Intracellular zinc increase inhibits p53-/- pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1793, Issue 2, 2009, Pages 273-280

  Donadelli, M ^a   Dalla Pozza, E ^a   Scupoli, M T ^a   Costanzo, C ^a   Scarpa, A ^a   Palmieri, M ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Oxidative stress; p53; Pancreatic adenocarcinoma; Pyrrolidine dithiocarbamate; Zinc

Indexed keywords

ACETYLCYSTEINE; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE; GEMCITABINE; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; PROTEASOME; PROTEIN P53; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; ZINC ION; ZINC SULFATE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL DEATH; CELL LEVEL; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME DEGRADATION; FIBROBLAST; GENE CONTROL; GOLD STANDARD; HUMAN; HUMAN CELL; MITOCHONDRION; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ADENOCARCINOMA; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ETHYLENEDIAMINES; FIBROBLASTS; HUMANS; INTRACELLULAR SPACE; LEUPEPTINS; MITOCHONDRIA; MODELS, BIOLOGICAL; PANCREATIC NEOPLASMS; PROTEIN TRANSPORT; PYRROLIDINES; REACTIVE OXYGEN SPECIES; THIOCARBAMATES; TUMOR SUPPRESSOR PROTEIN P53; ZINC;

EID: 58549096887     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.09.010     Document Type: Article

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