Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+-dependent, PKC-mediated mechanism: Protective effect of PKA

Free Radical Biology and Medicine

Volumn 40, Issue 11, 2006, Pages 2005-2017

  Pérez, Leonardo M ^a   Milkiewicz, Piotr ^b,c   Ahmed Choudhury, Jalal ^b,c   Elias, Elwyn ^c   Ochoa, Justina E ^a   Sánchez Pozzi, Enrique J ^a   Coleman, Roger ^c   Roma, Marcelo G ^a  

^a CONICET University of Rosario ^*  (Argentina)

^b POMERANIAN MEDICAL UNIVERSITY   (Poland)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Adenosine 3 :5 cyclic monophosphate; Ca2+ dependent PKCs; F actin; Fluorescent bile salt analogue; Free radicals; PKA; Signaling; tert Butylhydroperoxide; Tight junctional permeability

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ALPHA ACTIN; BUCLADESINE; CALCIUM ION; CHOLYLLYSYLFLUORESCEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DICHLOROFLUORESCEIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; F ACTIN; FLUORESCEIN DERIVATIVE; KT 5720; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN ZO1; REACTIVE OXYGEN METABOLITE; STAUROSPORINE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CELL MEMBRANE; CELL PROTECTION; CELL VACUOLE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; INTRACELLULAR SPACE; LIPID PEROXIDATION; LIVER CELL; MALE; MEMBRANE TRANSPORT; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; TIGHT JUNCTION;

EID: 33646566824     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.01.034     Document Type: Article

References (55)

