Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1

Lupus

Volumn 19, Issue 8, 2010, Pages 897-905

  Ichii, O ^a   Kamikawa, A ^a   Otsuka, S ^a   Hashimoto, Y ^a   Sasaki, N ^a   Endoh, D ^b   Kon, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

autoimmune glomerulonephritis; interferon activated gene 202; kidney; lupus nephritis; MRL congenic mouse

Indexed keywords

INTERFERON ACTIVATED GENE 202; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; IFI202B PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 1; CONGENIC STRAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HISTOPATHOLOGY; IMMUNE COMPLEX NEPHRITIS; LASER MICRODISSECTION; LUPUS ERYTHEMATOSUS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; ANIMAL; AUTOIMMUNE DISEASE; C57BL MOUSE; CHROMOSOME; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GLOMERULONEPHRITIS; HUMAN; IMMUNOLOGY; KIDNEY; METABOLISM; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NEW ZEALAND BLACK MOUSE; PATHOLOGY; SPLEEN; THYMUS; TISSUE DISTRIBUTION;

ANIMALS; AUTOIMMUNE DISEASES; CHROMOSOMES, MAMMALIAN; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GLOMERULONEPHRITIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, INBRED NZB; SPLEEN; THYMUS GLAND; TISSUE DISTRIBUTION;

EID: 77954070579     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310362534     Document Type: Article

References (21)

1. Takaoka A., Yanai H. Interferon signalling network in innate defence. Cell Microbiol 2006 ; 8: 907-922.
2. Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD How cells respond to interferons. Annu Rev Biochem 1998 ; 67: 227-264.
3. Asefa B., Klarmann KD, Copeland NG, Gilbert DJ, Jenkins NA, Keller JR The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation. Blood Cells Mol Dis 2004 ; 32: 155-167.
4. Choubey D., Panchanathan R. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett 2008 ; 119: 32-41.
5. Klinman DM, Steinberg AD Inquiry into murine and human lupus. Immunol Rev 1995 ; 144: 157-193.
6. Niewold TB, Hua J., Lehman TJ, Harley JB, Crow MK High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007 ; 8: 492-502.
7. Banchereau J., Pascual V. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006 ; 25: 383-392.
8. Feng X., Wu H., Grossman JM, Hanvivadhanakul P., Fitzgerald JD, Park GS Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006 ; 54: 2951-2962.
9. Santiago-Raber ML, Laporte C., Reininger L., Izui S. Genetic basis of murine lupus. Autoimmun Rev 2004 ; 3: 33-39.
10. Haywood ME, Rose SJ, Horswell S., et al. Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes Immun 2006 ; 7: 250-263.
11. Rozzo SJ, Allard JD, Choubey D., et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001 ; 15: 435-443.
12. Ichii O., Konno A., Sasaki N., Endoh D., Hashimoto Y., Kon Y. Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ. Histol Histopathol 2008 ; 23: 411-422.
13. Ichii O., Konno A., Sasaki N., Endoh D., Hashimoto Y., Kon Y. Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis. Kidney Int 2008 ; 74: 339-347.
14. Ichii O., Konno A., Sasaki N., Endoh D., Hashimoto Y., Kon Y. Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice. Lupus 2009 ; 18: 491-500.
15. Ikeda T., Kanazawa T., Otsuka S., Ichii O., Hashimoto Y., Kon Y. Analysis of caspases associated with skeletal myogenesis in mouse embryo. J Vet Med Sci 2009 ; 71: 1161-1168.
16. Fernando MM, Rigby RJ, Roberton CA, Rioux JD, Vyse TJ Interferon-inducible genes on chromosome 1 contribute to lupus susceptibility. Rheumatology 2006 ; 45: 15-17.
17. Chen J., Panchanathan R., Choubey D. Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway. Immunol Lett 2008 ; 118: 13-20.
18. Ludlow LE, Purton LE, Klarmann K., et al. The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res 2008 ; 28: 5-11.
19. Xin H., Pramanik R., Choubey D. Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth. Oncogene 2003 ; 22: 4775-4785.
20. Xin H., D'Souza S., Jørgensen TN, et al. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol 2006 ; 176: 5863-5870.
21. Tamaoki T., Tezuka H., Okada Y., et al. Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity. Nat Med 2005 ; 11: 11-12.