Activation of type i interferon pathway in systemic lupus erythematosus: Association with distinct clinical phenotypes

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Karageorgas, Theophanis P ^a,b   Tseronis, Dimitrios D ^a   Mavragani, Clio P ^b  

^a G GENNIMATAS GENERAL HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CXCL1 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN; INDOLEAMINE 2,3 DIOXYGENASE; INTERFERON; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT ALPHA INTERFERON; STAT4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VASCULOTROPIN A;

APOPTOSIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; CHROMOSOME 1; CLINICAL FEATURE; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM INJURY; GENE EXPRESSION; HUMAN; KERATINOCYTE; LUPUS ERYTHEMATOSUS NEPHRITIS; MORTALITY; NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS; NEUROPSYCHIATRY; NONHUMAN; PATHOGENESIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHENOTYPE; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN LUPUS ERYTHEMATOSUS; SYSTEMIC LUPUS ERYTHEMATOSUS; ULTRAVIOLET IRRADIATION; ANIMAL; BLOOD; BRAIN VASCULITIS; DISEASE MODEL; HOSPITALIZATION; MOUSE; NEPHRITIS; SIGNAL TRANSDUCTION;

ANIMALS; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, CUTANEOUS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS VASCULITIS, CENTRAL NERVOUS SYSTEM; MICE; NEPHRITIS; PHENOTYPE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

EID: 84855554046     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/273907     Document Type: Review

References (128)

1. Borchers A. T., Naguwa S. M., Shoenfeld Y., Gershwin M. E., The geoepidemiology of systemic lupus erythematosus Autoimmunity Reviews 2010 9 5 A277 A287
2. Hooks J. J., Moutsopoulos H. M., Geis S. A., Immune interferon in the circulation of patients with autoimmune disease The New England Journal of Medicine 1979 301 1 5 8 (Pubitemid 9226519)
3. Ronnblom L. E., Alm G. V., Oberg K. E., Possible induction of systemic lupus erythematosus by interferon -treatment in a patient with a malignant carcinoid tumour Journal of Internal Medicine 1990 227 3 207 210 (Pubitemid 20075945)
4. Bennett L., Palucka A. K., Arce E., Cantrell V., Borvak J., Banchereau J., Pascual V., Interferon and granulopoiesis signatures in systemic lupus erythematosus blood Journal of Experimental Medicine 2003 197 6 711 723 (Pubitemid 36350866)
5. Ronnblom L., Alm G. V., Eloranta M. L., The type I interferon system in the development of lupus Seminars in Immunology 2011 23 2 113 121
6. Lande R., Ganguly D., Facchinetti V., Frasca L., Conrad C., Gregorio J., Meller S., Chamilos G., Sebasigari R., Riccieri V., Bassett R., Amuro H., Fukuhara S., Ito T., Liu Y. -J., Gilliet M., Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus Science Translational Medicine 2011 3 73 73ra19
7. Garcia-Romo G. S., Caielli S., Vega B., Connolly J., Allantaz F., Xu Z., Punaro M., Baisch J., Guiducci C., Coffman R. L., Barrat F. J., Banchereau J., Pascual V., Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus Science Translational Medicine 2011 3 73 73ra20
8. Kanayama Y., Kim T., Inariba H., Negoro N., Okamura M., Takeda T., Inoue T., Possible involvement of interferon in the pathogenesis of fever in systemic lupus erythematosus Annals of the Rheumatic Diseases 1989 48 10 861 863 (Pubitemid 19258543)
9. Bengtsson A. A., Sturfelt G., Truedsson L., Blomberg J., Alm G., Vallin H., Ronnblom L., Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies Lupus 2000 9 9 664 671 (Pubitemid 32011791)
10. Baechler E. C., Batliwalla F. M., Karypis G., Gaffney P. M., Ortmann W. A., Espe K. J., Shark K. B., Grande W. J., Hughes K. M., Kapur V., Gregersen P. K., Behrens T. W., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2610 2615 (Pubitemid 36297546)
11. Dall'era M. C., Cardarelli P. M., Preston B. T., Witte A., Davis J. C., Type I interferon correlates with serological and clinical manifestations of SLE Annals of the Rheumatic Diseases 2005 64 12 1692 1697 (Pubitemid 41667141)
12. Kirou K. A., Lee C., George S., Louca K., Peterson M. G. E., Crow M. K., Activation of the interferon- pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease Arthritis and Rheumatism 2005 52 5 1491 1503 (Pubitemid 40663941)