1. Poli G., Albano E., and Dianzani M.U. The role of lipid peroxidation in liver damage. Chem. Phys. Lipids 45 (1987) 117-142
2. Di Monte D., Ross D., Bellomo G., Eklow L., and Orrenius S. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch. Biochem. Biophys. 235 (1984) 334-342
3. Poli G. Liver damage due to free radicals. Br. Med. Bull. 49 (1993) 604-620
4. Berson A., De B.V., Letteron P., Robin M.A., Moreau C., El Kahwaji J., Verthier N., Feldmann G., Fromenty B., and Pessayre D. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology 114 (1998) 764-774
5. Bacon B.R., and Britton R.S. The pathology of hepatic iron overload: a free radical-mediated process?. Hepatology 11 (1990) 127-137
6. Ahmed-Choudhury J., Orsler D.J., and Coleman R. Hepatobiliary effects of tertiary-butylhydroperoxide (tBOOH) in isolated rat hepatocyte couplets. Toxicol. Appl. Pharmacol. 152 (1998) 270-275
7. 2+ homeostasis on hepatocyte canalicular function in vitro. Biochem. Pharmacol. 47 (1994) 625-632
8. Lemasters J.J., Qian T., Bradham C.A., Brenner D.A., Cascio W.E., Trost L.C., Nishimura Y., Nieminen A.L., and Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J. Bioenerg. Biomembr. 31 (1999) 305-319
9. Orrenius S., Burkitt M.J., Kass G.E., Dypbukt J.M., and Nicotera P. Calcium ions and oxidative cell injury. Ann. Neurol. 32 (1992) S33-S42 (Suppl.)
10. Nishizuka Y. Studies and perspectives of protein kinase C. Science 233 (1986) 305-312
11. Wilton J.C., Coleman R., Lankester D.J., and Chipman J.K. Stability and optimization of canalicular function in hepatocyte couplets. Cell. Biochem. Funct. 11 (1993) 179-185
12. Wilton J.C., Williams D.E., Strain A.J., Parslow R.A., Chipman J.K., and Coleman R. Purification of hepatocyte couplets by centrifugal elutriation. Hepatology 14 (1991) 180-183
13. Baur H., Kasperek S., and Pfaff E. Criteria of viability of isolated liver cells. Hoppe Seylers Z. Physiol. Chem. 356 (1975) 827-838
14. Lyman G.E., and DeVincenzo J.P. Determination of picogram amounts of ATP using the luciferin-luciferase enzyme system. Anal. Biochem. 21 (1967) 435-443
15. Cathcart R., Schwiers E., and Ames B.N. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem. 134 (1983) 111-116
16. Buege J.A., and Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 52 (1978) 302-310
17. Borgognone M., Perez L.M., Basiglio C.L., Ochoa J.E., and Roma M.G. Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes. Toxicol. Sci. 83 (2005) 114-125
18. Lowry O.H., Rosembrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
19. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27 (1969) 502-522
20. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106 (1980) 207-212
21. Newton A.C. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. 101 (2001) 2353-2364
22. Carreras F.I., Gradilone S.A., Mazzone A., Garcia F., Huang B.Q., Ochoa J.E., Tietz P.S., LaRusso N.F., Calamita G., and Marinelli R.A. Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. Hepatology 37 (2003) 1026-1033
23. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 (1985) 3440-3450
24. Roma M.G., Orsler D.J., and Coleman R. Canalicular retention as a marker of tight junctional permeability in isolated hepatocyte couplets: effects of protein kinase modulation and cholestatic agents. Fundam. Appl. Toxicol. 37 (1997) 71-81
25. Wilton J.C., Matthews G.M., Burgoyne R.D., Mills C.O., Chipman J.K., and Coleman R. Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II. J. Cell Biol. 127 (1994) 401-410
26. Roma M.G., Stone V., Shaw R., and Coleman R. Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C. Hepatology 28 (1998) 1031-1041
27. Gores G.J., Herman B., and Lemasters J.J. Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury. Hepatology 11 (1990) 690-698
28. 2+ is mediated by the activation of a non-lysosomal proteolytic system. FEBS Lett. 209 (1986) 139-144
29. Houslay M.D. 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. Eur. J. Biochem. 195 (1991) 9-27
30. Yoshimasa T., Sibley D.R., Bouvier M., Lefkowitz R.J., and Caron M.G. Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. Nature 327 (1987) 67-70
31. Lemasters J.J., and Nieminen A.L. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. Biosci. Rep. 17 (1997) 281-291
32. Dickinson D.A., and Forman H.J. Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 64 (2002) 1019-1026
33. Ballatori N., and Truong A.T. Altered hepatic junctional permeability, bile acid excretion and glutathione efflux during oxidant challenge. J. Pharmacol. Exp. Ther. 251 (1989) 1069-1075
34. Kan K.S., and Coleman R. Menadione increases hepatic tight-junctional permeability: its effect can be decreased by butylated hydroxytoluene and verapamil. Biochem. J. 270 (1990) 241-243
35. Boyer J.L. Tight junctions in normal and cholestatic liver: does the paracellular pathway have functional significance?. Hepatology 3 (1983) 614-617
36. Elias E., Hruban Z., Wade J.B., and Boyer J.L. Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability. Proc. Natl. Acad. Sci. USA 77 (1980) 2229-2233
37. 4-induced oxidative stress. Biochem. Biophys. Res. Commun. 194 (1993) 635-641
38. Kass G.E., Duddy S.K., and Orrenius S. Activation of hepatocyte protein kinase C by redox-cycling quinones. Biochem. J. 260 (1989) 499-507
39. Keenan C., and Kelleher D. Protein kinase C and the cytoskeleton. Cell Signalling 10 (1998) 225-232
40. Romanelli A., and van de Werve G. Activation of mitogen-activated protein kinase in freshly isolated rat hepatocytes by both a calcium- and a protein kinase C-dependent pathway. Metabolism 46 (1997) 548-555
41. Webster C.R., and Anwer M.S. Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology 27 (1998) 1324-1331
42. Kim R.D., Stein G.S., and Chari R.S. Impact of cell swelling on proliferative signal transduction in the liver. J. Cell. Biochem. 83 (2001) 56-69
43. Kubitz R., Huth C., Schmitt M., Horbach A., Kullak-Ublick G., and Haussinger D. Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34 (2001) 340-350
44. Farshori P., and Kachar B. Redistribution and phosphorylation of occludin during opening and resealing of tight junctions in cultured epithelial cells. J. Membr. Biol. 170 (1999) 147-156
45. Turner J.R., Angle J.M., Black E.D., Joyal J.L., Sacks D.B., and Madara J.L. PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase. Am. J. Physiol. 277 (1999) C554-C562
46. Yamaguchi Y., Dalle-Molle E., and Hardison W.G. Vasopressin and A23187 stimulate phosphorylation of myosin light chain-1 in isolated rat hepatocytes. Am. J. Physiol. 261 (1991) G312-G319
47. Davies M.J. Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions. Biochem. J. 257 (1989) 603-606
48. O'Donnell V., and Burkitt M.J. Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: an electron spin resonance spin-trapping investigation. Biochem. J. 304 Pt. 3 (1994) 707-713
49. Frei B., Winterhalter K.H., and Richter C. Menadione- (2-methyl-1,4-naphthoquinone-) dependent enzymatic redox cycling and calcium release by mitochondria. Biochemistry 25 (1986) 4438-4443
50. Kasai S., Kakisaka A., Kudo K., and Mito M. Protective effects of dibutyryl cyclic AMP on acute hepatic failure in rats. J. Surg. Res. 66 (1996) 75-80
51. Ben Shaul V., Sofer Y., Bergman M., Zurovsky Y., and Grossman S. Lipopolysaccharide-induced oxidative stress in the liver: comparison between rat and rabbit. Shock 12 (1999) 288-293
52. Wen Y., Anwer K., Singh S.P., and Sanborn B.M. Protein kinase-A inhibits phospholipase-C activity and alters protein phosphorylation in rat myometrial plasma membranes. Endocrinology 131 (1992) 1377-1382
53. Liebmann C. Regulation of MAP kinase activity by peptide receptor Signalling pathway: paradigms of multiplicity. Cell Signalling 13 (2001) 777-785
54. Patel T., and Gores G.J. Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E. Toxicol. Appl. Pharmacol. 142 (1997) 116-122
55. Roma M.G., Milkiewicz P., Elias E., and Coleman R. Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: role of the cytoskeleton. Hepatology 32 (2000) 1342-1356