.
21. MOLLER, D.E. (2001). New drug targets for type 2 diabetes and the metabolic syndrome. Nature, 414, 821-827.
22. OUBRE, A.Y., CARLSON, T.J., KING, S.R. & REAVEN, G.M. (1997). From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia, 40, 614-617.
23. RASKIN, L, RIBNICKY, D.M., KOMARNYTSKY, S., ILIC, N., POULEV, A., BORISJUK, N., BRINKER, A., MORENO, D.A., RIPOLL, C., YAKOBY, N., O'NEAL, J.M., CORNWELL, T., PASTOR, I. & FRIDLENDER, B. (2002). Plants and human health in the twenty-first century. Trends Biotechnol., 20, 522-531.
24. SALTIEL, A.R. & PESSIN, J.E. (2002). Insulin signaling pathways in time and space. Trends Cell Biol., 12, 65-71.
25. TAFURI, S.R. (1996). Troglitazone enhances differentiation, basal glucose uptake, and GLUT1 protein levels in 3T3-L1 adipocytes. Endocrinology, 137, 4106-4712.
26. TAYLOR, S.I. (1999). Deconstructing type 2 diabetes. Cell, 97, 9-12.
27. TOULLEC, D., PIANETTI, P., COSTE, H., BELLEVERGUE, P., GRAND-PERRET, T., AJAKANE, M., BAUDET, V., BOISSIN, P., BOURSIER, E, LORIOLLE, F, LORIOLLE, F., DUHAMEL, L., CHARON, D. & KIRILOVSKY, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem., 266, 15771-15781.
28. U.K. PROSPECTIVE DIABETES STUDY GROUP (1995). Perspectives in Diabetes. U.K. Prospective Diabetes study 16. Overview of 6 years' therapy of type 2 diabetes: a progressive disease. Diabetes, 44, 1249-1258.
29. VATS, V., GROVER, J.K. & RATHI, S.S. (2002). Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenumgraecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J. Ethnopharmacol., 79, 95-100.
30. WHITE, M.F. & KAHN, C.R. (1994). The insulin signaling system. J. Biol. Chem., 269, 1-4.
31. YEH, G.Y., EISENBERG, D.M., KAPTCHUK, T.J. & PHILLIPS, R.S. (2003). Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care, 26, 1277-1294.
32. ZIA, T., HASNAIN, S.N. & KASAN, S.K. (2001). Evaluation of the oral hypoglycemic effect of Trigonella foenum-graecum L (methi) in normal mice. J. Ethnopharmacol., 75, 191-195.