Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

British Journal of Dermatology

Volumn 164, Issue 2, 2011, Pages 282-290

  Costa, S ^a,b   Borgogna, C ^a   Mondini, M ^a,b   De Andrea, M ^a,c   Meroni, P L ^d   Berti, E ^d   Gariglio, M ^a   Landolfo, Santo ^c  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b NoToPharm Srl   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; INTERFERON INDUCIBLE PROTEIN 16; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNITY; CELL DEATH; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIATION EXPOSURE; SKIN BIOPSY; SYSTEMIC LUPUS ERYTHEMATOSUS; ULTRAVIOLET B RADIATION;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; AUTOANTIGENS; BLOTTING, WESTERN; CYTOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; NUCLEAR PROTEINS; PHOSPHOPROTEINS; SKIN; ULTRAVIOLET RAYS; YOUNG ADULT;

EID: 79551502554     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.10097.x     Document Type: Article

References (25)

1. Shoenfeld Y, Szyper-Kravitz M, Witte T, et al. Autoantibodies against protective molecules-C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus. Ann N Y Acad Sci 2007; 1108: 227-39.
2. Rothfield N, Sontheimer RD, Bernstein M,. Lupus erythematosus: systemic and cutaneous manifestations. Clin Dermatol 2006; 24: 348-62. (Pubitemid 44332871)
3. Crowson AN, Magro C,. The cutaneous pathology of lupus erythematosus: a review. J Cutan Pathol 2001; 28: 1-23.
4. Casciola-Rosen LA, Anhalt G, Rosen A,. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317-30.
5. Caricchio R, McPhie L, Cohen PL,. Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution. J Immunol 2003; 171: 5778-86.
6. Ludlow LE, Johnstone RW, Clarke CJ,. The HIN-200 family: more than interferon-inducible genes? Exp Cell Res 2005; 308: 1-17.
7. Mondini M, Costa S, Sponza S, et al. The interferon-inducible HIN-200 gene family in apoptosis and inflammation: implication for autoimmunity. Autoimmunity 2010; 43: 226-31.
8. Gariglio M, Azzimonti B, Pagano M, et al. Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. J Interferon Cytokine Res 2002; 22: 815-21.
9. Gugliesi F, Mondini M, Ravera R, et al. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol 2005; 77: 820-9.
10. Mondini M, Vidali M, Airo P, et al. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann N Y Acad Sci 2007; 1110: 47-56.
11. Caposio P, Gugliesi F, Zannetti C, et al. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem 2007; 282: 33515-29.
12. Baggetta R, De Andrea M, Gariano GR, et al. The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response. Eur J Immunol 2010; 40: 2182-9.
13. Mondini M, Vidali M, De Andrea M, et al. A novel autoantigen to differentiate limited cutaneous systemic sclerosis from diffuse cutaneous systemic sclerosis: the interferon-inducible gene IFI16. Arthritis Rheum 2006; 54: 3939-44.
14. Hochberg MC,. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725.
15. WHO. Global Solar UV Index: A Practical Guide. Geneva: World Health Organization, 2002.
16. De Andrea M, Gioia D, Mondini M, et al. Effects of IFI16 overexpression on the growth and doxorubicin sensitivity of head and neck squamous cell carcinoma-derived cell lines. Head Neck 2007; 29: 835-44.
17. Cepeda V, Fuertes MA, Castilla J, et al. Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy. Recent Pat Anticancer Drug Discov 2006; 1: 39-53.
18. Lehmann B, Genehr T, Knuschke P, et al. UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in an in vitro human skin equivalent model. J Invest Dermatol 2001; 117: 1179-85.
19. Levy DE, Darnell JE Jr,. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3: 651-62.
20. Seelig HP, Ehrfeld H, Renz M,. Interferon-gamma-inducible protein p16. A new target of antinuclear antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1994; 37: 1672-83.
21. Bijl M, Reefman E, Limburg PC, Kallenberg CG,. Inflammatory clearance of apoptotic cells after UVB challenge. Autoimmunity 2007; 40: 244-8.
22. Janko C, Schorn C, Grossmayer GE, et al. Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmun Rev 2008; 8: 9-12.
23. Golan TD, Elkon KB, Gharavi AE, Krueger JG,. Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation. J Clin Invest 1992; 90: 1067-76.
24. Bave U, Magnusson M, Eloranta ML, et al. Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J Immunol 2003; 171: 3296-302.
25. Lovgren T, Eloranta ML, Bave U, et al. Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum 2004; 50: 1861-72.