The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 467-479

  Chen, Yue Lei ^a   Tang, Jing ^a   Kesler, Matthew J ^a   Sham, Yuk Y ^a   Vince, Robert ^a   Geraghty, Robert J ^a   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

2 Hydroxyisoquinoline 1,3 dione; Hepatitis C virus (HCV); NS5B polymerase

Indexed keywords

2 (2 METHOXY 2 OXOETHYL) 4 NITROBENZOIC ACID; 2 (CARBOXYMETHYL) 4 (5 METHYLFURAN 2 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (DIBENZO[B,D]FURAN 4 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (DIBENZO[B,D]THIOPHEN 4 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (FURAN 2 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (FURAN 3 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (THIOPHEN 2 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 (THIOPHEN 3 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 4 IODOBENZOIC ACID; 2 (CARBOXYMETHYL) 4 NITROBENZOIC ACID; 2 (CARBOXYMETHYL) 5 (FURAN 2 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 5 (THIOPHEN 2 YL)BENZOIC ACID; 2 (CARBOXYMETHYL) 5 IODOBENZOIC ACID; 2 HYDROXYISOQUINOLINE 1,3 DIONE DERIVATIVE; 3 (CARBOXYMETHYL) 3' (PHENYL)BIPHENYL 4 CARBOXYLIC ACID; 3 (CARBOXYMETHYL) 3',4' DIFLUOROBIPHENYL 4 CARBOXYLIC ACID; 3 (CARBOXYMETHYL) 4' (TRIFLUOROMETHYL)BIPHENYL 4 CARBOXYLIC ACID; 3 (CARBOXYMETHYL) 4' FLUOROBIPHENYL 4 CARBOXYLIC ACID; 4 (BENZO[B]THIOPHEN 3 YL) 2 (CARBOXYMETHYL)BENZOIC ACID; 4 (BENZO[D][1,3]DIOXOL 5 YL) 2 (CARBOXYMETHYL)BENZOIC ACID; 4 (BENZOFURAN 2 YL) 2 (CARBOXYMETHYL)BENZOIC ACID; 4 (CARBOXYMETHYL) 3' CHLORO 4' FLUOROBIPHENYL 3 CARBOXYLIC ACID; 4 (CARBOXYMETHYL) 3' METHOXYBIPHENYL 3 CARBOXYLIC ACID; 4 (CARBOXYMETHYL) 3',4' DIFLUOROBIPHENYL 3 CARBOXYLIC ACID; 4 AMINO 2 (CARBOXYMETHYL)BENZOIC ACID; 5 (BENZOFURAN 2 YL) 2 (CARBOXYMETHYL)BENZOIC ACID; 7 (FURAN 2 YL) 2 HYDROXYISOQUINOLINE 1,3 DIONE; ANTIVIRUS AGENT; RIBAVIRIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYCLIZATION; DEPROTECTION REACTION; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; REPLICON; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION; VIRUS INHIBITION;

ANTIVIRAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CYCLIZATION; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; ISOQUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84855186442     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.058     Document Type: Article

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