Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 2, 2012, Pages 544-557

  Carraway, Robert E ^a   Dobner, Paul R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Chelator; Ionophore; Necrosis; Prostate cancer; Zinc

Indexed keywords

ANDROGEN; CALCIUM ION; CALPASTATIN; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 7; CYCLOHEXIMIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P53; PYRITHIONE ZINC; REACTIVE OXYGEN METABOLITE; TROLOX C; UO 126; ZINC ION;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL METABOLISM; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; PREMEDICATION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CHELATING AGENTS; ETHYLENEDIAMINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IONOPHORES; KERATOLYTIC AGENTS; MALE; MITOCHONDRIA; NECROSIS; ORGANOMETALLIC COMPOUNDS; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PYRIDINES; REACTIVE OXYGEN SPECIES; ZINC;

EID: 84855805416     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.09.013     Document Type: Article

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