메뉴 건너뛰기




Volumn 302, Issue 2, 2012, Pages

Differential activations of PKC/PKA related to microvasculopathy in diabetic GK rats

Author keywords

Advanced glycation end products; Diabetic microvasculopathy; Diabetic nephropathy; Goto Kakizaki rat; Protein kinase A; Protein kinase C

Indexed keywords

ADVANCED GLYCATION END PRODUCT; BETA ACTIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN KINASE C; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; RUBOXISTAURIN;

EID: 84855307239     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00184.2011     Document Type: Article
Times cited : (9)

References (62)
  • 1
    • 0035087199 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes mellitus is associated with increased pancreatic tissue levels of noradrenaline and adrenaline in the rat
    • Adeghate E, Ponery AS, Sheen R. Streptozotocin-induced diabetes mellitus is associated with increased pancreatic tissue levels of noradrenaline and adrenaline in the rat. Pancreas 22: 311-316, 2001.
    • (2001) Pancreas , vol.22 , pp. 311-316
    • Adeghate, E.1    Ponery, A.S.2    Sheen, R.3
  • 2
    • 33745650900 scopus 로고    scopus 로고
    • PKC-B inhibition: A new therapeutic approach for diabetic complications?
    • Avignon A, Sultan A. PKC-B inhibition: a new therapeutic approach for diabetic complications? Diabetes Metab 32: 205-13, 2006.
    • (2006) Diabetes Metab , vol.32 , pp. 205-213
    • Avignon, A.1    Sultan, A.2
  • 4
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 5
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 7
    • 0036259920 scopus 로고    scopus 로고
    • Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses
    • Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M. Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes 51: 1681-1689, 2002.
    • (2002) Diabetes , vol.51 , pp. 1681-1689
    • Chan, O.1    Chan, S.2    Inouye, K.3    Shum, K.4    Matthews, S.G.5    Vranic, M.6
  • 8
    • 49649113482 scopus 로고    scopus 로고
    • Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy
    • Chance WW, Rhee C, Yilmaz C, Dane DM, Pruneda ML, Raskin P, Hsia CC. Diminished alveolar microvascular reserves in type 2 diabetes reflect systemic microangiopathy. Diabetes Care 31: 1596-1601, 2008.
    • (2008) Diabetes Care , vol.31 , pp. 1596-1601
    • Chance, W.W.1    Rhee, C.2    Yilmaz, C.3    Dane, D.M.4    Pruneda, M.L.5    Raskin, P.6    Hsia, C.C.7
  • 9
    • 67650503808 scopus 로고    scopus 로고
    • Diabetic hepatosclerosis: A 10-year autopsy series
    • Chen G, Brunt EM. Diabetic hepatosclerosis: a 10-year autopsy series. Liver Int 29: 1044-1050, 2009.
    • (2009) Liver Int , vol.29 , pp. 1044-1050
    • Chen, G.1    Brunt, E.M.2
  • 10
    • 0038297002 scopus 로고    scopus 로고
    • The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction
    • Chen Q, Chai YC, Mazumder S, Jiang C, Macklis RM, Chisolm GM, Almasan A. The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction. Cell Death Differ 10: 323-334, 2003.
    • (2003) Cell Death Differ , vol.10 , pp. 323-334
    • Chen, Q.1    Chai, Y.C.2    Mazumder, S.3    Jiang, C.4    Macklis, R.M.5    Chisolm, G.M.6    Almasan, A.7
  • 11
    • 34250702110 scopus 로고    scopus 로고
    • The role of protein kinase C activation and the vascular complications of diabetes
    • Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res 55: 498-510, 2007.
    • (2007) Pharmacol Res , vol.55 , pp. 498-510
    • Das Evcimen, N.1    King, G.L.2
  • 12
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 113: 546-593, 2007.
    • (2007) Pharmacol Ther , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 13
    • 0033857113 scopus 로고    scopus 로고
    • Aldose reductase and the role of the polyol pathway in diabetic nephropathy
    • Dunlop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl 77: S3-S12, 2000.
