2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 535-546

  Billamboz, Muriel ^a   Bailly, Fabrice ^a   Lion, Cédric ^a   Calmels, Christina ^b   Andréola, Marie Line ^b   Witvrouw, Myriam ^c   Christ, Frauke ^c   Debyser, Zeger ^c   De Luca, Laura ^d   Chimirri, Alba ^d   Cotelle, Philippe ^a  

^a UNIV LILLE   (France)

^b University Victor Segalen   (France)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF MESSINA   (Italy)

Author keywords

2 Hydroxyisoquinoline 1,3(2H,4H) dione; Antiretroviral; Integrase; Magnesium complexation; Ribonuclease H

Indexed keywords

2 HYDROXYISOQUINOLINE 1,3 (2H,4H)DIONE; ANTIVIRUS AGENT; INTEGRASE; MAGNESIUM DERIVATIVE; RIBONUCLEASE H; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; COMPLEX FORMATION; CYTOTOXICITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHYSICOCHEMICAL MODEL; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ALKYLATION; CRYSTALLOGRAPHY, X-RAY; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151473568     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.033     Document Type: Article

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