13. Feng X., Wu H., Grossman J. M., Hanvivadhanakul P., FitzGerald J. D., Park G. S., Dong X., Chen W., Kim M. H., Weng H. H., Furst D. E., Gorn A., McMahon M., Taylor M., Brahn E., Hahn B. H., Tsao B. P., Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis and Rheumatism 2006 54 9 2951 2962 (Pubitemid 44497776)
14. Weckerle C. E., Network analysis of associations between serum interferon- activity, autoantibodies, and clinical features in systemic lupus erythematosus Arthritis Rheumatism 2011 63 4 1044 1053
15. Bagavant H., Fu S. M., Pathogenesis of kidney disease in systemic lupus erythematosus Current Opinion in Rheumatology 2009 21 5 489 494
16. Rich S. A., Human lupus inclusions and interferon Science 1981 213 4509 772 775 (Pubitemid 11016456)
17. Peterson K. S., Huang J. F., Zhu J., D'Agati V., Liu X., Miller N., Erlander M. G., Jackson M. R., Winchester R. J., Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli Journal of Clinical Investigation 2004 113 12 1722 1733 (Pubitemid 39071664)
18. Papadimitraki E. D., Tzardi M., Bertsias G., Sotsiou E., Boumpas D. T., Glomerular expression of Toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response Lupus 2009 18 9 831 835
19. Moser K. L., Kelly J. A., Lessard C. J., Harley J. B., Recent insights into the genetic basis of systemic lupus erythematosus Genes and Immunity 2009 10 5 373 379
20. Harley J. B., Alarcn-Riquelme M. E., Criswell L. A., Jacob C. O., Kimberly R. P., Moser K. L., Tsao B. P., Vyse T. J., Langefeld C. D., Nath S. K., Guthridge J. M., Cobb B. L., Mirel D. B., Marion M. C., Williams A. H., Divers J., Wang W., Frank S. G., Namjou B., Gabriel S. B., Lee A. T., Gregersen P. K., Behrens T. W., Taylor K. E., Fernando M., Zidovetzki R., Gaffney P. M., Edberg J. C., Rioux J. D., Ojwang J. O., James J. A., Merrill J. T., Gilkeson G. S., Seldin M. F., Yin H., Baechler E. C., Li Q. Z., Wakeland E. K., Bruner G. R., Kaufman K. M., Kelly J. A., Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nature Genetics 2008 40 2 204 210 (Pubitemid 351171405)
21. Harley I. T., Kaufman K. M., Langefeld C. D., Harley J. B., Kelly J. A., Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies Nature Reviews Genetics 2009 10 5 285 290
22. Kariuki S. N., Moore J. G., Kirou K. A., Crow M. K., Utset T. O., Niewold T. B., Age- and gender-specific modulation of serum osteopontin and interferon- by osteopontin genotype in systemic lupus erythematosus Genes and Immunity 2009 10 5 487 494
23. Kariuki S. N., Crow M. K., Niewold T. B., The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon- activity and low tumor necrosis factor levels in patients with lupus Arthritis and Rheumatism 2008 58 9 2818 2823
24. Sigurdsson S., Nordmark G., Garnier S., Grundberg E., Kwan T., Nilsson O., Eloranta M. L., Gunnarsson I., Svenungsson E., Sturfelt G., Bengtsson A. A., Jonsen A., Truedsson L., Rantapaa-Dahlqvist S., Eriksson C., Alm G., Goring H. H. H., Pastinen T., Syvanen A. C., Ronnblom L., A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5 Human Molecular Genetics 2008 17 18 2868 2876
25. Remmers E. F., Plenge R. M., Lee A. T., Graham R. R., Hom G., Behrens T. W., De Bakker P. I. W., Le J. M., Lee H. S., Batliwalla F., Li W., Masters S. L., Booty M. G., Carulli J. P., Padyukov L., Alfredsson L., Klareskog L., Chen W. V., Amos C. I., Criswell L. A., Seldin M. F., Kastner D. L., Gregersen P. K., STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus The New England Journal of Medicine 2007 357 10 977 986 (Pubitemid 47367077)
26. Kariuki S. N., Kirou K. A., MacDermott E. J., Barillas-Arias L., Crow M. K., Niewold T. B., Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN- in lupus patients in vivo Journal of Immunology 2009 182 1 34 38
27. Graham R. R., Kyogoku C., Sigurdsson S., Vlasova I. A., Davies L. R. L., Baechler E. C., Plenge R. M., Koeuth T., Ortmann W. A., Hom G., Bauer J. W., Gillett C., Burtt N., Graham D. S. C., Onofrio R., Petri M., Gunnarsson I., Svenungsson E., Nordmark G., Gregersen P. K., Moser K., Gaffney P. M., Criswell L. A., Vyse T. J., Syvanen A. C., Bohjanen P. R., Daly M. J., Behrens T. W., Altshuler D., Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus Proceedings of the National Academy of Sciences of the United States of America 2007 104 16 6758 6763 (Pubitemid 47175574)