    • (2000) Kidney Int Suppl , vol.77
    • Dunlop, M.1
  • 14
    • 37349105431 scopus 로고    scopus 로고
    • Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy
    • Ejaz S, Chekarova I, Ejaz A, Sohail A, Lim CW. Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy. Diabetes Obes Metab 10: 53-63, 2008.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 53-63
    • Ejaz, S.1    Chekarova, I.2    Ejaz, A.3    Sohail, A.4    Lim, C.W.5
  • 16
    • 77954580620 scopus 로고    scopus 로고
    • Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice
    • Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology 151: 3026-3037, 2010.
    • (2010) Endocrinology , vol.151 , pp. 3026-3037
    • Fu, Z.1    Zhang, W.2    Zhen, W.3    Lum, H.4    Nadler, J.5    Bassaganya-Riera, J.6    Jia, Z.7    Wang, Y.8    Misra, H.9    Liu, D.10
  • 17
    • 0031922992 scopus 로고    scopus 로고
    • Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways
    • Grammas P, Moore P, Cashman RE, Floyd RA. Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways. Mol Chem Neuropathol 33: 113-124, 1998.
    • (1998) Mol Chem Neuropathol , vol.33 , pp. 113-124
    • Grammas, P.1    Moore, P.2    Cashman, R.E.3    Floyd, R.A.4
  • 19
    • 70349572489 scopus 로고    scopus 로고
    • Diabetic microangiopathy in the liver: An autopsy study of incidence and association with other diabetic complications
    • Hudacko RM, Sciancalepore JP, Fyfe BS. Diabetic microangiopathy in the liver: an autopsy study of incidence and association with other diabetic complications. Am J Clin Pathol 132: 494-499, 2009.
    • (2009) Am J Clin Pathol , vol.132 , pp. 494-499
    • Hudacko, R.M.1    Sciancalepore, J.P.2    Fyfe, B.S.3
  • 20
    • 0034852862 scopus 로고    scopus 로고
    • Protein kinase C activation: Isozymespecific effects on metabolism and cardiovascular complications in diabetes
    • Idris I, Gray S, Donnelly R. Protein kinase C activation: isozymespecific effects on metabolism and cardiovascular complications in diabetes. Diabetologia 44: 659-673, 2001.
    • (2001) Diabetologia , vol.44 , pp. 659-673
    • Idris, I.1    Gray, S.2    Donnelly, R.3
  • 21
    • 0034980688 scopus 로고    scopus 로고
    • Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide induced microvascular permeability change in mouse skin
    • Irie K, Fujii E, Ishida H, Wada K, Suganuma T, Nishikori T, Yoshioka T, Muraki T. Inhibitory effects of cyclic AMP elevating agents on lipopolysaccharide induced microvascular permeability change in mouse skin. Brit J Pharmacol 133: 237-242, 2001.
    • (2001) Brit J Pharmacol , vol.133 , pp. 237-242
    • Irie, K.1    Fujii, E.2    Ishida, H.3    Wada, K.4    Suganuma, T.5    Nishikori, T.6    Yoshioka, T.7    Muraki, T.8
  • 23
    • 0027381140 scopus 로고
    • GM3 regulates protein kinase systems in cultured brain microvascular endothelial cells
    • Kanda T, Ariga T, Yamawaki M, Yu RK. GM3 regulates protein kinase systems in cultured brain microvascular endothelial cells. J Neurochem 61: 1969-1972, 1993.
    • (1993) J Neurochem , vol.61 , pp. 1969-1972
    • Kanda, T.1    Ariga, T.2    Yamawaki, M.3    Yu, R.K.4
  • 24
    • 0029915447 scopus 로고    scopus 로고
    • Capillary lesion develop in retina rather than in cerebral cortex in diabetes and experimental galactosemia
    • Kern TS, Engerman RL. Capillary lesion develop in retina rather than in cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 114: 306-310, 1996.
    • (1996) Arch Ophthalmol , vol.114 , pp. 306-310
    • Kern, T.S.1    Engerman, R.L.2
  • 25
    • 0141755311 scopus 로고    scopus 로고
    • Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy
    • Kitada M, Koya D, Sugimoto T, Isono M, Araki S, Kashiwagi A, Haneda M. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 52: 2603-2614, 2003.
