Hyperinsulinaemia increases the gene expression of endothelial nitric oxide synthase and the phosphatidylinositol 3-kinase/Akt pathway in rat aorta

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 5-6, 2006, Pages 440-447

  Toba, Hiroe ^a   Gomyo, Eriko ^a   Miki, Shunsuke ^a   Shimizu, Takahiro ^a   Yoshimura, Akiko ^a   Inoue, Riyako ^a   Sawai, Naoki ^a   Tsukamoto, Rie ^a   Asayama, Jun ^b   Kobara, Miyuki ^a   Nakata, Tetsuo ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b Higashi ohmi General Medical Center   (Japan)

Author keywords

Aorta; Endothelial nitric oxide synthase; Hyperinsulinaemia; Insulin like growth factor I receptor; Phosphatidylinositol 3 kinase Akt; Vascular endothelial growth factor

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; URETHAN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION; VASCULAR TISSUE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33745202623     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04385.x     Document Type: Article

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