28. Lee-Kirsch M. A., Gong M., Chowdhury D., Senenko L., Engel K., Lee Y. A., De Silva U., Bailey S. L., Witte T., Vyse T. J., Kere J., Pfeiffer C., Harvey S., Wong A., Koskenmies S., Hummel O., Rohde K., Schmidt R. E., Dominiczak A. F., Gahr M., Hollis T., Perrino F. W., Lieberman J., Hubner N., Mutations in the gene encoding the 3'5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus Nature Genetics 2007 39 9 1065 1067 (Pubitemid 47340647)
29. Abelson A. K., Delgado-Vega A. M., Kozyrev S. V., Snchez E., Velzquez-Cruz R., Eriksson N., Wojcik J., Linga Reddy M. V. P., Lima G., D'Alfonso S., Migliaresi S., Baca V., Orozco L., Witte T., Ortego-Centeno N., Abderrahim H., Pons-Estel B. A., Gutiérrez C., Surez A., Gonzlez-Escribano M. F., Martin J., Alarcn-Riquelme M. E., Callejas-Rubio J. L., Jiménez-Alonso J., Sabio M., Snchez-Romn J., Garca-Hernndez F. J., De-Ramon E., Camps M., Garca-Portales R., Lpez-Nevot M. A., STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk Annals of the Rheumatic Diseases 2009 68 11 1746 1753
30. Jacob C. O., Zhu J., Armstrong D. L., Yan M., Han J., Zhou X. J., Thomas J. A., Reiff A., Myones B. L., Ojwang J. O., Kaufman K. M., Klein-Gitelman M., McCurdy D., Wagner-Weiner L., Silverman E., Ziegler J., Kelly J. A., Merrill J. T., Harley J. B., Ramsey-Goldman R., Vila L. M., Bae S. C., Vyse T. J., Gilkeson G. S., Gaffney P. M., Moser K. L., Langefeld C. D., Zidovetzki R., Mohan C., Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus Proceedings of the National Academy of Sciences of the United States of America 2009 106 15 6256 6261
31. Salloum R., Franek B. S., Kariuki S. N., Rhee L., Mikolaitis R. A., Jolly M., Utset T. O., Niewold T. B., Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon- activity in lupus patients Arthritis and Rheumatism 2010 62 2 553 561
32. Li P., Cao C., Luan H., Li C., Hu C., Zhang S., Zeng X., Zhang F., Zeng C., Li Y., Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population Human Immunology 2011 72 3 249 255
33. Ramos P. S., Williams A. H., Ziegler J. T., Genetic analyses of interferon pathway-related genes reveals multiple new loci associated with systemic lupus erythematosus (SLE) Arthritis Rheumatism 2011 63 7 2049 2057
34. Kawasaki A., Furukawa H., Kondo Y., Ito S., Hayashi T., Kusaoi M., Matsumoto I., Tohma S., Takasaki Y., Hashimoto H., Sumida T., Tsuchiya N., TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study Arthritis Research and Therapy 2011 13 2 R41
35. Fu Q., Zhao J., Qian X., Wong J. L.H., Kaufman K. M., Yu C. Y., Howe H. S., Mok M. Y., Harley J. B., Guthridge J. M., Song Y. W., Cho S. -K., Bae S. -C., Grossman J. M., Hahn B. H., Arnett F. C., Shen N., Tsao B. P., Association of a functional IRF7 variant with systemic lupus erythematosus Arthritis Rheumatism 2011 63 3 749 754
36. Namjou B., Kothari P. H., Kelly J. A., Glenn S. B., Ojwang J. O., Adler A., Alarcn-Riquelme M. E., Gallant C. J., Boackle S. A., Criswell L. A., Kimberly R. P., Brown E., Edberg J., Stevens A. M., Jacob C. O., Tsao B. P., Gilkeson G. S., Kamen D. L., Merrill J. T., Petri M., Goldman R. R., Vila L. M., Anaya J. -M., Niewold T. B., Martin J., Pons-Estel B. A., Sabio J. M., Callejas J. L., Vyse T. J., Bae S. -C., Perrino F. W., Freedman B. I., Scofield R. H., Moser K. L., Gaffney P. M., James J. A., Langefeld C. D., Kaufman K. M., Harley J. B., Atkinson J. P., Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort Genes and Immunity 2011 12 4 270 279
37. Sigurdsson S., Nordmark G., Goring H. H., Lindroos K., Wiman A. C., Sturfeit G., Jonsen A., Muller B., Kere J., Koskenmies S., Eloranta M. L., Julkunen H., Kristjansdottir H., Steinsson K., Alm G., Ronnblom L., Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus American Journal of Human Genetics 2005 76 3 528 537 (Pubitemid 40250533)