    • (2003) Diabetes , vol.52 , pp. 2603-2614
    • Kitada, M.1    Koya, D.2    Sugimoto, T.3    Isono, M.4    Araki, S.5    Kashiwagi, A.6    Haneda, M.7
  • 26
    • 33947301969 scopus 로고    scopus 로고
    • Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor
    • Koike N, Takamura T, Kaneko S. Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor. Life Sci 80: 1721-1728, 2007.
    • (2007) Life Sci , vol.80 , pp. 1721-1728
    • Koike, N.1    Takamura, T.2    Kaneko, S.3
  • 27
    • 0037609623 scopus 로고    scopus 로고
    • Paradoxes of nitric oxide in the diabetic kidney
    • Komers R, Anderson S. Paradoxes of nitric oxide in the diabetic kidney. Am J Physiol Renal Physiol 284: F1121-F1137, 2003.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Komers, R.1    Anderson, S.2
  • 28
    • 3042736838 scopus 로고    scopus 로고
    • Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells
    • Kouroedov A, Eto M, Joch H, Volpe M, Lüscher TF, Cosentino F. Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110: 91-96, 2004.
    • (2004) Circulation , vol.110 , pp. 91-96
    • Kouroedov, A.1    Eto, M.2    Joch, H.3    Volpe, M.4    Lüscher, T.F.5    Cosentino, F.6
  • 30
    • 0000358508 scopus 로고
    • Activation of protein kinase C by elevation of glucose concentration: Proposal for a mechanism in the development of diabetic vascular complication
    • Lee TS, Saltsman KA, Ohashi H, King GL. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complication. Proc Natl Acad Sci USA 86: 5141-5145, 1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5141-5145
    • Lee, T.S.1    Saltsman, K.A.2    Ohashi, H.3    King, G.L.4
  • 32
    • 0031739899 scopus 로고    scopus 로고
    • Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria
    • Lou J, Gasche Y, Zheng L, Critico B, Monso-Hinard C, Juillard P, Morel P, Buurman WA, Grau GE. Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria. Eur J Immunol 28: 3989-4000, 1998.
    • (1998) Eur J Immunol , vol.28 , pp. 3989-4000
    • Lou, J.1    Gasche, Y.2    Zheng, L.3    Critico, B.4    Monso-Hinard, C.5    Juillard, P.6    Morel, P.7    Buurman, W.A.8    Grau, G.E.9
  • 33
    • 4143102452 scopus 로고    scopus 로고
    • Diabetesrelated changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery
    • Matsumoto T, Wakabayashi K, Kobayashi T, Kamata K. Diabetesrelated changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery. Am J Physiol Heart Circ Physiol 287: H1064-H1071, 2004.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Matsumoto, T.1    Wakabayashi, K.2    Kobayashi, T.3    Kamata, K.4
  • 34
    • 67651099018 scopus 로고    scopus 로고
    • Inhibition of protein kinase C in diabetic nephropathy-where do we stand?
    • Menne J, Meier M, Park JK, Haller H. Inhibition of protein kinase C in diabetic nephropathy-where do we stand? Nephrol Dial Transplant 24: 2021-2023, 2009.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2021-2023
    • Menne, J.1    Meier, M.2    Park, J.K.3    Haller, H.4
  • 35
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 22: 8467-8477, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 8467-8477
    • Ming, X.F.1    Viswambharan, H.2    Barandier, C.3    Ruffieux, J.4    Kaibuchi, K.5    Rusconi, S.6    Yang, Z.7
  • 38
    • 77953959949 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 prevents reactive oxygen speciesinduced endothelial cell senescence through the activation of protein kinase A
    • Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Silljé HH. Glucagon-like peptide 1 prevents reactive oxygen speciesinduced endothelial cell senescence through the activation of protein kinase A. Arterioscler Thromb Vasc Biol 30: 1407-1414, 2010.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1407-1414
    • Oeseburg, H.1    de Boer, R.A.2    Buikema, H.3    van der Harst, P.4    van Gilst, W.H.5    Silljé, H.H.6
  • 40
    • 33748310586 scopus 로고    scopus 로고
    • Adiponectin suppression of highglucose- induced reactive oxygen species in vascular endothelial cells: Evidence for involvement of a cAMP signaling pathway
    • Ouedraogo R, Wu X, Xu SQ, Fuchsel L, Motoshima H, Mahadev K, Hough K, Scalia R, Goldstein BJ. Adiponectin suppression of highglucose- induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. Diabetes 55: 1840-1846, 2006.
