Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+-dependent, PKC-mediated mechanism: Protective effect of PKA

Free Radical Biology and Medicine

Volumn 40, Issue 11, 2006, Pages 2005-2017

  Pérez, Leonardo M ^a   Milkiewicz, Piotr ^b,c   Ahmed Choudhury, Jalal ^b,c   Elias, Elwyn ^c   Ochoa, Justina E ^a   Sánchez Pozzi, Enrique J ^a   Coleman, Roger ^c   Roma, Marcelo G ^a  

^a Universidad Nacional de Río Cuarto Consejo Nacional de Investigaciones Científicas y Técnicas   (Argentina)

^b POMERANIAN MEDICAL UNIVERSITY   (Poland)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adenosine 3 :5 cyclic monophosphate; Ca2+ dependent PKCs; F actin; Fluorescent bile salt analogue; Free radicals; PKA; Signaling; tert Butylhydroperoxide; Tight junctional permeability

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ALPHA ACTIN; BUCLADESINE; CALCIUM ION; CHOLYLLYSYLFLUORESCEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DICHLOROFLUORESCEIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; F ACTIN; FLUORESCEIN DERIVATIVE; KT 5720; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN ZO1; REACTIVE OXYGEN METABOLITE; STAUROSPORINE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL MEMBRANE; CELL PROTECTION; CELL VACUOLE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; INTRACELLULAR SPACE; LIPID PEROXIDATION; LIVER CELL; MALE; MEMBRANE TRANSPORT; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; TIGHT JUNCTION;

EID: 33646566824     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.01.034     Document Type: Article

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