38. Taylor K. E., Remmers E. F., Lee A. T., Ortmann W. A., Plenge R. M., Tian C., Chung S. A., Nititham J., Hom G., Kao A. H., Demirci F. Y., Kamboh M. I., Petri M., Manzi S., Kastner D. L., Seldin M. F., Gregersen P. K., Behrens T. W., Criswell L. A., Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus PloS Genetics 2008 4 5
39. Kawasaki A., Ito I., Hikami K., Ohashi J., Hayashi T., Goto D., Matsumoto I., Ito S., Tsutsumi A., Koga M., Arinami T., Graham R. R., Hom G., Takasaki Y., Hashimoto H., Behrens T. W., Sumida T., Tsuchiya N., Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region Arthritis Research and Therapy 2008 10 5 R113
40. Qin L., Lv J., Zhou X., Hou P., Yang H., Zhang H., Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population Nephrology 2010 15 7 710 713
41. Vuong M. T., Gunnarsson I., Lundberg S., Svenungsson E., Wramner L., Fernstrom A., Syvanen A. C., Do L. T., Jacobson S. H., Padyukov L., Genetic risk factors in lupus nephritis and IgA nephropathyno support of an overlap Plos one 2010 5 5
42. Luan H., Li P., Cao C., Li C., Hu C., Zhang S., Zeng X., Zhang F., Zeng C., Li Y., A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population. Rheumatology International. In press
43. Braun D., Geraldes P., Demengeot J., Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice Journal of Autoimmunity 2003 20 1 15 25 (Pubitemid 36207624)
44. Jorgensen T. N., Thurman J., Izui S., Falta M. T., Metzger T. E., Flannery S. A., Kappler J., Marrack P., Kotzin B. L., Genetic susceptibility to polyI:C-induced IFN / -dependent accelerated disease in lupus-prone mice Genes and Immunity 2006 7 7 555 567 (Pubitemid 44614870)
45. Triantafyllopoulou A., Franzke C. W., Seshan S. V., Perino G., Kalliolias G. D., Ramanujam M., Van Rooijen N., Davidson A., Ivashkiv L. B., Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages Proceedings of the National Academy of Sciences of the United States of America 2010 107 7 3012 3017
46. Mathian A., Weinberg A., Gallegos M., Banchereau J., Koutouzov S., IFN- induces early lethal lupus in preautoimmune (New Zealand Black New Zealand White)F1 but not in BALB/c mice Journal of Immunology 2005 174 5 2499 2506 (Pubitemid 40279662)
47. Fairhurst A. M., Mathian A., Connolly J. E., Wang A., Gray H. F., George T. A., Boudreaux C. D., Zhou X. J., Li Q. Z., Koutouzov S., Banchereau J., Wakeland E. K., Systemic IFN- drives kidney nephritis in B6.Sle123 mice European Journal of Immunology 2008 38 7 1948 1960
48. Ramanujam M., Kahn P., Huang W., Tao H., Madaio M. P., Factor S. M., Davidson A., Interferon- treatment of female (NZW BXSB)F1 mice mimics some but not all features associated with the Yaa mutation Arthritis and Rheumatism 2009 60 4 1096 1101
49. Liu Z., Bethunaickan R., Huang W., Lodhi U., Solano I., Madaio M. P., Davidson A., Interferon- accelerates murine systemic lupus erythematosus in a T cell-dependent manner Arthritis and Rheumatism 2011 63 1 219 229
50. Reeves W. H., Lee P. Y., Weinstein J. S., Satoh M., Lu L., Induction of autoimmunity by pristane and other naturally occurring hydrocarbons Trends in Immunology 2009 30 9 455 464
51. Santiago-Raber M. L., Baccala R., Haraldsson K. M., Choubey D., Stewart T. A., Kono D. H., Theofilopoulos A. N., Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice Journal of Experimental Medicine 2003 197 6 777 788 (Pubitemid 36350872)
52. Agrawal H., Jacob N., Carreras E., Bajana S., Putterman C., Turner S., Neas B., Mathian A., Koss M. N., Stohl W., Kovats S., Jacob C. O., Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease Journal of Immunology 2009 183 9 6021 6029
53. Nacionales D. C., Kelly-Scumpia K. M., Lee P. Y., Weinstein J. S., Lyons R., Sobel E., Satoh M., Reeves W. H., Deficiency of the type I interferon receptor protects mice from experimental lupus Arthritis and Rheumatism 2007 56 11 3770 3783 (Pubitemid 350100710)
54. Hron J. D., Peng S. L., Type I IFN protects against murine lupus Journal of Immunology 2004 173 3 2134 2142 (Pubitemid 38971652)
55. Lee P. Y., Kumagai Y., Li Y., Takeuchi O., Yoshida H., Weinstein J., Kellner E. S., Nacionales D., Barker T., Kelly-Scumpia K., Van Rooijen N., Kumar H., Kawai T., Satoh M., Akira S., Reeves W. H., TLR7-dependent and Fc R-independent production of type I interferon in experimental mouse lupus Journal of Experimental Medicine 2008 205 13 2995 3006
