Transgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats

Gene Therapy

Volumn 19, Issue 1, 2012, Pages 101-108

  Sun, J ^a   Liu, S ^a,b   Mata, M ^a   Fink, D J ^a   Hao, S ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

cytokines; morphine tolerance; TNF soluble receptor

Indexed keywords

HERPESVIRUS VECTOR; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHINE; P55 TUMOR NECROSIS FACTOR SOLUBLE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HERPES SIMPLEX VIRUS; HINDLIMB; HOT PLATE TEST; IN VIVO STUDY; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; REPEATED DRUG DOSE; SPINAL GANGLION; TAIL FLICK TEST; TRANSCRIPTION REGULATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; DRUG TOLERANCE; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1BETA; MALE; MORPHINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR; SIMPLEXVIRUS; SPINAL CORD; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSGENES;

RATTUS; SIMPLEXVIRUS;

EID: 84855450568     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.76     Document Type: Article

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