Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1854-1865

  Bogen, Stéphane L ^a   Arasappan, Ashok ^a   Velazquez, Francisco ^a   Blackman, Melissa ^a   Huelgas, Regina ^a   Pan, Weidong ^a   Siegel, Elise ^a   Nair, Latha G ^a   Venkatraman, Srikanth ^a   Guo, Zhuyan ^a   Doll, Ronald ^a   Shih, Neng Yang ^a   George Njoroge, F ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Boceprevir; HCV; Ketoamide; Sulfonamide

Indexed keywords

AMIDE; GENOMIC RNA; KETOAMIDE; NONSTRUCTURAL PROTEIN 3; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; VIRUS RNA;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; RNA REPLICATION;

AMIDES; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; COMPUTER SIMULATION; DOGS; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI PROTEINS; HAPLORHINI; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; RATS; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; UREA; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

CANIS FAMILIARIS; HEPATITIS C VIRUS; RATTUS; RNA VIRUSES;

EID: 77249109262     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.044     Document Type: Article

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