56. Fairhurst A. M., Hwang S. H., Wang A., Tian X. H., Boudreaux C., Zhou X. J., Casco J., Li Q. Z., Connolly J. E., Wakeland E. K., Yaa autoimmune phenotypes are conferred by overexpression of TLR7 European Journal of Immunology 2008 38 7 1971 1978
57. Savarese E., Steinberg C., Pawar R. D., Reindl W., Akira S., Anders H. J., Krug A., Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis Arthritis and Rheumatism 2008 58 4 1107 1115 (Pubitemid 351564013)
58. Thibault D. L., Chu A. D., Graham K. L., Balboni I., Lee L. Y., Kohlmoos C., Landrigan A., Higgins J. P., Tibshirani R., Utz P. J., IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice Journal of Clinical Investigation 2008 118 4 1417 1426 (Pubitemid 351500435)
59. Pawar R. D., Patole P. S., Ellwart A., Lech M., Segerer S., Schlondorff D., Anders H. J., Ligands to nucleic acid-specific Toll-like receptors and the onset of lupus nephritis Journal of the American Society of Nephrology 2006 17 12 3365 3373 (Pubitemid 44865279)
60. Barrat F. J., Meeker T., Chan J. H., Guiducci C., Coffmann R. L., Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms European Journal of Immunology 2007 37 12 3582 3586
61. Tucci M., Quatraro C., Lombardi L., Pellegrino C., Dammacco F., Silvestris F., Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18 Arthritis and Rheumatism 2008 58 1 251 262
62. Lee P. Y., Weinstein J. S., Nacionales D. C., Scumpia P. O., Li Y., Butfiloski E., Van Rooijen N., Moldawer L., Satoh M., Reeves W. H., A novel type i IFN-producing cell subset in murine lupus Journal of Immunology 2008 180 7 5101 5108
63. Lee P. Y., Li Y., Kumagai Y., Xu Y., Weinstein J. S., Kellner E. S., Nacionales D. C., Butfiloski E. J., Van Rooijen N., Akira S., Sobel E. S., Satoh M., Reeves W. H., Type I interferon modulates monocyte recruitment and maturation in chronic inflammation American Journal of Pathology 2009 175 5 2023 2033
64. Fairhurst A. M., Xie C., Fu Y., Wang A., Boudreaux C., Zhou X. J., Cibotti R., Coyle A., Connolly J. E., Wakeland E. K., Mohan C., Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis Journal of Immunology 2009 183 10 6831 6838
65. Ichii O., Kamikawa A., Otsuka S., Hashimoto Y., Sasaki N., Endoh D., Kon Y., Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1 Lupus 2010 19 8 897 905
66. Bauer J. W., Petri M., Batliwalla F. M., Koeuth T., Wilson J., Slattery C., Panoskaltsis-Mortari A., Gregersen P. K., Behrens T. W., Baechler E. C., Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study Arthritis and Rheumatism 2009 60 10 3098 3107
67. Fu Q., Chen X., Cui H., Guo Y., Chen J., Shen N., Bao C., Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients Arthritis Research and Therapy 2008 10 5
68. Kulkarni O., Pawar R. D., Purschke W., Eulberg D., Selve N., Buchner K., Ninichuk V., Segerer S., Vielhauer V., Klussmann S., Anders H. J., Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice Journal of the American Society of Nephrology 2007 18 8 2350 2358 (Pubitemid 47203851)
69. Zagury D., Buanec H. L., Mathian A., Larcier P., Burnett R., Amoura Z., Emilie D., Peltre G., Bensussan A., Bizzini B., Gallo R. C., Koutouzov S., IFN kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model Proceedings of the National Academy of Sciences of the United States of America 2009 106 13 5294 5299
70. Schwarting A., Paul K., Tschirner S., Menke J., Hansen T., Brenner W., Kelley V. R., Relief M., Galle P. R., Interferon- : a therapeutic for autoimmune lupus in MRL-Fas lpr mice Journal of the American Society of Nephrology 2005 16 11 3264 3272 (Pubitemid 46179332)
71. Yao Y., Richman L., Higgs B. W., Morehouse C. A., De Los Reyes M., Brohawn P., Zhang J., White B., Coyle A. J., Kiener P. A., Jallal B., Neutralization of interferon- / -inducible genes and downstream effect in a phase I trial of an anti-interferon- monoclonal antibody in systemic lupus erythematosus Arthritis and Rheumatism 2009 60 6 1785 1796