    • (2006) Diabetes , vol.55 , pp. 1840-1846
    • Ouedraogo, R.1    Wu, X.2    Xu, S.Q.3    Fuchsel, L.4    Motoshima, H.5    Mahadev, K.6    Hough, K.7    Scalia, R.8    Goldstein, B.J.9
  • 41
    • 0023898903 scopus 로고
    • Differential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3=,5=-monophosphate (cAMP)-dependent protein kinase by cAMP in rat sertoli cells
    • Oyen O, Sandberg M, Eskild W, Levy FO, Knutsen G, Beebe S, Hansson V, Jahnsen T. Differential regulation of messenger ribonucleic acids for specific subunits of cyclic adenosine 3=,5=-monophosphate (cAMP)-dependent protein kinase by cAMP in rat sertoli cells. Endocrinology 122: 2658-2666, 1988.
    • (1988) Endocrinology , vol.122 , pp. 2658-2666
    • Oyen, O.1    Sandberg, M.2    Eskild, W.3    Levy, F.O.4    Knutsen, G.5    Beebe, S.6    Hansson, V.7    Jahnsen, T.8
  • 42
    • 33645810797 scopus 로고    scopus 로고
    • Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: A role for protein kinase C and prevention by protein kinase A
    • Pérez LM, Milkiewicz P, Elias E, Coleman R, Sánchez Pozzi EJ, Roma MG. Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Toxicol Sci 91: 150-158, 2006.
    • (2006) Toxicol Sci , vol.91 , pp. 150-158
    • Pérez, L.M.1    Milkiewicz, P.2    Elias, E.3    Coleman, R.4    Sánchez Pozzi, E.J.5    Roma, M.G.6
  • 43
    • 33646566824 scopus 로고    scopus 로고
    • Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2-dependent, PKC-mediated mechanism: Protective effect of PKA
    • Pérez LM, Milkiewicz P, Ahmed-Choudhury J, Elias E, Ochoa JE, Sánchez Pozzi EJ, Coleman R, Roma MG. Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2-dependent, PKC-mediated mechanism: protective effect of PKA. Free Radic Biol Med 40: 2005-2017, 2006.
    • (2006) Free Radic Biol Med , vol.40 , pp. 2005-2017
    • Pérez, L.M.1    Milkiewicz, P.2    Ahmed-Choudhury, J.3    Elias, E.4    Ochoa, J.E.5    Sánchez Pozzi, E.J.6    Coleman, R.7    Roma, M.G.8
  • 44
    • 14644419622 scopus 로고    scopus 로고
    • Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance
    • Rask-Madsen C, King GL. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol 25: 487-496, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 487-496
    • Rask-Madsen, C.1    King, G.L.2
  • 46
    • 0024439172 scopus 로고
    • Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C
    • Scheurich P, Köbrich G, Pfizenmaier K. Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C. J Exp Med 170: 947-958, 1989.
    • (1989) J Exp Med , vol.170 , pp. 947-958
    • Scheurich, P.1    Köbrich, G.2    Pfizenmaier, K.3
  • 47
    • 33749078023 scopus 로고    scopus 로고
    • Activation of protein kinase A improves vascular endothelial dysfunction
    • Shah DI, Singh M. Activation of protein kinase A improves vascular endothelial dysfunction. Endothelium 13: 267-277, 2006.
