The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-jun N-terminal kinase

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 1, 2012, Pages 23-33

  Hristova, Milena ^a   Spiess, Page C ^a   Kasahara, David I ^a   Randall, Matthew J ^a   Deng, Bin ^b   Van Der Vliet, Albert ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Cigarette smoking; Electrophile; Glutathione; Inflammation; NF E2 related factor 2

Indexed keywords

ACROLEIN; BACTERIUM LIPOPOLYSACCHARIDE; BIOTIN; CIGARETTE SMOKE; GLUTATHIONE; HYDRAZIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CONTROLLED STUDY; DEPLETION; IMMUNE SYSTEM; MACROPHAGE; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHOSPHORYLATION;

ACROLEIN; ALKYLATION; ANIMALS; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-12 SUBUNIT P40; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; SMOKE; TOBACCO; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); MUS; NICOTIANA TABACUM;

EID: 84855388872     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0134OC     Document Type: Article

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