72. Yao Y., Higgs B. W., Richman L., White B., Jallal B., Use of type I interferon-inducible mRNAs as pharmacodynamic markers and potential diagnostic markers in trials with sifalimumab, an anti-IFN antibody, in systemic lupus erythematosus Arthritis Research Therapy 2010 12 supplement 1 S6
73. Merrill J. T., Wallace D. J., Petri M., Safety profile and clinical activity of sifalimumab, a fully human anti-interferon { } monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study Annals of the Rheumatic Diseases 2011 70 11 1905 1913
74. Wenzel J., Zahn S., Bieber T., Tuting T., Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus Archives of Dermatological Research 2009 301 1 83 86
75. Klein R. S., Morganroth P. A., Werth V. P., Cutaneous lupus and the cutaneous lupus erythematosus disease area and severity index instrument Rheumatic Disease Clinics of North America 2010 36 1 33 51
76. Arrue I., Saiz A., Ortiz-Romero P. L., Rodriguez-Peralto J. L., Lupus-like reaction to interferon at the injection site: report of five cases Journal of Cutaneous Pathology 2007 34 supplement 1 18 21 (Pubitemid 350098887)
77. Wenzel J., Bieber T., Uerlich M., Tuting T., Systemic treatment of cutaneous lupus erythematosus Journal of the German Society of Dermatology 2003 1 9 694 704 (Pubitemid 37205280)
78. Fah J., Pavlovic J., Burg G., Expression of MxA protein in inflammatory dermatoses Journal of Histochemistry and Cytochemistry 1995 43 1 47 52
79. Farkas L., Beiske K., Lund-Johansen F., Brandtzaeg P., Jahnsen F. L., Plasmacytoid dendritic cells (natural interferon- / -producing cells) accumulate in cutaneous lupus erythematosus lesions American Journal of Pathology 2001 159 1 237 243 (Pubitemid 33704208)
80. Wenzel J., Uerlich M., Worrenkamper E., Freutel S., Bieber T., Tuting T., Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA British Journal of Dermatology 2005 153 5 1011 1015 (Pubitemid 41540770)
81. Blomberg S., Eloranta M. L., Cederblad B., Nordlind K., Alm G. V., Ronnblom L., Presence of cutaneous interferon- producing cells in patients with systemic lupus erythematosus Lupus 2001 10 7 484 490 (Pubitemid 32675048)
82. Meller S., Winterberg F., Gilliet M., Muller A., Lauceviciute I., Rieker J., Neumann N. J., Kubitza R., Gombert M., Bunemann E., Wiesner U., Franken-Kunkel P., Kanzler H., Dieu-Nosjean M. C., Amara A., Ruzicka T., Lehmann P., Zlotnik A., Homey B., Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: an amplification cycle triggering cutaneous lupus erythematosus Arthritis and Rheumatism 2005 52 5 1504 1516 (Pubitemid 40663942)
83. Cederblad B., Blomberg S., Vallin H., Perers A., Alm G. V., Ronnblom L., Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon- -producing cells Journal of Autoimmunity 1998 11 5 465 470 (Pubitemid 28520202)
84. Vermi W., Lonardi S., Morassi M., Rossini C., Tardanico R., Venturini M., Sala R., Tincani A., Poliani P. L., Calzavara-Pinton P. G., Cerroni L., Santoro A., Facchetti F., Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage Immunobiology 2009 214 9-10 877 886
85. Obermoser G., Schwingshackl P., Weber F., Stanarevic G., Zelger B., Romani N., Sepp N., Recruitment of plasmacytoid dendritic cells in ultraviolet irradiation-induced lupus erythematosus tumidus British Journal of Dermatology 2009 160 1 197 200
86. Wenzel J., Worenkamper E., Freutel S., Henze S., Haller O., Bieber T., Tuting T., Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus Journal of Pathology 2005 205 4 435 442 (Pubitemid 40361331)
87. Kuhn A., Herrmann M., Kleber S., Beckmann-Welle M., Fehsel K., Martin-Villalba A., Lehmann P., Ruzicka T., Krammer P. H., Kolb-Bachofen V., Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation Arthritis and Rheumatism 2006 54 3 939 950
88. Guiducci C., Tripodo C., Gong M., Sangaletti S., Colombo M. P., Coffman R. L., Barrat F. J., Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9 Journal of Experimental Medicine 2010 207 13 2931 2942
89. Naschberger E., Wenzel J., Kretz C. C., Herrmann M., Sturzl M., Kuhn A., Increased expression of guanylate binding protein-1 in lesional skin of patients with cutaneous lupus erythematosus Experimental Dermatology 2011 20 2 102 106
90. Costa S., Borgogna C., Mondini M., De Andrea M., Meroni P. L., Berti E., Gariglio M., Landolfo S., Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing British Journal of Dermatology 2011 164 2 282 290
