Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

Journal of Molecular Biology

Volumn 415, Issue 1, 2012, Pages 175-192

  Azoitei, Mihai L ^a   Ban, Yih En Andrew ^a,g   Julien, Jean Philippe ^b,f   Bryson, Steve ^b,c   Schroeter, Alexandria ^a   Kalyuzhniy, Oleksandr ^a   Porter, Justin R ^a,d   Adachi, Yumiko ^a   Baker, David ^a   Pai, Emil F ^b,c,e   Schief, William R ^a,f  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

^g Arzeda Corporation   (United States)

Author keywords

epitope scaffold; flexible backbone design; immunogen design; protein grafting

Indexed keywords

CYSTEINE; EPITOPE; MONOCLONAL ANTIBODY 2F5; SCAFFOLD PROTEIN;

AMINO ACID SEQUENCE; ANTIGEN ANTIBODY REACTION; ARTICLE; BINDING AFFINITY; BIOLOGY; BIOPHYSICS; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIMERIZATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 84855258847     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.10.003     Document Type: Article

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