    • (2006) Endothelium , vol.13 , pp. 267-277
    • Shah, D.I.1    Singh, M.2
  • 52
    • 51049092142 scopus 로고    scopus 로고
    • Oxidative stress mediates protein kinase C activation and advanced glycation end product formation in a mesangial cell model of diabetes and high protein diet
    • Tuttle KR, Anderberg RJ, Cooney SK, Meek RL. Oxidative stress mediates protein kinase C activation and advanced glycation end product formation in a mesangial cell model of diabetes and high protein diet. Am J Nephrol 29: 171-180, 2008.
    • (2008) Am J Nephrol , vol.29 , pp. 171-180
    • Tuttle, K.R.1    Anderberg, R.J.2    Cooney, S.K.3    Meek, R.L.4
  • 53
    • 77949394652 scopus 로고    scopus 로고
    • Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: Vascular changes or neurodegeneration?
    • Umegaki H. Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration? Age Ageing 39: 8-10, 2010.
    • (2010) Age Ageing , vol.39 , pp. 8-10
    • Umegaki, H.1
  • 54
    • 0023525917 scopus 로고
    • Down regulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase c activators
    • Unglaub R, Maxeiner B, Thoma B, Pfizenmaier K, Scheurich P. Down regulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase c activators. J Exp Med 166: 1788-1797, 1987.
    • (1987) J Exp Med , vol.166 , pp. 1788-1797
    • Unglaub, R.1    Maxeiner, B.2    Thoma, B.3    Pfizenmaier, K.4    Scheurich, P.5
  • 55
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • Way KJ, Katai N, King GL. Protein kinase C and the development of diabetic vascular complications. Diabet Med 18: 945-59, 2001.
    • (2001) Diabet Med , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 57
    • 26844519964 scopus 로고    scopus 로고
    • Diabetes causes inhibition of glucose- 6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex
    • Xu Y, Osborne BW, Stanton RC. Diabetes causes inhibition of glucose- 6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am J Physiol Renal Physiol 289: F1040-F1047, 2005.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Xu, Y.1    Osborne, B.W.2    Stanton, R.C.3
  • 58
    • 0037341594 scopus 로고    scopus 로고
    • Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition
    • Yamakawa H, Jezova M, Ando H, Saavedra JM. Normalization of endothelial and inducible nitric oxide synthase expression in brain microvessels of spontaneously hypertensive rats by angiotensin II AT1 receptor inhibition. J Cereb Blood Flow Metab 23: 371-380, 2003.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 371-380
    • Yamakawa, H.1    Jezova, M.2    Ando, H.3    Saavedra, J.M.4
  • 59
    • 42449109476 scopus 로고    scopus 로고
    • Mechanisms of disease: Advanced glycation end-products and their receptor in inflammation and diabetes complications
    • Yan SF, Ramasamy R, Schmidt AM. Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 4: 285-293, 2008.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 285-293
    • Yan, S.F.1    Ramasamy, R.2    Schmidt, A.M.3
  • 60
    • 4544299661 scopus 로고    scopus 로고
    • Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13)
    • Yang S, Fransson U, Fagerhus L, Holst LS, Hohmeier HE, Renstrom E, Mulder H. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol 18: 2312-2320, 2004.
    • (2004) Mol Endocrinol , vol.18 , pp. 2312-2320
    • Yang, S.1    Fransson, U.2    Fagerhus, L.3    Holst, L.S.4    Hohmeier, H.E.5    Renstrom, E.6    Mulder, H.7
  • 61
    • 0037343260 scopus 로고    scopus 로고
    • Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes
    • Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes 52: 829-837, 2003.
    • (2003) Diabetes , vol.52 , pp. 829-837
    • Yokota, T.1    Ma, R.C.2    Park, J.Y.3    Isshiki, K.4    Sotiropoulos, K.B.5    Rauniyar, R.K.6    Bornfeldt, K.E.7    King, G.L.8
  • 62
    • 0042344708 scopus 로고    scopus 로고
    • Protein kinase signaling in the modulation of microvascular permeability
    • Yuan SY. Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol 39: 213-23, 2002.
    • (2002) Vascul Pharmacol , vol.39 , pp. 213-223
    • Yuan, S.Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.