91. Brey R. L., Holliday S. L., Saklad A. R., Navarrete M. G., Hermosillo-Romo D., Stallworth C. L., Valdez C. R., Escalante A., Gronseth G., Rhine C. B., Padilla P., McGlasson D., Neuropsychiatric syndromes in lupus: prevalence using standardized definitions Neurology 2002 58 8 1214 1220 (Pubitemid 34411865)
92. Wichers M., Maes M., The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans International Journal of Neuropsychopharmacology 2002 5 4 375 388 (Pubitemid 35470357)
93. Santer D. M., Yoshio T., Minota S., Moller T., Elkon K. B., Potent induction of IFN- and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus Journal of Immunology 2009 182 2 1192 1201
94. Dieperink E., Willenbring M., Ho S. B., Neuropsychiatric symptoms associated with hepatitis C and interferon : a review American Journal of Psychiatry 2000 157 6 867 876 (Pubitemid 30412335)
95. Ronnblom L. E., Alm G. V., Oberg K. E., Autoimmunity after -interferon therapy for malignant carcinoid tumors Annals of Internal Medicine 1991 115 3 178 183
96. Ehrenstein M. R., McSweeney E., Swana M., Worman C. P., Goldstone A. H., Isenberg D. A., Appearance of anti-DNA antibodies in patients treated with interferon- Arthritis and Rheumatism 1993 36 2 279 280 (Pubitemid 23059344)
97. Campbell I. L., Krucker T., Steffensen S., Akwa Y., Powell H. C., Lane T., Carr D. J., Gold L. H., Henriksen S. J., Siggins G. R., Structural and functional neuropathology in transgenic mice with CNS expression of IFN- Brain Research 1999 835 1 46 61 (Pubitemid 29336549)
98. Ramantani G., Niggemann P., Bast T., Lee-Kirsch M. A., Reconciling neuroimaging and clinical findings in Aicardi-Goutieres syndrome: an autoimmune-mediated encephalopathy American Journal of Neuroradiology 2010 31 7 E62 E63
99. Winfield J. B., Shaw M., Silverman L. M., Intrathecal IgG synthesis and blood-brain barrier impairment in patients with systemic lupus erythematosus and central nervous system dysfunction American Journal of Medicine 1983 74 5 837 844 (Pubitemid 13080128)
100. Shiozawa S., Kuroki Y., Kim M., Hirohata S., Ogino T., Interferon- in lupus psychosis Arthritis and Rheumatism 1992 35 4 417 422
101. Jonsen A., Bengtsson A. A., Nived O., Ryberg B., Truedsson L., Alms G. V., Sturfelt G., The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles Lupus 2003 12 11 846 850 (Pubitemid 37463102)
102. Levy Y., Sherer Y., Ahmed A., Langevitz P., George J., Fabbrizzi F., Terryberry J., Meissner M., Lorber M., Peter J. B., Shoenfeld Y., A study of 20 SLE patients with intravenous immunoglobulinclinical and serologic response Lupus 1999 8 9 705 712
103. Dalakas M. C., Role of IVIg in autoimmune, neuroinflammatory and neurodegenerative disorders of the central nervous system: present and future prospects Journal of Neurology 2006 253 5 V25 V32
104. Linker R. A., Gold R., Use of intravenous immunoglobulin and plasma exchange in neurological disease Current Opinion in Neurology 2008 21 3 358 365 (Pubitemid 351653989)
105. Svenungusson E., Mavragani C. P., Hopia L., Acute flares of neuropsychiatric systemic lupus erythematosus (NPSLE) are sometimes associated with spikes of interferon-alpha activity in the CSF Arthritis Rheumatism 2010 62 1181
106. Pashenkov M., Huang Y. M., Kostulas V., Haglund M., Soderstrom M., Link H., Two subsets of dendritic cells are present in human cerebrospinal fluid Brain 2001 124, part 3 480 492 (Pubitemid 32221315)
107. Kellner E. S., Lee P. Y., Li Y., Switanek J., Zhuang H., Segal M. S., Sobel E. S., Satoh M., Reeves W. H., Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus Journal of Neuroimmunology 2010 223 1-2 13 19
108. Fischer L. M., Schlienger R. G., Matter C., Jick H., Meier C. R., Effect of rheumatoid arthritis or systemic lupus erythematosus on the risk of first-Time acute myocardial infarction American Journal of Cardiology 2004 93 2 198 200 (Pubitemid 38058729)
109. Hak A. E., Karlson E. W., Feskanich D., Stampfer M. J., Costenbader K. H., Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study Arthritis Rheumatism 2009 61 10 1396 1402
