The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity

Journal of Molecular Biology

Volumn 383, Issue 4, 2008, Pages 885-893

  Shaw, David ^a   Wang, Sandra M ^a   Villaseñor, Armando G ^a   Tsing, Stan ^a   Walter, David ^a   Browner, Michelle F ^a   Barnett, Jim ^a   Kuglstatter, Andreas ^a  

^a Discovery Technologies   (United States)

Author keywords

high throughput protein engineering; JNK2; MAP kinase insert; protein crystallography; site directed surface mutagenesis

Indexed keywords

INDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME STABILITY; GENE INSERTION; HUMAN; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 53149130515     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.08.086     Document Type: Article

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