A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population

Rheumatology International

Volumn 32, Issue 5, 2012, Pages 1251-1255

  Luan, Haixia ^a   Li, Ping ^a   Cao, Chunwei ^b   Li, Chaohua ^b   Hu, Chaojun ^a   Zhang, Shulan ^a   Zeng, Xiaofeng ^a   Zhang, Fengchun ^a   Zeng, Changqing ^b   Li, Yongzhe ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b China National Center for Bioinformation   (China)

Author keywords

Female patients; Genetic susceptibility; Polymorphism; SLE; STAT4

Indexed keywords

STAT4 PROTEIN;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STAT4 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 84863607441     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1767-9     Document Type: Article

References (25)

1. Jonsen A, Bengtsson AA, Nived O, Truedsson L, Sturfelt G (2007) Gene-environment interactions in the aetiology of systemic lupus erythematosus. Autoimmunity 40:613-617
2. Rahman A, Isenberg DA (2008) Systemic lupus erythematosus. N Engl J Med 358:929-939
3. Xiang YJ, Dai SM (2009) Prevalence of rheumatic diseases and disability in china. Rheumatol Int 29:481-490
4. Kim I, Kim YJ, Kim K et al (2009) Genetic studies of systemic lupus erythematosus in asia: where are we now? Genes Immun 10:421-432
5. Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA (2009) Genetic susceptibility to SLE: New insights from fine mapping and genome-wide association studies. Nat Rev Genet 10:285-290
6. Namjou B, Sestak AL, Armstrong DL et al (2009) High-density genotyping of stat4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum 60:1085-1095
7. Korman BD, Kastner DL, Gregersen PK, Remmers EF (2008) STAT4: Genetics, mechanisms, and implications for autoimmu-nity. Curr Allergy Asthma Rep 8:398-403
8. Bengtsson AA, Sturfelt G, Truedsson L et al (2000) Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 9:664-671
9. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG (2009) Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis. Rheumatol Int 30:661-666
10. Glas J, Seiderer J, Nagy M et al (2010) Evidence for STAT4 as a common autoimmune gene: Rs7574865 is associated with colo-nic crohn's disease and early disease onset. PLoS One 5:e10373
11. Pykalainen M, Kinos R, Valkonen S et al (2005) Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol 115:80-87
12. Rueda B, Broen J, Simeon C et al (2009) The STAT4 gene influences the genetic predisposition to systemic sclerosis phe-notype. Hum Mol Genet 18:2071-2077
13. Korman BD, Alba MI, Le JM et al (2008) Variant form of STAT4 is associated with primary sjogren's syndrome. Genes Immun 9:267-270
14. Hom G, Graham RR, Modrek B et al (2008) Association of systemic lupus erythematosus with c8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358:900-909
15. Harley JB, Alarcon-Riquelme ME, Criswell LA et al (2008) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40:204-210
16. Han JW, Zheng HF, Cui Y et al (2009) Genome-wide association study in a chinese han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 41:1234-1237
17. Yang W, Shen N, Ye DQ et al (2010) Genome-wide association study in asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 6:e1000841
18. Taylor KE, Remmers EF, Lee AT et al (2008) Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet 4:e1000084
19. Sigurdsson S, Nordmark G, Garnier S et al (2008) A risk hap-lotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet 17:2868-2876
20. Hellquist A, Sandling JK, Zucchelli M et al (2009) Variation in STAT4 is associated with systemic lupus erythematosus in a finnish family cohort. Ann Rheum Dis 69:883-886
21. Purcell S, Neale B, Todd-Brown K et al (2007) Plink: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575
22. Jacob CO, Zang S, Li L et al (2003) Pivotal role of STAT4 and STAT6 in the pathogenesis of the lupus-like disease in the new zealand mixed 2328 mice. J Immunol 171:1564-1571
23. Vieira AR, Avila JR, Daack-Hirsch S et al (2005) Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet 1:e64
24. Burfoot RK, Jensen CJ, Field J et al (2008) Snp mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in tasmanians. Tissue Antigens 71:42-50
25. Edghill EL, Minton JA, Groves CJ et al (2010) Sequencing of candidate genes selected by beta cell experts in monogenic diabetes of unknown aetiology. JOP 11:14-17