110. Manzi S., Meilahn E. N., Rairie J. E., Conte C. G., Medsger T. A., Jansen-McWilliams L., D'Agostino R. B., Kuller L. H., Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham study American Journal of Epidemiology 1997 145 5 408 415 (Pubitemid 27084212)
111. Esdaile J. M., Abrahamowicz M., Grodzicky T., Li Y., Panaritis C., Berger R. D., Cé R., Grover S. A., Fortin P. R., Clarke A. E., Senécal J. L., Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus Arthritis and Rheumatism 2001 44 10 2331 2337 (Pubitemid 32977500)
112. Zampetaki A., Kirton J. P., Xu Q., Vascular repair by endothelial progenitor cells Cardiovascular Research 2008 78 3 413 421 (Pubitemid 351769775)
113. Briasoulis A., Tousoulis D., Antoniades C., Papageorgiou N., Stefanadis C., The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development Cardiovascular Therapeutics 2011 29 2 125 139
114. Baker J. F., Zhang L., Imadojemu S., Sharpe A., Patil S., Moore J. S., Mohler III E. R., Von Feldt J., Circulating endothelial progenitor cells are reduced in SLE in the absence of coronary artery calcification. Rheumatology International. In press
115. Deng X. L., Li X. X., Liu X. Y., Sun L., Liu R., Comparative study on
116. Grisar J., Steiner C. W., Bonelli M., Karonitsch T., Schwarzinger I., Weigel G., Steiner G., Smolen J. S., Systemic lupus erythematosus patients exhibit functional deficiencies of endothelial progenitor cells Rheumatology 2008 47 10 1476 1483
117. Westerweel P. E., Luijten R. K., Hoefer I. E., Koomans H. A., Derksen R. H., Verhaar M. C., Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus Annals of the Rheumatic Diseases 2007 66 7 865 870 (Pubitemid 46999785)
118. Moonen J. R., de Leeuw K., van Seijen X. J., Kallenberg C. G., van Luyn M. J., Bijl M., Harmsen M. C., Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus Arthritis Research and Therapy 2007 9 4 R84
119. Lee P. Y., Li Y., Richards H. B., Chan F. S., Zhuang H., Narain S., Butfiloski E. J., Sobel E. S., Reeves W. H., Segal M. S., Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus Arthritis and Rheumatism 2007 56 11 3759 3769 (Pubitemid 350100709)
120. Denny M. F., Thacker S., Mehta H., Somers E. C., Dodick T., Barrat F. J., McCune W. J., Kaplan M. J., Interferon- promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis Blood 2007 110 8 2907 2915 (Pubitemid 350006944)
121. Thacker S. G., Duquaine D., Park J., Kaplan M. J., Lupus-prone New Zealand Black/New Zealand white F1 mice display endothelial dysfunction and abnormal phenotype and function of endothelial progenitor cells Lupus 2010 19 3 288 299
122. Thacker S. G., Berthier C. C., Mattinzoli D., Rastaldi M. P., Kretzler M., Kaplan M. J., The detrimental effects of IFN- on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction Journal of Immunology 2010 185 7 4457 4469
123. Niessner A., Weyand C. M., Dendritic cells in atherosclerotic disease Clinical Immunology 2010 134 1 25 32
124. Denny M. F., Yalavarthi S., Zhao W., Thacker S. G., Anderson M., Sandy A. R., McCune W. J., Kaplan M. J., A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs Journal of Immunology 2010 184 6 3284 3297
125. Amuro H., Ito T., Miyamoto R., Sugimoto H., Torii Y., Son Y., Nakamichi N., Yamazaki C., Hoshino K., Kaisho T., Ozaki Y., Inaba M., Amakawa R., Fukuhara S., Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production Arthritis and Rheumatism 2010 62 7 2073 2085
126. Lood C., Amisten S., Gullstrand B., Jonsen A., Allhorn M., Truedsson L., Sturfelt G., Erlinge D., Bengtsson A. A., Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease Blood 2010 116 11 1951 1957
127. Li J., Fu Q., Cui H., Qu B., Pan W., Shen N., Bao C., Interferon- priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon- and atherosclerosis in lupus Arthritis and Rheumatism 2011 63 2 492 502
128. Svenungsson E., Gustafsson J., Leonard D., Sandling J., Gunnarsson I., Nordmark G., Jonsen A., Bengtsson A. A., Sturfelt G., Rantapaa-Dahlqvist S., Elvin K., Sundin U., Garnier S., Simard J. F., Sigurdsson S., Padyukov L., Syvanen A. C., Ronnblom L., A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus Annals of the Rheumatic Diseases 2010 69 5 834 840